Antibody profile and isotypic patterns on HIV infected patients under drug treatment. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Antibody profile and isotypic patterns on HIV infected patients under drug treatment.

Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-11). Unique Identifier : AIDSLINE ASM94/94313089
Rivera L; Montealegre F; Diaz AM; Univ. of P.R.

Abstract: In this study we correlated the isotype and specificity of the IgG antibody response from 100 Puerto Rican HIV-infected patients with the treatment which they were given. Western Blots have been performed to determine the isotype as well as protein specificity of antibodies contained in the patient's serum. Clinical data like sex, age, rate of infection, stage according to the classification of CDC, number of T-CD4 cells, antiviral treatment and treatment against opportunistic infection were collected from patient's records that were treated in P.R. Concra. The detection of isotypes by Western Blots allowed an evaluation of the host response to specific viral proteins and the effect of drug therapy in the humoral response. The results of this work would be a useful tool for finding of the best treatment against the infection by HIV-1. The treatment which increases the reactivity of isotypes like IgG1, and IgG3 which have an important role in defense as neutralizing antibodies and anti-HIV ADCC, have been determined.
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/*DRUG THERAPY/ *IMMUNOLOGY Antibody Formation Antiviral Agents/*THERAPEUTIC USE Blotting, Western CD4-Positive T-Lymphocytes/IMMUNOLOGY Female Human HIV Infections/BLOOD/*DRUG THERAPY/*IMMUNOLOGY *HIV-1 IgG/*BLOOD/CLASSIFICATION Immunoglobulin Isotypes/*BLOOD Male ABSTRACTKWDacquiredimmunodeficiencysyndrome/blood/KWDdrugtherapy/KWDimmunologyantibodyformationantiviralagents/KWDtherapeuticuseblotting,westerncd4-positivet-lymphocytes/immunologyfemalehumanhivinfections/blood/KWDdrugtherapy/KWDimmunologyKWDhiv-1igg/KWDblood/classificationimmunoglobulinisotypes/KWDbloodmaleabstract
941030
M94A0865

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