1994

AIDS 101. [Version 4.0]. [sound recording].: Seattle, Wash. : AIDS Impact, c1993- 3 sound cassettes : analog + 1 guide (103 p.) (HIV/AIDS series) Unique Identifier : AIDSLINE AV/9433031
Tuberculosis update. [videorecording]: Washington, D.C. : Universal Health Associates, c1993 1 videocassette (59 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9430597; Grimes DE; Nursing
AIDS : HIV educational video clips. [videorecording]: Washington, DC : VA, [1993] 1 videocassette (17 min., 9 sec.) : sd., col. ; 1/2 in. + 1 guide (viii, 36 p.) Unique Identifier : AIDSLINE AV/9434018; Shaffer MK; Jensen P; (Producer) This videotape contains a series of seven short scenes of medical center situations to help generate discussion of major concerns surrounding HIV and AIDS. VA clinicians and educators developed the situations.
Jacquelyn Flaskerud, Ph. D., UCLA School of Nursing, studies the cultural impact of AIDS-related education, testing, and counseling for low-income Latina women. [videorecording]: St. Louis, Mo. : Mosby Year-Book, c1993 1 videocassette (32 min.) : sd., col. with b&w ; 1/2 in (Cameo, outstanding nurse researchers and their work ; v. 5) Unique Identifier : AIDSLINE AV/9432506; Flaskerud JH; Cronenwett L; (Producer) Jacquelyn H. Flaskerud is internationally recognized for her cultural research on AIDS education, HIV testing, and counseling for minority women and for her studies examining Asian American clients and mental health services. Dr. Flaskerud is involved in AIDS education and outreach through the UCLA AIDS I
Arizona HIV infection surveillance report.: [Phoenix, Ariz. : The Division, v Unique Identifier : AIDSLINE CAT/9422573
NIAID AIDS agenda.: Bethesda, MD : Office of Communications, National Institute of Allergy and Infectious Diseases (NIAID), v Unique Identifier : AIDSLINE CAT/9432911
HIV-infected health workers : debating the issues.: Denver, Colo. (1560 Broadway, Suite 700, Denver 80202) : National Conference of State Legislatures, 1992 15 p (State legislative report ; vol. 17, no. 18) Unique Identifier : AIDSLINE CAT/9405660; Craig RT; Bryant LL
[Ve stinu AIDS.] Vyd. 1.: Praha : Academia, 1992 164 p. : ill Unique Identifier : AIDSLINE CAT/9410034; Dvorak J
The:AIDS war : propaganda, profiteering, and genocide from the medical-industrial complex.: New York : Asklepios, 1993 479 p. : ill., ports Unique Identifier : AIDSLINE CAT/9421821; Lauritsen J
Health care utilization and charges for AIDS and HIV disease : Massachusetts, 1988-1991.: Boston, MA : Massachusetts Dept. of Public Health, [1993] 29 p. : ill Unique Identifier : AIDSLINE CAT/9434885; Kasabula S
Medical alert : a publication of the National Association of People with AIDS.: Washington, DC : NAPWA, v Unique Identifier : AIDSLINE CAT/9419236
Needle exchange : dimensions of HIV prevention.: Menlo Park, CA : H.J. Kaiser Family Foundation, c1993 xxviii, 182 p. : ill Unique Identifier : AIDSLINE CAT/9421820; Stryker J; Smith MD
5th Annual Conference.: [Melbourne? : The Society, 1993] 112 leaves Unique Identifier : AIDSLINE CAT/9437138
AIDS : 1,000 full-text statistical abstracts from the A Matter of fact database, 1984-1992.: Ann Arbor, Mich. : Pierian Press, 1993 vi, 106 p (Statistical perspectives series ; no. 1) Unique Identifier : AIDSLINE CAT/9423713
AIDS : a modern epidemic.: Washington, D.C. : Pan American Health Organization, Pan American Sanitary Bureau, Regional Office of the World Health Organization, c1993 v, 58 p. : ill (Communicating for health series ; no. 5) Unique Identifier : AIDSLINE CAT/9434043; Chelala CA
A:Death in the family : orphans of the HIV epidemic.: New York, NY : United Hospital Fund of New York, c1993 xv, 157 p. : ill Unique Identifier : AIDSLINE CAT/9431653; Levine C
Management guidelines for the control of infectious disease hazards in health care establishments : report of the Joint NHMRC/ANCA Working Party on Management Guidelines for the Control of Infectious Disease Hazards in Health Care Establishments.: Control of Infectious Disease Hazards in Health Care Establishments Canberra : Australian Govt. Pub. Service, c1993 vi, 64 p Unique Identifier : AIDSLINE CAT/9423796
AIDS care at home : a guide for caregivers, loved ones, and people with AIDS.: New York : J. Wiley & Sons, Inc., c1994 xviii, 360 p. : ill Unique Identifier : AIDSLINE CAT/9434393; Greif J; Golden BA
Measuring patient-reported health status in advanced HIV disease : HIV-PARSE survey instrument.: Santa Monica, CA : Rand, 1994 xi, 61 p. : ill Unique Identifier : AIDSLINE CAT/9437327; Berry SH; Group
Sexual networking and AIDS in sub-Saharan Africa : behavioural research and the social context.: Camberra, ACT, Australia : Health Transition Centre, the Australian National University : Distributed by Bibliotech, ANUTECH, 1994 x, 275 p. : ill (Health transition series ; no. 4) Unique Identifier : AIDSLINE CAT/9433489; Orubuloye IO
Journal of the Physicians Association for AIDS Care. Vol. 1, no. 1 (Jan. 1994)-v. 2, no. 1 (Jan. 1995),: Chicago, IL : PAAC Pub., c1994-c1995 2 v. : ill., ports Unique Identifier : AIDSLINE CAT/9431848
Hives of sickness : public health and epidemics in New York City.: New Brunswick, N.J. : Published for the Museum of the City of New York by Rutgers University Press, c1995 223 p. : ill Unique Identifier : AIDSLINE CAT/9436206; Rosner D
Oncology nursing.: Albany : Delmar Publishers, c1995 xii, 371 p (Plans of care for specialty practice) Unique Identifier : AIDSLINE CAT/9436416; Miaskowski C
Color atlas of ocular manifestations of AIDS : diagnosis and management.: New York : Igaku-Shoin, c1995 xii, 105 p. : ill Unique Identifier : AIDSLINE CAT/9436493; Orellana J; Lieberman RM; Teich SA
HIV/AIDS : a guide to nursing care. 3rd ed.: Philadelphia : Saunders, c1995 xiv, 544 p. : ill Unique Identifier : AIDSLINE CAT/9436868; Flaskerud JH; Ungvarski PJ
Primary care of women and children with HIV infection : a multidisciplinary approach.: Boston : Jones and Bartlett Publishers, c1995 xvi, 308 p. : ill (Jones and Bartlett books on oncology and HIV-related illnesses) Unique Identifier : AIDSLINE CAT/9436871; Kelly P
Forgotten children of the AIDS epidemic.: New Haven : Yale University Press, c1995 xiv, 283 p. : ill Unique Identifier : AIDSLINE CAT/9437464; Geballe S; Gruendel J; Andiman W
Heat shock activation of human T cell leukemia/lymphoma virus type I (HTLV-I) in HTLV-I-transformed cells (MT-2) is associated with down-regulation of cellular heat shock protein (HSP27/28).: Diss Abstr Int [B]; 53(12):6238 1993. Unique Identifier : AIDSLINE ICDB/94696171; Sun D; Univ. of Maryland Baltimore Professional Schools; Temperature elevation constitutes a beneficial component of host defense against viral pathogens. However, virally infected cells may exhibit altered cellular tolerance to thermal stress. Additionally, increased viral oncoprotein expression in virally infected cells during thermal stress may contribute to cellular neo
Results by match-control study from HIV and uterine cervix preneoplasias in population with high and low risk (Meeting abstract).: Gynaecological Oncology, 8th International Meeting of the European Society of Gynaecological Oncology. June 9-12, 1993, Barcelona, Spain, 1993.. Unique Identifier : AIDSLINE ICDB/94698786; Romeo F; No affiliation given; Since the last century, cervical carcinoma became a great medical and social problem. From the beginning studies of Rigoni-Stern to the more recent virologic and immunologic studies, the goal is still the same: find factors that can induct the disease and select risk groups. Actually all the attentions are focused on
Detection of EBV-encoded mRNA in primary central nervous system lymphomas (Meeting abstract).: J Pathol; 170(Suppl):349A 1993. Unique Identifier : AIDSLINE ICDB/94699878; Sanderson P; Angel CA; Royds JA; Clark A; Smith C; Timperley W; Ironside J; Dept. of Pathology, Univ. of Sheffield Medical School, Sheffield,; UK; In recent years, a number of lymphoproliferative diseases have been shown to contain EBV DNA, and evidence to support an etiological relationship between EBV and a variety of lymphomas is accumulating. Primary central nervous system lymphomas are rare, but occur with an increased incidence in immunocompromised individ
Preirradiation chemotherapy (CTX) with cytoxan, Adriamycin, vincristine, and decadron (CHOD) for primary CNS lymphomas (PCNSL): initial report of Radiation Therapy Oncology Group (RTOG) protocol 88-06 (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 13:A485 1994. Unique Identifier : AIDSLINE ICDB/94600481; Schultz C; Scott C; Wasserman T; Fisher B; Abrams R; Sherman W; Fetell M; Nelson J; No affiliation given; From 1988 to 1992, a prospective Phase I/II trial was carried out by the RTOG to test the tolerance and efficacy of preirradiation (RT) CHOD CTX followed by large vol, high-dose brain RT for patients (pts) with PCNSL. Fifty-four (51 evaluable) HIV-negative pts with PCNSL were entered and received 2 (19 pts) or 3 (32 p
BOMES: a promising combination chemotherapy in the treatment of CNS lymphoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 13:A500 1994. Unique Identifier : AIDSLINE ICDB/94600496; Cheng AL; Yeh KH; Chen BR; Uen WC; Tien HF; Wang CH; Chen YC; Cancer Res. Center, Natl. Taiwan Univ. Coll. of Medicine, Taipei,; Taiwan; Although with occasionally excellent results with corticosteroid treatment, the response of CNS lymphoma to systemic chemotherapy remains unsatisfactory. This is presumably partly due to the blood-brain barrier (BBB). To cope with this, we designed a protocol which, in addition to
A pilot study of chemotherapy (CTx) of non-Hodgkin's lymphoma arising in the CNS or eye (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 13:A510 1994. Unique Identifier : AIDSLINE ICDB/94600506; Stark-Vancs V; Setser A; Kohler D; Heiss J; Martin D; Nussenblatt R; Whitcup S; deSmet M; Jaffe E; Patronas N; et al; NIH, Bethesda, MD 20892; Eight minimally pretreated patients (pts) with primary CNS lymphoma or CNS metastases from ocular lymphoma (all HIV-) were treated on a pilot study to evaluate the feasibility of a regimen using high-dose methotrexate (MTX) with leucovorin rescue (LCV; Cancer Treat Rev 4:87, 1977),
Interferon-alpha is effective in patients with hairy cell leukemia relapsing after 2-chlorodeoxyadenosine (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 13:A1033 1994. Unique Identifier : AIDSLINE ICDB/94601029; Seymour JF; Estey EH; Keating MJ; Kurzrock R; Department of Clinical Investigation, MD Anderson Cancer Center,; Houston, TX; Interferon-alpha (IFN) produces responses in about 90% of patients (pts) with untreated hairy cell leukemia (HCL). 2-chlorodeoxyadenosine (2-CdA) induces a higher proportion of complete responses (CR) than IFN but also induces prolonged suppression of normal CD4+ and CD8+ lymphocyte counts. The optimal treatment of pt
Conserved sequence homology of cysteine rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species.: Abstr Gen Meet Am Soc Microbiol. 1994;94:141 (abstract no. D-253). Unique Identifier : AIDSLINE ASM94/94313065; Wright T; Haidaris P; Gigliotti F; Harmsen A; Haidaris C; University of Rochester, NY.; Pneumocystis carinii (Pc) surface glycoprotein A (gpA) exhibits host-species specific phenotypic and genotypic variation. Despite this heterogeneity, the gpAs of Pc isolated from different host species appear to be homologous molecules sharing certain biochemical and antigenic characteristics. Using two degenerate oli
Sequence variations in the internal transcribed spacers of the ribosomal RNA genes of Pneumocystis carinii strains that infect humans.: Abstr Gen Meet Am Soc Microbiol. 1994;94:141 (abstract no. D-255). Unique Identifier : AIDSLINE ASM94/94313066; Lu J; Lee C; Bartlett M; Smith J; Indiana Univ. Sch. of Med., Indianapolis.; Pneumocystis carinii is a major cause of life-threatening pneumonia in immunocompromised patients. It is unknown at present whether the P. carinii infecting humans represents a single type of organism or a group of organisms. To answer this question, we have examined the nucleotide sequences of the internal transcribe
Stabilization and expression of HIVMN genes in Salmonella typhimurium.: Abstr Gen Meet Am Soc Microbiol. 1994;94:151 (abstract no. E-46). Unique Identifier : AIDSLINE ASM94/94313067; Sizemore D; Branstrom A; Sadoff J; Warren R; Walter Reed Army Inst. of Res., Washington, DC.; Stabilization and expression of recombinant plasmids in Salmonella carriers for oral vaccination has proven problematic. Previously, we showed that pSC101 derived plasmids were maintained in Salmonella carriers without selection. However, foreign genes were expressed at low levels. We report the construction of a nove
Parenteral or intranasal immunization with HIV gp160 formulated with proteosomes and/or PA adjuvants enhances epitope-specific IgG or IgA.: Abstr Gen Meet Am Soc Microbiol. 1994;94:155 (abstract no. E-70). Unique Identifier : AIDSLINE ASM94/94313068; Kaminski R; Amselem S; Levi M; Loomis L; Kersey K; Vancott T; Friedman D; Smith G; Wahren B; Redfield R; et al; Walter Reed Army Institute of Research, Washington, DC.; We have immunized mice i.m. or intranasally and rabbits i.m. with HIV gp160 (MicroGeneSys) formulated with alum or proprietary adjuvants (PA, Pharmos) and/or meningococcal outer membrane protein proteosomes. When administered i.m., proteosomes plus alum or PA formulations (with or without proteosomes) induced improved
