EBV mRNA expression in primary gastrointestinal non-Hodgkin's lymphomas (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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EBV mRNA expression in primary gastrointestinal non-Hodgkin's lymphomas (Meeting abstract).

J Pathol; 170(Suppl):349A 1993. Unique Identifier : AIDSLINE ICDB/94699879
Lo ST; Angel CA; Royds JA; Clark A; Ng CS; Chan CJ; Dept. Health Sciences, Hong Kong Polytechnic, Kowloon, Hong Kong

Abstract: Epstein-Barr virus (EBV) has been associated with some cases of Hodgkin's disease and a variety of non-Hodgkin's lymphomas. Recently, EBV DNA was also found in up to 16% of gastric adenocarcinomas. Prompted by these findings, gastrointestinal lymphomas (GI NHL) were investigated for the presence of EBV. Using FITC labelled oligonucleotide probes against EBV EBERs (latent infection) and BHLF (lytic infection), a series of 54 GI NHL (Sheffield n=28, Hong Kong n=26) were stained by in situ hybridization on paraffin embedded material. None of the patients had any known immunodeficiency. In 2 cases (3.7%, one from each group), tumor cells were stained with EBERs. These were high grade B-NHL of MALT. In addition, 16 cases (29.6%, Sheffield n=7, Hong Kong n=9) were found to have rare scattered EBER-positive lymphocytes. BHLF expression was not detected. Adjacent or overlying epithelial cells were negative for both probes. Our results show that EBV is associated with a low percentage of primary GI NHL, in particular high grade lymphomas of MALT, occurring in immunocompetent patients. No significant difference in EBV detection was found in the two ethnic groups studied.
Keywords: Gastrointestinal Neoplasms/*GENETICS/METABOLISM *Gene Expression Herpesvirus 4, Human/*GENETICS Human Lymphoid Tissue/PATHOLOGY Lymphoma, B-Cell/GENETICS Lymphoma, Non-Hodgkin's/*GENETICS/METABOLISM RNA-Binding Proteins/METABOLISM RNA, Messenger/*GENETICS ABSTRACT

KWDgastrointestinalneoplasms/KWDgenetics/metabolismKWDgeneexpressionherpesvirus4,human/KWDgeneticshumanlymphoidtissue/pathologylymphoma,b-cell/geneticslymphoma,non-hodgkin's/KWDgenetics/metabolismrna-bindingproteins/metabolismrna,messenger/KWDgeneticsabstract
941130
M94B0786

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