Complementarities and network interactions in AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Complementarities and network interactions in AIDS.

J Autoimmun. 1993 Oct;6(5):601-10. Unique Identifier : AIDSLINE MED/94059348
Susal C; Hoffman GW; Daniel V; Grant M; Opelz G; Department of Transplantation Immunology, University of; Heidelberg, Germany.

Abstract: The contribution of autoimmune phenomena to the development of AIDS is not fully understood. In this paper we provide new evidence that idiotypic network interactions are operative in the development of AIDS. We furthermore present a model that involves two groups of antibodies and other molecules that are related to each other by a network of specific complementarities. We define Group I molecules to include antibodies and other molecules that have direct or indirect similarities with class I MHC molecules, and Group II substances that have similarities with class II MHC. We observe an inverse relationship between Group I antibodies (including anti-Fab) and Group II antibodies (including anti-anti-gp120, anti-anti-CD8 and anti-rCD4). The potential roles of members of these two groups in AIDS pathogenesis and/or protection are discussed.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Antigens, CD4/IMMUNOLOGY Antigens, CD8/IMMUNOLOGY Antigens, Differentiation, T-Lymphocyte/IMMUNOLOGY Autoimmune Diseases/*IMMUNOLOGY Histocompatibility Antigens Class I/*IMMUNOLOGY Human HIV Envelope Protein gp120/IMMUNOLOGY HLA-D Antigens/*IMMUNOLOGY Immunoglobulins, Fab/*IMMUNOLOGY Support, Non-U.S. Gov't JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDacquiredimmunodeficiencysyndrome/KWDimmunologyantigens,cd4/immunologyantigens,cd8/immunologyantigens,differentiation,t-lymphocyte/immunologyautoimmunediseases/KWDimmunologyhistocompatibilityantigensclassi/KWDimmunologyhumanhivenvelopeproteingp120/immunologyhla-dantigens/KWDimmunologyimmunoglobulins,fab/KWDimmunologysupport,non-uKWDsKWDgov'tjournalarticlereviewreview,tutorial
940330
M9430979

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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