Floridians' perceptions of AIDS transmission.: Abstr Gen Meet Am Soc Microbiol. 1994;94:156 (abstract no. E-74). Unique Identifier : AIDSLINE ASM94/94313069; Ganguly R; Vincent A; Sinnott JT; Hoecherl S; University of South Florida.; AIDS transmission is heavily influenced by behavior, attitudes and knowledge about the disease among those at risk. This study is based upon the 1991 Florida Behavioral Risk Factor Surveillance System (BRFSS) data which included a module of questions about AIDS transmission and several demographic variables. Through a
Effect of HIV-1 infection on natural killer cells and neutrophils of chimpanzees.: Abstr Gen Meet Am Soc Microbiol. 1994;94:158 (abstract no. E-85). Unique Identifier : AIDSLINE ASM94/94313070; Javadian MA; Lafrado LJ; Couch RC; Marr JM; Boisford JL; Coulston Foundation, WSRC, Alamogordo, NM.; Human infection with HIV-1 is characterized by a variety of profound defects in cellular immunity, including depression in natural killer (NK) cell activity and phagocytic activity of neutrophils which perform important inflammatory and immune functions. In the present experiment, natural killer cell and neutrophil ph
Genetic analysis of Mycobacterium avium superoxide dismutase.: Abstr Gen Meet Am Soc Microbiol. 1994;94:176 (abstract no. U-21). Unique Identifier : AIDSLINE ASM94/94313071; Escuyer V; Haddad N; Berche P; Laboratoire de Microbiologie, INSERM, Faculte de Medecine; Necker-Enfants Malades, Paris, France.; Mycobacterium avium is a major opportunistic pathogen widely spread in the environment and responsible for severe infections in immunocompromised patients with AIDS. It is able to survive and replicate in the phagocytic cells of the host immune system and resists the oxidative burst of activated macrophages. M. avium
Isolation of fastidious mycobacteria from patients with AIDS.: Abstr Gen Meet Am Soc Microbiol. 1994;94:180 (abstract no. U-45). Unique Identifier : AIDSLINE ASM94/94313072; Yajko DM; Clancy MN; Goodman C; Hadley WK; Univ. of California, San Francisco General Hospital.; During a recent 14 month period (6/92-8/93) slow-growing fastidious mycobacteria were recovered at San Francisco General Hospital from 22 specimens submitted from 10 patients with AIDS. Twenty of the isolates (from 9 patients) were recovered from blood and two isolates (from a single patient) were recovered from AFB s
Polymerase chain reaction (PCR) detection of Mycobacterium avium-intracellulare (MAI) DNA from peripheral blood mononuclear cells (PBMCs) of HIV-infected patients.: Abstr Gen Meet Am Soc Microbiol. 1994;94:188 (abstract no. U-91). Unique Identifier : AIDSLINE ASM94/94313073; Kostman J; Mair M; Byrne B; Gekowski K; Baxter J; Cooper Hospital/UMC, Robert Wood Johnson Medical School, Camden,; N.J.; Rapid detection and identification of MAI from the blood of HIV-infected patients is necessary for the prompt initiation of treatment. We performed DNA amplification with the polymerase chain reaction of mycobacterial DNA from frozen PBMCs collected from HIV-infected patients. Heparinized blood was collected from HIV-
Induction of immune mediators by defined lipid fractions from Mycobacterium avium serovar 8.: Abstr Gen Meet Am Soc Microbiol. 1994;94:190 (abstract no. U-102). Unique Identifier : AIDSLINE ASM94/94313074; Barrow W; Davis T; Wright E; Labrousse V; Bachelet M; Rastogi N; Institut Pasteur, Paris, France.; Because of increasing evidence that M. avium lipids can modulate host responses, lipid fractions from M. avium serovar 8 were evaluated for their ability to modulate the immune function of human peripheral blood mononuclear cells. A total lipid fraction was obtained by the Folch extraction procedure and processed by c
Serum markers of immune activation in HIV-associated pulmonary tuberculosis.: Abstr Gen Meet Am Soc Microbiol. 1994;94:190 (abstract no. U-99). Unique Identifier : AIDSLINE ASM94/94313075; Wallis R; Helfand M; Vjecha M; Whalen C; Mugerwa R; Okwera A; Ellner J; Case Western Reserve University, Cleveland, Ohio.; Survival is shortened in HIV-infected patients with tuberculosis (TB) as compared to CD4-matched HIV-infected controls. We measured serum markers of immune activation in HIV-infected patients beginning treatment for pulmonary TB in Kampala, Uganda . Patients were followed for 16 mon
T cell reactivity against antigen 85 in HIV-infection.: Abstr Gen Meet Am Soc Microbiol. 1994;94:190 (abstract no. U-100). Unique Identifier : AIDSLINE ASM94/94313076; Huygen K; Gerard M; Farber CM; Drowart A; van Vooren JP; Clumeck N; Pasteur Instituut van Brabant, Brussels, Belgium.; Antigen 85 (30-32 kD) is the major secreted protein antigen from M. tuberculosis/bovis BCG culture filtrate. We have previously shown that 32 kD component (Ag85A) of this antigen demonstrates powerful T cell stimulatory properties resulting in T cell proliferation and IFN-gamma secretion by PBMC from all healthy tuber
Radiometric susceptibility testing of Mycobacterium tuberculosis against second-line drugs.: Abstr Gen Meet Am Soc Microbiol. 1994;94:197 (abstract no. U-138). Unique Identifier : AIDSLINE ASM94/94313077; Salfinger M; Gross W; Kornblum J; Laszlo A; Pfyffer G; Roberts G; Siddiqi S; NY State Dept. of Health, Albany.; AIDS epidemic, deterioration of the public health infrastructure and inadequate training of health care providers are some factors contributing to the increase of tuberculosis (TB), especially multidrug-resistant TB. In vitro drug susceptibility testing is now required for all TB patients. Since faster turnaround time
Analysis of sewage effluent for human immunodeficiency virus (HIV) using infectivity assay and reverse-transcriptase polymerase chain reaction.: Abstr Gen Meet Am Soc Microbiol. 1994;94:415 (abstract no. Q-154). Unique Identifier : AIDSLINE ASM94/94313078; Palmer CJ; Lee MH; Bonilla GF; Javier BJ; Tsai YL; Sangermano LR; Orange County Sanitation Districts, Fountain Valley, CA.; Environmental survival of human immunodeficiency virus (HIV) is an important public health concern. Survival of HIV in wastewater is of particular interest to those who work at treatment facilities and to the general public who have contact with rivers or ocean water receiving treated sewage effluent. Other researcher
The removal of human immunodeficiency virus (HIV) from fluids containing serum with a 0.04 micron nylon membrane filter.: Abstr Gen Meet Am Soc Microbiol. 1994;94:424 (abstract no. Q-205). Unique Identifier : AIDSLINE ASM94/94313079; Oshima K; Comans T; Rowe T; Orloff S; Highsmith A; Ades E; Centers for Disease Control and Prevention, Atlanta, GA.; The risks associated with blood and blood products contaminated with human immunodeficiency virus (HIV) has been an ongoing concern in the health care industry. We tested the ability of a 0.04 micron nylon membrane filter to remove human immunodeficiency virus (HIV) from fluid containing serum and characterized the ef
Synergistic antiretroviral activities of the herb, Prunella vulgaris, with AZT, ddI, and ddC.: Abstr Gen Meet Am Soc Microbiol. 1994;94:481 (abstract no. S-27). Unique Identifier : AIDSLINE ASM94/94313080; John JF; Kuk R; Rosenthal A; Robert Wood Johnson Medical School, New Brunswick, N.J.; There is a urgent need for new, safe, and inexpensive therapy for HIV infection. We tested a group of commonly available herbs for their activity in aqueous solution against HIV. In screening tests of four commonly used herbs, Prunella vulgaris (PV) was found to exert the best anti-HIV activity. The antiretroviral act
Identification of three distinct HIV-1 subtypes in Brazil based on the protease gene.: Abstr Gen Meet Am Soc Microbiol. 1994;94:482 (abstract no. T-1). Unique Identifier : AIDSLINE ASM94/94313081; Janini LM; Luo CC; Peralta M; Schecther M; Kalish ML; Pieniazek N; de la Torre N; Schochetman G; Rayfield M; Pieniazek D; CDC, Atlanta, GA.; OBJECTIVE: To study genotypic differences in the protease gene from HIV-1 infected persons in Brazil . METHODS: HIV-1 proviral DNA from 40 specimens were surveyed for genetic similarity to reference strains using a PCR typing procedure based on the polymorphism of restriction sites
Identification of HIV-1 variants transmitted from mothers to fetus.: Abstr Gen Meet Am Soc Microbiol. 1994;94:482 (abstract no. T-2). Unique Identifier : AIDSLINE ASM94/94313082; Furtado MR; Hoeft J; Garcia PM; Department of Pathology, Northwestern University, Chicago, IL; 60611.; Identification of HIV-1 sequence variants that are transmitted to infants and determination of the timing of transmission are crucial to understanding the underlying mechanisms. We analyzed fetal tissue from five abortuses and detected HIV-1 DNA in four. Analysis for maternal DNA in the fetal samples by PCR amplificat
p24 Antigen is not primarily virion-associated in peripheral blood of HIV-infected individuals: a comparison with quantitation of HIV RNA.: Abstr Gen Meet Am Soc Microbiol. 1994;94:483 (abstract no. T-8). Unique Identifier : AIDSLINE ASM94/94313083; Wilber J; Yeghiazarian T; Todd J; Urdea M; Chiron Corporation, Emeryville, CA.; The level of p24 antigen has been used as a surrogate marker for the level of viremia in HIV-infected patients. To understand the extent to which p24 antigen (p24Ag) is associated with virions, EDTA plasma was collected from 12 HIV-infected individuals and assayed for the quantity of virion-associated HIV p24Ag and RN
A rapid sensitive, solution based fluorescent in situ hybridization (FISH) assay for the detection of HIV mRNA in infected cell lines by multi-colored flow cytometry.: Abstr Gen Meet Am Soc Microbiol. 1994;94:483 (abstract no. T-3). Unique Identifier : AIDSLINE ASM94/94313084; Poindexter B; Cubbage M; Weber W; Ku J; Bresser J; Aprogenex, Inc., Houston, TX.; Rapid detection of low levels of HIV infected cells is necessary for the screening of donated blood as well as in the clinical diagnosis of infection. Aprogenex has developed an HIV diagnostic test, Virafy, sensitive enough to detect infected cell lines diluted down to 1 in 10,000 with uninfected cell lines by flow cy
Expression of HIV-1 core/envelope chimeric virus-like particles in baculovirus-infected cells.: Abstr Gen Meet Am Soc Microbiol. 1994;94:483 (abstract no. T-7). Unique Identifier : AIDSLINE ASM94/94313085; Truong C; Brand D; Roingeard P; Mallet F; Goudeau A; Barin F; Lab. Virologie, URA CNRS 1334 CHU Bretonneau Tours, France.; The viral envelope, involved in the first steps of HIV-1 infection, contains two neutralizing epitopes. The V3 loop induces an early, type-specific HIV-1 neutralizing activity but is highly variable among isolates. Later in infection, broad spectrum neutralizing activity is induced by the conformational CD4 binding si
Role of Ca(++)-dependent and Ca(++)-independent protein kinase C isozymes on activation of HIV-1.: Abstr Gen Meet Am Soc Microbiol. 1994;94:483 (abstract no. T-6). Unique Identifier : AIDSLINE ASM94/94313086; Kim C; Lim S; Gollapudi S; Gupta S; University of California, Irvine.; Protein kinase C (PKC) plays a crucial role in HIV-1 replication. Because of the recognized molecular and biochemical heterogeneity of PKC, we have studied the effects of various PKC isozyme agonists on HIV-1 activation in chronically infected promonocytic U1 cells that produce minimal or no virus. U1 cells were incub
Sensitivity and application of a new method for isolating purified compartmentalized HIV-1 unintegrated and integrated DNA.: Abstr Gen Meet Am Soc Microbiol. 1994;94:483 (abstract no. T-4). Unique Identifier : AIDSLINE ASM94/94313087; Bush CE; Golembieski A; Donovan RM; Baxa D; Markowitz N; Saravolatz LD; Henry Ford Hospital, Detroit, MI.; Measurement of the relative amounts of HIV unintegrated DNA (uDNA) and integrated DNA (iDNA) is a promising marker of therapeutic efficacy. The Hirt procedure for isolating total uDNA requires multiple extractions leading to DNA loss. We developed a novel column-based method for the isolation of cytoplasmic and nuclea
The upregulation of the promoter gene encoding the p105/p50 subunit of NF-kB by HIV is dependent upon one specific kB motif.: Abstr Gen Meet Am Soc Microbiol. 1994;94:483 (abstract no. T-5). Unique Identifier : AIDSLINE ASM94/94313088; Ten R; MacMorran W; Rolli V; Israel A; Paya C; Division of Experimental Pathology, Mayo Clinic, Rochester, MN; 55905.; Our previous cloning and sequencing of the promoter of the gene encoding the p50 subunit of NF-kB indicated that it is upregulated by NF-kB. Furthermore, we have shown that in persistently HIV-infected monocytic cells, which contain increased NF-kB activity, the transcriptional regulation of this promoter is increased
Antibody profile and isotypic patterns on HIV infected patients under drug treatment.: Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-11). Unique Identifier : AIDSLINE ASM94/94313089; Rivera L; Montealegre F; Diaz AM; Univ. of P.R.; In this study we correlated the isotype and specificity of the IgG antibody response from 100 Puerto Rican HIV-infected patients with the treatment which they were given. Western Blots have been performed to determine the isotype as well as protein specificity of antibodies contained in the patient s serum. Clinical d
