Immune and serologic profiles of HIV-infected and non-infected hemophilic children and adolescents. HGDS.

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Immune and serologic profiles of HIV-infected and non-infected hemophilic children and adolescents. HGDS.

Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-10). Unique Identifier : AIDSLINE ASM94/94313091
Jason J; Murphy J; Sleeper LA; Donfield SM; Warrier I; Arkin S; Evatt B; Gomperts ED; CDC, Atlanta, GA.

Abstract: To assess relationships among HIV's effects on hemophilic children and adolescents' immunologic parameters and vaccine-related serology, we analyzed extensive baseline immunologic evaluations of 207 HIV antibody-positive (HIV+) and 126 HIV antibody-negative (HIV-) hemophilic children and adolescents. All group comparisons were age-adjusted. HIV+, compared to HIV-, participants had lower CD4+ lymphocyte counts (medians: HIV+ 423/microliters, HIV- 895/microliters; p < .0001), NK cell counts (medians: HIV+ 109/microliters, HIV- 210/microliters; p < .0001), and CD19+ lymphocyte counts (medians: HIV+ 229/microliters, HIV- 387/microliters; p < .0001). The HIV+ participants also had higher CD8+ lymphocyte counts (medians: HIV+ 841/microliters, HIV- 678/microliters; p = .001) and serum immunoglobulin levels (IgG 1788 vs 1232 mg/dL, p < .0001; IgA 219 vs 156 mg/dL, p < .0001; IgM 141 vs 114 mg/dL, p = .0199. Seroprevalence rates for diphtheria toxoid, measles, and mumps antigens were significantly lower in the HIV+ group compared to the HIV- group. IgG levels, IgM levels, and serologic titers to vaccine antigens showed little correlation with T cell parameters. HIV had significant, largely independent T- and B-lymphocyte effects on this pediatric cohort. The effects of HIV on infected hemophilic youth in this study are severe, broad, and not necessarily all secondary to infection of CD4+ lymphocytes. Our results support additional, independent effects on B-lymphocytes, antigen presenting cells, and/or cytokine production.

Keywords: Adolescence Antigens, CD/BLOOD Antigens, Differentiation, B-Lymphocyte/BLOOD Antigens, Viral/BLOOD B-Lymphocytes/IMMUNOLOGY Child Cohort Studies Comparative Study Hemophilia/BLOOD/COMPLICATIONS/*IMMUNOLOGY Human HIV Infections/BLOOD/COMPLICATIONS/*IMMUNOLOGY HIV Seronegativity HIV Seropositivity/BLOOD/*IMMUNOLOGY IgG/BLOOD IgM/BLOOD Killer Cells, Natural/IMMUNOLOGY Lymphocytes/*IMMUNOLOGY T-Lymphocytes/IMMUNOLOGY ABSTRACT
941030
M94A0863

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