1994

Universal precautions : guidelines for hospital employees. [videorecording]: Control Committee [Houston, Tex.] : The Center, [1989] 1 videocassette (8 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9408957
Bloodborne pathogens. [videorecording]: Boston, Mass. : Jones & Bartlett Publishers, c1993 1 videocassette (20 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9421132; Hall K; Jackson M; McKinnon S; (Producer) Millions of workers around the world are at risk of occupational exposure to bloodborne pathogens, such as Human Immunodeficiency Virus (HIV) and Hepatitis B Virus. This video, developed by the National Safety Council s First Aid Institute, thoroughly reviews the new standards issued by the Occupational S
Facing AIDS : stories of healthcare workers : a documentary. [videorecording]: New York, N.Y. : National League for Nursing, c1993 1 videocassette (28 min.) : sd., col. ; 1/2 in. + 1 guide (19 p.) (Pub. / National League for Nursing ; no. 42-2594) Unique Identifier : AIDSLINE AV/9421275; Rosenberg R; Gold T
The:Medical informatics response to the HIV epidemic. [sound recording]: Elkridge, MD : Chesapeake Audio/Video Communications, [1993?] 1 sound cassette : analog Unique Identifier : AIDSLINE AV/9430918
Kaposi's sarcoma in Illinois : a comparison of AIDS cases to classic cases.: Springfield, Ill. : Illinois Dept. of Public Health, Division of Epidemiologic Studies, [1989] 14 leaves (Epidemiologic report series ; 89:4) Unique Identifier : AIDSLINE CAT/9404760; Lehnherr M; Howe HL
[Neunte und zehnte Alfred-Marchionini-Gedachtnisvorlesung.]: Reinbek bei Hamburg : Alfred-Marchionini-Stiftung, [1990] 96 p. : ill., ports (Schriften der Alfred-Marchionini-Stiftung ; Heft 15) Unique Identifier : AIDSLINE CAT/9407670
Positively aware : the monthly journal of the Test Positive Aware Network. Dec. 1990-: Chicago, Ill. : The Network, 1990- v. : ill., ports Unique Identifier : AIDSLINE CAT/9413754
Guidelines for the clinical management of HIV infection in adults : December 1991.: [Geneva, Switzerland] : World Health Organization, [1991] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9416170
HIV in the health care workplace.: Washington, DC : Congress of the United States, Office of Technology Assessment, [1991] 18 p (HIV-related issues. Background paper 7) Unique Identifier : AIDSLINE CAT/9413130
[Primera evaluacion del Plan Nacional a Mediano Plazo de Prevencion y Control del Sindrome de Inmunodeficiencia Adquirida (SIDA), de la Republica de Honduras.]: Tegucigalpa : Secretaria de Estado en los Despachos de Salud Publica, [1991] 57 leaves Unique Identifier : AIDSLINE CAT/9409882
[SIDA : la plaga del siglo XXI.]: Barcelona : Editorial CLIE, c1991 144 p. : ill., ports (Libros CLIE) Unique Identifier : AIDSLINE CAT/9410012; Sansano R
The:Challenge of HIV/AIDS in communities of color.: Syndrome Washington, DC : National Commission on AIDS, [1992] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9423410
[Investigacion de la seroepidemiologia de la infeccion por el virus de la inmunodeficiencia humana (VIH) : de los conocimientos, actitudes y practicas sobre el sindrome de inmunodeficiencia humana (SIDA) en el casco urbano de la ciudad de San Pedro Sula, Honduras, C.A., 1989.]: [Honduras] : Cruz Roja Hondurena, [1992?] 118 leaves : ill Unique Identifier : AIDSLINE CAT/9410082; Rivera Cardona AJ; Rivera Cardona AJ
Pediatric AIDS-related discharges in a sample of U.S. hospitals : demographics, diagnoses, and resource use.: Rockville, Md. (2101 E. Jefferson St., Suite 501, Rockville 20852) : U.S. Dept. of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, [1992] 13 p (Publication ; no. (AHCPR) 92-0031) Unique Identifier : AIDSLINE CAT/9414131; Ball JK; Thaul S
[Guia para enfermeras en la atencion del paciente con HIV/SIDA.]: Mexico, D.F. : El Hospital, [1992] xiii, 65 p. : ill Unique Identifier : AIDSLINE CAT/9413768
[AIDS--tabu : ursprung, utveckling, behandling.]: Stockholm : Carlsson, c1992 255 p. : ill., ports Unique Identifier : AIDSLINE CAT/9432613; Ljungqvist KI
Difficult-to-reuse needles for the prevention of HIV infection among injecting drug users.: Washington, D.C. : Congress of the United States, Office of Technology Assessment : For sale by the U.S. G.P.O., Supt. of Docs., [1992] vi, 17 p (HIV-related issues ; 9) Unique Identifier : AIDSLINE CAT/9411289
Abstracts of papers presented at the 1993 meeting on modern approaches to new vaccines including prevention of AIDS : September 20-September 24, 1993.: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory, [1993?] xxvi, 99 p Unique Identifier : AIDSLINE CAT/9417281; Brown F
Medical record abstraction form and guidelines for assessing quality of care for hospitalized patients with AIDS-related pneumocystis carinii pneumonia.: Santa Monica, CA : Rand, 1993 xv, 172 p (A Rand note ; N-3549-AHCPR) Unique Identifier : AIDSLINE CAT/9423398; Bennett CL
[Entrevista al SIDA.]: Santafe de Bogota, D.C. : Editorial Hojas e Ideas, 1993 131 p Unique Identifier : AIDSLINE CAT/9418232; Romero VJ
A:Guide for epidemiological studies of oral manifestations of HIV infections.: Geneva : World Health Organization, 1993 ix, 27 p Unique Identifier : AIDSLINE CAT/9431169; Melnick SL
Patients with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS).: Affairs Chicago, Ill. : American Dental Association, Council on Community Health, Hospital, Institutional, and Medical Affairs, [1993] 13 leaves (Oral health care guidelines) Unique Identifier : AIDSLINE CAT/9431413
The:slow plague : a geography of the AIDS pandemic.: Oxford, UK ; Cambridge, USA : Blackwell Publishers, 1993 xvi, 228 p. : ill Unique Identifier : AIDSLINE CAT/9421103; Gould P
Learning about AIDS : scientific and social issues. 2nd ed.: Edinburgh ; New York : Churchill Livingstone, 1994 xii, 125 p. : ill Unique Identifier : AIDSLINE CAT/9431791; Aggleton P
HIV and the pathogenesis of AIDS.: Washington, D.C. : ASM Press, c1994 xiv, 359 p. : ill Unique Identifier : AIDSLINE CAT/9432520; Levy JA
An:atlas of differential diagnosis in HIV disease.: New York : Parthenon Pub. Group, 1995 139 p. : ill (The Encyclopedia of visual medicine series) Unique Identifier : AIDSLINE CAT/9432810; Lipman MC; Gluck TA; Johnson MA
Cytokines in health and disease.: Cytokines in Health and Disease. Kunkel SL and Remick DG, eds. New York, Marcel Dekker, 568 p., 1992.. Unique Identifier : AIDSLINE ICDB/94605808; Anonymous; No affiliation given; Cytokines as a group may be defined as soluble mediators secreted by one cell that acts on another cell or organ; the term is generally reserved for protein mediators. Recent advances in molecular biology have provided purified recombinant material for exacting studies of the unique roles of cytokines. The availabilit
Gastrointestinal and genitourinary tract tumors in patients at risk or with HIV infection (Meeting abstract).: Third Annual Pittsburgh Cancer Conference. November 19-20, 1992. Pittsburgh, PA, p. 10, 1992.. Unique Identifier : AIDSLINE ICDB/94698060; Douglas D; Patel A; Wolf B; Remick S; Albany Medical Coll., Albany, NY 12208; AIDS-defining neoplasms include Kaposi s sarcoma, primary central nervous system lymphoma, and non-Hodgkin s lymphoma . As we enter the second decade of the HIV epidemic, it is apparent that other solid tumors are seen in these patients (pts) as well. The AIDS Program of the Albany
Recurrent cervical intraepithelial neoplasia (CIN) in human immunodeficiency virus (HIV) seropositive women (Meeting abstract).: 24th Annual Meeting of the Society of Gynecologic Oncologists. February 7-10, 1993, Palm Desert, CA, A31 1993. Unique Identifier : AIDSLINE ICDB/94698472; Maiman M; Fruchter R; Serur E; Levine P; SUNY-Health Science Center at Brooklyn, Brooklyn, NY 11203; To determine the effect of HIV infection on patterns of recurrence of CIN, 184 patients of known HIV serostatus were followed after standard ablative therapy. The clinical course of 45 HIV positive (+) women was compared with 139 HIV negative (-) women. Patients were treated with cryotherapy, laser vaporization or con