Cellular mechanisms account for decreased anti-HIV-1 activity of nucleoside analogs.: Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-14). Unique Identifier : AIDSLINE ASM94/94313090; Doerr HW; Cinatl J Jr; Weber B; Cinatl J; Department of Medical Virology, J.W. Goethe University,; Frankfurt/M, Federal Republic of Germany.; We tested whether cellular mechanisms (cell resistance) may account for decreased anti-HIV-1 activity of nucleoside analogs. For this aim several MOLT-4 cell sublines were established which exerted resistance against toxic effects of nucleoside analogs including
Immune and serologic profiles of HIV-infected and non-infected hemophilic children and adolescents. HGDS.: Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-10). Unique Identifier : AIDSLINE ASM94/94313091; Jason J; Murphy J; Sleeper LA; Donfield SM; Warrier I; Arkin S; Evatt B; Gomperts ED; CDC, Atlanta, GA.; To assess relationships among HIV s effects on hemophilic children and adolescents immunologic parameters and vaccine-related serology, we analyzed extensive baseline immunologic evaluations of 207 HIV antibody-positive (HIV+) and 126 HIV antibody-negative (HIV-) hemophilic children and adolescents. All group compari
Plasma-levels of IL-2R and IL-6 in perinatally HIV-infected children.: Abstr Gen Meet Am Soc Microbiol. 1994;94:484 (abstract no. T-12). Unique Identifier : AIDSLINE ASM94/94313092; Fendt D; Cruciani M; Fioredda F; Loy A; Concia E; Bassetti D; Institute of Infectious Diseases, University of Verona, Italy.; OBJECTIVE: The relationship between plasma-levels of IL-2R and IL-6, known prognostic markers of HIV-infection (CD4 count, p24 antigenemia) and progression into symptomatic disease in children was investigated. METHODS: 10 children (5 male, 5 female, aged 3-7 years) with perinatal HIV-infection in different clinical s
Combination of peptide protease inhibitor and recombinant interferon-alpha A synergistically inhibited acute and chronic HIV-1 infection in vitro.: Abstr Gen Meet Am Soc Microbiol. 1994;94:485 (abstract no. T-15). Unique Identifier : AIDSLINE ASM94/94313093; Pagano PJ; Chong KT; Upjohn Laboratories, Kalamazoo, MI.; Effective treatment of human immunodeficiency virus (HIV) infections may require combinations of agents that attack different molecular targets in the viral replicative cycle. We investigated the effect of combining U-75875, a peptide protease inhibitor containing a non-hydrolyzable dihydroxyethylene isostere, with re
Dilutional analysis with a nested PCR--a method for quantitating feline immunodeficiency virus provirus in cat tissues.: Abstr Gen Meet Am Soc Microbiol. 1994;94:485 (abstract no. T-19). Unique Identifier : AIDSLINE ASM94/94313094; Read R; Nie LC; Lu YS; Richardson JA; Pakes SP; University of Texas Southwestern Medical Center, Dallas.; Most quantitative methods in PCR are subject to error due to the efficiency with which chosen primers amplify target sequences compared to reference sequences, and in some systems, the degree to which the amplified product hybridizes with a labelled probe. To quantitate provirus in biological samples, we use a highly
Feline bone marrow stromal fibroblasts are a target of feline immunodeficiency virus infection in vitro and in vivo.: Abstr Gen Meet Am Soc Microbiol. 1994;94:485 (abstract no. T-18). Unique Identifier : AIDSLINE ASM94/94313095; Lu YS; Ho SI; Read RW; Richardson JA; Pakes SP; University of Texas Southwestern Medical Center, Dallas.; Similar to HIV infection in humans, cats infected with feline immunodeficiency virus (FIV) develop anemia, neutropenia and lymphopenia. These hematologic abnormalities are thought to be due to altered marrow micro-environments because of infected marrow stromal cells. Susceptibility of marrow stromal cells to FIV infe
Genetic heterogeneity of HTLV-II infecting Italian drug abusers.: Abstr Gen Meet Am Soc Microbiol. 1994;94:485 (abstract no. T-17). Unique Identifier : AIDSLINE ASM94/94313096; Salemi M; Cimarelli A; Achilli G; Cattaneo E; Casoli C; Bertazzoni U; IGBE/CNR, Pavia, Italy.; The infection of intravenous drug users (IVDU) by the Human T-cell Leukemia virus type II (HTLV-II) has been demonstrated in North America and in Europe, frequently associated to HIV-1. We have obtained from Italian IVDUs two isolates of HTLV-II, Gu and Va, and the characterization of their genomic structure by sequen
Monoclonal antibodies to the MLV protease active site that crossreact with the HIV protease.: Abstr Gen Meet Am Soc Microbiol. 1994;94:485 (abstract no. T-16). Unique Identifier : AIDSLINE ASM94/94313097; Luftig RB; Calkins P; Yeh HY; Louisiana State University Medical Center, New Orleans.; The retroviral proteases are essential for cleavage of gag and gag-pol polyproteins during the virus assembly. Inhibitors that inactivate the protease activity will reduce production of mature particles and, thus, spread of diseases. In this study, we generated mouse monoclonal antibodies specific to protease active s
Peripheral blood and milk-derived leukocytes harbor BIV provirus.: Abstr Gen Meet Am Soc Microbiol. 1994;94:486 (abstract no. T-22). Unique Identifier : AIDSLINE ASM94/94313098; Nash JW; Hanson LA; St. Cyr Coats K; Mississippi State University.; Bovine immunodeficiency virus (BIV), a lentivirus, infects a large population of cattle in the southern United States . The mode of transmission of BIV is unknown, but its similarity to HIV suggests analogous mechanisms of transmission. The purpose of this study was to develop a PCR pro
Clostridium difficile-associated diarrhea (CDAD) in HIV positive (HIV+) patients.: Abstr Gen Meet Am Soc Microbiol. 1994;94:491 (abstract no. C-3). Unique Identifier : AIDSLINE ASM94/94313099; Fischer S; Pulvirenti J; Lisowski J; Citronberg R; Lollar R; Rice T; Goodman L; Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL.; Because the clinical course of CDAD in HIV+ pts. is not well characterized, we conducted a retrospective study of pts. with this co-infection occurring between 1/92 and 8/93 at two urban medical centers. Case definition included diarrhea (loose or watery stools), a positive HIV test, and evidence of C. difficile toxin
Association of HEp-2 cell adherent Escherichia coli with diarrhea among adults infected with HIV.: Abstr Gen Meet Am Soc Microbiol. 1994;94:544 (abstract no. C-303). Unique Identifier : AIDSLINE ASM94/94313100; Mathewson JJ; Jiang ZD; Luo N; Chintu C; Zumla A; DuPont HL; University of Texas, Houston.; Both acute and chronic diarrhea are common problems in African patients infected with the human immunodeficiency virus (HIV). There are many different agents responsible for diarrhea in this population, but a recognized cause is not found in most cases. We tested E. coli from Zambians for adherence to HEp-2 cells. Amo
Molecular epidemiology of tuberculosis in New York City.: Abstr Gen Meet Am Soc Microbiol. 1994;94:550 (abstract no. C-342). Unique Identifier : AIDSLINE ASM94/94313101; Friedman CR; Riley L; Kreiswirth B; Johnson WD; Manoach S; Sathianathan K; Stoeckle MY; Cornell University Medical College, Public Health Research; Institute, New York, N.Y.; Tuberculosis (TB) in the United States is usually due to reactivation, but may occur as a result of recent exogenous infection. Restriction Fragment Length Polymorphism (RFLP) analysis has been used to identify clonal spread of recent TB infection. We used RFLP analysis to determine th
A similar microbiologic profile in HIV-seropositive (HIV+) and seronegative (HIV-) women with pelvic inflammatory disease (PID). Multicenter HIV and PID Study Group.: Abstr Gen Meet Am Soc Microbiol. 1994;94:553 (abstract no. C-356). Unique Identifier : AIDSLINE ASM94/94313102; Moorman A; Rice R; Irwin K; O'Sullivan M; Sperling R; Brodman M; Droese A; CDC, Atlanta, GA.; To compare the microbiologic findings in HIV+ women with PID who may be immunosuppressed with those in HIV- women with PID, we started a prospective study in 1992 at two urban hospitals to evaluate women who have had PID diagnosed using standard criteria. Vaginal and endocervical secretions and endometrial biopsy tiss
Evaluation of a direct ELISA HIV-1/HIV-2 EIA using synthetic peptides: detect-HIV (version 2).: Abstr Gen Meet Am Soc Microbiol. 1994;94:554 (abstract no. C-362). Unique Identifier : AIDSLINE ASM94/94313103; Chalifour RJ; Ha NH; Barbeau S; Lacroix M; BioChem ImmunoSystems Inc., Montreal, Que., Canada.; A direct ELISA version of BioChem ImmunoSystems synthetic peptide EIA was evaluated to establish if detecting all immunoglobulin classes improves the sensitivity of this test. HRP conjugates of 3 peptides from HIV-1 GP120, HIV-1 GP41 and HIV-2 GP36 were used to detect antibodies captured by these peptides on microtit
Evaluation of a new HIV-1/HIV-2 assay.: Abstr Gen Meet Am Soc Microbiol. 1994;94:554 (abstract no. C-363). Unique Identifier : AIDSLINE ASM94/94313104; Betlach B; Hanson M; Valinsky J; Sacramento Medical Foundation Center for Blood Research, CA.; Three blood donor sites in the United States evaluated a new MicroTrak II enzyme immunoassay pending FDA approval for the detection of antibodies to HIV-1 and/or HIV-2. It was compared with licensed reference assays. Fresh samples from 10,468 volunteer
Evaluation of the Murex SUDS HIV-1 antibody test in a mixed population.: Abstr Gen Meet Am Soc Microbiol. 1994;94:554 (abstract no. C-364). Unique Identifier : AIDSLINE ASM94/94313105; Johnson JE; Ely DD; Overman SB; Goodman NL; University of Kentucky Medical Center, Lexington.; Serum specimens from 304 patients and 116 blood donors were tested for HIV-1 antibody using the Murex SUDS HIV-1 and the Genetic Systems LAV EIA test systems. There were 320 specimens non-reactive with both SUDS and LAV (116 blood donor specimens and 204 patient specimens). There were 53 patient specimens which were r
Screening a low prevalence population for HIV-2 using a combination HIV-1/HIV-2 enzyme immunoassay and an immunofluorescence assay.: Abstr Gen Meet Am Soc Microbiol. 1994;94:554 (abstract no. C-361). Unique Identifier : AIDSLINE ASM94/94313106; Zanto SN; Treichel LJ; Abbott DO; Montana Public Health Laboratory, Helena.; The Montana Public Health Laboratory has conducted screening for HIV-1 since 1985, with an estimated prevalence of HIV infection of 0.06%. To evaluate test performance and to determine the feasibility of incorporating screening for HIV-2, 2000 random serum specimens received for routine screening were tested using bot
Detection of HIV-1 proviral DNA by polymerase chain reaction using an electrochemiluminescent-tagged probe.: Abstr Gen Meet Am Soc Microbiol. 1994;94:555 (abstract no. C-367). Unique Identifier : AIDSLINE ASM94/94313107; Schutzbank TE; Smith J; Greeley C; Children's Hospital National Medical Center, Washington, D.C.; We have developed a rapid, pseudo-homogeneous assay for the detection of PCR amplicons, based on the use of electroluminescence generated from a Tris-bipyridine ruthinium (II) (Ru(bpy)3(3+)) label. PCR amplification of highly conserved HIV-1 gag gene sequences were performed using SK38/SK39 primers, where the latter w
Immunomagnetic capture of CD4+ cells from whole blood for HIV detection by PCR.: Abstr Gen Meet Am Soc Microbiol. 1994;94:555 (abstract no. C-366). Unique Identifier : AIDSLINE ASM94/94313108; Piccoli SP; Ekeze TE; Gross S; Mehta RR; Kerschner JH; Immunicon Corp., Huntingdon Valley, PA.; Rapid diagnosis of HIV infection may be greatly facilitated by direct identification of the provirus, regardless of the time course of antibody response. Toward this end, we have developed a system to permit specific isolation of CD4+ T-cells for subsequent genetic analysis by PCR. Samples of whole blood (50-75% v/v i
Polymerase chain reaction detection of HIV-1 2-LTR circular DNA may predict CD4 decline.: Abstr Gen Meet Am Soc Microbiol. 1994;94:555 (abstract no. C-368). Unique Identifier : AIDSLINE ASM94/94313109; Byrne BC; Parisi JM; Baxter JD; UMDNJ/RWJ Medical School, Camden 08103.; CD4(+)-T cell counts reflect a consequence of HIV infection but are not markers of viral activity. We seek ways to monitor aspects of HIV infection as potential tools in clinical trials of antiretroviral agents or clinical management of infected patients. HIV RNA genomes are reverse transcribed into double stranded li
VIDAS vs ELISA in the serodiagnosis of HIV 1 + 2, rubella and toxoplasma.: Abstr Gen Meet Am Soc Microbiol. 1994;94:555 (abstract no. C-365). Unique Identifier : AIDSLINE ASM94/94313110; Araj GF; Bizri AR; Fattouh LG; Nassif RE; American Univ. Med. Ctr., Beirut, Lebanon.; Rapid, automated and self-contained instruments that minimize exposure to potentially infectious blood samples are attractive addition to the serodiagnostic laboratory. The performance of Vitek Immuno Diagnostic Assay Systems (VIDAS, biomerieux Vitek Inc., Hazelwood, MO) was tried in a developing country for the detec
