Molecular epidemiology of tuberculosis in New York City. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Molecular epidemiology of tuberculosis in New York City.

Abstr Gen Meet Am Soc Microbiol. 1994;94:550 (abstract no. C-342). Unique Identifier : AIDSLINE ASM94/94313101
Friedman CR; Riley L; Kreiswirth B; Johnson WD; Manoach S; Sathianathan K; Stoeckle MY; Cornell University Medical College, Public Health Research; Institute, New York, N.Y.

Abstract: Tuberculosis (TB) in the United States is usually due to reactivation, but may occur as a result of recent exogenous infection. Restriction Fragment Length Polymorphism (RFLP) analysis has been used to identify clonal spread of recent TB infection. We used RFLP analysis to determine the pattern of transmission of TB in New York City. We performed RFLP analysis on TB isolates obtained during 1992 at four New York City hospitals (TBNetwork), which had no recognized TB outbreaks. Eighty-one isolates were analyzed. Thirteen of 81 (16%) were multi-drug resistant (MDR), 7 (9%) were resistant to INH alone, and 58 (72%) were drug-sensitive. Sixteen different RFLP patterns that were previously determined to be clonal in origin were found in 36 of the 81 isolates (44%). Forty-five distinct (non-clonal) RFLP patterns were found in the remaining 45 isolates (56%). A clonal pattern was found in 11 of 13 (85%) MDRTB isolates and 23 of 65 (35%) non-MDR strains (p = .003, Yates). Among isolates from patients with known HIV status, a clonal RFLP pattern was observed in 18 of 30 (60%) HIV-seropositive patients and 9 of 28 (32%) HIV-seronegative patients. These results indicate that recent exogenous infection is playing a major role in the TB epidemic in New York City, particularly in persons with HIV and MDRTB.
Keywords: AIDS-Related Opportunistic Infections/EPIDEMIOLOGY/TRANSMISSION Comparative Study Drug Resistance, Microbial Hospitals, Urban Human HIV Seronegativity HIV Seropositivity New York City/EPIDEMIOLOGY *Polymorphism, Restriction Fragment Length Tuberculosis/DIAGNOSIS/*EPIDEMIOLOGY/TRANSMISSION ABSTRACTKWDaids-relatedopportunisticinfections/epidemiology/transmissioncomparativestudydrugresistance,microbialhospitals,urbanhumanhivseronegativityhivseropositivitynewyorkcity/epidemiologyKWDpolymorphism,restrictionfragmentlengthtuberculosis/diagnosis/KWDepidemiology/transmissionabstract
941030
M94A0853

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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