Mutations in the coding region of c-myc occur frequently in acquired immunodeficiency syndrome-associated lymphomas. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Mutations in the coding region of c-myc occur frequently in acquired immunodeficiency syndrome-associated lymphomas.

Blood. 1994 Aug 1;84(3):883-8. Unique Identifier : AIDSLINE MED/94318966
Bhatia K; Spangler G; Gaidano G; Hamdy N; Dalla-Favera R; Magrath I; Lymphoma Biology Section, National Cancer Institute, National; Institutes of Health, Bethesda, MD 20892.

Abstract: We have analyzed 30 cases of high- and intermediate-grade acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma (AIDS-NHL) for mutations in the c-myc coding region. In addition, in these same tumors, we have sought the presence of mutations in a regulatory region within the first c-myc intron defined by the binding to a factor that inhibits c-myc transcription (MYC intron factor, or mif). Mutations in the c-myc coding region were present in 10 of 16 small noncleaved cell lymphoma (SNCL), but in only 3 of 14 other histologic subtypes tested (0/3 large non-cleaved cell, 2/8 immunoblastic, and 1/3 anaplastic large cell lymphomas). Nineteen of the AIDS-NHLs analyzed contained a c-myc rearrangement and in 10 of these the c-myc gene was mutated in its coding region. In contrast, we could detect a mutation in the coding region in only 2 of 8 AIDS-NHL without a c-myc rearrangement. Mutations in the mif region were detected in 5 of 16 SNCL. Among AIDS-NHL carrying mutations in the c-myc coding region, only 4 carried mutations in the regulatory region. These results suggest that the mutations in the coding region of the c-myc protein may either be a consequence of the translocations involving c-myc, or may be necessary only in tumors where c-myc is deregulated as a result of a c-myc/lg translocation.
Keywords: Base Sequence DNA Primers/CHEMISTRY Exons *Genes, myc Human Lymphoma, AIDS-Related/*GENETICS Molecular Sequence Data Mutation Regulatory Sequences, Nucleic Acid Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

KWDbasesequencednaprimers/chemistryexonsKWDgenes,mychumanlymphoma,aids-related/KWDgeneticsmolecularsequencedatamutationregulatorysequences,nucleicacidsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
941130
M94B0747

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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