Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.
Nasal lymphoma a clinicopathological study (Meeting abstract).
J Pathol; 170(Suppl):351A 1993. Unique Identifier : AIDSLINE ICDB/94699886 Lonsdale RN; Thomas GA; Davies H; Grant JW; Histopathology Dept., Addenbrooke's Hosp., Cambridge CB2 2QQ, UK
Abstract:
In this study, we describe 19 patients who presented to Addenbrooke's Hospital between 1978 and 1993 with a variety of nasal symptoms which were found to be due to malignant lymphoma in the nasal cavity. The patients were 8 men and 11 women, ranging in age from 16 to 77 years (mean 55 years, median 51 years). In 17 cases there was no overt immunodeficiency. One patient had been successfully treated for Hodgkin's disease ten years previously and another was HIV+. All the lymphomas had a diffuse pattern. They were classified morphologically and immunophenotypically. 12 were B-cell lymphomas, 11 being high grade follicle center cell (n=8), immunoblastic (n=1) or lymphoblastic lymphomas (n=2). One was a low grade tumor of MALT type. There were 7 T-cell lymphomas (4 high grade and 3 low grade lesions). There is increasing evidence that the Epstein-Barr virus (EBV) is involved in the development of some sinonasal lymphomas. In this series immunoreactivity using an antibody to EBV latent membrane protein (LMP-1) was demonstrated in scattered cells in 3 B-cell and 1 T-cell tumor. EBV mRNA was demonstrated using an in situ hybridization technique in many tumor cells in 2 T-cell lymphomas and in the B-cell lymphoma arising in the HIV+ patient. The majority of patients were treated with a combination of radiotherapy and chemotherapy. 5 patients had no relapse and are free of disease for between 2 months and 5 years after diagnosis. 11 patients have died, generally of disseminated disease, having survived for periods ranging from 1 week to 50 months following diagnosis.
Keywords: Adolescence Adult Aged Antigens, Viral/ANALYSIS Female Herpesvirus 4, Human/GENETICS/ISOLATION & PURIF Human Lymphoma/IMMUNOLOGY/MICROBIOLOGY/*PATHOLOGY/THERAPY Male Middle Age Nasal Cavity/*PATHOLOGY Nose Neoplasms/IMMUNOLOGY/MICROBIOLOGY/*PATHOLOGY/THERAPY RNA, Messenger Viral Matrix Proteins/ANALYSIS ABSTRACT
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Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.