Pseudomonas aeruginosa bacteremia in HIV-infected patients.: Abstr Gen Meet Am Soc Microbiol. 1994;94:573 (abstract no. C-469). Unique Identifier : AIDSLINE ASM94/94313111; Gilbert L; Peters B; Peoples D; Frederick W; Howard University Hospital, Washington, DC.; In order to analyze epidemiological and clinical aspects of Pseudomonas aeruginosa bacteremia (PAB) in HIV+ patients (pts), we conducted a retrospective study of PAB during the period 1983-1993. Of the 281 pts identified, 25 (20 males, 5 females) were HIV+. Their mean age was 34.5 years and 96% were black. HIV risk fa
Pneumocystis carinii pneumonia (PCP) diagnosis and follow-up by polymerase chain reaction (PCR) in bronchoalveolar lavage (BAL) of immunocompromised patients.: Abstr Gen Meet Am Soc Microbiol. 1994;94:588 (abstract no. C-548). Unique Identifier : AIDSLINE ASM94/94313112; Moonens F; Liesnard C; Van Vooren JP; Struelens M; Erasme Hospital, Universite libre de Bruxelles, Belgium.; Several PCR protocols have been developed for the diagnosis of PCP. The aims of this study were to evaluate the sensitivity and specificity of simple and nested PCR compared with direct examination on cytospin slides after Giemsa and immunofluorescent staining, and to estimate the duration of post-PCP carriage by nest
Cloning and sequencing of the cDNA encoding Pneumocystis carinii inosine monophosphate dehydrogenase (IMPDH).: Abstr Gen Meet Am Soc Microbiol. 1994;94:590 (abstract no. F-13). Unique Identifier : AIDSLINE ASM94/94313113; O'Gara MJ; Queener SF; Lee CH; Indiana University School of Medicine, Indianapolis.; Pneumocystis carinii is an opportunistic pathogen that causes pneumonia in immunocompromised hosts. Chemotherapy is available for treating P. carinii pneumonia, but severe toxicity is a significant problem with the compounds currently considered drugs of choice. IMP dehydrogenase (IMPDH; EC 1.1.1.205) may be a good al
Genetic variation within and between human, rat and mouse-derived Pneumocystis carinii.: Abstr Gen Meet Am Soc Microbiol. 1994;94:590 (abstract no. F-10). Unique Identifier : AIDSLINE ASM94/94313114; Keely SP; Pai HJ; Sunkin SM; Baughman R; Sidman CL; Stringer SL; Stringer JR; University of Cincinnati College of Medicine, Ohio.; Pneumocystis carinii is an opportunistic pulmonary pathogen that causes P. carinii pneumonia (PCP) in immunocompromised individuals and is the major cause of death in AIDS patients. The organism thrives in a wide variety of mammals and is generally referred to as P. carinii regardless of host species. Recent reports i
Genetic and serological analysis of Pneumocystis carinii genes encoding major surface glycoprotein (MSG).: Abstr Gen Meet Am Soc Microbiol. 1994;94:597 (abstract no. F-52). Unique Identifier : AIDSLINE ASM94/94313115; Sunkin SM; Stringer SL; Stringer JR; University of Cincinnati College of Medicine, Ohio.; Pneumocystis carinii contains a large (90-120 kDa) surface glycoprotein that is recognized by antibodies in the serum of immune and infected hosts and seems to play a role in binding to host cells. Recent genetic analysis of MSG cDNAs has shown that MSG is likely to be a family of proteins. A fragment from the genome
Fungi in the gingival sulcus: frequency and speciation in HIV+ and HIV- heterosexual patients.: Abstr Gen Meet Am Soc Microbiol. 1994;94:600 (abstract no. F-70). Unique Identifier : AIDSLINE ASM94/94313116; Quart A; Gialanella P; McEachrane S; Reich D; AIDS Initiative, North Central Bronx Hospital, N.Y.; Oral candidiasis is one of the earliest and most common signs of HIV infection, suggesting that the oral cavity may be a reservoir of yeast colonization in both immunocompetent and immunosuppressed individuals. In this study 1168 samples taken from the gingival sulci of 237 Bronx methadone clinic patients were assayed
Antigen clearance for evaluation of treatment of histoplasmosis.: Abstr Gen Meet Am Soc Microbiol. 1994;94:605 (abstract no. F-95). Unique Identifier : AIDSLINE ASM94/94313117; Blair R; Garringer T; Limjoco M; Korzun A; Hafner R; Wheat J; Indiana University, Indianapolis.; Evaluation of new antifungal agents may be assisted by measurement of Histoplasma antigen clearance. We compared antigen clearance in patients treated successfully with itraconazole to that in historical controls treated with amphotericin B. Patients receiving itra were participants in an AIDS Clinical Trials Group pr
Evaluation of a human immunodeficiency virus-1 antibody immunoblot for the confirmation of oral specimens.: Abstr Gen Meet Am Soc Microbiol. 1994;94:622 (abstract no. V-29). Unique Identifier : AIDSLINE ASM94/94313118; Griffin CK; Chun JK; Allen NM; Gaudette ND; Erbling MC; Jacobs AL; Goldstein AS; Cimler BM; Epitope, Inc., Beaverton, Oregon.; Western blot (WB) assays are considered the gold standard for confirming retroviral screening test results. Specimens obtained with the OraSure oral specimen collection device have been extensively tested for the detection of antibodies to HIV and other viral infections. An HIV-1 WB was developed for the confirmation
Evaluation of the MicroTrak II HIV-1/HIV-2 recombinant antigen enzyme immunoassay.: Abstr Gen Meet Am Soc Microbiol. 1994;94:622 (abstract no. V-28). Unique Identifier : AIDSLINE ASM94/94313119; Kline R; Newhouse R; Granade T; Phillips S; Moss M; Quinn TC; Johns Hopkins Univ., Baltimore, MD.; In a study, the reliability, sensitivity, and specificity of the MicroTrak II HIV-1/HIV-2 EIA (MT II) were compared to licensed EIAs and Western Blot (WB). 2490 sera from various populations in the US, Africa, and India were evaluated at 3 different sites using the MT II and license
HIV p24 antigen (Ag) in the CSF using immune complex dissociation (ICD): correlation with p24 antibodies (Ab) in CSF, CD4, and cerebral atrophy.: Abstr Gen Meet Am Soc Microbiol. 1994;94:622 (abstract no. V-30). Unique Identifier : AIDSLINE ASM94/94313120; Valdez LM; Donovan RM; Mateo NB; Manzor O; Baxa D; Markowitz NP; Saravolatz LD; Department of Infectious Diseases, Henry Ford Hospital, Detroit,; Michigan.; The central nervous system is a major target for HIV infection. Studies have suggested that p24 Ag in the CSF is associated with the AIDS Dementia Complex (ADC). We studied 22 HIV infected patients for the presence of p24 Ag and correlated these findings with the presence of p24 Ab, cerebral atrophy by CT or MRI, and
Modulation of HIV-1 expression in monocyte derived macrophages by substance P.: Abstr Gen Meet Am Soc Microbiol. 1994;94:622 (abstract no. V-31). Unique Identifier : AIDSLINE ASM94/94313121; Ho WZ; Douglas SD; Children's Hospital of Philadelphia, PA.; The monocyte-macrophage system is a valuable in vitro model to investigate the pathogenesis of HIV-1 infection and AIDS dementia . Substance P (SP) modulates a number of important immunological functions of monocyte-macrophages. We have studied the effects of SP on HIV-1 p24 antigen
Rapid identification of Pneumocystis carinii isolates by random amplification polymorphic DNA fingerprinting.: Abstr Gen Meet Am Soc Microbiol. 1994;94:622 (abstract no. V-27). Unique Identifier : AIDSLINE ASM94/94313122; Chary-Reddy S; Graves DC; Univ. of Okla. Hlth. Sci. Ctr., Oklahoma City.; Pneumocystis carinii is an opportunistic pathogen that causes pneumonia in immunocompromised hosts including humans. It is the leading cause of morbidity and mortality in patients with AIDS. To understand more clearly the transmission of this organism, it is important to develop methods that can distinguish P. carinii
Detection of JC virus DNA by PCR in brain tissue and cerebrospinal fluid from HIV infected patients.: Abstr Gen Meet Am Soc Microbiol. 1994;94:623 (abstract no. V-36). Unique Identifier : AIDSLINE ASM94/94313123; Caldarelli Stefano R; Omodeo Zorini E; Rivolta GE; Achilli G; Cattaneo E; Vago L; Boldorini R; Ferrante P; Biology Lab., Fondazione Don C. Gnocchi IRCCS, Milano, Italy.; The correct diagnosis of progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease caused from JC Virus, is of particular relevance in AIDS patients. For these reasons we set a Polymerase Chain Reaction (PCR) method to detect JCV DNA both in brain tissues collected at autopsy from 17 cases and i
Susceptibility of mice with MAIDS to cytomegalovirus retinitis at times relative to Th1/Th2 shift.: Abstr Gen Meet Am Soc Microbiol. 1994;94:623 (abstract no. V-32). Unique Identifier : AIDSLINE ASM94/94313124; Dix RD; Cray C; Cousins SW; Bascom Palmer Eye Institute, University of Miami School of; Medicine, FL.; Prior to absolute decline in CD4+ T cell number in late-stage AIDS, HIV-1 infection produces a relative immune dysregulation caused by a shift in CD4+ T helper (Th) function from a mechanism that promotes cell-mediated immunity (Th1 response) to one that favors humoral immunity (Th2 response). Theoretically, this dysr
Concomitant multiple mycobacterial infections in patients infected with HIV.: Abstr Gen Meet Am Soc Microbiol. 1994;94:624 (abstract no. V-38). Unique Identifier : AIDSLINE ASM94/94313125; Hafiz I; Pulvirenti J; Benson C; Kocka F; Cook County Hospital, Rush Medical College, Chicago, Illinois.; OBJECTIVE: Evaluate the epidemiology, clinical manifestations, and course of patients with multiple concomitant mycobacterial infections and determine associated risk factors. DESIGN: Retrospective chart review of all patients culture positive for two or more concomitant mycobacteria between 1991 and 1993. SETTING: Co
Quantitative determination of HIV-1 p24 antigen in HIV antibody positive sera following alkaline dissociation of immune complexes.: Abstr Gen Meet Am Soc Microbiol. 1994;94:624 (abstract no. V-37). Unique Identifier : AIDSLINE ASM94/94313126; Swack N; Ramirez M; Berberich S; Stapleton J; Hygienic Laboratory, Univ. of Iowa, Iowa City.; Assays for the detection of HIV-1 antigen have been used for the detection of circulating virus early in infection and also for assessment of disease progression and response to antiviral therapy. However HIV-1 p24 antigen may be complexed with HIV antibody and thus escape detection by antigen capture immunoassay. Pre
Comparison of direct fluorescence antibody and calcofluor white stain for detection of Pneumocystis carinii in respiratory specimens.: Abstr Gen Meet Am Soc Microbiol. 1994;94:625 (abstract no. V-47). Unique Identifier : AIDSLINE ASM94/94313127; Aslanzadeh J; Kowalski I; Stelmach PS; Ryan RW; University of Connecticut School of Medicine, Farmington.; Direct fluorescence monoclonal antibody stain (DFA) was compared, prospectively, with calcofluor white stain (CFW) for diagnosis of Pneumocystis carinii in 163 respiratory specimens from 97 patients. The patient population included HIV infection (58%), bone marrow transplant recipient (10%), immunosuppressed due to ch
Tuberculosis, back to the future: a multimedia presentation to complement infectious diseases lectures.: Abstr Gen Meet Am Soc Microbiol. 1994;94:628 (abstract no. W-8). Unique Identifier : AIDSLINE ASM94/94313128; Glosser W; McCandless D; Jensen L; el Sawi N; Univ. of Health Sci., Kansas City, MO.; An interactive multimedia presentation was used as a lecture-support module to communicate concepts of mycobacterial pulmonary infections to second-year medical students. The presentation was developed on the Macintosh using Macromind Director (version 3.1) authoring system. The computer generated color text and figur
Intracellular activity of roxithromycin used alone and in association with other drugs against the Mycobacterium avium complex in human macrophages.: Abstr Gen Meet Am Soc Microbiol. 1994;94:9 (abstract no. A-44). Unique Identifier : AIDSLINE ASM94/94313129; Rastogi N; Labrousse V; Bryskier A; Institut Pasteur, Point-a-Pitre, Guadeloupe, French West Indies.; Activity of roxithromycin alone or in association with ethambutol, ofloxacin, rifampin, amikacin and clofazimine against 5 clinical isolates of MAC (3 from HIV+ and 2 from HIV- patients) growing in human macrophages was assessed. Macrophage monolayers were allowed to phagocytize bacteria for 4 h at 37 degrees C. After
[Viral infections of blood mononuclear cells and regulation of the immune response]: Duodecim. 1990;106(12):913-21. Unique Identifier : AIDSLINE MED/94298562; Salonen R; Ilonen J; Salmi A; TYKS:n neurologian klinikka, Turku, Finland.
[HIV infection in a child]: Duodecim. 1990;106(12):940-5. Unique Identifier : AIDSLINE MED/94298566; Eskola J; Hiippala A; Uhari M; Auroran sairaala, lasten sisatautien osastoryhma, Helsinki,; Finland.
[AIDS and intravenous drug abuse]: Acta Psychiatr Belg. 1990 Jan-Feb;90(1):20-36. Unique Identifier : AIDSLINE MED/94310956; Schuster CR; Pickens RW; National Institute on Drug Abuse, Rockville, M.D. 20857.; The importance of intravenous drug-abuse as a vehicle of HIV and AIDS is evidenced on the basis of recent epidemiological data gathered in the USA. The rate of seropositivity among intravenous drug-addicts (whose total number i is close to one million) is estimated at more than 20 percent. Besides direct contamination
[The rheumatological manifestations of infection with the human immunodeficiency virus (HIV)]: Med Interna. 1992;44(1):40-4. Unique Identifier : AIDSLINE MED/94297939; Gheorghiu O; Suteanu S; Centrul Metodologic de Reumatologie, Bucuresti.
