Oxygen radical release by neutrophils of HIV-infected patients. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Oxygen radical release by neutrophils of HIV-infected patients.

Chem Biol Interact. 1994 Jun;91(2-3):141-6. Unique Identifier : AIDSLINE MED/94251840
Jarstrand C; Akerlund B; Department for Clinical Microbiology, Huddinge University; Hospital, Sweden.

Abstract: Neutrophils from asymptomatic HIV-infected patients have an increased Nitroblue tetrazolium (NBT) reduction, that is an increased production of oxygen radicals. Plasma from these patients can activate normal neutrophils to an increased NBT-reduction and the neutrophil activating factor thus seems to be mainly plasma bound. Further, the patients also have increased levels of plasma malondialdehyde and thus an increased lipid peroxidation. Plasma cysteine levels are low, a sign of increased consumption of antioxidants. Treatment of the asymptomatic HIV-infected patients with N-acetylcysteine corrected the plasma cysteine levels and had some beneficial effects, but did not inhibit the increased radical production by the neutrophils.
Keywords: Acetylcysteine/*THERAPEUTIC USE Acquired Immunodeficiency Syndrome/BLOOD Adult AIDS-Related Complex/BLOOD Cysteine/BLOOD Female Free Radicals Human HIV Infections/*BLOOD/DRUG THERAPY Male Neutrophils/*METABOLISM Oxidation-Reduction Randomized Controlled Trials Superoxides/*BLOOD JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL

KWDacetylcysteine/KWDtherapeuticuseacquiredimmunodeficiencysyndrome/bloodadultaids-relatedcomplex/bloodcysteine/bloodfemalefreeradicalshumanhivinfections/KWDblood/drugtherapymaleneutrophils/KWDmetabolismoxidation-reductionrandomizedcontrolledtrialssuperoxides/KWDbloodjournalarticlereviewreview,tutorial
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