Anti-neutrophil antibodies of the immunoglobulin M class in autoimmune neutropenia.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Anti-neutrophil antibodies of the immunoglobulin M class in autoimmune neutropenia.

Am J Med Sci. 1994 Aug;308(2):102-5. Unique Identifier : AIDSLINE MED/94317680
Hartman KR; Department of Hematology, Walter Reed Army Institute of Research,; Washington, DC 20307-5100.

Abstract: Anti-neutrophil antibodies of the immunoglobulin G (IgG) class have been implicated in the pathogenesis of autoimmune neutropenia, but few reports have described immunoglobulin M (IgM) anti-neutrophil antibodies. To investigate the prevalence of IgM anti-neutrophil antibodies, sera from 130 patients with possible autoimmune neutropenia were studied for IgG and IgM anti-neutrophil antibodies using an immunofluorescence flow cytometric assay. Twenty-five patients (19%) had IgG anti-neutrophil antibodies exclusively, 21 patients (16%) had both IgG and IgM anti-neutrophil antibodies, and 11 patients (8%) had IgM anti-neutrophil antibodies exclusively. Immunoglobulin M anti-neutrophil antibodies were found in adults and children with isolated chronic neutropenia and in patients with Felty's syndrome, systemic lupus erythematosus, immune thrombocytopenic purpura, and human immunodeficiency virus. Patients with neutropenia with only IgM anti-neutrophil antibodies comprised almost 20% of antibody-positive patients in this study.

Keywords: Adult Aged Aged, 80 and over Autoantibodies/*BLOOD Autoimmune Diseases/*IMMUNOLOGY Child, Preschool Female Flow Cytometry Human IgG/BLOOD IgM/*BLOOD Immunoblotting Infant Male Middle Age Neutropenia/*IMMUNOLOGY Neutrophils/*IMMUNOLOGY JOURNAL ARTICLE
941030
M94A0131

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