Elevated serum levels of a 90-kD tumor-associated antigen in cancer and in infection by human immunodeficiency virus (HIV) (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Elevated serum levels of a 90-kD tumor-associated antigen in cancer and in infection by human immunodeficiency virus (HIV) (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 35:A81 1994. Unique Identifier : AIDSLINE ICDB/94601770
Natoli C; Tinari N; D'Egidio M; Ghinelli F; Fusco O; D'Ostilio N; Grassadonia A; Ortona L; Piazza M; Iacobelli S; Med. Oncology, Univ. 'G. D'Annunzio,' 66100 Chieti, Italy

Abstract: Levels of a 90-kD monoclonal antibody-defined tumor-associated antigen, termed 90K, were measured in the serum from 649 patients with various types of cancer and 1215 patients infected by HIV. Significantly increased antigen levels (12.1+0.5 U/ml) were found in cancer patients with respect to healthy controls (5.7+0.3 U/ml), with the highest levels and sensitivity in neoplasms of the breast and of the gastrointestinal tract. Mean levels of 90K for HIV-infected asymptomatic subjects (13.6+0.5 U/ml) were significantly higher than controls. The levels progressively increased with disease worsening, ie 22.4+0.9 U/ml in AIDS-related complex (ARC) and 27.8+1.4 U/ml in AIDS. Mean 90K levels in any of the HIV-infected subgroups were higher than in cancer patients. 90K was also measured in peripheral blood mononuclear cells: the concentration was low in healthy controls (0.41+0.09 U/10(6) cells), intermediate in cancer patients (1.65+0.15 U/10(6) cells) and elevated in HIV-infected subjects (4.75+0.25 U/10(6) cells in ARC and 7.73+0.91 U/10(6) cells in AIDS). Comparative analysis of 90K purified from serum of patients infected by HIV and patients with breast cancer revealed identical electrophoretic profiles, immunoreactivity and amino-terminal sequence. The sequence was found to be highly homologous to that of L3 lung cancer antigen (Linsley et al, 1986), a protein belonging to the scavenger receptor cysteine-rich family. We conclude that 90K is not merely a tumor-associated antigen and postulate it to be a 'signaling' molecule whose production might be related to immune responsive mechanisms shared by pathogenetic events such as oncogenic transformation and viral infection.
Keywords: Acquired Immunodeficiency Syndrome/*BLOOD Antibodies, Monoclonal Antigens, Neoplasm/*BLOOD AIDS-Related Complex/*BLOOD Breast Neoplasms/BLOOD Comparative Study Female Gastrointestinal Neoplasms/BLOOD Human HIV Infections/*BLOOD Lung Neoplasms/BLOOD Molecular Weight Neoplasms/*BLOOD Reference Values Tumor Markers, Biological/*BLOOD ABSTRACT

KWDacquiredimmunodeficiencysyndrome/KWDbloodantibodies,monoclonalantigens,neoplasm/KWDbloodaids-relatedcomplex/KWDbloodbreastneoplasms/bloodcomparativestudyfemalegastrointestinalneoplasms/bloodhumanhivinfections/KWDbloodlungneoplasms/bloodmolecularweightneoplasms/KWDbloodreferencevaluestumormarkers,biological/KWDbloodabstract
941130
M94B0784

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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