AZT studies reinforce benefits of combination. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

AZT studies reinforce benefits of combination. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

AIDS Alert. 1995 Jan;10(1):11-2. Unique Identifier : AIDSLINE AIDS/95700027

Abstract: A new anti-HIV drug, 3TC, taken with AZT is yielding exciting results. An analysis of 6,000 subjects followed for 4 years indicated that patients taking AZT in combination with ddC or ddI survived longer than those who switched to ddC or ddI alone. Data also showed that CD4 counts were the most significant marker for predicting survival, favoring early treatment. Three studies of patients taking AZT and 3TC show that the two antiretrovirals may have a synergistic effect that may increase benefits even more than other drug combinations. The data on the AZT-3TC combination demonstrate increased maintenance of CD4 cell counts, reduced levels of HIV, and continued viral suppression.

Keywords: Antiviral Agents/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE *CD4-Positive T-Lymphocytes Didanosine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE Drug Synergism Drug Therapy, Combination Human HIV Infections/BLOOD/*DRUG THERAPY Lymphocyte Count Zalcitabine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE Zidovudine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE NEWSLETTER ARTICLE REVIEW
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