Detection of EBV-encoded mRNA in primary central nervous system lymphomas (Meeting abstract).

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Detection of EBV-encoded mRNA in primary central nervous system lymphomas (Meeting abstract).

J Pathol; 170(Suppl):349A 1993. Unique Identifier : AIDSLINE ICDB/94699878
Sanderson P; Angel CA; Royds JA; Clark A; Smith C; Timperley W; Ironside J; Dept. of Pathology, Univ. of Sheffield Medical School, Sheffield,; UK

Abstract: In recent years, a number of lymphoproliferative diseases have been shown to contain EBV DNA, and evidence to support an etiological relationship between EBV and a variety of lymphomas is accumulating. Primary central nervous system lymphomas are rare, but occur with an increased incidence in immunocompromised individuals, particularly those with HIV infection. Previous studies have suggested that CNS lymphomas may be associated with EBV, and that this association is stronger in those lymphomas occurring in AIDS. In this study, a series of 23 primary CNS lymphomas were analyzed by in situ hybridization using digoxigenin-labeled probes to EBER1 and EBER2. 3 of the specimens were taken at post mortem from AIDS patients. Of the remaining 20 cases, 6 were samples taken at autopsy. Two of the AIDS cases and one of the non-AIDS biopsies contained tumor cells staining positively with both probes. There were no apparent histological or clinical differences between the EBER positive and negative cases, in both the AIDS and non-AIDS cases. This finding suggests a low incidence of EBV detection in primary CNS lymphomas occurring in immunocompetent individuals, in contrast to those occurring in HIV infection.

Keywords: Acquired Immunodeficiency Syndrome/GENETICS Central Nervous System Neoplasms/*GENETICS/METABOLISM/ *MICROBIOLOGY *Gene Expression Herpesvirus 4, Human/*GENETICS Human Lymphoma/*GENETICS/METABOLISM/*MICROBIOLOGY Lymphoma, AIDS-Related/GENETICS/MICROBIOLOGY RNA-Binding Proteins/METABOLISM RNA, Messenger/*GENETICS ABSTRACT
941030
M94A0894

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