Susceptibility of mice with MAIDS to cytomegalovirus retinitis at times relative to Th1/Th2 shift.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Susceptibility of mice with MAIDS to cytomegalovirus retinitis at times relative to Th1/Th2 shift.

Abstr Gen Meet Am Soc Microbiol. 1994;94:623 (abstract no. V-32). Unique Identifier : AIDSLINE ASM94/94313124
Dix RD; Cray C; Cousins SW; Bascom Palmer Eye Institute, University of Miami School of; Medicine, FL.

Abstract: Prior to absolute decline in CD4+ T cell number in late-stage AIDS, HIV-1 infection produces a relative immune dysregulation caused by a shift in CD4+ T helper (Th) function from a mechanism that promotes cell-mediated immunity (Th1 response) to one that favors humoral immunity (Th2 response). Theoretically, this dysregulation predisposes to opportunistic infections. Mice with retrovirus-induced immunodeficiency syndrome (MAIDS) also exhibit a Th1/Th2 shift that becomes evident approximately 3 wks after retrovirus infection. We therefore explored the susceptibility of mice with MAIDS to murine cytomegalovirus (MCMV) retinitis at times relative to Th1/Th2 shift. Groups of adult C57BL/6 mice were infected with a mixture of murine retroviruses (LP-BM5 MuLV); control animals received PBS. At 2 wks (MAIDS-2), 4 wks (MAIDS-4), and 12 wks (MAIDS-12), MuLV-infected and age-matched control mice were inoculated by subretinal injection with MCMV and compared 10 days postinfection for evidence of MCMV replication and typical retinitis. When compared with immunocompetent controls, MAIDS-4 and MAIDS-12 mice demonstrated increased ocular MCMV titers. Whereas the frequency of typical necrotizing retinitis in MAIDS-12 animals was 88%, retinitis was not observed in immunocompetent, MAIDS-2 or MAIDS-4 animals. Nonetheless, evidence of retinal infection without retinitis was observed in 0%, 12% and 70% of immunocompetent, MAIDS-2, and MAIDS-4 animals, respectively. We conclude that although typical MCMV retinitis cannot be induced at time of initial Th1/Th2 shift, increased MCMV replication and evidence of retinal infection is observed.

Keywords: Animal Antibody Formation Comparative Study Cytomegalovirus Retinitis/*IMMUNOLOGY CD4-Positive T-Lymphocytes/*IMMUNOLOGY Disease Susceptibility Immunity, Cellular Mice Murine Acquired Immunodeficiency Syndrome/*COMPLICATIONS/ *IMMUNOLOGY Muromegalovirus T-Lymphocytes, Helper-Inducer/*IMMUNOLOGY Time Factors ABSTRACT
941030
M94A0830

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