Thoracic AIDS-related lymphoma:CT appearance and CD4 counts (Meeting abstract).

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Thoracic AIDS-related lymphoma:CT appearance and CD4 counts (Meeting abstract).

Am J Roentgenol; 160(4, Suppl):97 1993. Unique Identifier : AIDSLINE ICDB/94697401
Sider L; Melany M; Chicago, IL

Abstract: It is now well recognized that AIDS-related lymphoma (ARL) usually presents as extranodal disease different from lymphoma in immune-competent patients (pts). In this series, we will review our experience in an 8-yr period in order to detect the most frequent presentations of thoracic ARL. In addition, further correlation will be made with the pts' CD4 counts to determine if, at different levels of cellular immunity, one presentation predominates. Materials and methods: Chest CT scans and medical records of 36 pts with biopsy proven thoracic ARL were evaluated. The series included 344 male and 2 female pts ranging in age from 22 to 52 yr. All pts' CD4 counts were obtained within 2 wk of diagnosis. Results: The majority of pts presented with more than one site of thoracic involvement. The two most common findings were pleural effusion and axillary adenopathy, each occurring in 14 of 36 pts (39%). Pulmonary parenchymal nodules were identified in 13 pts (36%). Eight pts (22%) demonstrated an interstitial pattern of lung disease and only 2 pts (6%) had alveolar infiltrates as a manifestation of their disease. Mediastinal adenopathy was seen in 7 pts (19%) and hilar adenopathy in only 3 pts (8%). Conclusion: Extranodal involvement in thoracic ARL is confirmed in our series of 36 pts with pleural effusion and parenchymal processes predominating. When adenopathy was present it most frequently involved unsuspected axillary nodes. Findings were often multiple in each pt. We will further correlate the different CT findings with CD4 counts in order to determine if, given a particular CD4 count and specific pathologic finding on CT, one can more confidently suggest the diagnosis of ARL.

Keywords: Adult Antigens, CD4/*ANALYSIS Female Human Lymphoma, AIDS-Related/COMPLICATIONS/IMMUNOLOGY/*RADIOGRAPHY Male Middle Age Pleural Effusion/COMPLICATIONS Thoracic Neoplasms/IMMUNOLOGY/*RADIOGRAPHY Tomography, X-Ray Computed ABSTRACT
940530
M9450898

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