[HIV infection in women. Psychological and somatic obstacle]: Acta Psychiatr Belg. 1992 Mar-Apr;92(2):109-19. Unique Identifier : AIDSLINE MED/94310999; Krings M; Defourny J; Sondag-Thull D; Luminet D; Centre de Reference SIDA, Universite de Liege.; We consider the word impediment in the meaning of what compels someone, makes someone feel uncomfortable. What are the consequences/implications of seropositivity for the woman in her sexual life, in her motherhood and how does she then cope with it? The following clinical observations account for the suffering induce
[Integrated care of HIV-seropositive patients: liaison psychiatry revisited]: Acta Psychiatr Belg. 1992 Mar-Apr;92(2):78-87. Unique Identifier : AIDSLINE MED/94311000; Hirsch D; Misrachi A; Josse E; Matot JP; Service des Maladies Infectieuses, Hopital Universitaire; Saint-Pierre, ULB, Bruxelles.; Psychiatric, psychologic and psychotherapeutic care of HIV patients is integrated inside a specific medical institution. The psychological representations that AIDS mobilizes pervade the intense medical relationship between internists, nurses and the HIV patients. This relationship becomes the central node for the dif
[AIDS, burnout and fear of knowing. Dialectic observations for the benefit of clinical psychology and liaison psychiatry]: Acta Psychiatr Belg. 1992 Mar-Apr;92(2):88-92. Unique Identifier : AIDSLINE MED/94311001; Dachy V; Roelandts A; Centre de Reference SIDA, Cliniques Universitaires Saint-Luc,; Bruxelles.; A review of the literature regarding burn-out provide a sample of specific variables that describes the phenomenon. This could potentially leads to the emergence of a set of actions intending to facilitate the task of health workers (at least if personnel managers pay it attention). However, it does not preclude the r
[AIDS: challenge to liaison psychiatry. Various expectations by clinicians concerning liaison psychiatry]: Acta Psychiatr Belg. 1992 Mar-Apr;92(2):93-8. Unique Identifier : AIDSLINE MED/94311002; Gennotte AF; Centre de prise en charge, Cliniques Universitaires St-Luc,; Bruxelles.; Interdisciplinary group work could be conceived as shared common abilities in order to provide a global management of diseases. In this regard, psychologists should assumed several tasks: to advise on patient s psychological resources to keep them less anxious or more cooperative, to humanize hospital and death, to pr
[Prevalence of human immunodeficiency virus infection in a psychiatric population in Central Africa]: Acta Psychiatr Belg. 1992 Mar-Apr;92(2):99-108. Unique Identifier : AIDSLINE MED/94311003; Bleyenheuft L; Janne P; Reynaert C; Munyandamutsa N; Verhoeven F; Muremyangango B; Cassiers L; Unite de Medecine Psychosomatique, Cliniques Universitaires UCL; de Mont-Godinne.; In an African population of 292 women, hospitalised for psychiatric reasons, the seropositivity for HIV was clearly found higher than in the general corresponding population; this was particularly significant for first hospitalisations; furthermore, the seropositivity became twice as high in the group hospitalised sev
HIV-seroprevalence in the Northern Mariana Islands [letter]: Asia Pac J Public Health. 1992-93;6(4):235. Unique Identifier : AIDSLINE MED/94312194; Weinstein S
[HIV infection in ENT: risk of infection and preventive health precautions]: Laryngorhinootologie. 1994 May;73(5):291-3. Unique Identifier : AIDSLINE MED/94288864; Gurtler LG; Max von Pettenkofer Institut fur Hygiene und Med. Mikrobiologie; Universitat Munchen.; Risk of HIV transmission during the different modes of treatment depends on the HIV prevalence within the patient population and the instruments used during invasive procedures. Generally HIV may be transmitted from patient to the health care worker, from patient to patient and from health care worker to patient. Prev
World AIDS Day 1993 [news]: World Health Forum. 1994;15(2):209-10. Unique Identifier : AIDSLINE MED/94288916
Sex education essential [news]: World Health Forum. 1994;15(2):210-1. Unique Identifier : AIDSLINE MED/94288917
New research to protect against AIDS [news]: World Health Forum. 1994;15(2):211. Unique Identifier : AIDSLINE MED/94288918
Adverse effects and drug interactions of clinical importance with antiviral drugs.: Drug Saf. 1994 Apr;10(4):281-91. Unique Identifier : AIDSLINE MED/94288920; Morris DJ; Department of Pathological Sciences, Medical School, Manchester,; England.; Most antiviral drugs are nucleoside analogues with potential teratogenic, embryotoxic, carcinogenic and antiproliferative activities. They must be administered with caution during pregnancy, because some are known teratogens (e.g. amantadine) and a similar propensity cannot be entirely excluded for others (e.g. aciclo
Tenth anniversary perspectives on AIDS. FIV as a model for AIDS vaccination.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):225-8. Unique Identifier : AIDSLINE MED/94289058; Johnson CM; Torres BA; Koyama H; Yamamoto JK; Department of Comparative and Experimental Pathology, College of; Veterinary Medicine, University of Florida, Gainesville 32610.
Molecular design of CPF analogs [letter]: AIDS Res Hum Retroviruses. 1994 Mar;10(3):229-30. Unique Identifier : AIDSLINE MED/94289059; Crabbe MJ; Plater ML; Gaca M
HIV-1 virion-cell interactions: an electrostatic model of pathogenicity and syncytium formation.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):231-3. Unique Identifier : AIDSLINE MED/94289060; Callahan L
Frequent and early HIV-1MN neutralizing capacity in sera from Dutch HIV-1 seroconverters is related to antibody reactivity to peptides from the gp120 V3 domain.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):245-51. Unique Identifier : AIDSLINE MED/94289062; Zwart G; Back NK; Ramautarsing C; Valk M; van der Hoek L; Goudsmit J; Department of Virology, University of Amsterdam, The Netherlands.; The temporal development of HIV-1 neutralizing activity and antibodies to the gp120-V3 neutralization domain were studied in sera from 20 Dutch HIV-1-infected individuals followed from seroconversion on. Serum neutralizing capacity was assessed with three T cell line-tropic isolates: HIV-1MN, HIV-1HXB2, and the patien
Biological, serological, and genetic characterization of HIV-1 subtype E isolates from northern Thailand.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):263-9. Unique Identifier : AIDSLINE MED/94289064; Ichimura H; Kliks SC; Visrutaratna S; Ou CY; Kalish ML; Levy JA; Department of Medicine, School of Medicine, University of; California, San Francisco 94143-0128.; Twenty-three HIV-1 isolates were recovered from PBMCs from 26 HIV-1-seropositive individuals in northern Thailand . The viruses grew readily in human PBMCs but only 7 of 17 (41.2%) and 5 of 17 (29.4%) replicated and only at a low level in primary macrophages and in established T c
Genetic analysis of HIV-1 during rapid progression to AIDS in an apparently healthy man.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):271-7. Unique Identifier : AIDSLINE GENBANK/S73399; Oka S; Ida S; Shioda T; Takebe Y; Kobayashi N; Shibuya Y; Ohyama K; Momota K; Kimura S; Shimada K; Department of Infectious Diseases, University of Tokyo, Japan.; We encountered a case of HIV-1 infection in a previously healthy man, which was characterized by rapid progression to AIDS and death within 7 months in association with high levels of antigenemia throughout the clinical course and no humoral immune response for at least 6 months. Genetic changes of the third variable
Quantitative assessment of human immunodeficiency virus type 1 replication in human xenografts of acutely infected Hu-PBL-SCID mice.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):279-84. Unique Identifier : AIDSLINE MED/94289066; Koup RA; Hesselton RM; Safrit JT; Somasundaran M; Sullivan JL; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016.; Replication of the IIIB strain of human immunodeficiency virus type 1 (HIV-1IIIB) in CB.17 scid/scid mice reconstituted with human peripheral blood lymphocytes (Hu-PBL-SCID) was investigated. Hu-PBL-SCID mice could be infected, in a dose-dependent manner, when HIV-1IIIB was injected intraperitoneally. Replication-comp
Defective infection of rabbit peripheral blood monocyte cultures with human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):285-93. Unique Identifier : AIDSLINE MED/94289067; Tseng CK; Leibowitz J; Sell S; Department of Pathology and Laboratory Medicine, Medical School,; University of Texas Health Science Center at Houston 77225.; Human immunodeficiency virus type 1 (HIV-1) produces abortive infections of primary cultures of rabbit peripheral blood mononuclear cells (PMBCs). Mitogen activation of rabbit PBMCs or the addition of exogenous cytokines to the cultures does not change the level of release of the early HIV core protein, p24, into the
A sensitive reporter cell line for HIV-1 tat activity, HIV-1 inhibitors, and T cell activation effects.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):295-301. Unique Identifier : AIDSLINE MED/94289068; Aguilar-Cordova E; Chinen J; Donehower L; Lewis DE; Belmont JW; Institute for Molecular Genetics, Baylor College of Medicine,; Houston, Texas 77030.; The production and characterization of a cell line for quantitative HIV-1 Tat function and T cell activation assays is described. 1G5 is a clonal cell line derived from Jurkat T cells stably transfected with a luciferase gene driven by an HIV-1 long terminal repeat (HIV-LTR). The 1G5 clone was selected for low basal l
Effect of p40tax trans-activator of human T cell lymphotropic virus type I on expression of autoantigens.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):303-8. Unique Identifier : AIDSLINE MED/94289069; Banki K; Ablonczy E; Nakamura M; Perl A; Department of Medicine, State University of New York, Syracuse; 13210.; The possibility of a retroviral etiology has long been raised in a number of autoimmune disorders. More recently, Sjogren s syndrome and rheumatoid arthritis were noted in transgenic mice carrying the tax gene of human T cell leukemia virus type I (HTLV-I). To evaluate the involvement of HTLV-I Tax in autoimmunity, it
SIVmac expressing hybrid envelope proteins containing HIV-1 V3 and/or C4 sequences is not competent for replication.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):309-13. Unique Identifier : AIDSLINE MED/94289070; Kirchhoff F; Morrison HG; Murray MG; Rennert P; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772-9102.; The V3- and C4-coding regions in the envelope gene of the infectious, pathogenic SIVmac239 clone were replaced by the corresponding HIV-1 sequences. Viral particles were obtained after transfection of COS-1 cells. Chimeric SIVmac constructs were not replication competent in the human T cell lines CEMx174, AA2, H9, and
Complex splicing of simian immunodeficiency virus (mac 251-32H) rev gene transcript from infected macaques.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):315-8. Unique Identifier : AIDSLINE MED/94289071; Szotyori Z; Almond N; Kitchin P; National Institute for Biological Standards and Control, Potters; Bar, Herts, England.; Sequences of the simian immunodeficiency virus (SIV) rev mRNA transcripts were characterized from peripheral blood lymphocytes (PBLs) of two macaques experimentally infected with SIVmac251 (32H reisolate). This analysis has demonstrated that the complex splicing patterns observed for the rev mRNA transcripts originall
Silent mutation pattern in V3 sequences distinguishes virus according to risk group in Europe.: AIDS Res Hum Retroviruses. 1994 Mar;10(3):319-20. Unique Identifier : AIDSLINE MED/94289072; Kuiken CL; Goudsmit J; Department of Virology, Academic Medical Centre, Amsterdam, The; Netherlands.
Outcome of psychoeducation for HIV risk reduction.: AIDS Educ Prev. 1994 Apr;6(2):113-25. Unique Identifier : AIDSLINE MED/94289146; Malow RM; West JA; Corrigan SA; Pena JM; Cunningham SC; University of Miami School of Medicine, FL.; Our objectives were to assess the effects of a psychoeducational (PE) program designed to reduce HIV risk behaviors in recovering drug abusers and to evaluate mediating variables associated with risk reduction as described by the AIDS Risk Reduction Model (ARRM). Consecutive admissions to a Department of Veterans Affa
AIDS prevention struggles in ethnocultural neighborhoods: why research partnerships with community based organizations can't wait.: AIDS Educ Prev. 1994 Apr;6(2):126-39. Unique Identifier : AIDSLINE MED/94289147; Stevenson HC; White JJ; University of Pennsylvania, Graduate School of Education,; Psychology in Education Division, Philadelphia 19104-6216.; Community based AIDS prevention programming and research in minority neighborhoods are growing. The AIDS epidemic has demoralized many minority communities and has added to enormously stressing social conditions. Obstacles to effective AIDS prevention programming must be removed before stable, accessible, and cultural
AIDS knowledge and sexual behavior among Mexican gay and bisexual men.: AIDS Educ Prev. 1994 Apr;6(2):163-74. Unique Identifier : AIDSLINE MED/94289150; Ramirez J; Suarez E; de la Rosa G; Castro MA; Zimmerman MA; School of Public Health, University of Michigan.; Little knowledge exists about AIDS and Human Immunodeficiency Virus (HIV) infection among Latin American gay males. In Latin America, sexual transmission from man to man is the leading cause of HIV infection. In Mexico , which ranks third in number of AIDS cases in the Americas, mor
Attitudes toward people with AIDS and implications for school-based youth AIDS education.: AIDS Educ Prev. 1994 Apr;6(2):175-83. Unique Identifier : AIDSLINE MED/94289151; Handler A; Lampman C; Levy S; Weeks K; Rashid J; Flay B; Department of Community Health Sciences, University of Illinois; at Chicago.; This study examines attitudes toward people with AIDS (PWAs) of a group of 853 7th, 8th, and 9th graders living in high-risk communities in the suburbs of a large Midwestern city. Females appear to be more tolerant than males, and whites appear to be more tolerant than other racial/ethnic groups with respect to attitu
HIV/AIDS education and prevention for Asian and Pacific Islander communities: toward the development of general guidelines.: AIDS Educ Prev. 1994 Apr;6(2):184-6. Unique Identifier : AIDSLINE MED/94289152; Yep GA; Department of Communication Studies, California State University,; Los Angeles 90032.
