IL-2 restores immune sytem. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

IL-2 restores immune sytem. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Posit Aware. 1995 May/Jun;:8. Unique Identifier : AIDSLINE AIDS/95700401
Grodeck B

Abstract: Researchers at the National Institute of Allergy and Infectious Diseases (NIAID) found that intermittent infusions of IL-2, an immune system protein, boosted T-cells in some patients with HIV for more than two years--far longer than any current antiretroviral. NIAID studied the effects of intravenous IL-2 in combination with AZT or ddI in 25 people with HIV or AIDS. Of the ten patients with T-cell counts greater than 200 who started the study, six had increases of more than fifty percent after one year. Alternately, of the fifteen patients who started the study with T-cell counts fewer than 200, only two patients showed a fifty percent increase in cell counts. Side effects were considerably more pronounced in the remaining thirteen participants in that group, and no significant increases in T-cell counts were observed. IL-2 is a naturally occurring substance produced by the body. However, NIAID used recombinant DNA technology produced by Chiron Corporation in Emeryville, California for its studies. Several IL-2 clinical trials are currently enrolling.

Keywords: Clinical Trials CD4 Lymphocyte Count Didanosine/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Drug Therapy, Combination Human HIV Infections/DRUG THERAPY/IMMUNOLOGY/*THERAPY Interleukin-2/ADVERSE EFFECTS/*THERAPEUTIC USE Zidovudine/ADMINISTRATION & DOSAGE/THERAPEUTIC USE NEWSLETTER ARTICLE
951230
M95C3194

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