Plasma-levels of IL-2R and IL-6 in perinatally HIV-infected children.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Plasma-levels of IL-2R and IL-6 in perinatally HIV-infected children.

Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-12). Unique Identifier : AIDSLINE ASM94/94313092
Fendt D; Cruciani M; Fioredda F; Loy A; Concia E; Bassetti D; Institute of Infectious Diseases, University of Verona, Italy.

Abstract: OBJECTIVE: The relationship between plasma-levels of IL-2R and IL-6, known prognostic markers of HIV-infection (CD4 count, p24 antigenemia) and progression into symptomatic disease in children was investigated. METHODS: 10 children (5 male, 5 female, aged 3-7 years) with perinatal HIV-infection in different clinical stages were included in a prospective study with follow-up over a one-year period. At study entry 2 pts. were classified in stage P1B, 3 in P2A, 2 in P2AF and 3 in AIDS. Four children were p24-antigenemia negative and had CD4 count > 400/mm3 (> 20%) (Group I), while 6 pts. had positive p24 antigenemia and CD4 count < 400/mm3 (< 20%) (Group II). Every 3 months clinical/nutritional status, CD4 count and p24 antigenemia were evaluated and plasma samples were stored for determination of IL-2R and IL-6 levels by ELISA-testing. RESULTS: Levels of IL-R ranged from 217-884 U/ml. There was significant difference between IL-2R levels found in Group I (mean value 248 U/ml, range 217-289 U/ml) and those found in Group II (mean value 360 U/ml, range 235-884 U/ml) (p < 0.001). One child of Group II had disease progression in AIDS during follow-up (CMV-chorioretinitis) preceded 4 months before diagnosis by 2-fold increase of IL-2R levels. Plasma-levels of IL-6 ranged from 0-270 pg/ml. Positive determinations > 10 pg/ml were found significantly more frequently in patients in stage P2AF and AIDS (p < 0.02) and exclusively in children with deficit of weight for height (wasting score < 97) (p < 0.001). No clear relationship between CD4-count, p24 antigenemia and plasma IL-6 levels was found. CONCLUSION: Monitoring plasma-levels of IL-2R and IL-6 may have prognostic value in perinatal HIV-infection. Further observations would be needed to confirm these findings.

Keywords: Acquired Immunodeficiency Syndrome/BLOOD/IMMUNOLOGY Biological Markers/BLOOD Child Child, Preschool Enzyme-Linked Immunosorbent Assay/METHODS Female Human HIV Infections/*BLOOD/IMMUNOLOGY/TRANSMISSION Interleukin-6/*BLOOD Male Monitoring, Physiologic Pregnancy Pregnancy Complications, Infectious Receptors, Interleukin-2/*ANALYSIS ABSTRACT
941030
M94A0862

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