International Association for Comparative Research on Leukemia and Related Diseases, 16th symposium. July 11-16, 1993, Montreal, Quebec, Canada.: International Association for Comparative Research on Leukemia and Related Diseases, 16th Symposium. July 11-16, 1993, Montreal, Quebec, Canada, 1993.. Unique Identifier : AIDSLINE ICDB/94698607; Anonymous; No affiliation given; The International Association for Comparative Research on Leukemia and Related Diseases held their 16th symposium on July 11-16, 1993 in Montreal, Quebec, Canada . The main topics covered at this meeting include molecular abnormalities in leukemia, mechanisms of signal transduction
Interactions between HTLV-1 Tax and NF-kappa B/rel oncoproteins in T cells (Meeting abstract).: International Association for Comparative Research on Leukemia and Related Diseases, 16th Symposium. July 11-16, 1993, Montreal, Quebec, Canada, A18, 1993.. Unique Identifier : AIDSLINE ICDB/94698625; Lanoix J; Lacoste J; Pepin N; Le L; Roulston A; Rice N; Hiscott J; Lady Davis Inst., Jewish General Hospital and Dept. of; Microbiology and Immunology, McGill Univ., Montreal H3T 1E2,; Canada; Molecular, biochemical and epidemiological evidence strongly implicate HTLV-1 as an etiologic agent of adult T cell leukemia (ATL). The Tax protein of HTLV-1, a positive transcriptional activator of HTLV-1 gene expression is a viral oncogene that also increases transcription of cellular genes. One of the cellular targ
No advantage for the use of an early high dose chemotherapy (HDCT) with autologous bone marrow transplant (ABMT) in first line treatment of poor risk nonseminomatous germ cell tumors (NSGCT) (Meeting abstract).: Fourth International Congress on Anti-cancer Chemotherapy. February 2-5, 1993, Paris, France, p. 131, 1993.. Unique Identifier : AIDSLINE ICDB/94697878; Cure H; Droz JP; Pico JL; Biron P; Kerbrat P; Heron JH; Chevreau C; Chevallier B; Fargeot P; Bouzy J; et al; French Federation of Cancer Centers, Clermont Ferrand, France; In order to evaluate the place of HDCT + ABMT in first line treatment of NSGCT we have conducted between 1/1988 and 6/1991 a randomized trial in 115 non-pretreated patients with poor risk characteristics according to the Institut Gustave Roussy prognostic mathematical model (Droz, Cancer 62:54, 1988). Arm A was the NC
Crucial needs in AIDS research.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 1. Unique Identifier : AIDSLINE PRIM11/94191593; Gallo RC; [No abstract appeared in the published proceedings]
AIDS animal models program.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 108. Unique Identifier : AIDSLINE PRIM11/94191594; April M; NIH, DHHS, Bethesda, Maryland 20892.; AIDS ANIMAL MODELS PROGRAM: The AIDS Animal Models Program promotes the characterization and validation of existing models, expands development of new models, and coordinates these common interests with other NIH institutes. Basic and clinical research on AIDS-related diseases has been greatly accelerated by the devel
Characterization of SIV isolates from macaques treated with the nucleoside analog, 9-(2-phosphonylmethoxyethyl)adenine (PMEA).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 102. Unique Identifier : AIDSLINE PRIM11/94191595; Sabo A; Grant R; Follis K; Bischofberger N; Tsai CC; University of Washington Regional Primate Research Center,; Medical Lake 99022.; Simian immunodeficiency virus (SIVMne) was isolated from 2 macaques after 4 and 6 weeks of treatment with the reverse transcriptase inhibitor PMEA. The first animal was pretreated with PMEA for 48 hours prior to SIV inoculation and was maintained on drug therapy for a total of 4 weeks. The second animal was chronicall
Evaluation of antiviral drugs in cynomolgus monkeys infected with SIV or HIV-2.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 100. Unique Identifier : AIDSLINE PRIM11/94191596; Bottiger D; Oberg B; Dept. of Virology, Karolinska Institute, Stockholm, Sweden.; Results from the SIVsm/HIV-2SBL6669/cynomolgus macaque models for preclinical evaluation of drugs active against HIV/AIDS will be presented. Substances with proven clinical antiviral efficacy have been evaluated to validate the model ( AZT , ddI,
Evaluation of PMEA efficacy in macaques chronically infected with simian immunodeficiency virus (SIV).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 101. Unique Identifier : AIDSLINE PRIM11/94191597; Follis KE; Tsai CC; Grant R; Sabo A; Bischofberger N; University of Washington Primate Research Center, Seattle.; Macaque monkeys infected with SIV can be utilized for preclinical evaluation of antiretroviral drugs/compounds. For this study we used 10 Macaca fascicularis which had been chronically infected with SIVmne for over 11 months to test 9-(-2-phosphonylmethoxyethyl)adenine (PMEA). PMEA was previously shown to inhibit in v
Immunotherapy of SIV-infected Macaca fascicularis with an inactivated whole SIV immunogen.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 104. Unique Identifier : AIDSLINE PRIM11/94191598; Titti F; De Rossi A; Geraci A; Corrias F; Panzini GL; Sernicola L; Baroncelli S; Turillazzi GB; Amadori A; Chieco-Bianchi L; et al; Lab. of Virology, Istituto Superiore di Sanita, Rome, Italy.; OBJECTIVE: To evaluate the hypothesis that appropriately formulated immunogens, while inducing an anamnestic response in SIV infected monkeys, could affect viral burden or delay the development of the disease. RESULTS: Six Macaca fascicularis (Mf) (23, 26, 8202, 4, C1, 8302) immunized with inactivated whole SIV virus
Serologic and molecular analysis of rhesus cytomegalovirus.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 107. Unique Identifier : AIDSLINE PRIM11/94191599; Barry PA; Vogel P; Weigler BJ; Kerr H; Powers M; Alcendor D; Luciw PA; Dept. of Medical Pathology, University of California, Davis; 95616.; Cytomegalovirus ( CMV ) is a ubiquitous infectious agent in humans that normally results in no overt pathology. CMV-induced disease is usually observed only in individuals without a fully competent immune system (e.g., fetuses/neonates, AIDS patients, and transpla
Toxic, prophylactic and therapeutic effects of AZT on SIVmac infection of newborn rhesus macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 103. Unique Identifier : AIDSLINE PRIM11/94191600; Van Rompay K; Otsyula M; Joye S; Ghafourpour K; McChesney M; Pedersen N; Marthas M; California Reg. Primate Res. Center, Davis 95616.; GOAL: To study the toxic and antiviral effects of AZT on the course of SIV infection of newborn rhesus macaques. METHODS: TABULAR DATA, SEE ABSTRACT VOLUME. Twelve newborn (
Trans-dominant HIV-1 rev mutants inhibit replication of SIVmac.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 105. Unique Identifier : AIDSLINE PRIM11/94191601; Wong SW; Bergquam E; Endres CL; Axthelm MK; Division of Primate Medicine, Oregon Regional Primate Research; Center, Beaverton 97006.; Replication of SIV, as well as HIV-1 and -2, requires the functional expression of the virally encoded rev protein. The rev protein acts posttranscriptionally to control the cytoplasmic expression of certain viral RNAs that are otherwise retained in the nucleus. Results of transient transfection assays have shown that
Vaccine induction of SIVmac GAG-specific cytotoxic T lymphocytes in rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 10. Unique Identifier : AIDSLINE PRIM11/94191602; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.; In view of the importance of cell-associated virus in AIDS virus transmission, an HIV vaccine should be able to induce a virus-specific cytotoxic T lymphocyte (CTL) response. We have employed the SIVmac/rhesus monkey model to explore approaches to vaccine induction of CD8+, major histocompatibility complex (MHC) class
