Diazolidinyl urea: incidence of sensitivity, patterns of cross-reactivity and clinical relevance. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Diazolidinyl urea: incidence of sensitivity, patterns of cross-reactivity and clinical relevance.

Contact Dermatitis. 1994 Jan;30(1):16-9. Unique Identifier : AIDSLINE MED/94208233
Hectorne KJ; Fransway AF; Department of Dermatology, Mayo Clinic, Rochester, MN 55905.

Abstract: Diazolidinyl urea (DIAZ) is a formaldehyde-releasing preservative used in cosmetics and personal-care products, which has been identified as a sensitizing agent in contact dermatitis. To determine whether DIAZ sensitization is secondary to formaldehyde release or due to its own allergenic properties, we reviewed 708 consecutive patch tests of patients with various dermatologic complaints. Profiles of the 58 individuals (8%) with DIAZ sensitivity were analyzed with respect to sex, age, exposures, and chronicity of dermatitis. Significant coexistent biocide reactivity was demonstrated for DIAZ and formaldehyde (81%); 12% reacted to DIAZ alone. We conclude that the primary mode of sensitization of DIAZ is via formaldehyde release and that independent contact allergy is less frequent.
Keywords: Adolescence Adult Age Factors Aged Aged, 80 and over Blister/CHEMICALLY INDUCED Child Cross Reactions Dermatitis, Allergic Contact/*ETIOLOGY/IMMUNOLOGY Erythema/CHEMICALLY INDUCED Female Formaldehyde/*ADVERSE EFFECTS/CHEMISTRY/IMMUNOLOGY Human Male Methenamine/ANALOGS & DERIVATIVES/ADVERSE EFFECTS/CHEMISTRY/ IMMUNOLOGY Middle Age Pharmaceutic Aids/ADVERSE EFFECTS/CHEMISTRY Preservatives, Pharmaceutical/ADVERSE EFFECTS/CHEMISTRY Propanediols/ADVERSE EFFECTS/CHEMISTRY/IMMUNOLOGY Urea/*ANALOGS & DERIVATIVES/ADVERSE EFFECTS/CHEMISTRY/IMMUNOLOGY JOURNAL ARTICLEKWDadolescenceadultagefactorsagedaged,80andoverblister/chemicallyinducedchildcrossreactionsdermatitis,allergiccontact/KWDetiology/immunologyerythema/chemicallyinducedfemaleformaldehyde/
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Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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