Salk's HIV immunogen: an immune-based therapy in human trials since 1988. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Salk's HIV immunogen: an immune-based therapy in human trials since 1988. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Crit Path AIDS Proj. 1994-95 Winter;(No 30):1, 20-3. Unique Identifier : AIDSLINE AIDS/95700001

Abstract: Jonas Salk, the developer of the first polio vaccine, has created a therapeutic vaccine for HIV which helps the immune system fight disease progression. Salk uses inactivated HIV-1 virus combined with Incomplete Freund's Adjuvant (IFA) in the vaccine preparation. The resulting HIV-1 immunogen was first studied in 1987, and since then, 235 seropositive individuals have received inoculations without serious adverse effects. Data from the first 25 subjects indicate that immunization with the HIV-1 immunogen results in improvement of cell-mediated response against the virus, a slower increase in the amount of virus present, and a reduced rate of clinical progression. Subsequent studies also show that higher doses of immunogen may produce stronger cell-mediated responses and high HIV-DTH (delayed-type hypersensitivity responsiveness immunogen) is associated with better outcome. Additional trials of HIV-1 immunogen are awaiting Food and Drug Administration approval.

Keywords: AIDS Vaccines/*ADMINISTRATION & DOSAGE/THERAPEUTIC USE Drug Approval Human Hypersensitivity, Delayed HIV Infections/*THERAPY HIV-1/*IMMUNOLOGY Immunity, Cellular *Immunotherapy, Active Vaccines, Inactivated/ADMINISTRATION & DOSAGE/THERAPEUTIC USE NEWSLETTER ARTICLE
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