Efficacy of inactivated whole-virus and subunit vaccines in preventing HIV-2 infection in cynomolgus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 11. Unique Identifier : AIDSLINE PRIM11/94191603; Putkonen P; Thorstensson R; Ghavamzadeh L; Gilljam G; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.; The goal with this study was to compare the protective effect of vaccination of cynomolgus monkeys with a whole-virus vaccine and viral envelope glycoprotein subunit vaccine following challenge with homologous cell-free HIV-2. The challenge virus was grown on cynomolgus monkey PBMC. The challenge dose was 10 to 100 MI
Whole inactivated SIV vaccine protects from disease but not infection after cell-associated SIV challenge.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 12. Unique Identifier : AIDSLINE PRIM11/94191604; Hirsch VM; Goldstein S; Hynes N; London WT; Elkins WR; Zack PM; Byrum R; Johnson PR; Laboratory of Infectious Diseases, NIAID, NIH, Rockville, MD.; Simian immunodeficiency virus (SIV) infection of macaques is an ideal model for evaluating candidate HIV vaccines since SIV induces an immunodeficiency syndrome similar to human AIDS. Thus, potential vaccines can be evaluated for their ability not only to prevent infection but also for efficacy in preventing or delayi
Selection of an SIVmac LTR sequence upon mucosal inoculation of rhesus macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 13. Unique Identifier : AIDSLINE PRIM11/94191605; Meyer KK; Trivedi P; Streblow DN; Emau P; Pauza CD; University of Wisconsin, Madison 53706.; The primate retroviruses SIV and HIV, develop into complex virus populations in infected hosts. A less complex virus subset is established upon sexual transmission of HIV in man. The loss of complexity during transmission may be due to a titration effect (inefficient transmission or low doses of virus in the inoculum)
Mucosal immunization with a live, virulence-attenuated SIV vaccine elicits antiviral cytotoxic T lymphocytes and antibodies in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 14. Unique Identifier : AIDSLINE PRIM11/94191606; Marthas ML; Lohman BL; McChesney MB; Miller CJ; California Regional Primate Research Center, Davis.; An effective AIDS vaccine must protect against sexual transmission of HIV. Although intravenous (i.v.) inoculation with a molecularly cloned, live virulence-attenuated SIV (SIVmac1A11) provided durable protection against i.v. challenges with virulent SIVmac, intravaginal (IVAG) inoculation with SIVmac1A11 induced weak
Subtotal immunity and virus suppression induced by recombinant SIV vaccines.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 15. Unique Identifier : AIDSLINE PRIM11/94191607; Hoover EA; Israel ZR; Edmonson PF; Mossman SP; O'Neil SP; Bex F; Thiriart C; Fabry L; Van Opstal O; Bruck C; et al; Colorado State University, Fort Collins 80523.; We evaluated the efficacy of SIV recombinant envelope (env) and gag proteins and whole inactivated virus (wiv) vaccines, with or without recombinant live vaccinia vector (vv) priming, in protecting 23 rhesus macaques from SIVmac251 clone BK28 challenge. We used serial and terminal assessment of virus replication, prov
TH1/TH2 subset analysis in PBMC samples of sooty mangabeys and rhesus macaques naturally and experimentally infected with SIV.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 16. Unique Identifier : AIDSLINE PRIM11/94191608; Ansari AA; Mayne A; Hunt D; Villinger F; Dept of Pathology, Emory School of Medicine, Yerkes Reg. Primate; Res. Center, Emory Univ., Atlanta, GA.; Differential production of cytokines by T cell subsets during an immune response has been shown to have an important regulatory effect on the nature of the immune response and the eventual clinical outcome for the host. Based on the view that disease resistance vs susceptibility could be secondary to differential freq
Phases of SIV infection in rhesus macaques: role of lymphoid organs in pathogenesis.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 17. Unique Identifier : AIDSLINE PRIM11/94191609; Joag SV; Adams RJ; Foresman L; Narayan O; University of Kansas Medical Center, Kansas City 66160.; Pathogenesis studies were undertaken in 15 macaques inoculated with either lymphocyte-tropic SIVmac239 or a neurotropic variant of this virus. Both viruses caused typical persistent infection but studies on the dynamics of virus cell interactions during the infection showed 3 distinct phases that prognosticated clinic
Immunopathogenic events in the acute infection of rhesus monkeys with SIVmac.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 18. Unique Identifier : AIDSLINE PRIM11/94191610; Reimann KA; Yasutomi Y; Lin W; Tenner-Racz K; Racz P; Letvin NL; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.; Infection of the rhesus monkey with SIVmac was employed to explore the early immune events associated with the initial containment of an acute AIDS virus infection. In 9 rhesus monkeys infected intravenously with uncloned SIVmac251, p27 antigenemia was usually detected transiently from approximately day 7 through day
Pathogenesis of encephalitis caused by SIVmac.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 19. Unique Identifier : AIDSLINE PRIM11/94191611; Mankowski JL; Spelman JP; Ressetar HG; Clements JE; Zink MC; Div. Comparative Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.; SIVmac causes an immune deficiency syndrome in Asian macaques that is very similar to AIDS in man. Like HIV, SIV induces encephalitis characterized by perivascular infiltrates of macrophages and giant cells. The perivascular localization of these signature histopathologic lesions strongly suggests that the virus enter
Intramucosal transmission of primate retroviruses.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 2. Unique Identifier : AIDSLINE PRIM11/94191612; Pauza CD; Trivedi P; Meyer KK; Streblow DN; Malkovsky M; Salvato MS; Schultz KT; Emau P; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53706.; The development of vaccines to block sexual transmission of HIV-1 in man, requires a thorough understanding of factors affecting intramucosal transmission. In particular, it is necessary to determine the inoculum size and complexity, the relationship between virus dose and disease progression, the factors affecting in
Cytotoxic T lymphocyte specificity in cynomolgus macaques--identification of viral epitopes using reverse immunogenetics.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 20. Unique Identifier : AIDSLINE PRIM11/94191613; Gotch F; Institute of Molecular Medicine, Oxford.; The nature of what would constitute a protective immune response in HIV-1, HIV-2 or experimental SIV infection is unclear and therefore the protective components of a putative vaccine are not known. High levels of virus specific MHC restricted cytotoxic T lymphocytes (CTL) are seen early in infection and during the as
Using SIV in rhesus monkeys for AIDS vaccine development.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 21. Unique Identifier : AIDSLINE PRIM11/94191614; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.; Historically, vaccines have been our most potent weapon against viral diseases of medical importance. Development of an effective vaccine against HIV holds the greatest promise for preventing what will otherwise be a public health disaster of catastrophic proportions. Unfortunately, there are good reasons for believin
Association between immunological events and changes in viral DNA and RNA burden in lymphoid organs of SIV-infected macaques and disease progression.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 22. Unique Identifier : AIDSLINE PRIM11/94191615; Rosenberg YJ; Lewis MG; Leon EC; Eddy GA; Greenhouse J; Henry M. Jackson Foundation Research Laboratory, Rockville, MD.; Decline in the CD4+ T cells and HIV viral burden in the blood have been used as closely related correlates of disease progression. However since lymphocytes in the blood constitute only 1-2% of the total lymphocyte pool, it is important to understand how viral load in various organs in the lymphoid compartment are ass