Psychoeducational group approach: HIV risk reduction in drug users.: AIDS Educ Prev. 1994 Apr;6(2):95-112. Unique Identifier : AIDSLINE MED/94289153; Sorensen JL; London J; Heitzmann C; Gibson DR; Morales ES; Dumontet R; Acree M; University of California, San Francisco.; In two trials of a small-group AIDS prevention approach, 50 methadone maintenance patients and 98 heroin abusers in outpatient detoxification were randomly assigned to experimental or comparison conditions. Experimental condition subjects received a 6-hour, small-group intervention that aimed to improve their knowledg
Activated T and B lymphocytes in peripheral blood of patients with Chagas' disease.: Int Immunol. 1994 Apr;6(4):499-506. Unique Identifier : AIDSLINE MED/94289330; Dutra WO; Martins-Filho OA; Cancado JR; Pinto-Dias JC; Brener Z; Freeman Junior GL; Colley DG; Gazzinelli G; Parra JC; Centro de Pesquisas Rene Rachou, FIOCRUZ, Belo Horizonte,; Brazil.; Whole blood preparations from patients with either the indeterminate (asymptomatic) or cardiac clinical forms of chronic Trypanosoma cruzi infection were analyzed by flow cytometry using double-labeling to identify subsets of circulating lymphocytes. Several significant differences were demonstrated between the blood
Fetal immunological and haematological changes in intrauterine infection [see comments]: Br J Obstet Gynaecol. 1994 May;101(5):418-21. Unique Identifier : AIDSLINE MED/94289360; Thilaganathan B; Carroll SG; Plachouras N; Makrydimas G; Nicolaides KH; Harris Birthright Research Centre for Fetal Medicine, King's; College Hospital School of Medicine, London, UK.; OBJECTIVE: To study fetal immunological and haematological changes to intrauterine infection. DESIGN: In 37 pregnancies at risk of intrauterine infection, fetal blood obtained by cordocentesis at 20 to 36 weeks gestation was used for differential leucocyte counts, platelet count, enumeration of lymphocyte subpopulatio
Sexual behavior of American adolescents: results from a U.S. national survey.: J Adolesc Health. 1994 Mar;15(2):117-25. Unique Identifier : AIDSLINE MED/94289439; Leigh BC; Morrison DM; Trocki K; Temple MT; Medical Research Institute of San Francisco, California.; PURPOSE: This paper reports on data from a 1990 U.S. national survey of the sexual behavior of male and female adolescents aged 12-17. METHODS: A household survey using a multi-stage area probability sample of the United States was undertaken in 1990. Adolescents were interviewed about
Female adolescents at high, moderate, and low risk of exposure to HIV: differences in knowledge, beliefs, and behavior.: J Adolesc Health. 1994 Mar;15(2):133-41. Unique Identifier : AIDSLINE MED/94289441; Millstein SG; Moscicki AB; Broering JM; Department of Pediatrics, University of California, San Francisco; 94143.; PURPOSE: To examine differences in the beliefs and behaviors of female adolescents at varying degrees of probable risk for HIV transmission. METHODS: A clinically-based, ethnically diverse sample of 696 sexually active female adolescents was recruited from urban and suburban general adolescent, family planning, and pu
Cognitive and behavioral adaptations to HIV/AIDS among gay and bisexual adolescents.: J Adolesc Health. 1994 Mar;15(2):142-8. Unique Identifier : AIDSLINE MED/94289442; Remafedi G; Department of Pediatrics, University of Minnesota, Minneapolis; 55455.; PURPOSE: To examine short-term changes in HIV knowledge, beliefs, and behaviors among gay and bisexual adolescents, 139 gay and bisexual male adolescents (13-21 years of age) completed interviews and self-administered surveys of HIV-related knowledge, attitudes, and behaviors during an initial assessment (Time 1) and
HIV risk behavior and medical status of underprivileged youths in Belo Horizonte, Brazil.: J Adolesc Health. 1994 Mar;15(2):179-85. Unique Identifier : AIDSLINE MED/94289448; Pinto JA; Ruff AJ; Paiva JV; Antunes CM; Adams IK; Halsey NA; Greco DB; Service of Parasitic and Infectious Diseases, School of Medicine,; Federal University of Minas Gerais, Belo Horizonte, Brazil.; METHODS: From June 1989 to April 1991, 394 adolescents aged 10-18 years randomly selected upon admission at a state shelter in Belo Horizonte, Brazil underwent health history interview, physical examination, serology for HIV, hepatitis B, and syphilis, and stool examination. Partic
Gene therapy for genetic diseases [editorial]: Hum Gene Ther. 1994 Mar;5(3):281-2. Unique Identifier : AIDSLINE MED/94289502; Anderson WF
AIDS: unanswered questions or unquestioned answers? [editorial]: Biomed Pharmacother. 1993;47(5):181-2. Unique Identifier : AIDSLINE MED/94289596; Mathe G
Levels of free purine nucleotides in continuous T-cell lines infected with virus HIV-1.: Biomed Pharmacother. 1993;47(5):207-11. Unique Identifier : AIDSLINE MED/94289602; Tabucchi A; Carlucci F; Monari P; Re MC; Furlini G; Bisozzi L; Consol-Magno E; Pizzichini M; Leoncini R; Pagani R; et al; Istituto di Biochimica e di Enzimologia, Universita di Siena,; Italy.
Effect of human immunodeficiency virus type-1 envelope glycoprotein gp160 on cytokine production from cord-blood T cells.: Blood. 1994 Jul 1;84(1):184-8. Unique Identifier : AIDSLINE MED/94289699; Than S; Oyaizu N; Pahwa RN; Kalyanaraman VS; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, NY 11030.; We have recently demonstrated that the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp160 enhances the in vitro differentiation of hematopoietic myeloid progenitor cells derived from cord blood by inducing secretion of colony-stimulating factor(s) (CSF) in T cells, presumably through the interacti
A plague in prostitution: HIV and AIDS in Thailand.: R I Med. 1994 May;77(5):145-9. Unique Identifier : AIDSLINE MED/94289830; Shih J; Brown University.
Symptomatic amebic colitis in a Japanese homosexual AIDS patient.: Intern Med. 1994 Feb;33(2):120-2. Unique Identifier : AIDSLINE MED/94289877; Ohnishi K; Murata M; Okuzawa E; Department of Infectious Diseases, Tokyo Metropolitan Bokutoh; General Hospital.; A 30-year-old Japanese homosexual AIDS patient was admitted to hospital because of Kaposi s sarcoma and mild diarrhea on February 4, 1993. Mud-like stool with blood and mucous was recognized after admission. Although serologic tests for Entamoeba histolytica were negative, trophozoites of E. histolytica were identifie
The need for a uniform law governing AIDS testing, reporting and confidentiality.: Trends Health Care Law Ethics. 1994 Spring;9(2):39-42. Unique Identifier : AIDSLINE MED/94289947; Tamborlane TA
Bioethics in the news....: Trends Health Care Law Ethics. 1994 Spring;9(2):4-6, 34. Unique Identifier : AIDSLINE MED/94289948; Stolman CJ
Three-dimensional 1H NMR structure of the nucleocapsid protein NCp10 of Moloney murine leukemia virus.: J Biomol NMR. 1994 Mar;4(2):153-70. Unique Identifier : AIDSLINE MED/94289983; Demene H; Jullian N; Morellet N; de Rocquigny H; Cornille F; Maigret B; Roques BP; Departemente de Pharmacochimie Moleculaire et Structurale, U266; INSERM-URA D 1500 CNRS, Faculte de Pharmacie, Paris, France.; The nucleocapsid protein of Moloney murine leukemia virus (NCp10) is a 56-amino acid protein which contains one zinc finger of the CysX2CysX4HisX4Cys form, a highly conserved motif present in most retroviruses and retroelements. At pH > or = 5, NCp10 binds one zinc atom and the complexation induces a folding of the Cy
[Status and future of infection control in gynecology and obstetrics]: Gynakol Geburtshilfliche Rundsch. 1994;34(1):52-3. Unique Identifier : AIDSLINE MED/94290029; Weissenbacher ER; Klinik und Poliklinik fur Frauenheilkunde,; Ludwig-Maximilians-Universitat Munchen, BRD.
Immunodeficiency without HIV. Clinical presentation vary [letter; comment]: BMJ. 1994 May 28;308(6941):1436. Unique Identifier : AIDSLINE MED/94290145; Monteil MA; Henderson DC; Obaro S
Immunodeficiency without HIV. Consider HIV negative immunodeficiency in cryptococcosis [letter; comment]: BMJ. 1994 May 28;308(6941):1436. Unique Identifier : AIDSLINE MED/94290146; Dev D; Basran GS; Slater D; Taylor P; Wood M
Controlling AIDS in India [letter; comment]: BMJ. 1994 May 28;308(6941):1436-7. Unique Identifier : AIDSLINE MED/94290147; Padki K
AIDS vaccine suffers setback in US [news]: BMJ. 1994 Jun 11;308(6943):1527. Unique Identifier : AIDSLINE MED/94290199; Roberts J
Recent advances in tropical medicine.: BMJ. 1994 Jun 11;308(6943):1559-62. Unique Identifier : AIDSLINE MED/94290211; Lockwood DN; Pasvol G; Department of Infection and Tropical Medicine, St Mary's Hospital; Medical School, Imperial College of Science, Technology and; Medicine, Northwick Park Hospital, Harrow.
Leiomyoma of the adrenal gland in a patient with AIDS.: Abdom Imaging. 1994 May-Jun;19(3):259-61. Unique Identifier : AIDSLINE MED/94290253; Dahan H; Beges C; Weiss L; Abitbol M; Ledreff O; Teman G; Belattar K; Rymer R; Department of Radiology, Hopital Lariboisiere, Paris, France.; Leiomyoma of the adrenal gland is an exceptional localization. We report a case occurring in a young patient with AIDS. Diagnosis was a surprise on pathologic examination. On enhanced computed tomographic (CT) scan, the adrenal mass had a low central attenuation area and a thin enhancing peripheral ring. On magnetic r
AIDS awareness in medical personnel [letter]: Natl Med J India. 1994 Mar-Apr;7(2):102. Unique Identifier : AIDSLINE MED/94290292; Bambery P; Narasimhan KL; Dilawari JB
Herpes zoster in an HIV-positive 14-month-old baby.: Natl Med J India. 1994 Mar-Apr;7(2):63-4. Unique Identifier : AIDSLINE MED/94290300; Panda S; Nabachandra T; Sarkar S; Chakraborty S; Naik TN; Deb BC; Indian Council of Medical Research Unit, Manipur.; BACKGROUND. In Manipur, a state in northeast India bordering Myanmar , within one year of reports of a high human immunodeficiency virus (HIV) seroprevalence among young injecting drug users, there has been a rapid spread of HIV infection in the
Inhibition of NF-kappa B transcription factor by catechol derivatives.: Biochem Mol Biol Int. 1994 Feb;32(2):299-305. Unique Identifier : AIDSLINE MED/94290341; Suzuki YJ; Packer L; Department of Molecular & Cell Biology, University of California,; Berkeley 94720.; Therapeutic agents which target NF-kappa B transcription factor may be useful in the management of AIDS, cancer and inflammation. Since oxidative stress has been implicated in the signaling pathway, the use of antioxidants to inhibit NF-kappa B activation has gained attention. In the present study, we examined the eff
Candida osteomyelitis.: J Foot Ankle Surg. 1994 Mar-Apr;33(2):173-6. Unique Identifier : AIDSLINE MED/94290473; Lasday SD; Jay RM; Graduate Hospital, Affiliate of the University of Pennsylvania,; Philadelphia.; Medical care of the hospital patient has become increasingly complicated due to the rising incidence of risk factors for opportunistic infection. With intravenous drug use, HIV infection, and alcoholism complicating an immunocompromised host such as a diabetic, fungal and mycobacterial infections are no longer as rare
A new approach to the limiting dilution assay.: J Biopharm Stat. 1994 Mar;4(1):101-12. Unique Identifier : AIDSLINE MED/94290523; Balch AH; Hitchcock MJ; Brockwell PJ; Bristol-Myers Squibb, PRI, Wallingford, Connecticut.; Improved methods of human immunodeficiency virus isolation have sparked an increased interest in determination of the number and proportion of infected cells in plasma samples. The limiting dilution assay is a popular method of determining the proportion of infected cells. We propose a new estimator of the proportion
[Update of anal-perineal and rectal lesions observed in AIDS]: Contracept Fertil Sex. 1994 Mar;22(3):187-94. Unique Identifier : AIDSLINE MED/94290558; Cope R; College de medecine des hopitaux de Paris.; Anorectal lesions in patients carrying the HIV virus are uncommon (13%, in our personal life, 1 women/15 men). The following raise the possibility of AIDS: Kaposi sarcoma, non Hodgkin s lymphoma and also with the young patients, intraepithelial dysplasia, in situ carcinoma or squamous carcinoma of the anus. Other anor
Pediatric acquired immunodeficiency syndrome: testing as a barrier to recognizing the role of child sexual abuse.: Arch Pediatr Adolesc Med. 1994 Jul;148(7):766-8. Unique Identifier : AIDSLINE MED/94290591; Gellert G; Berkowitz CD; Project HOPE Health Sciences Education Center, Millwood, VA; 22646.
Young people and sex/HIV education: the debate continues....: Promot Educ. 1994 Jun;1(2):21-3, 46. Unique Identifier : AIDSLINE MED/94290866; Grunseit A; National Centre for HIV Social Research (Macquarie U. Unit),; Macquarie University, North Ryde N.S.W., Australia.; The legal age of consent for heterosexual sex is 16 years. Large numbers of young people at school are sexually active. Indicators, such as sexually transmitted diseases, show that in spite of education programmes a large proportion of sexually active young people are practising unsafe sex. Access to anonymous sources
[Have you ever embraced a PWA? (person with AIDS)]: Promot Educ. 1994 Jun;1(2):36. Unique Identifier : AIDSLINE MED/94290870; Martin J; Faculte de medecine, Lausanne, Suisse.
