Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.
Analysis of genetic diversity in maternally-transmitted SIV-infected rhesus macaque neonates (September 19-22, 1993).
Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 3. Unique Identifier : AIDSLINE PRIM11/94191623 Martin-Amedee A; Davison-Fairburn B; Trichel A; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA 70433.
Abstract:
We have previously reported the delivery of two SIV-infected rhesus monkeys from females inoculated with SIV/DeltaB670. The females were inoculated prior to pregnancy or in the third trimester, and the infants were delivered vaginally. These females became immunodeficient during their pregnancies and histopathological examination of placental tissue revealed lesions within the decidua and/or chorion. A comparison of the disease status during pregnancy and the placental pathology found in these mothers and several other SIV infected macaques has shown that both immunosuppression and placental lesions appear to be required for fetal infection. To extend this study, we have characterized the genetic diversity in both maternal and neonate viruses. The genetic variants were identified by sequences specific for the V1 hypervariable region of the SIV envelope gene. These sequences were determined directly from the infected tissue by polymerase chain reaction amplification of this region followed by cloning and dideoxy sequencing. The females, as expected, had a swarm of genetically distinct variants. Twelve independent clones derived from the spleens of each infected neonate, however, contained a single genetic variant that was identical to one of the variants found in each respective mother. The selection of a single genetic variant in the neonate from a swarm of genetically distinct forms in the mother suggests that certain phenotypes (e.g. the ability to replicate in certain cell types) may be one factor promoting infection of the fetus.
Keywords: Animal Animals, Newborn Female Fetus *Genes, env Macaca mulatta Phenotype Pregnancy Pregnancy Complications, Infectious/*MICROBIOLOGY Simian Acquired Immunodeficiency Syndrome/MICROBIOLOGY/ *TRANSMISSION SIV/*GENETICS *Variation (Genetics) ABSTRACT 940730
M9470895
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Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.