Sequential analysis of viral load in lymph nodes of SIV infected rhesus macaques: correlates with disease evolution.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 23. Unique Identifier : AIDSLINE PRIM11/94191616; Chakrabarti L; Cumont MC; Montagnier L; Hurtrel B; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.; Lymphoid organs are now recognized as the major reservoir of HIV and SIV viruses in the organism. To elucidate the initial pathogenic events in these organs, we performed a quantitative follow up of viral load and pathologic changes in lymph nodes (LN) early in the course of SIV infection. 8 Rhesus macaques were inocu
Cellular immune responses in rhesus macaques with low dose SIV infection.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 24. Unique Identifier : AIDSLINE PRIM11/94191617; Salvato MS; Emau P; Malkovsky M; Schultz K; McKenzie D; Johnson E; Pauza CD; University of Wisconsin, Dept. of Pathology and Laboratory; Medicine, Madison.; Ten juvenile rhesus monkeys were infected via the rectal mucosa with doses of SIVmac251 ranging from 0.1 to 1000 animal infectious doses (Pauza et al. J Med Primatol., in press, 1993). The infectious dose (ID) is the minimum intravenous inoculum needed to infect 50% of age and sex-matched animals. Two monkeys were inf
Conserved T cell receptor repertoire in SIVmac-infected rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 25. Unique Identifier : AIDSLINE PRIM11/94191618; Chen ZW; Kou ZC; Shen L; Reimann KA; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.; Studies to assess the possibility that the human immunodeficiency virus (HIV) may encode a superantigen that plays a role in the depletion of functional CD4+ lymphocytes in the infected individual have yielded discrepant results. The problem in performing conclusive examinations of this issue may be attributed, at lea
Antiviral cytotoxic responses of primate gamma delta T cells isolated by magnetic cell separation.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 26. Unique Identifier : AIDSLINE PRIM11/94191619; Wallace M; Pauza CD; Malkovsky M; Dept. of Medical Microbiology and Immunology, Univ. of Wisconsin; at Madison.; We have previously reported that certain human or rhesus monkey gamma delta T cell clones lyse lymphoid cells infected with immunodeficiency viruses (Malkovsky et al., J. Med. Primatol. 21:113, 1992). The same uninfected lymphoid cells are not lysed. This observation and the report that elevated numbers of gamma delta
Species-specific responses to MHC molecules in SIV vaccination and infection.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 27. Unique Identifier : AIDSLINE PRIM11/94191620; Cranage M; Polyanskaya N; Cook N; Webster S; Dennis M; Sharpe S; Ashworth T; Hall G; Centre for Applied Microbiology and Research, Porton Down,; Salisbury, U.K.; It is known that some retroviruses, including HIV and SIV selectively incorporate host cell proteins into their envelopes during virus egress from the infected cell. Recent results have shown that vaccine mediated protection in macaques, seen when vaccine and challenge virus are prepared in human cells, is, at least i
Characterization of a highly pathogenic SIVagm isolate.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 28. Unique Identifier : AIDSLINE PRIM11/94191621; Dapolito GA; Elkins WR; London WT; Goldstein S; Johnson PR; Hirsch VM; LID, NIAID, NIH, Rockville, MD 20852.; SIV pathogenesis studies have been restricted primarily to viruses isolated from sooty mangabeys (SIVsm) or macaques (SIVmac) since these viruses induce immunodeficiency similar to human AIDS in inoculated macaques. In contrast, infection of macaques with SIV isolated from African green monkeys (SIVagm) generally resu
A mosaic SIVAGM genome provides evidence for simian/simian cross-species transmission in the wild (September 19-22, 1993).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 29. Unique Identifier : AIDSLINE PRIM11/94191622; Hahn BH; Jin MJ; Hui H; Robertson DL; Allan JS; Shaw GM; Sharp PM; University of Alabama at Birmingham 35294.; African Green Monkeys (Cercopithecus aethiops) are naturally infected with a non-pathogenic lentivirus, termed SIVAGM. There are four major AGM species (vervet, grivet, tantalus, sabaeus), all of which are known to harbor SIVAGM. Because of their abundance, African green monkeys comprise the largest reservoir of prima
Analysis of genetic diversity in maternally-transmitted SIV-infected rhesus macaque neonates (September 19-22, 1993).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 3. Unique Identifier : AIDSLINE PRIM11/94191623; Martin-Amedee A; Davison-Fairburn B; Trichel A; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA 70433.; We have previously reported the delivery of two SIV-infected rhesus monkeys from females inoculated with SIV/DeltaB670. The females were inoculated prior to pregnancy or in the third trimester, and the infants were delivered vaginally. These females became immunodeficient during their pregnancies and histopathological
Viral genetic determinants in SIVsmmPBj pathogenesis.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 30. Unique Identifier : AIDSLINE PRIM11/94191624; Novembre FJ; Hirsch VM; Lewis MG; Johnson PR; Klumpp S; Anderson DC; McClure HM; Yerkes Regional Primate Research Center, Atlanta, GA.; SIVsmmPBj (PBj) induces an acutely lethal disease when inoculated into pigtailed macaques. This disease syndrome, characterized by a fulminant diarrhea, acidosis and wasting, has been likened to a cytokine induced enteritis. As a means to investigate the molecular basis of PBj-induced disease, we have utilized molecul
Extensive ENV gene heterogeneity in tissues from SIV infected macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 31. Unique Identifier : AIDSLINE PRIM11/94191625; Campbell BJ; Hirsch VM; NIH/NIAID/LID, Rockville, MD 20852.; Recently investigations of SIV and HIV infections have demonstrated that the viral burden in the peripheral blood vastly underestimates the extent of lymphoid involvement. Therefore, tissues may be a reservoir for viruses of different biologic and pathogenic properties than those observed in the blood. However, little
Viral domains contributing to SIV replication in brain.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 32. Unique Identifier : AIDSLINE PRIM11/94191626; Kodama T; Kawahara T; Desrosiers R; Axthelm M; Oregon Regional Primate Research Center, Beaverton 97006.; We have isolated SIVmac155/NT variants from the brain of a rhesus macaque that displayed encephalitis after infection with cloned SIVmac239. Compared to parental SIVmac239, the NT variant exhibited high replicative capacity for peripheral macrophages and primary brain cell cultures from rhesus macaques, but it replica
Role of the lentivirus Vpu gene in virus replication.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 33. Unique Identifier : AIDSLINE PRIM11/94191627; Geraghty RJ; Callahan M; Harper W; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin,; Madison 53706.; Lentiviruses such as SIV and HIV express a group of genes termed the accessory genes because they are not found in simpler retroviruses. Although SIV contains most of the accessory genes found in HIV-1, there is no obvious counterpart to the HIV-1 vpu gene. Vpu apparently functions in two separate ways during the proc
