Cytokines in health and disease.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Cytokines in health and disease.

Cytokines in Health and Disease. Kunkel SL and Remick DG, eds. New York, Marcel Dekker, 568 p., 1992.. Unique Identifier : AIDSLINE ICDB/94605808
Anonymous; No affiliation given

Abstract: Cytokines as a group may be defined as soluble mediators secreted by one cell that acts on another cell or organ; the term is generally reserved for protein mediators. Recent advances in molecular biology have provided purified recombinant material for exacting studies of the unique roles of cytokines. The availability of these purified products has allowed for their use as biological response modifiers in treatment of human diseases. This book endeavors to provide, in a single source, much of the currently available knowledge in the field of cytokines. There are four areas covered in this volume: general overviews of each of the major cytokines, listings of the important interactions these cytokines have with inflammatory cells, discussions of current and future areas of important research, and descriptions of cytokine interactions with several of the major organ systems. These topics are presented: quantitation of the biological activities of cytokines; structure and function of interleukin (IL)-1, of IL-2, of IL-3, erythropoietin and the colony-stimulating factors, of IL-4 and IL-5, and of IL-6; IL-6 and the inflammatory response; structure and function of tumor necrosis factor (TNF); TNF, IL-1, IL-6, IL-8, and interferon-gamma in septic shock; cytokines and bacterial infection; cytokine modulation of viral infections; cytokines and malaria; beneficial role of cytokine, particularly IL-1, in host response to injury, infection, and inflammation; hematological effects of cytokines in vivo; role of cytokines in experimental lung injury; fibroblasts and cytokines; functional responses elicited in endothelial cells by cytokines; cytokines and lymphocytes, and macrophages; cytokine biology and transplantation; cytokines and rheumatic diseases; cytokines in pulmonary injury; cytokine networks in skin disease; use of recombinant cytokines in cancer therapy; cytokines and renal disease; TNF-alpha, PAF, and intestinal injury (relevance to necrotizing enterocolitis); cytokine receptors; and cytokines and AIDS.

Keywords: Acquired Immunodeficiency Syndrome/THERAPY Cytokines/*THERAPEUTIC USE Human Inflammation Kidney Diseases/THERAPY Leukemia/THERAPY Lung Diseases/THERAPY Neoplasms/*THERAPY Skin Diseases/THERAPY Structure-Activity Relationship MONOGRAPH
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