Neurotropism of human immunodeficiency virus. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Neurotropism of human immunodeficiency virus.

Brain Pathol. 1991 Apr;1(3):185-91. Unique Identifier : AIDSLINE MED/94122950
Chiodi F; Fenyo EM; Department of Virology, Karolinska Institute, Stockholm, Sweden.

Abstract: Three major characteristics of human immunodeficiency virus (HIV) infection define HIV as neurotropic. 1) Clinically, distinct neurological syndromes are associated with HIV infection and 2) presence of the virus as well as 3) pathological changes can be demonstrated in the central nervous system. Spread of HIV to the brain seems to be the general rule. Virus expression appears to be restricted during the asymptomatic period but increases with severity of HIV infection. Whether this reflects the emergence of virus variants with increased replicative capacity in brain cells has yet to be elucidated.
Keywords: Animal AIDS Dementia Complex/*MICROBIOLOGY/PATHOLOGY Brain/MICROBIOLOGY Cerebrospinal Fluid/MICROBIOLOGY Disease Susceptibility Encephalitis/MICROBIOLOGY/PATHOLOGY Glioma/PATHOLOGY Haplorhini Human HIV/ISOLATION & PURIF/PHYSIOLOGY/*PATHOGENICITY Neuroblastoma/PATHOLOGY Neurons/*MICROBIOLOGY Organ Specificity Retroviridae Infections/MICROBIOLOGY/PATHOLOGY Simian Acquired Immunodeficiency Syndrome/PATHOLOGY Support, Non-U.S. Gov't Tumor Cells, Cultured Virus Replication JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDanimalaidsdementiacomplex/KWDmicrobiology/pathologybrain/microbiologycerebrospinalfluid/microbiologydiseasesusceptibilityencephalitis/microbiology/pathologyglioma/pathologyhaplorhinihumanhiv/isolation&purif/physiology/KWDpathogenicityneuroblastoma/pathologyneurons/KWDmicrobiologyorganspecificityretroviridaeinfections/microbiology/pathologysimianacquiredimmunodeficiencysyndrome/pathologysupport,non-uKWDsKWDgov'ttumorcells,culturedvirusreplicationjournalarticlereviewreview,tutorial
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Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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