Are there roles for heat shock proteins in the replication of HIV and SIV?: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 34. Unique Identifier : AIDSLINE PRIM11/94191628; Bartz SR; Pauza CD; Ivanyi J; Jindal S; Welch WJ; Malkovsky M; Dept. of Medical Microbiology and Immunology, Univ. of Wisconsin.; The role of host cell proteins in the assembly of, the pathogenesis of, and the immune response to HIV and SIV is not well understood. Heat shock proteins (Hsp s) are potentially important for viral production because of their known functions in cellular protein maturation and assembly of macromolecular complexes. Als
Role of beta-2 microglobulin, HLA I and HLA II DR in protection of macaques from infection by SIV grown in HuT 78 cells.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 35. Unique Identifier : AIDSLINE PRIM11/94191629; Benveniste R; Henderson L; Bess J Jr; Sowder R; Mann D; Nolte R; Bartz C; Kuller L; Morton W; Arthur L; National Cancer Institute, Frederick, MD.; We have previously shown that beta-2 microglobulin (beta-2M), HLA I (alpha-chain), and HLA II DR (alpha- and beta- chains) are specifically associated with purified preparations of HIV-1, HIV-2, and SIV. These cellular antigens are each present at approximately 15% of the levels of gag on a molar basis, based on recov
In vivo anti-viral effect of CD4-specific monoclonal antibodies in SIVmac-infected rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 36. Unique Identifier : AIDSLINE PRIM11/94191630; Reimann KA; Waite BC; Cate RL; Wu Y; Olson D; Letvin NL; Burkly LC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.; Since monoclonal antibodies (mAb) specific for CD4 are potent inhibitors of HIV and SIV replication in vitro, we explored their potential usefulness in vivo as an AIDS therapy. The anti-CD4 mAb 5A8 efficiently inhibits HIV and SIVmac replication in vitro and virus-induced cell fusion. This antibody binds to domain 2 o
Adaptation of HIV-1 to pig-tailed macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 37. Unique Identifier : AIDSLINE PRIM11/94191631; Gartner S; Liu Y; Lewis M; Polonis V; Hunter E; Brown C; Elkins WR; Zack P; Eddy G; Henry M. Jackson Foundation, Rockville, MD.; Prior to animal studies, in vitro experiments were performed to assess the relative susceptibility of cells from various monkey species to HIV-1. We found: (1) Cultured T cells from pig-tailed macaques were more susceptible and/or permissive for HIV-1 than T cells from cynomolgus and rhesus monkeys, although peak expr
Antibody to the human IFN alpha receptor reduces the loss of CD4 + T cells in macaques infected with the simian immunodeficiency virus (SIV).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 38. Unique Identifier : AIDSLINE PRIM11/94191632; Tovey MG; Lebon P; Meyer F; Hurtrel B; Gresser I; Venet A; Girard M; Aubertin AM; IRSC-CNRS, Villejuif, France.; Co-factors including cytokines are thought to play a determining role in the development of the acquired immunodeficiency syndrome (AIDS) following infection by the human immunodeficiency virus (HIV). The presence of acid-labile interferon (IFN) alpha in the sera of AIDS patients has been shown to correlate with disea
Cell-cell interactions regulating the expression of immunodeficiency viruses in CD4+ T lymphocytes.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 39. Unique Identifier : AIDSLINE PRIM11/94191633; Clark EA; University of Washington Regional Primate Research Center,; Seattle 98195.; A number of cell-cell interaction regulate CD4+ T cell responses to antigen presented on antigen presenting cells (APC) such as dendritic cells (DC) or B cells. In particular, reciprocal interactions between CD28 (or CTLA-4) and CD40 ligand (CD40L) on T cells and their coreceptors B7/BB1 and CD40 on APC are required f
Dual infection of rhesus macaques with SIVE11s and SIV239.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 4. Unique Identifier : AIDSLINE PRIM11/94191634; Lewis MG; Bellah S; McKinnon K; Yalley-Ogunro J; Greenhouse J; Elkins WR; Rosenberg Y; Gartner S; Eddy G; Henry M. Jackson Foundation, Rockville, MD.; The purpose for this study was to determine if dual infection by two virulent and pathogenic SIV isolates is possible in rhesus macaques. In addition, we wanted to determine if pre-existing immunity alters the anticipated course of infection. The two isolates used in this study, SIVmac239 and SIVmne/E11s, differ genet
NIAID research priorities in tuberculosis.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 40. Unique Identifier : AIDSLINE PRIM11/94191635; Rosenberg ZF; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892.; After decades of steady decline, the number of cases of tuberculosis in the U.S. has risen 20% between 1985 and 1992. In addition, the percentage of tuberculosis cases that are resistant to standard therapies is also increasing. The growth of the AIDS epidemic with significant numbers of immunocompromised, HIV-infecte
Total lymphoid irradiation of SIV-infected macaques as a potential therapy for HIV infection.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 41. Unique Identifier : AIDSLINE PRIM11/94191636; Fultz PN; Schwiebert R; Su L; Salter M; Department of Microbiology, University of Alabama at Birmingham; 35294.; Lymph nodes appear to be reservoirs for large amounts of virus in HIV-infected persons. It is also clear that many manifestations of HIV-related disease are due to immune activation and autoimmune reactions. Total lymphoid irradiation (TLI), an effective therapy for Hodgkin s disease, has been used more recently to tr
Passive immunization of rhesus macaques against SIV: failure to protect and apparent enhancement of infection and disease (September 19-22, 1993).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 42. Unique Identifier : AIDSLINE PRIM11/94191637; Gardner MB; Jennings M; Rosenthal A; McKenzie M; University of California at Davis 95616.; We have used the macaque model to test the effect of passive immunization on SIV infection and disease. We had two goals in mind: 1) to investigate the role of humoral immunity in SIV vaccine protected as compared to SIV infected monkeys, in hopes of better understanding the mechanism of vaccine protection; and 2) to
Comparison of the efficacy of AZT and PMEA treatment on acute SIVMNE infection in macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 43. Unique Identifier : AIDSLINE PRIM11/94191638; Tsai CC; Follis KE; Grant R; Sabo A; Nolte R; Bartz C; Bischofberger N; Benveniste R; University of Washington Primate Research Center, Seattle.; The efficacy of the antiviral agents azidothymidine ( AZT ) and 9-(-2-phosphonylmethoxyethyl)adenine (PMEA) against SIV was compared in long-tailed macaques (Macaca fascicularis). A total of 48 macaques were used for this study and treated employing the
Impairment of alveolar macrophage-mediated killing of Cryptococcus neoformans in rhesus monkeys with SIV-induced AIDS.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 44. Unique Identifier : AIDSLINE PRIM11/94191639; Brodie S; Sasseville V; Simon M; Sehgal P; Desrosiers R; Ringler D; Division of Pathology, Harvard Medical School, Southborough, MA.; Because alveolar macrophages (Mphi) play a major role in the host defense against inhaled microorganisms and are susceptible targets of lentivirus infection, we investigated if lentiviral infection of M phi alters microbicidal potential. Alveolar Mphi infected with SIVmac were assessed for their ability to kill encaps
How the nonhuman primate model serves the worldwide fight against AIDS: identification of crucial needs and priorities.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 45. Unique Identifier : AIDSLINE PRIM11/94191640; Bolognesi D; Duke University Center for AIDS Research.; [No abstract appeared in the published proceedings]
B-cell lymphomagenesis in SIV immunosuppressed cynomolgus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 46. Unique Identifier : AIDSLINE PRIM11/94191641; Biberfeld P; Kaaya EE; Feichtinger H; Li SL; Ekman M; Ernberg I; Voevodin AF; Putkonen P; Biberfeld G; Immunopathology Lab., Karolinska Institute, Stockholm, Sweden.; OBJECTIVE: To characterize lymphomagenic mechanisms in SIV immunosuppressed cynomolgus monkeys (Macaca fascicularis). MATERIAL AND METHODS: Monkeys immunosuppressed by SIVsm (SMM3) developed malignant lymphoma in high frequency (approx. 40%). These lymphomas were studied by immunohistopathology, anticomplement immunof
