Primary central nervous system lymphoma (PCNSL) in Saskatchewan (SK): A 30-year trend (Meeting abstract).

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Primary central nervous system lymphoma (PCNSL) in Saskatchewan (SK): A 30-year trend (Meeting abstract).

Proc Annu Meet Am Soc Clin Oncol; 13:A513 1994. Unique Identifier : AIDSLINE ICDB/94600509
Williams CK; Allan Blair Memorial Clinic, Saskatchewan Cancer Foundation,; Regina, SK, S4T 7T1, Canada

Abstract: The incidence of PCNSL has recently been increasing world-wide primarily among AIDS patients, but also in immune competent population (ICP). The epidemiology of PCNSL in SK, a region of Canada where AIDS's impact on community health has been negligible, was evaluated by identifying 31 cases conforming to the disease definition in the local cancer registry between 1960 and 1990. These included 24 patients with intracranial (ICD) and 7 with intraspinal disease (ISD). The male/female (m/f) distributions were 7/17 and 6/1 in ICD and ISD respectively (p less than 0.01). Incidence (x 10[-5]) of ICD was 0.03, 0.04 and 0.17, and of ISD was 0.0, 0.02 and 0.05 in the decades 1960-1970, 1970-1980, and 1980-1990 respectively, ie almost 6-fold for ICP, but just 2-fold for ISD respectively, in 1960-1990 and 1980-1990 respectively. Availability of relevant professionals was constant in all 3 decades but CT and stereotactic surgery were preferentially performed in 1980-1990. ICD was multifocal in 7/24; of non-low grade histology in 14/16 (87.5%) and 3/7 (42.9%) in ISD. Antecedent disorders included AIDS (1), prolonged steroid therapy (1), previous cancers (6), diabetes (2) and alcoholism (2). 13 (m/f=3:10) of 17 ICP and 2 (m/f=2:0) of 7 ISD were farmers, their wives or rural dwellers. PCNSL was rarely associated with AIDS in the 1960-1990 period in SK. The increasing trend in non-AIDS PCNSL may be partly due to improved recognition but the cause of its predominance among women in rural SK is unknown.

Keywords: Central Nervous System Neoplasms/*EPIDEMIOLOGY Female Human Lymphoma/*EPIDEMIOLOGY Male Prevalence Risk Factors Saskatchewan/EPIDEMIOLOGY ABSTRACT

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