AIDS dementia complex and HIV-1 infection: a view from the clinic. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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AIDS dementia complex and HIV-1 infection: a view from the clinic.

Brain Pathol. 1991 Apr;1(3):155-62. Unique Identifier : AIDSLINE MED/94122947
Price RW; Sidtis JJ; Brew BJ; Department of Neurology, University of Minnesota, Minneapolis; 55455-0323.

Abstract: The AIDS dementia complex (ADC) is a clinical syndrome which characteristically presents as a subcortical dementia with cognitive, motor and behavioral changes. While the pathogenesis remains puzzling in a number of critical aspects, ADC likely relates in a fundamental way to HIV-1, itself, rather than to a secondary, opportunistic condition. This review focuses on some of the clinical information which bears on the pathogenesis of this syndrome and its relation to HIV-1 infection. This information derives from studies of the clinical character of ADC, its epidemiology and natural history, cerebrospinal fluid analysis, neuroimaging results, clinical correlates of pathological findings and its response to antiviral therapy.
Keywords: Antiviral Agents/THERAPEUTIC USE *AIDS Dementia Complex/CEREBROSPINAL FLUID/DRUG THERAPY/ EPIDEMIOLOGY/ETIOLOGY/PATHOLOGY/PSYCHOLOGY Human *HIV-1 Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDantiviralagents/therapeuticuseKWDaidsdementiacomplex/cerebrospinalfluid/drugtherapy/epidemiology/etiology/pathology/psychologyhumanKWDhiv-1support,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticlereviewreview,tutorial
940530
M9450889

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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