Sequence analysis of the gag and env genes of HIV-1 in children from Romania. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Sequence analysis of the gag and env genes of HIV-1 in children from Romania.

Natl Conf Hum Retroviruses Relat Infect (2nd). 1995 Jan 29-Feb 2;:115. Unique Identifier : AIDSLINE AIDS/95920358
Bandea CI; Pascu R; Baldwin A; Lobont V; Wright A; Luo CC; Rapier J; Schochetman G; Kalish ML; Centers for Disease Control and Prevention, Atlanta, GA.

Abstract: We have previously identified and HIV-1 envelope subtype called F in cultured viral isolates recovered from infected children in southeastern Romania. Here we report the genetic analysis of HIV-1 env and gag genes amplified directly from the peripheral blood mononuclear cells of 11 children hospitalized in a clinic in north-central Romania. Direct sequencing of the C2-V3 env and p17 gag regions yielded 321 and 333 nucleotides, respectively. Pair-wise comparisons within the env and gag nucleotide sequences showed a low range of divergence: 1.87% to 6.23% (mean of 3.61%) in the env region and 0.30% to 3.6% (mean of 1.61%) in the gag region. Phylogenetic analysis clustered these HIV-1 strains with previously identified romanian subtype F viruses. The prevalence of highly related HIV-1 strains infecting children in different geographic regions of Romania suggests that the pediatric HIV-1 epidemic in this country originated from a common source.
Keywords: Acquired Immunodeficiency Syndrome/EPIDEMIOLOGY Base Sequence Child Disease Outbreaks Gene Amplification Genes, env/*GENETICS Genes, gag/*GENETICS HIV-1/*GENETICS Nucleotide Mapping Romania/EPIDEMIOLOGY Species Specificity ABSTRACTKWDacquiredimmunodeficiencysyndrome/epidemiologybasesequencechilddiseaseoutbreaksgeneamplificationgenes,env/KWDgeneticsgenes,gag/KWDgeneticshiv-1/KWDgeneticsnucleotidemappingromania/epidemiologyspeciesspecificityabstract
951230
M95C2781

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