Automat: a novel software system for the systematic search for protein (or DNA) similarities with a notable application to autoimmune diseases and AIDS.: Comput Appl Biosci. 1994 Apr;10(2):153-61. Unique Identifier : AIDSLINE MED/94290911; Cantalloube H; Nahum C; Achour A; Lehner T; Callebaut I; Burny A; Bizzini B; Mornon JP; Zagury D; Zagury JF; Universite P. et M. Curie, Paris, France.; Automat is a novel program which finds exhaustively all the oligopeptide segments shared by a given protein of any size with the proteins of a whole databank. It allows the user to collect statistics on the composition of the sequence studied in reference to the databank used. We present here the rationale and the alg
[Tumor necrosis factor (TNF) and oxygen free radicals: potential effects for immunity]: C R Seances Soc Biol Fil. 1993;187(3):296-307. Unique Identifier : AIDSLINE MED/94290960; Ferlat S; Favier A; Groupe de recherche sur les pathologies oxydatives, GREPO,; Universite de Grenoble, La Tronche.; During various biological processes as inflammation or septic shock, free radical damages are produced by a direct production of oxygen radicals by phagocytes, but also by a TNF-mediated generation in target cells. Antioxidants have been demonstrated as protective against TNF cytotoxicity. We try to measure directly t
Comparison of four commercial enzyme-linked immunosorbent and one agglutination assays for the detection of HIV antibodies in sera from Zimbabwe.: Cent Afr J Med. 1993 Oct;39(10):198-201. Unique Identifier : AIDSLINE MED/94291172; Tswana SA; Moyo SR; Nystrom L; Blomerg J; Department of Medical Microbiology, University of Zimbabwe; Medical School, Harare.; Sera from 871 AIDS and AIDS related complex patients were used to evaluate four ELISA and one agglutination assays. Commercial tests compared were Abbot, Wellcoyzyme, Biotest, Du Pont and Serodia. Wellcozyme and Serodia had the highest sensitivity (96.8 pc and 98.8 pc respectively) but the lowest specificity (53.3 pc
Long-term dietary vitamin E retards development of retrovirus-induced disregulation in cytokine production.: Clin Immunol Immunopathol. 1994 Jul;72(1):70-5. Unique Identifier : AIDSLINE MED/94291303; Wang Y; Huang DS; Eskelson CD; Watson RR; Department of Family and Community Medicine, University of; Arizona, Tucson 85724.; A 15-fold increase in dietary vitamin E (160 IU/liter) normalized hepatic and serum levels of vitamin E normally reduced by retrovirus infection. It also significantly retarded development of splenomegaly and hypergammaglobulinemia induced by retrovirus infection, while significantly restoring release of interleukin-2
Establishment and characterization of synovial cell clones with integrated human T-cell leukemia virus type-I.: Clin Immunol Immunopathol. 1994 Jul;72(1):90-7. Unique Identifier : AIDSLINE MED/94291307; Hasunuma T; Nakajima T; Aono H; Sato K; Matsubara T; Yamamoto K; Nishioka K; Division of Rheumatology and Molecular Immunology, St. Marianna; University School of Medicine, Kanagawa-ken, Japan.; Human T cell leukemia virus type-I (HTLV-I)-integrated synovial cell clones (SCCs) were established from four HTLV-I-infected patients with chronic proliferative arthropathy. Extracted DNAs of these SCCs were examined for the existence of HTLV-I proviral DNA. Electron microscopic analysis and immunohistochemical stain
Significance of interleukin 6 in patients with sarcoidosis.: Chest. 1994 Jul;106(1):156-60. Unique Identifier : AIDSLINE MED/94291373; Sahashi K; Ina Y; Takada K; Sato T; Yamamoto M; Morishita M; Second Department of Internal Medicine, Nagoya City, University; Medical School, Japan.; Interleukin 6 (IL-6) levels in various materials from patients with sarcoidosis were determined. The subjects of the study were 38 patients with sarcoidosis and 28 healthy controls. For detection of IL-6, an enzyme-linked immunosorbent assay method was used. Interleukin 6 activity in serum was detected in 4 of 30 pati
Tuberculosis in young adults and the elderly. A prospective comparison study [see comments]: Chest. 1994 Jul;106(1):28-32. Unique Identifier : AIDSLINE MED/94291394; Korzeniewska-Kosela M; Krysl J; Muller N; Black W; Allen E; FitzGerald JM; Respiratory Division, Vancouver General Hospital, BC, Canada.; OBJECTIVES: To compare the clinical, bacteriologic, and radiologic features of pulmonary and pleural tuberculosis in young adults and the elderly and determine if any differences exist between both groups. DESIGN: Prospective recruitment of all patients diagnosed as having pulmonary and pleural tuberculosis in British
Tracheoesophageal fistula in an HIV-1-positive man due to dual infection of Candida albicans and cytomegalovirus.: Chest. 1994 Jul;106(1):284-5. Unique Identifier : AIDSLINE MED/94291396; Rusconi S; Meroni L; Galli M; Clinica delle Malattie Infettive, Universita degli Studi di; Milano, Ospedale Luigi Sacco, Italy.; We report a 35-year-old HIV-1-positive man who presented with severe dyspnea and a nonproductive cough. Three fiberoptic bronchoscopic examination revealed an infiltrating and vegetating tracheal mass that was diagnosed as necrotizing candidiasis of the trachea. The lesion resulted in the formation of a tracheoesophag
[HIV-associated histoplasmosis with pulmonary manifestation in Europe]: Dtsch Med Wochenschr. 1994 Jun 24;119(25-26):909-14. Unique Identifier : AIDSLINE MED/94291508; Wockel W; Neher A; Morresi A; Pathologisches Institut, Zentralkrankenhaus Gauting der LVA; Oberbayern.; A 35-year-old man developed weight loss, lower abdominal pain, diarrhoea, cough, fever and general deterioration in his health. He had been born and resident in the USA until 1991, when he moved to Germany . Since 1991 he had known that he was HIV-positive. The chest radiograph sho
[HIV infection in children]: Dtsch Med Wochenschr. 1994 Jun 24;119(25-26):941. Unique Identifier : AIDSLINE MED/94291514
Coping and depressive symptoms among people with AIDS.: Health Psychol. 1994 Mar;13(2):156-69. Unique Identifier : AIDSLINE MED/94291613; Fleishman JA; Fogel B; Center for Gerontology and Health Care Research, Brown; University.; This study examined coping behaviors of people with AIDS, using a large sample (N = 736) that was both geographically and sociodemographically diverse. In-person interviews were conducted with people receiving AIDS-related medical or social services; follow-up interviews were conducted approximately 11 months later. F
Identification of functional sites on bovine leukemia virus envelope glycoproteins using structural and immunological data.: Eur J Biochem. 1994 Jun 1;222(2):405-14. Unique Identifier : AIDSLINE MED/94291634; Callebaut I; Portetelle D; Burny A; Mornon JP; Departement des Macromolecules Biologiques--Laboratoire de; Mineralogie-Cristallographie, CNRS URA09, Universites Paris,; France.; Sequence analysis using the sensitive hydrophobic cluster analysis method shows that the bovine leukemia virus envelope glycoproteins conserve the general organization of the influenza hemagglutinin into a stem , containing the external part of the transmembrane glycoprotein and the N-terminal and C-terminal parts of
Different proliferative response of human and chimpanzee lymphocytes after contact with human immunodeficiency virus type 1 gp120.: Eur J Immunol. 1994 Jan;24(1):34-40. Unique Identifier : AIDSLINE MED/94291738; Di Rienzo AM; Furlini G; Olivier R; Ferris S; Heeney J; Montagnier L; Department of Retroviruses, Institut Pasteur, Paris.; T cell functional defects are a common aspect of human immunodeficiency virus (HIV) infection. Moreover, it has been suggested that indirect mechanisms are involved in CD4+ cell depletion. Unresponsiveness to proliferative stimuli of lymphocytes incubated with HIV particles or with viral proteins is well documented. N
Haemochromatosis as a window into the study of the immunological system: a novel correlation between CD8+ lymphocytes and iron overload.: Eur J Haematol. 1994 May;52(5):283-90. Unique Identifier : AIDSLINE MED/94291806; Porto G; Reimao R; Goncalves C; Vicente C; Justica B; de Sousa M; Abel Salazar Institute for the Biomedical Sciences, Santo Antonio; General Hospital, Porto, Portugal.; In the present study we report a serial investigation of the numbers of the peripheral blood cells--erythrocytes, polymorphonuclear neutrophils, total lymphocytes, T-lymphocyte subpopulations (CD2, CD4, CD8), B lymphocytes and monocytes--in a group of 21 patients with haemochromatosis during the time of intensive phle
[The occurrence of immunological tolerance to inhibitors of factors VIII and IX in hemophilia patients]: Gematol Transfuziol. 1993 Feb;38(2):18-20. Unique Identifier : AIDSLINE MED/94291906; Brakman GG; To abolish inhibitors, 40 out of 60 hemophiliacs (57 patients and 3 with hemophilia A and B, respectively) were treated according to the therapeutic scheme specified as Bonn protocol. A complete disappearance of the inhibitors was achieved in all the patients. These were followed up for 13 years during which they rece
[Rapidly growing tumor of the hand--is tuberculosis as differential diagnosis gaining increased importance?]: Handchir Mikrochir Plast Chir. 1994 Mar;26(2):91-4. Unique Identifier : AIDSLINE MED/94292059; Weber P; Rosslein R; Kinderchirurgischen Universitatsklinik, Kinderspital Basel.; A two-year-old healthy, Portuguese girl presented with a prominent, painless tumor over the first web space of the left hand. The tumor increased rapidly in size over a few weeks, but caused no functional problems. On X-ray films, a cystic structure of the first metacarpal bone with erosion of the corticalis was demon
[Current developments in antiviral chemotherapy. Part 4: Foscarnet, zidovudine, didanosine]: Fortschr Med. 1994 May 10;112(13):190-1. Unique Identifier : AIDSLINE MED/94292065; Stamminger T; Fleckenstein B; Institut fur Klinische u. Molekulare Virologie der Univ.,; Erlangen.
Psychoeducation about sexual issues in an acute treatment setting.: Hosp Community Psychiatry. 1994 Apr;45(4):380-1. Unique Identifier : AIDSLINE MED/94292154; Steiner JL; Lussier RG; Maust GC; DiPalma LM; Allende MJ; Department of Psychiatry, Yale University School of Medicine, New; Haven, CT.
Oral mucosal disease: a decade of new entities, aetiologies and associations.: Int Dent J. 1994 Feb;44(1):33-43. Unique Identifier : AIDSLINE MED/94292266; Scully C; Porter SR; Centre for the Study of Oral Disease, University Department of; Oral Medicine, Surgery and Pathology, Bristol Dental Hospital and; School, UK.; New patterns of oral mucosal disease and indeed new disorders have been emerging over the past decade. Although infection with human immunodeficiency viruses (HIV) is having the most profound impact, there are also major changes in oral health and the standard of health care required, because of other new disorders an
AIDS and hepatitis: a problem for the dental team.: Int Dent J. 1994 Feb;44(1):49-54. Unique Identifier : AIDSLINE MED/94292268; Reichart PA; Department of Oral Surgery, North Free University of Berlin,; Germany.; The different types of viral hepatitis are briefly reviewed in relation to transmission during dental treatment, hepatitis B remaining the greatest threat to the dental team which is not immunised. The significance of hepatitis C for the dental profession is as yet undetermined. Transmission of HIV in the dental pract
HIV infection and AIDS: educational and ethical aspects in relation to dentistry: report from a workshop held in London, 11-13 February 1993.: Int Dent J. 1994 Feb;44(1):55-8. Unique Identifier : AIDSLINE MED/94292269; Department of Oral Pathology, School of Clinical Dentistry,; University of Sheffield, UK.
Giant molluscum contagiosum presenting as a tumor in an HIV-infected patient.: Int J Dermatol. 1994 Apr;33(4):266-7. Unique Identifier : AIDSLINE MED/94292318; Izu R; Manzano D; Gardeazabal J; Diaz-Perez JL; Dermatology Department, Hospital de Cruces, Bilbao, Spain.
[Cytomegalovirus in the etiology of bleeding stomach ulcer. Emergency endoscopy in a 70-year-old patient of unknown HIV status]: Internist (Berl). 1994 May;35(5):480-3. Unique Identifier : AIDSLINE MED/94292354; Meuthen I; Hummerich W; Kunstmann G; Kirsch L; Salzberger B; Schrappe M; Medizinische Klinik, Stadtisches Krankenhaus Koln-Holweide.
