Ultraviolet irradiation and cytokines as regulators of HIV latency and expression. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Ultraviolet irradiation and cytokines as regulators of HIV latency and expression.

Chem Biol Interact. 1994 Jun;91(2-3):101-9. Unique Identifier : AIDSLINE MED/94251836
Vicenzi E; Poli G; AIDS Immunopathogenesis Unit, San Raffaele Hospital, Centro San; Luigi, Milan, Italy.

Abstract: The ability of the human immunodeficiency virus (HIV) to persist and replicate in human CD4+ T lymphocytes and mononuclear phagocytes is under the control of both virally encoded proteins and a variety of host-related factors. Ultraviolet (UV) light has been shown to induce transcription and expression of HIV. Both DNA damage and repair and DNA damage/repair-independent pathways caused by UV irradiation lead to expression of proviral HIV genomes via activation of the cellular transcription factor NF-kappa B. Transgenic mice that contain either long terminal repeat (LTR)-reporter genes or HIV genomes, either full length or deleted in the gag-pol region, express RNA and proteins at the epidermal level, particularly after UV irradiation. Furthermore, UV-triggered release of soluble factors capable of inducing expression of HIV in non-irradiated cells has been observed. Among other host factors, the functional network of pro-inflammatory and immunoregulatory cytokines has been demonstrated to act as a potent regulator of HIV replication, at least in different in vitro systems of infection.
Keywords: Animal Cytokines/PHARMACOLOGY/*PHYSIOLOGY Gene Expression Regulation, Viral/DRUG EFFECTS/RADIATION EFFECTS Human HIV/DRUG EFFECTS/GENETICS/*PHYSIOLOGY/RADIATION EFFECTS Mice Mice, Transgenic NF-kappa B/METABOLISM *Ultraviolet Rays Up-Regulation (Physiology) Virus Activation/DRUG EFFECTS/RADIATION EFFECTS *Virus Latency/DRUG EFFECTS/RADIATION EFFECTS Virus Replication/DRUG EFFECTS/RADIATION EFFECTS JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDanimalcytokines/pharmacology/KWDphysiologygeneexpressionregulation,viral/drugeffects/radiationeffectshumanhiv/drugeffects/genetics/KWDphysiology/radiationeffectsmicemice,transgenicnf-kappab/metabolismKWDultravioletraysup-regulation(physiology)virusactivation/drugeffects/radiationeffectsKWDviruslatency/drugeffects/radiationeffectsvirusreplication/drugeffects/radiationeffectsjournalarticlereviewreview,tutorial
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Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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