Radiation therapy without biopsy of AIDS-related central nervous system lymphomas (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Radiation therapy without biopsy of AIDS-related central nervous system lymphomas (Meeting abstract).

International Congress of Radiation Oncology 1993. June 21-25, 1993, Kyoto, Japan, p. 309, 1993.. Unique Identifier : AIDSLINE ICDB/95606040
Nisce LZ; Kaufmann T; Metroka C; Dept. of Radiation Oncology, New York Hosp.-Cornell Medical; Center

Abstract: The purpose of this presentation is to evaluate the role of radiation therapy in the management of lymphomas (NHL) of the CNS in the acquired immune deficiency syndrome (AIDS). Between 1986 and 1992, 18 patients, with AIDS-related CNS NHL, were seen at the New York Hospital-Cornell Medical Center. All patients were symptomatic and had neurologic deficits, with no histologic confirmation; however, magnetic resonance imaging (MRI) of the brain was highly suspicious of NHL, and other causes of HIV encephalopathy were ruled out. The patients received whole brain radiation therapy (XRT) to a total dose of 3000-3600 cGy in 3-4 weeks. Rapid tumor response to XRT was interpreted as highly confirmatory of NHL and the patients then received a 'boost' dose of 400 to 600 cGy in about a week. Significant response was obtained in 13/18 (72.2%), with a mean survival of 5.2 months (range 1-15). None of the responders had recurrence of their pre-XRT neurologic symptoms. None of the patients had to interrupt their antiretroviral therapy. In conclusion, XRT, although unlikely to produce a major impact on survival, can markedly improve the quality of life with no significant attendant morbidity.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Biopsy Central Nervous System Neoplasms/COMPLICATIONS/PATHOLOGY/ *RADIOTHERAPY Human Lymphoma/COMPLICATIONS/PATHOLOGY/*RADIOTHERAPY Magnetic Resonance Imaging Radiotherapy Dosage ABSTRACTKWDacquiredimmunodeficiencysyndrome/KWDcomplicationsbiopsycentralnervoussystemneoplasms/complications/pathology/KWDradiotherapyhumanlymphoma/complications/pathology/KWDradiotherapymagneticresonanceimagingradiotherapydosageabstract
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