Infection of Macaca nemestrina by human immunodeficiency virus types 1 and 2.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 47. Unique Identifier : AIDSLINE PRIM11/94191642; Morton WR; Schmidt AM; Agy MB; Katze MG; Florey MJ; Corey L; Frumkin LR; Ochs HD; Hu SL; McClure J; et al; Regional Primate Research Center, Univ Washington, Seattle.; We have previously reported acute HIV-1 infection in eight Macaca nemestrina (pigtailed macaques), inoculated with cell-associated and/or cell-free virus. HIV-1 was recovered from the PBMC from all eight animals during two to eight weeks post-inoculation and rarely thereafter. PCR analysis revealed HIV-1-specific DNA
Serosurvey of nonhuman primates in Kenya: evidence for SIVsmm-related infection in a baboon.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 48. Unique Identifier : AIDSLINE PRIM11/94191643; Novembre FJ; Chege G; Ishahakia M; McClure HM; Yerkes Regional Primate Research Center, Emory University,; Atlanta, GA.; The Yerkes Regional Primate Research Center and the Institute of Primate Research have an ongoing collaboration to examine the prevalence of lentiviral infections in feral nonhuman primates. A recent serosurvey was conducted with six species of nonhuman primates utilizing a standard HIV-2 ELISA kit. Positive samples b
Molecular investigations of higher primate foamy viruses.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 49. Unique Identifier : AIDSLINE PRIM11/94191644; Bieniasz PD; Ali M; McClure MO; Department of G.U. Medicine and Communicable Diseases, St Mary's; Hospital Medical School, Paddington, London, U.K.; We have undertaken a comparative study of foamy viruses isolated from higher primates: human (HFV), chimpanzee (SFV-6, SFV-7), gorilla (GFV) and orangutan (OFV) using serology, PCR, sequencing, and an assay for transactivation. Serologically, using virus infected BHK cells as antigen and sera from infected primates, H
In vivo passage of HIV-2EHO in Macaca nemestrina results in increased virulence.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 5. Unique Identifier : AIDSLINE PRIM11/94191645; McClure J; Steele J; Dorofeeva N; Scheibel M; Misher L; Schmidt A; Morton W; Hu SL; Bristol-Myers Squibb, Seattle, WA 98121.; HIV-2EHO is representative of a subgroup of HIV-2 which demonstrates enhanced cytopathogenicity, increased replicative rate, and extended host range in vitro as compared to the prototype HIV-2ROD. As previously reported, HIV-2EHO infects M. nemestrina and causes an AIDS-like disease in 50% of the infected animals. We
The mucosal barrier selects for SIV with unique envelope sequences.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 50. Unique Identifier : AIDSLINE PRIM11/94191646; Trivedi P; Emau P; Pauza CD; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53706.; One year old juvenile rhesus monkeys were infected intravenously or intrarectally with varying doses of SIVmac. This biological isolate proved to be a complex mixture of viruses based on extensive sequence analysis of viral long terminal repeats. Peripheral blood mononuclear cells (PBMC) were collected from infected a
Performance characteristics of HIV-2 serology reagents on blood from SIV/HIV-2 infected monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 52. Unique Identifier : AIDSLINE PRIM11/94191647; Yee JL; Jennings MB; Lowenstine LJ; Lerche NW; Dept. of Medical Pathology, University of California, Davis.; Over the past five years, we have tested more than 20,000 sera from humans and non-human primates for antibodies to SIV/HIV-2, using first generation reagents prepared from HIV-2 viral lysate. The increasing demands for testing, and the wider commercial availability of new generation reagents have led us to evaluate t
HIV-2 infected monkeys as a model for HIV seroprevalence studies on exchanged needles from intravenous drug users.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 53. Unique Identifier : AIDSLINE PRIM11/94191648; Yee J; Bucardo J; Guydish J; Jennings M; Dept. of Medical Pathology, University of California, Davis.; To evaluate and establish testing strategies for needles/syringes (as a minimally intrusive means of determining HIV seroprevalence in intravenous drug users in needle exchange programs) we have used blood from rhesus macaques experimentally infected with HIV-2. This model provides repeated, controlled access to blood
The molecular characterisation of vaccine trials using recombinant envelope immunogens and live SIV containing distinct nef genes.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 54. Unique Identifier : AIDSLINE PRIM11/94191649; Almond N; Rud E; Kent K; Chan L; Page M; Jones W; Mills K; Clarke B; Kitchin P; Stott J; NIBSC, Potters Bar, United Kingdom.; The effect of pre-existing anti-envelope immunity on the evolution of the SIVenv gene in vivo has been studied in immunised macaques, which were not protected upon challenge with SIVmav32H. Cynomolgus macaques have now been immunised with envelope immunogens derived from SIV clones homologous with or heterologous to S
Variation of HIV-2 env gene in vaccinated but not protected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 55. Unique Identifier : AIDSLINE PRIM11/94191650; Byon-Auboyer MH; Boussin FD; Vogt G; Legrand R; Vaslin B; Dormont D; CRSSA/CEA, Fontenayaux Roses, France.; We investigated molecular variations of HIV-2 env gene in experimentally infected rhesus macaques involved in a vaccinal trial. Fourteen rhesus macaques were treated as follows: 5 monkeys were vaccinated with recombinant vaccinia viruses expressing gag, pol, nef and vif, genes of HIV-2Rod, 5 monkeys received the same
Titration in pig-tailed macaques of the HIV-1 III-B chimpanzee virus challenge stock.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 56. Unique Identifier : AIDSLINE PRIM11/94191651; Benveniste R; Agy M; Arthur L; Bess J Jr; Katze M; Corey L; Schmidt A; Morton W; NCI, Frederick, MD.; Despite the similarities of SIV-induced AIDS in macaques and HIV-induced AIDS in humans, these two viruses differ in their regulatory genes and in the composition of their envelope genes to a sufficient extent so as to warrant performing vaccine and therapeutic studies with HIV-1 in animals. The expense of maintaining
Concomitant high level T helper and humoral responses in vaccinated rhesus monkeys do not protect against SIV challenge.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 57. Unique Identifier : AIDSLINE PRIM11/94191652; Benveniste O; Vaslin B; Le Grand R; Vogt G; Gras G; Salk J; Dormont D; Laboratoire de Neuropathologie Experimentale et Neurovirologie,; Commissariat a l'Energie Atomique, Fontenay aux Roses, France.; Two groups of 5 rhesus macaques received 3 intramuscular 100 microgram doses of inactivated SIV delta B670 virus, emulsified in adjuvant, at 0, 2, and 7 months. First group (A) received the immunogen in an oil-in-water emulsion consisting of RIBI detox with mycobacterial cell wall skeleton and monophosphoryl lipid A (
IgG antibodies predominate in mucosal and genital secretions of HIV-1 positive chimpanzees.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 58. Unique Identifier : AIDSLINE PRIM11/94191653; Israel ZR; Frost PA; Marx PA; Dept. of Biology, New Mexico State University, Holloman AFB; 88330.; Heterosexual transmission of HIV in Africa, Asia, North America and Europe emphasizes the need to identify immunization strategies that will protect against HIV infection at the genital mucosa. In previous studies in macaques, mucosal IgG was the predominant SIV vaginal antibody in SIV immunized and infected animals.
