Dietary carotenoids, cigarette smoking and Kaposi's sarcoma in the San Francisco Men's Health Study. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Dietary carotenoids, cigarette smoking and Kaposi's sarcoma in the San Francisco Men's Health Study.

Diss Abstr Int [B]; 53(9):4596 1993. Unique Identifier : AIDSLINE ICDB/94690808
Duncan DM; Univ. of California, Berkeley

Abstract: This study utilized data from the San Francisco Men's Health Study (SFMHS) to explore the relationship between dietary intake and subsequent development of Kaposi's sarcoma (KS) in a cohort of men at high risk for acquired immunodeficiency syndrome (AIDS). The SFMHS is a prospective study observing the natural history of AIDS conducted on a probability sample of over 1000 men aged 25 to 54 yr, who resided in the census tracts of San Francisco with the highest cumulative incidence of AIDS through December 1983. In 1984, dietary information was obtained during the first cycle of data collection, using the Health Habits and History Questionnaire (HHHQ), a food frequency questionnaire developed by the National Cancer Institute (NCI). Univariate analysis revealed a statistically significant relationship between energy-adjusted tertiles of carotenoid intake and KS development, with the lowest tertile of intake increasing the risk of KS, relative risk (RR) = 2.91. After adjusting for covariates that remained significant in multiple logistic regression analysis (college education, cigarette smoking and poor health at study baseline), the risk of KS appeared to be highly inversely associated with carotenoid intake (odds ratio for lowest tertile = 4.06, 95% confidence interval (Cl) 1.39-11.89, odds ratio for middle tertile = 3.01, 95% Cl 1.03-8.85, test for trend p-value = 0.02, and Likelihood Ratio Test chi square = 7.80, p-value = 0.020). No other nutrient was significantly associated with KS development in multivariate analysis. Stratification by smoking status showed the relationship between a low carotenoid intake and an increased risk of KS to be in smokers only (for smokers, odds ratio for lowest tertile = 7.67, 95% Cl 1.68-35.09, odds ratio for middle tertile = 3.25, 95% Cl 0.66-15.88, test for trend p-value = 0.05, and Likelihood Ratio Test chi square = 8.48, p-value = 0.014). (Full text available from University Microfilms International, Ann Arbor, MI, as Order No. AAD92-28635.)
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/EPIDEMIOLOGY Adult Carotenoids/*THERAPEUTIC USE Cohort Studies *Diet Human Male Middle Age Odds Ratio Questionnaires Regression Analysis San Francisco/EPIDEMIOLOGY Sarcoma, Kaposi's/DIET THERAPY/*ETIOLOGY *Smoking THESIS

KWDacquiredimmunodeficiencysyndrome/complications/epidemiologyadultcarotenoids/KWDtherapeuticusecohortstudiesKWDdiethumanmalemiddleageoddsratioquestionnairesregressionanalysissanfrancisco/epidemiologysarcoma,kaposi's/diettherapy/KWDetiologyKWDsmokingthesis
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