Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.
[Natural killer activity in B cell type chronic lymphocytic leukemia]
Diss Abstr Int [C]; 54(1):164 1993. Unique Identifier : AIDSLINE ICDB/94690739 Villamor i Casas N; Univ. of Barcelona, Spain
Abstract:
Natural killer (NK) cells play a role in immune surveillance against tumoral and infected cells, and display immunoregulatory functions over B and T lymphocytes. In B cell chronic lymphocytic leukemia (B-CLL) there exist immune alterations affecting B and T lymphocytes. Recently NK disfunction was also noticed regarding activity (NKa) and surface phenotype. NKa was analyzed in 67 pts with B-CLL using the 51Cr-release assay and the lymphocytic phenotype by means of CD2, CD4, CD8, CD16, CD11b, CD57, CD56 and CD19. NKa was correlated with clinical and analytical characteristics of pts. The mean age was 68 yr, 36 were males and 31 females. Staging according IWCLL was A 71.6%, B 13.4% and C 10.4%, and 28% of pts fulfilled criteria of latent B-CLL. 36 pts were untreated and 31 were treated (chlorambucil alone or plus prednisone). NKa in B-CLL pts was significantly lower than in controls (19.4% +/- 16.2 vs 40.2% +/- 17.4). A linear inverse relationship was observed between lymphocyte count and NKa. No relation was observed between NKa and other biological parameters. The percentage of NK or T lymphocytes showed a linear relationship with NKa. 13 pts displayed a normal NKa (stage A(0) in 70%). In sequential studies the relationship between NKa and lymphocyte count was also noticed. The group of pts treated displayed similar NKa than untreated ones. Taking it together the low NKa observed in the majority of B-CLL pts may be attributed to dilution of effector lymphocytes by leukemic cells. Recycling capacity of NK cells were studied by prolonging NK assay from 4 to 20 hr. The NKa behavior in B-CLL pts (increase in cytotoxicity) is similar to that observed in controls in contrast that observed in HIV hemophilic pts. Finally, chlorambucil followed by interferon was administered on a group of untreated stage A pts. NKa during interferon treatment became normal without modifications in absolute number T and NK lymphocytes.
Keywords: Aged Antigens, CD Female Human Killer Cells, Natural/*IMMUNOLOGY Leukemia, B-Cell, Chronic/*IMMUNOLOGY Male Phenotype T-Lymphocytes/IMMUNOLOGY THESIS
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Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.
