Changes of IgE production, splenic helper and suppressor T lymphocytes in mice infected with Paragonimus westermani. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Changes of IgE production, splenic helper and suppressor T lymphocytes in mice infected with Paragonimus westermani.

Korean J Parasitol. 1993 Sep;31(3):231-8. Unique Identifier : AIDSLINE MED/94059903
Min DY; Ryu JS; Shin MH; Department of Parasitology, College of Medicine, Hanyang; University, Seoul, Korea.

Abstract: Effects of Paragonims westermani infection were observed in mice on the change of serum IgE level, the number of peripheral eosinophils and the distribution of Thy 1.2+ (CD3), L3T4+ (CD4), and Lyt-2+ (CD8) splenic T lymphocytes without mitogen stimulation. BALB/c mice were infected with 20 metacercariae of P. westermani each. Total serum IgE increased at 3 weeks after the infection and reached a peak on week 4 and maintained high levels of IgE until the 23rd week. Peripheral eosinophil numbers increased at the second week and attained peak level on week 9. The frequency of L3T4+ (CD4) and Lyt-2+ (CD8) T lymphocytes decreased slightly until 4 weeks after the infection, but not significantly. Absolute number of L3T4+ and Lyt-2+ T lymphocytes, and the ratio of L3T4/Lyt-2 were not markedly changed over the period of observation. The frequency of Thy 1.2+ (CD3) T lymphocytes in the infected group slightly decreased until 4 weeks after the infection and showed significant reductions at the 2nd and 4th week of the infection (p < 0.05).
Keywords: Animal Antibodies, Helminth/BLOOD Crayfish/PARASITOLOGY CD4-CD8 Ratio Eosinophils IgE/*BLOOD Leukocyte Count Mice Mice, Inbred BALB C Paragonimiasis/*IMMUNOLOGY Paragonimus/*IMMUNOLOGY Spleen/CYTOLOGY Support, Non-U.S. Gov't *T-Lymphocyte Subsets *T-Lymphocytes, Helper-Inducer *T-Lymphocytes, Suppressor-Effector JOURNAL ARTICLEKWDanimalantibodies,helminth/bloodcrayfish/parasitologycd4-cd8ratioeosinophilsige/KWDbloodleukocytecountmicemice,inbredbalbcparagonimiasis/KWDimmunologyparagonimus/KWDimmunologyspleen/cytologysupport,non-uKWDsKWDgov'tKWDt-lymphocytesubsetsKWDt-lymphocytes,helper-inducerKWDt-lymphocytes,suppressor-effectorjournalarticle
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M9430969

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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