Animal model for anti-viral therapy: effect of AZT treatment on cellular and seric viral loads during early stages of SIVmac251 infection of macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 59. Unique Identifier : AIDSLINE PRIM11/94191654; Le Grand R; Clayette P; Vaslin B; Noack O; Theodoro F; Roques P; Dormont D; Laboratoire de Neuropathologie Experimentale et Neurovirologie,; CEA/SSA, Fontenay aux Roses, France.; OBJECTIVES: To evaluate the efficiency of prophylactic treatment with AZT during primo-infection of SIVmac251 (monkey PBL grown virus stock) inoculated cynomolgus monkeys. MATERIALS AND METHODS: Two groups of four Macaca fascicularis were treated eith
Replication of SIVmac251 and SIVB670 in vitro in placental syncytiotrophoblasts.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 6. Unique Identifier : AIDSLINE PRIM11/94191655; Krugner-Higby LA; Schultz KT; Johnson KJ; Golos TG; Wisconsin Regional Primate Research Center, Madison.; We have infected rhesus placental cells with SIV as an in vitro model for studying mechanisms of maternal/fetal HIV transmission. Placental chorionic villi were obtained from rhesus macaques at Cesarean section and cytotrophoblast cells were isolated by differential centrifugation on a Percoll gradient. Cells were cul
SIV-GP120 recombinant viruses are avirulent and immunogenic.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 60. Unique Identifier : AIDSLINE PRIM11/94191656; Lohman BL; Van Rompay KK; McChesney MB; McGowan E; Joye S; Luciw P; Marthas M; Pedersen NC; California Regional Primate Research Center, University of; California, Davis 95616.; The molecularly cloned SIVmac1A11 is a model for a live virus vaccine because rhesus macaques infected with this virus are transiently viremic, do not develop disease, and withstand low-dose challenge with a pathogenic strain of SIVmac. The molecular clone SIVmac239 causes persistent viremia and a fatal immunodeficien
ADCC function in sera from infected but not from immunized rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 61. Unique Identifier : AIDSLINE PRIM11/94191657; Ohkawa S; Wilson LA; Miller M; Montelaro R; Martin L; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA 70433.; Using vaccinia recombinants, we prepared target cells expressing SIV env specific for SIV/B670 or SIVmac251. Serum samples collected from SIV/B670 infected, SIVmacBK28 infected, or SIVmac251 recombinant glycoprotein immunized monkeys were assessed for complement-mediated lysis (ACC) or antibody dependent cellular cyto
Analysis of immune responses induced by whole killed SIV with various adjuvants.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 62. Unique Identifier : AIDSLINE PRIM11/94191658; Ohkawa S; Wilson LA; Yamamoto F; Kiyono H; Martin L; Murphey-Corb M; Tulane Regional Primate Res. Center, Covington, LA 70433.; Cellular and humoral immune responses were assessed in monkeys immunized with killed SIV virus alone or combined with different adjuvants. Adjuvant groups included no adjuvant (I), SAF-M (II), Freund s complete (III), alum (IV), detoxified lipid A (V), Freund s incomplete + MDP (VI), MTP-PE (VII), liposomes (VIII), li
Challenge of rhesus monkeys with SIV after immunization with a combination regimen.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 63. Unique Identifier : AIDSLINE PRIM11/94191659; Schlienger K; Mancini M; Riviere Y; Tiollais P; Michel ML; Unite de Recombinaison et Expression Genetique, Institut; Pasteur, Paris, France.; We recently reported that recombinant Hepatitis B surface antigen (HBsAg) particles presenting the HIV-1BRU envelope principal neutralizing determinant on their surface (V3/HBsAg) allowed us to generate proliferative T-cell responses, cellular cytotoxicity and neutralizing antibodies in immunized rhesus monkeys. To ev
The MHC class I loci of the rhesus monkey.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 65. Unique Identifier : AIDSLINE PRIM11/94191660; Watkins DI; Boyson JE; McAdam SN; Rojo S; Lopez de Castro JA; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53715.; Knowledge of MHC molecules play a crucial role in the design of vaccine strategies. Since alloantisera have been ineffective in the definition of MHC class I molecules in rhesus monkeys, we have initiated a biochemical and molecular biological analysis of rhesus monkey MHC class I genes and gene products. One-dimensio
Reduced virus load in rhesus macaques immunized with recombinant gp160 and challenged with simian immunodeficiency virus.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 66. Unique Identifier : AIDSLINE PRIM11/94191661; Yilma T; Lohman B; Marthas M; Giavedoni L; el-Amad Z; Haigwood N; Scandella C; Gardner M; Luciw P; Ahmad S; California Regional Primate Research Center, University of; California, Davis 95616.; We have evaluated the potential of SIVmac239 gp160 expressed by recombinant vaccinia virus (vSIVgp160) and baculovirus (bSIVgp160) to protectively immunize rhesus macaques against intravenous (i.v.) infection with pathogenic SIVmac isolates. The challenge viruses, propagated in rhesus peripheral blood mononuclear cell
HIV-1 infection and replication in PBMC from three macaque species in vitro: a comparative study.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 67. Unique Identifier : AIDSLINE PRIM11/94191662; Agy MB; Acker RL; Katze MG; University of Washington Regional Primate Research Center,; Seattle 98195.; We have previously reported in vitro infections of M. nemestrina PBMC where we showed de novo synthesis and accumulation of HIV-1 proteins, as well as production of a low levels of infectious virions, in the infected culture supernatants. We then decided to carefully examine HIV-1 infection of M. fascicularis and M. m
Monoclonal antibody to a cellular component and its potential for defining cellular tropism.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 68. Unique Identifier : AIDSLINE PRIM11/94191663; Allan JS; Whitehead E; Southwest Foundation for Biomedical Research, San Antonio, TX; 78228.; The process of viral entry is represented by a complex series of events beginning with the binding of the virus to its receptor, CD4, and culminating in viral fusion. Recent evidence has linked virus neutralization and cell tropism to the V3 loop domain of HIV. Additionally, previous studies in this laboratory have sh
Association between hematologic abnormalities and pregnancy outcome in SIV infected macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 69. Unique Identifier : AIDSLINE PRIM11/94191664; Davison-Fairburn B; Baskin G; Harrison R; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA 70433.; Eight of 21 pregnancies in rhesus monkeys inoculated with a pathogenic strain of SIV resulted in abortion, intrauterine death, term stillbirth, or an SIV infected infant. Of these 8, 6 were associated with anemia and/or thrombocytopenia in the dam prior to delivery or fetal demise. One abortion and 1 intrauterine deat
Whole inactivated SIV vaccine protects macaques from infection with cell-free SIV generated in human but not macaque cells.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 7. Unique Identifier : AIDSLINE PRIM11/94191665; Goldstein S; London WT; Elkins WR; Hirsch VM; Laboratory of Infectious Diseases, NIAID, NIH, Rockville, MD.; Previous studies demonstrated that the species of cell line used to generate SIV vaccine and challenge stocks influence protection mediated by whole inactivated SIV vaccine (WI-SIV). Thus, protection is observed if the vaccine and challenge are generated in human cells, but not if the challenge virus is grown in macaq
Differential localization of SIV replication in lymphoid tissues of rhesus monkeys after intravenous or intrarectal infection.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 70. Unique Identifier : AIDSLINE PRIM11/94191666; Emau P; Uno H; Zimbric M; Bro S; Pauza CD; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53706.; We studied the localization of virus replication and pathology in lymphoid tissues of rhesus monkeys infected intravenously (i.v., n = 2) or intrarectally (ir, n = 1) with uncloned SIVmac. At the end stage of disease the pathology of lymphoid tissues in the i.v.-infected animals was characterized by acute spleenitis a
Gonadal function in male rhesus macaques inoculated with simian immunodeficiency virus.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 71. Unique Identifier : AIDSLINE PRIM11/94191667; Nadler RD; Manocha AD; McClure HM; Yerkes Regional Primate Research Center, Emory University,; Atlanta, GA 30322.; A characteristic postmortem finding in men who die of AIDS is an absence of normal spermatogenesis, regardless of age at death, duration of the infection or cause of death. We sought to confirm this finding in the monkey animal model and to determine if the effect on the testes was a primary one or secondary to change
A neutralizing assay for SIV in an adherent CD4+ macaque cell line.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 72. Unique Identifier : AIDSLINE PRIM11/94191668; Goldstein S; Fomsgaard A; Hirsch VM; Laboratory of Infectious Diseases, NIAID, NIH, Rockville, MD; 20852.; The quantitation of neutralizing antibodies from SIV-infected or immunized animals would be assisted by a reliable and rapid neutralization assay. Current assays that measure inhibition of cell death are rapid, but are limited due to variation in cytopathology, and tropism of SIV isolates. In contrast, assays rely upo
Does the amount of MHC class II expressed on blood monocytes affect the pathology of macaques infected with SIV?: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 74. Unique Identifier : AIDSLINE PRIM11/94191669; Hall G; Ashworth T; Sharpe S; Cook R; Dennis M; Andrews C; Cranage M; Centre for Applied Microbiology and Research, Porton Down,; Salisbury, UK.; The severity of the pathology that develops in rhesus macaques inoculated experimentally with SIV and the speed of its development varies between animals, but the host cell factors responsible for this variability are poorly understood. Pathology was reviewed in 14 rhesus macaques used in vaccine trials that had been
