Immunodeficiency and IL-6 production by peripheral blood monocytes in multicentric Castleman's disease. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Immunodeficiency and IL-6 production by peripheral blood monocytes in multicentric Castleman's disease.

Br J Haematol. 1994 Mar;86(3):483-9. Unique Identifier : AIDSLINE MED/94318460
Ishiyama T; Nakamura S; Akimoto Y; Koike M; Tomoyasu S; Tsuruoka N; Murata Y; Sato T; Wakabayashi Y; Chiba S; Department of Haematology, Showa University School of Medicine,; Japan.

Abstract: To study the pathogenesis of multicentric Castleman's disease (MCD), IL-6 producing cells and immune function were investigated in four MCD patients. The expression of IL-6 mRNA in one MCD lymph node was analysed by in situ hybridization. IL-6 mRNA expressing cells were scattered in the interfollicular areas and did not resemble plasma cells. Spontaneous IL-6 production was detected in the culture supernatants of peripheral blood mononuclear cells (PBMNC) from four patients. The IL-6 producing cells among the PBMNC were found to be monocytes by both in situ hybridization and immunohistochemistry. We evaluated immune function in four MCD patients. These studies show: (1) a negative PPD skin test in 3/4 patients, (2) decreased IL-2 production in 3/4 patients, (3) decreased T cell colony formation in 3/4 patients, (4) decreased NK activity and NK cell number in 2/4 patients, (5) increased soluble IL-2 receptor in 4/4 patients, and (6) decreased CD4/CD8 ratio in 3/4 patients. These results show that MCD resembles, in several ways, acquired immunodeficiency syndrome (AIDS).
Keywords: Aged Aged, 80 and over CD4-CD8 Ratio Female Giant Lymph Node Hyperplasia/*IMMUNOLOGY Human Immune Tolerance/*IMMUNOLOGY In Situ Hybridization Interleukin-1/BLOOD Interleukin-6/*BIOSYNTHESIS/BLOOD/GENETICS Killer Cells, Natural/IMMUNOLOGY Lymph Nodes/IMMUNOLOGY Male Middle Age Monocytes/*IMMUNOLOGY Phytohemagglutinins/IMMUNOLOGY Receptors, Interleukin-2/ANALYSIS RNA, Messenger/ANALYSIS T-Lymphocytes/IMMUNOLOGY JOURNAL ARTICLE

KWDagedaged,80andovercd4-cd8ratiofemalegiantlymphnodehyperplasia/KWDimmunologyhumanimmunetolerance/KWDimmunologyinsituhybridizationinterleukin-1/bloodinterleukin-6/KWDbiosynthesis/blood/geneticskillercells,natural/immunologylymphnodes/immunologymalemiddleagemonocytes/KWDimmunologyphytohemagglutinins/immunologyreceptors,interleukin-2/analysisrna,messenger/analysist-lymphocytes/immunologyjournalarticle
941130
M94B0756

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1994. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1994. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .