Report: immune restoration think tank. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Report: immune restoration think tank. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

PI Perspect. 1995 May;(no 16):5-7. Unique Identifier : AIDSLINE AIDS/95700458
Lein B

Abstract: The Immune Restoration Think Tank's fourth meeting, held in February 1995 in Oakland, California, discussed recent progress in the field of immune restoration and new strategies to rebuild the immune systems of people with advanced AIDS. Discussions about where to intervene with immune strategies generally fell into the following four areas: the environment where immune cells originate and mature, the number of immune cells necessary to battle HIV and opportunistic infections, the protection of existing and new immune cells against infection and destruction by HIV, and the function and repertoire of existing and new cells necessary to respond to a spectrum of bacteria, fungi, and virus. Specific topics covered such areas as thymic transplantation and microbiology, bone marrow-derived stem cells, xenogeneic tissue transplantation, cell expansion and transfer, and cytokines. One therapeutic goal involves a combination of thymus transplantation, genetically manipulated stem cell treatment, and combination antiviral therapy, possibly including therapy with IL-2 to help cells thrive. This approach addresses all four immune strategies simultaneously.

Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/THERAPY Cell Transplantation CD4 Lymphocyte Count CD4-Positive T-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY Hematopoietic Stem Cells/*IMMUNOLOGY Human Immunotherapy, Adoptive Interleukin-2/THERAPEUTIC USE Thymus Gland/*IMMUNOLOGY Transplantation, Homologous NEWSLETTER ARTICLE
951230
M95C3176

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