Association of HEp-2 cell adherent Escherichia coli with diarrhea among adults infected with HIV.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Association of HEp-2 cell adherent Escherichia coli with diarrhea among adults infected with HIV.

Abstr Gen Meet Am Soc Microbiol. 1994;94:544 (abstract no. C-303). Unique Identifier : AIDSLINE ASM94/94313100
Mathewson JJ; Jiang ZD; Luo N; Chintu C; Zumla A; DuPont HL; University of Texas, Houston.

Abstract: Both acute and chronic diarrhea are common problems in African patients infected with the human immunodeficiency virus (HIV). There are many different agents responsible for diarrhea in this population, but a recognized cause is not found in most cases. We tested E. coli from Zambians for adherence to HEp-2 cells. Among the 99 HIV+ patients: there were 19 asymptomatic controls, 42 with acute diarrhea (< 72 hrs), and 38 with chronic diarrhea (> 30 days). Among the 15 HIV-patients, there were 3 asymptomatic controls and 6 with each acute and chronic diarrhea. E. coli that adhered to HEp-2 cells were the most common enteropathogen among the HIV+ patients with diarrhea. HEp-2 cell adherent E. coli were identified significantly more frequently from all HIV+ individuals than from the HIV-group (p < 0.01). Adherent E. coli were found more commonly among HIV+ patients with acute diarrhea, than among the HIV+ asymptomatic controls (60% versus 37%) and significantly more often among HIV+ patients with chronic diarrhea (79%) compared to HIV+ controls (p < 0.001). These organisms were also found significantly more often in HIV+ patients with chronic diarrhea than among HIV-patients with chronic diarrhea (p < 0.007). The different adherence patterns of the adherence of strains isolated from the AIDS patients varied. None of the locally adherent E. coli hybridized with the enteropathogenic E. coli adherence factor (EAF) probe. Adherent E. coli strains may explain a considerable portion of AIDS associated diarrhea in the African form of the disease and deserve further study.

Keywords: Acute Disease Adult AIDS-Related Opportunistic Infections/*MICROBIOLOGY *Bacterial Adhesion Cell Line Chronic Disease Comparative Study Diarrhea/EPIDEMIOLOGY/*MICROBIOLOGY Escherichia coli/ISOLATION & PURIF/*PHYSIOLOGY Escherichia coli Infections/*MICROBIOLOGY/PHYSIOPATHOLOGY Human HIV Seronegativity *HIV Seropositivity Tumor Cells, Cultured ABSTRACT
941030
M94A0854

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