Effect of HIV-1 infection on natural killer cells and neutrophils of chimpanzees. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Effect of HIV-1 infection on natural killer cells and neutrophils of chimpanzees.

Abstr Gen Meet Am Soc Microbiol. 1994;94:158 (abstract no. E-85). Unique Identifier : AIDSLINE ASM94/94313070
Javadian MA; Lafrado LJ; Couch RC; Marr JM; Boisford JL; Coulston Foundation, WSRC, Alamogordo, NM.

Abstract: Human infection with HIV-1 is characterized by a variety of profound defects in cellular immunity, including depression in natural killer (NK) cell activity and phagocytic activity of neutrophils which perform important inflammatory and immune functions. In the present experiment, natural killer cell and neutrophil phagocytic activities of HIV-1 infected chimpanzees were assayed against the erythroleukemia cell line K562 and fluorescent latex beads, respectively. In addition, the in vitro effect of interleukin-2 (IL-2) on depressed NK cells was evaluated. Data obtained from this study demonstrate that NK cell activity in HIV-1 infected chimpanzees was less (p < 0.05) than their cytotoxic activity in the naive controls. The NK cell activity was significantly enhanced by in vitro interleukin-2 treatment of peripheral blood lymphocytes from both naive control and experimental chimpanzees. Neutrophils from HIV-1 infected animals exposed to fluorescein isothiocyanate (FITC) conjugated latex beads showed decreased phagocytosis. We conclude that HIV-1 infection in chimpanzees causes reduction in cytotoxic activity of NK cells and phagocytosis by polymorphonuclear leukocytes, as seen in humans.
Keywords: Acquired Immunodeficiency Syndrome/*BLOOD/*IMMUNOLOGY Animal Cell Line Chimpansee troglodytes Cytotoxicity, Immunologic Human *HIV-1 Killer Cells, Natural/*IMMUNOLOGY Leukemia, Myeloid, Chronic Neutrophils/*PHYSIOLOGY Phagocytosis Tumor Cells, Cultured ABSTRACTKWDacquiredimmunodeficiencysyndrome/KWDblood/KWDimmunologyanimalcelllinechimpanseetroglodytescytotoxicity,immunologichumanKWDhiv-1killercells,natural/KWDimmunologyleukemia,myeloid,chronicneutrophils/KWDphysiologyphagocytosistumorcells,culturedabstract
941030
M94A0884

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1994. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1994. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .