[CT and MRT in progressive multifocal leukoencephalopathy (PML)] NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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[CT and MRT in progressive multifocal leukoencephalopathy (PML)]

Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 1994 Jul;161(1):38-43. Unique Identifier : AIDSLINE MED/94318837
Lanfermann H; Heindel W; Schroder R; Lackner K; Institut und Poliklinik fur Radiologische Diagnostik,; Universitat zu Koln.

Abstract: Radiological findings and course of progressive multifocal leukoencephalopathy in 14 patients (1 woman, 13 men; 13 HIV seropositive, 1 chronic lymphatic leukaemia) were analysed retrospectively and correlated with clinical symptoms. A total of 21 CT and 16 MRI studies were evaluated. CT scans and MR images of 9 patients, which had been obtained in less than two weeks, could be compared to each other. MRI was superior to CT: 6 lesions with a diameter of 1 cm and below were not detected on CT scans, in 5 patients the extent of lesions was underestimated. Cortical involvement, mass effect or signs of atrophy were missing. Only 1 of 67 lesions showed a tiny enhancement after Gd injection. Due to the pattern and spread of lesions, which showed a close correlation to the neurologic symptoms, three different types of PML are suggested: 1. initial precentral demyelinisation with contralateral hemiparesis (n = 8); 2. lesions in temporo-occipital locations with visual disturbances (n = 2); 3. predominantly bilateral lesions of cerebellar white matter with ataxia (n = 4).
Keywords: Adult Biopsy Brain/PATHOLOGY Comparative Study English Abstract Female Human HIV Seropositivity/COMPLICATIONS HIV-1/IMMUNOLOGY Leukemia, Lymphocytic, Chronic/COMPLICATIONS Leukoencephalopathy, Progressive Multifocal/*DIAGNOSIS/ EPIDEMIOLOGY/ETIOLOGY *Magnetic Resonance Imaging Male Middle Age Retrospective Studies Time Factors *Tomography, X-Ray Computed JOURNAL ARTICLE

KWDadultbiopsybrain/pathologycomparativestudyenglishabstractfemalehumanhivseropositivity/complicationshiv-1/immunologyleukemia,lymphocytic,chronic/complicationsleukoencephalopathy,progressivemultifocal/KWDdiagnosis/epidemiology/etiologyKWDmagneticresonanceimagingmalemiddleageretrospectivestudiestimefactorsKWDtomography,x-raycomputedjournalarticle
941130
M94B0750

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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