Update on legislative issues. HIV notification.: Iowa Med. 1994 May;84(5):201-2. Unique Identifier : AIDSLINE MED/94292361
Working memory in individuals with HIV infection.: J Clin Exp Neuropsychol. 1994 Apr;16(2):173-82. Unique Identifier : AIDSLINE MED/94292566; Law WA; Martin A; Mapou RL; Roller TL; Salazar AM; Temoshok LR; Rundell JR; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, Maryland.; The central executive component (CE) of Baddeley s working memory model (Baddeley, 1992) was evaluated in 26 asymptomatic human immunodeficiency virus-infected individuals (HIV+) and 23 HIV-control subjects using a dual-task working memory paradigm. The HIV+ and HIV- groups showed an equivalent reduction in performanc
Oro-facial tumours in Ethiopian patients. Clinical analysis of 108 cases and a review of the literature.: J Craniomaxillofac Surg. 1994 Apr;22(2):76-80. Unique Identifier : AIDSLINE MED/94292585; Neway M; Eshete S; Minasse M; Department of Oral Maxillofacial Surgery and Dentistry, Yekatit; 12 Teaching Hospital, Addis Ababa, Ethiopia.; Maxillofacial surgery is a new medical discipline in Ethiopia . Between May 1991 and December 1992, 108 patients with maxillofacial tumours were treated in our Department. These cases are analysed according to their age, sex, anatomical site, histopathological classification of be
The relationship between type of care planning system and patient outcomes in hospitalized AIDS patients.: J Adv Nurs. 1994 Apr;19(4):691-8. Unique Identifier : AIDSLINE MED/94292668; Henry SB; Holzemer WL; Reilly CA; Department of Mental Health, Community, and Administrative; Nursing, University of California, San Francisco 94143-0608.; The purpose of this study was to describe the problems of HIV-infected patients, hospitalized for Pneumocystis carinii pneumonia (PCP), as documented in the nursing care plan and to examine differences in the number and type of activated patient problems and patient outcomes between manually generated, computer-suppor
A study on existing knowledge about AIDS among undergraduates of a Nigerian University.: J Commun Dis. 1993 Jun;25(2):52-6. Unique Identifier : AIDSLINE MED/94292705; Gugnani A; Ukeje MA; University of Nigeria Teaching Hospital, Enugu (Enugu State),; Nigeria.; This study, carried out during August-October, 1991, involved 236 respondents to a questionnaire designed to determine awareness and attitudes to AIDS and the consequent effect of such awareness on their sexual behaviour. Almost all the medical students were aware of the existence of the disease, while a few (3.8 per
HIV infection and AIDS in Latin America. Epidemiologic features and clinical manifestations.: Infect Dis Clin North Am. 1994 Mar;8(1):1-11. Unique Identifier : AIDSLINE MED/94292721; Murillo J; Castro KG; Hospital Vargas, Caracas, Venezuela.; This article updates the epidemiologic situation of HIV and AIDS infection and summarizes the most common clinical manifestations in Latin American countries. As of December 1992, a total of 59,723 AIDS cases had been reported to the Pan American Health Organization from Mexico , Ce
Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression.: J Immunol. 1994 Jul 15;153(2):566-73. Unique Identifier : AIDSLINE MED/94292786; Hollsberg P; Ausubel LJ; Hafler DA; Center for Neurologic Diseases, Brigham & Women's Hospital,; Boston, MA 02115.; T cell proliferation is potently suppressed by TGF-beta during the G1 phase of the cell cycle. The mechanism appears to involve inhibition of cell cycle kinases that phosphorylate the retinoblastoma protein (pRb), a key regulator of cell cycle progression from G1 to S phase. Although productive infection with the huma
Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.: J Immunol. 1994 Jul 15;153(2):862-72. Unique Identifier : AIDSLINE MED/94292818; Sarin A; Clerici M; Blatt SP; Hendrix CW; Shearer GM; Henkart PA; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bthesda, MD 20892.; In vitro activation of PBLs from HIV+ individuals resulted in programmed cell death (PCD) within 2 days in 58 of 95 HIV+ blood donors, in contrast to only two of 30 control HIV- donors. CD4+ and CD8+ T cells from HIV+ donors died under these conditions, and these cells showed apoptotic nuclear morphology and DNA fragm
Projection structures of human immunodeficiency virus type 1 (HIV-1) observed with high resolution electron cryo-microscopy.: J Electron Microsc (Tokyo). 1994 Feb;43(1):16-9. Unique Identifier : AIDSLINE MED/94292879; Goto T; Ashina T; Fujiyoshi Y; Kume N; Yamagishi H; Nakai M; Department of Microbiology, Osaka Medical College, Japan.; An electron microscopical study was made of human immunodeficiency virus type 1 (HIV-1) in the unstained, frozen, hydrated state at liquid helium temperature. The findings were compared with those obtained from negative staining and ultrathin sectioning. Electron cryo-microscopy confirms and extended the findings obta
Circulating cytotoxic T lymphocyte precursors in maedi-visna virus-infected sheep.: J Gen Virol. 1994 Jul;75 ( Pt 7):1589-96. Unique Identifier : AIDSLINE MED/94292909; Blacklaws BA; Bird P; Allen D; McConnell I; Department of Veterinary Pathology, University of Edinburgh,; Summerhall, U.K.; Maedi-visna virus (MVV)-specific cytotoxic T lymphocytes (CTL) were detected, after in vitro culture with MVV antigen and recombinant human interleukin-2, in the efferent lymph and peripheral blood of sheep chronically infected with MVV. Cytotoxicity was mediated by CD8+ lymphocytes and was specific for particular str
Definition of the range and distribution of human immunodeficiency virus macrophage tropism using PCR-based infectivity measurements.: J Gen Virol. 1994 Jul;75 ( Pt 7):1597-603. Unique Identifier : AIDSLINE MED/94292910; Collin M; Illei P; James W; Gordon S; Sir William Dunn School of Pathology, University of Oxford, U.K.; The tropism of human immunodeficiency virus (HIV) for macrophages (m phi) is a well recognized phenomenon, but the range and distribution of m phi-tropic phenotypes have not been defined by quantitative means. This study uses a PCR-based infectivity assay to derive an index of m phi tropism for several common strains
Phylogenetic relationship between human immunodeficiency virus type 1 (HIV-1) long terminal repeat natural variants present in the lymph node and peripheral blood of three HIV-1-infected individuals.: J Gen Virol. 1994 Jul;75 ( Pt 7):1615-21. Unique Identifier : AIDSLINE MED/94292912; Ait-Khaled M; Emery VC; Division of Communicable Diseases, Royal Free Hospital School of; Medicine, Hampstead, London, U.K.; PCR has been used to amplify a 540 base pair fragment of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat region encompassing the U5/R/U3 regions from proviral HIV DNA that was present in the lymph nodes and peripheral blood mononuclear cells of three HIV-infected individuals. The resulting PCR pro
Calcium-mediated inhibition of phorbol ester and Tax trans-activation of the human T cell leukaemia virus type 1.: J Gen Virol. 1994 Jul;75 ( Pt 7):1623-31. Unique Identifier : AIDSLINE MED/94292913; Copeland KF; Haaksma AG; Goudsmit J; Heeney JL; Department of Chronic and Infectious DiseaseS, TNO-Rijswijk, The; Netherlands.; Human Jurkat T cells containing a stably integrated human T cell leukaemia virus type 1 (HTLV-1) long terminal repeat (LTR) reporter gene construct were used to study the role of calcium-dependent cellular activation pathways in LTR trans-activation. Treatment of these cells with the calcium ionophore ionomycin result
Cerebrospinal fluid HIV-1 p24 antigen and culture: sensitivity and specificity for AIDS-dementia complex.: J Neurol Neurosurg Psychiatry. 1994 Jul;57(7):784-9. Unique Identifier : AIDSLINE MED/94292990; Brew BJ; Paul MO; Nakajima G; Khan A; Gallardo H; Price RW; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, NY.; We prospectively evaluated 94 patients with AIDS- dementia complex (ADC) and a smaller group of 27 patients with other HIV-1 related neurological conditions to determine the usefulness of cerebrospinal fluid (CSF) p24 antigen and HIV-1 culture in the diagnosis of ADC. The presence o
Successful immunosuppressive therapy for HTLV-I associated myelopathy.: J Neurol Sci. 1994 Apr;122(2):155-6. Unique Identifier : AIDSLINE MED/94293029; Misra AK; Mishra SK; Eigen AC; Tourtellotte WW; Neurology Service (752/127), School of Medicine, Department of; Veterans Affairs Outpatient Clinic, Los Angeles, CA.
Characterization of adherent T cells to human endothelial cells in patients with HTLV-I-associated myelopathy.: J Neurol Sci. 1994 Apr;122(2):204-9. Unique Identifier : AIDSLINE MED/94293035; Ichinose K; Nakamura T; Nishiura Y; Nagasato K; Ohishi K; Watanabe H; Fujita A; Kurouji K; Tsujihata M; Nagataki S; First Department of Internal Medicine, Nagasaki University School; of Medicine, Japan.; To clarify the phenomenon of increased adherence of T cells to endothelial cells (EC) in patients with HTLV-I-associated myelopathy (HAM), we determined the surface markers and expression of lymphocyte function antigen-1 (LFA-1) in T cells adherent or nonadherent to EC. The percentage of activated or HLA-DR+ T cells a
Appetite effect of dronabinol [letter; comment]: J Clin Oncol. 1994 Jul;12(7):1524-5. Unique Identifier : AIDSLINE MED/94293084; Beal JA
Pharmacokinetic evaluation of the combination of zidovudine and didanosine in children with human immunodeficiency virus infection.: J Pediatr. 1994 Jul;125(1):142-6. Unique Identifier : AIDSLINE MED/94293107; Mueller BU; Pizzo PA; Farley M; Husson RN; Goldsmith J; Kovacs A; Woods L; Ono J; Church JA; Brouwers P; et al; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, MD 20892.; As part of a phase I/II trial in children infected with human immunodeficiency virus, we studied the pharmacokinetics of zidovudine and didanosine administered as single agents and in combination. Zidovudine (60 to 180 mg/m2 per dose) was given orally every 6 hours, and didanosine (60 to 180 mg/m2 per dose) every 12 h
Hepatitis B vaccination in infants of mothers infected with human immunodeficiency virus.: J Pediatr. 1994 Jul;125(1):70-2. Unique Identifier : AIDSLINE MED/94293131; Zuccotti GV; Riva E; Flumine P; Locatelli V; Fiocchi A; Tordato G; Giovannini M; Fifth Pediatric Department, University of Milan, Italy.; Eighteen infants of mothers with human immunodeficiency virus (HIV) infection were given hepatitis B vaccine at birth. Seroconversion occurred in all 13 infants whose HIV antibody disappeared, versus one of five HIV-infected children. The four of five HIV-infected infants who did not mount an antibody response progres
Responses to measles immunization in children infected with human immunodeficiency virus.: J Pediatr. 1994 Jul;125(1):72-4. Unique Identifier : AIDSLINE MED/94293132; Rudy BJ; Rutstein RM; Pinto-Martin J; Division of General Pediatrics, Children's Hospital of; Philadelphia, University of Pennsylvania School of Medicine.; The responses to measles immunization administered between 6 and 12 months and after 12 months were compared in children with and without human immunodeficiency virus infection. No difference in response was found when primary measles immunization was administered between 6 and 12 months; however, children with human
Immunity to Haemophilus influenzae type b polysaccharide capsule in children with human immunodeficiency virus infection immunized with a single dose of Haemophilus vaccine.: J Pediatr. 1994 Jul;125(1):74-7. Unique Identifier : AIDSLINE MED/94293133; Peters VB; Sood SK; Department of Pediatrics, Mount Sinai School of Medicine, New; York, New York.; We studied immunity to Haemophilus influenzae type b (Hib) polysaccharide capsule in 19 children infected with human immunodeficiency virus (HIV) immunized with a single dose of a Hib vaccine at a mean age of 28 months (range, 15 to 56 months). Four to eighty-five months after immunization, only 7 children (37%) were
Antibodies to pneumococcal capsular polysaccharides in children with human immunodeficiency virus infection given polyvalent pneumococcal vaccine.: J Pediatr. 1994 Jul;125(1):77-9. Unique Identifier : AIDSLINE MED/94293134; Arpadi SM; Back S; O'Brien J; Janoff EN; Bronx Lebanon Hospital Center, New York.; Antibody to 7 common pneumococcal capsular polysaccharides was measured in 11 children with human immunodeficiency virus (HIV) infection who had been previously vaccinated with 23-valent polysaccharide pneumococcal vaccine, 11 unvaccinated children with HIV infection, and 11 healthy subjects. No differences in capsule
Effect of MTP-PE liposomes and interleukin-7 on induction of antibody and cell-mediated immune responses to a recombinant HIV-envelope protein.: J Acquir Immune Defic Syndr. 1994 Aug;7(8):799-806. Unique Identifier : AIDSLINE MED/94293161; Bui T; Dykers T; Hu SL; Faltynek CR; Ho RJ; Department of Pharmaceutics, University of Washington, Seattle; 98195.; We investigated the ability of human recombinant interleukin-7 (IL-7) to enhance the immune responses of mice vaccinated with either the alum-associated or liposome-formulated recombinant human immunodeficiency virus (HIV)-envelope protein, env-2-3SF2 (a nonglycosylated denatured gp 120 of HIV-1SF2 produced in genetic
HIV antibody testing: the gap between policy and practice.: J Acquir Immune Defic Syndr. 1994 Aug;7(8):816-22. Unique Identifier : AIDSLINE MED/94293163; Pomeroy C; Sandry J; Moldow DG; Department of Veterans Affairs Medical Center, Minneapolis, MN; 55417.; In response to recent laws regulating human immunodeficiency virus (HIV) antibody testing practices in all federal hospitals, our university-affiliated Veterans Affairs Hospital instituted several interventions designed to increase appropriate testing. Specific hospital policy requiring restriction of testing to high-
Serious Pseudomonas aeruginosa infection in AIDS.: J Acquir Immune Defic Syndr. 1994 Aug;7(8):823-31. Unique Identifier : AIDSLINE MED/94293164; Shepp DH; Tang IT; Ramundo MB; Kaplan MK; Department of Medicine, North Shore University Hospital-Cornell,; University Medical College, Manhasset, New York 11030.; During a 7-year period, 32 patients with Pseudomonas aeruginosa infection were identified on an HIV treatment service at a university-affiliated teaching hospital. The number of cases increased from 2 in 1986 to 13 in 1992. Affected patients had evidence of advanced HIV infection. In those treated with antiretroviral
Is HIV-1 likely to become a leading cause of adult mortality in sub-Saharan Africa?: J Acquir Immune Defic Syndr. 1994 Aug;7(8):839-52. Unique Identifier : AIDSLINE MED/94293166; Gregson S; Garnett GP; Anderson RM; Department of Zoology, University of Oxford, United Kingdom.; Concerns are sometimes expressed at the extent to which HIV-1 is prioritized within international and national health budgets and as a research issue, on the grounds that much larger numbers of people in developing countries currently die from other diseases, such as malaria and tuberculosis. We use a previously descr
Identification of low-level contamination of blood as basis for detection of human immunodeficiency virus (HIV) DNA in anti-HIV-negative specimens.: J Acquir Immune Defic Syndr. 1994 Aug;7(8):853-9. Unique Identifier : AIDSLINE GENBANK/L20380; Sabino EC; Delwart E; Lee TH; Mayer A; Mullins JI; Busch MP; Irwin Memorial Blood Centers, San Francisco, CA 94118.; The significance of detection of human immunodeficiency virus (HIV) DNA by the polymerase chain reaction (PCR) in seronegative or seroconverting (SC) subjects remains controversial. In a previously reported study, we identified a case in which a specimen collected 12 months before seroconversion (pre-SC) was found rep
The impact of lengthening AIDS reporting delays and uncertainty about underreporting on incidence trends and projections.: J Acquir Immune Defic Syndr. 1994 Aug;7(8):860-5. Unique Identifier : AIDSLINE MED/94293168; Bacchetti P; Department of Epidemiology and Biostatistics, University of; California, San Francisco 94143-0840.; This article extends existing methods for estimating reporting delays to allow nonparametric estimation of how delays are changing over time. Also implemented are refinements to estimate calendar month effects and to improve the accuracy of trend estimates by focusing on delays of > 6 months. Applying the method to 19
Anal intercourse and disclosure of HIV infection among seropositive gay and bisexual men.: J Acquir Immune Defic Syndr. 1994 Aug;7(8):866-9. Unique Identifier : AIDSLINE MED/94293169; Marks G; Ruiz MS; Richardson JL; Reed D; Mason HR; Sotelo M; Turner PA; Department of Preventive Medicine, University of Southern; California, Los Angeles 90033.; Human immunodeficiency virus (HIV)-infected gay and bisexual men (n = 609) randomly selected from two HIV outpatient clinics in Los Angeles completed confidential, self-administered questionnaires at the clinics, reporting sexual activities and disclosure during the previous 2 months. Approximately 9% had engaged in u
Human T-cell lymphotropic virus type I disease in Argentine intravenous drug users with human immunodeficiency virus type 1 infection [letter]: J Acquir Immune Defic Syndr. 1994 Aug;7(8):870-1. Unique Identifier : AIDSLINE MED/94293170; Zala C; Zapiola I; Bouzas MB; Benetucci J; Lopez L; Gallo D; Hanson C; Muchinik GR
Hypercalcemia in a patient with the acquired immunodeficiency syndrome and Mycobacterium avium intracellulare infection [letter]: J Acquir Immune Defic Syndr. 1994 Aug;7(8):871-2. Unique Identifier : AIDSLINE MED/94293171; Delahunt JW; Romeril KE
PCP among AIDS patients in India [letter; comment]: J Acquir Immune Defic Syndr. 1994 Aug;7(8):872-3. Unique Identifier : AIDSLINE MED/94293172; Singh YN
Impact of the AIDS epidemic on mortality of young men in Italy [letter]: J Acquir Immune Defic Syndr. 1994 Aug;7(8):873-4. Unique Identifier : AIDSLINE MED/94293173; La Vecchia C; Franceschi S; Dal Maso L; Parazzini F
Prevalence of HIV infection and