Simian foamy virus and SIV expression in macaque lymphoid cells.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 75. Unique Identifier : AIDSLINE PRIM11/94191670; Hunter E; Lewis M; Brown C; Eddy G; Gartner S; Henry M. Jackson Foundation, Rockville, MD 20850.; Simian Spumaviruses, or foamy viruses (SFV), are ubiquitous retroviruses present in large numbers of macaques. These viruses exhibit lytic properties in vitro, but appear latent in vivo, and to date, have not been associated with any disease. Because SFV expression occurs spontaneously in macaque lymphocyte cultures,
Quantitative differences in the levels of IL-2 and IFN gamma produced by PBMC of naturally SIV infected sooty mangabeys and rhesus macaques experimentally infected with SIV.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 76. Unique Identifier : AIDSLINE PRIM11/94191671; Mayne A; Villinger F; Findley H; Ansari AA; Dept of Pathology, Emory School of Medicine, Yerkes Reg. Primate; Res. Center, Emory Univ., Atlanta, GA.; Equivalent numbers of PBMC from a group of sooty mangabeys naturally infected with SIV and a group of asymptomatic macaques experimentally infected with SIVsmm9 as well as uninfected macaques were cultured in vitro with a variety of mitogens in varying concentrations. Supernatant fluids were collected at 0, 24, 48 and
Enteropathy in pigtail macaques inoculated with SIVsmmPBj14-bcl.3.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 77. Unique Identifier : AIDSLINE PRIM11/94191672; Mossman SP; O'Neil SP; Maul DH; Fultz PN; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523.; Inoculation of pigtail macaques with SIVsmmPBj14-bcl.3, a biological clone, produces a fatal acute gastrointestinal disease characterized by profuse diarrhea. Characteristic lesions in the intestines of symptomatic animals include the blunting and fusion of villi, loss of the crypt and absorptive epithelial cells, ede
Comparative pathogenicity of molecular and biologic clones of SIVsmmPBj14.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 78. Unique Identifier : AIDSLINE PRIM11/94191673; O'Neil SP; Mossman SP; Maul DH; Israel ZR; Dean GA; Fultz PN; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523.; We have studied clinical, virologic, histopathologic, and hematologic parameters of the preclinical and clinical phases of the acute PBj14 syndrome produced in pigtailed macaques by either molecular or biologic clones of SIVsmmPBj14. We found that both molecular clone 1.9 and biologic clone bcl.3 consistently produced
Role of accessory cell molecules in dendritic cell-dependent HIV-replication.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 79. Unique Identifier : AIDSLINE PRIM11/94191674; Pinchuk L; Polacino P; Agy MB; Liang A; Clark EA; University of Washington, Regional Primate Research Center,; Seattle.; Previous studies have suggested that after exposure to HIV-1, dendritic cells (DC) continue to present normal antigens and superantigens, forming clusters with T cells that are driven to replicate. Infection of the DC cannot be detected, but the clustered T cells release virions and die (Cameron et al., Science, 257:3
Prior exposure to subinfectious doses of SIV protects macaques from subsequent virus challenge.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 8. Unique Identifier : AIDSLINE PRIM11/94191675; Benveniste R; Kuller L; Hu SL; Clark E; Clerici M; Shearer G; Morton W; National Cancer Institute, Frederick, MD 21702.; As part of an in vivo titration study of SIV/Mne molecular and single-cell clones, macaques were inoculated intravenously with various dilutions of these infectious virus stocks. Animals received dilutions containing from 10(4) to 10(-3) tissue culture infectious doses (TCID) of SIV. Seroconversion and evidence of inf
Effect of CD3 and CD28 stimulation on the initial infection of resting T-cells with simian immunodeficiency virus.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 80. Unique Identifier : AIDSLINE PRIM11/94191676; Polacino P; Liang A; Clark E; University of Washington, Primate Center, Seattle.; The simian immunodeficiency virus (SIV) is highly tropic for cells expressing CD4 receptor. The early molecular events that occur after infection of CD4 T cells with SIV are not yet well defined. After HIV enters host cells, viral DNA is synthesized and can be integrated into the host genome. In vitro, HIV can infect
Distribution of SIVMNE in tissues and organs of Macaca fascicularis treated with AZT or PMEA.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 81. Unique Identifier : AIDSLINE PRIM11/94191677; Tsai CC; Follis K; Sabo A; Grant R; University of Washington Primate Research Center, Seattle.; At necropsy, we examined the distribution of SIV in various tissues and organs of longtailed macaques (Macaca fascicularis) that were previously inoculated with SIV and treated with azidothymidine ( AZT ) or 9-(-2-phosphonylmethoxyethyl)adenine (PMEA).
Functional comparison of LTRs from acutely pathogenic and non-acutely pathogenic derivatives of SIVSMMPBJ14.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 83. Unique Identifier : AIDSLINE PRIM11/94191678; Dewhurst S; Dollard SC; Fultz PN; University of Rochester Medical Center, NY 14642.; Molecularly cloned SIVs capable of inducing acute fatal disease in pig-tailed macaques have been derived previously from a biological clone (bcl-3) of the PBj14 isolate of SIV from sooty mangabey monkeys (SIVSMMPBj14). A closely related biological clone (bcl-1), also derived from the PBj14 isolate, fails to induce acu
Neurobehavioral test battery for assessment of cognitive changes following SIV infection in rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 84. Unique Identifier : AIDSLINE PRIM11/94191679; Gold LH; Polis I; Roberts AC; Robbins TW; Bloom FE; Koob GF; Dept. of Neuropharmacology, Scripps Research Institute, La Jolla,; CA.; A computerized, neuropsychological testing battery has been developed to detect changes in cognitive performance in rhesus monkeys following infection with simian immunodeficiency virus (SIV). The neurobehavioral test battery consists of probes for memory (delayed non-matching to sample and spatial working memory task
Simian AIDS type D retrovirus serotype 2 and variant viruses: isolation of infectious molecular clones.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 85. Unique Identifier : AIDSLINE PRIM11/94191680; Marracci GH; Pilcher KY; Shiigi SM; Hallick LM; Axthelm MK; Machida CA; Department of Molecular Microbiology and Immunology, Oregon; Health Sciences University, Portland 97201.; Type D serogroup 2 simian retroviruses (D2 SRVs) have been associated with severe immunodeficiency and retroperitoneal fibromatosis in Celebes, pig-tailed, and long-tailed macaques; severe immunodeficiency, anemia, and thrombocytopenia in Japanese macaques; and immunodeficiency of variable severity in rhesus macaques.
New variant of simian T-lymphotropic retrovirus (STLV-1F) among Papio hamadryas of Sukhumi monkey stock.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 86. Unique Identifier : AIDSLINE PRIM11/94191681; Chikobava M; Schatzl H; Rose D; Bush U; Yakovleva L; von der Helm K; Deinhardt F; Lapin B; Institute of Medical Primatology, Russian Academy of Medical; Sciences.; Polymerase chain reaction (PCR) was developed for the detection of simian T-lymphotropic virus type 1 (STLV-1) infection of P.hamadryas and was used for direct sequencing using oligonucleotide primer pairs specific for the tax and env regions of the related human T-lymphotropic virus type 1 (HTLV-1). Perfect specifici
Foamy viruses (spumaretroviruses) from chimpanzees: genetic organization and relationship to other simian foamy viruses (SFVs) and human foamy virus (HFV).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 87. Unique Identifier : AIDSLINE PRIM11/94191682; Herchenroeder O; Renne R; Mergia A; Loncar D; Murthy K; Luciw P; Department of Medical Pathology, University of California, Davis; 95616.; Foamy viruses, members of one of the seven genera of retroviruses, have been recovered from several species of non-human primates, and a foamy virus, designated HFV, has also been isolated from a human. In in vitro tissue culture systems, the SFVs and HFV display a wide cell tropism and cause extensive cytopathology;
Simian foamy virus type 3 (SFV-3) is a spumaretrovirus that exhibits a complex transcription pattern.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 88. Unique Identifier : AIDSLINE PRIM11/94191683; Renne R; Mergia A; Herchenroeder O; Barry PA; Neumann-Haefelin D; Luciw PA; Department of Medical Pathology, University of California, Davis; 95616.; Foamy viruses, also designated spumaviruses and spumaretroviruses, are one of seven genera in the retroviridae family, and unique isolates have been recovered from many mammalian species including cats, hamsters, cows, several non-human primates, and man. The genomes of two simian foamy viruses (i.e., SFV-1 from a rhe
Cis-acting elements required for lentivirus RNA encapsidation.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 89. Unique Identifier : AIDSLINE PRIM11/94191684; McBride MS; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin,; Madison 53706.; Efficient and specific incorporation of viral RNA into the assembling particle is an essential process for all retroviruses. In the case of type-C retroviruses the cis acting signal required for encapsidation is typically located in the 5 untranslated leader region, at a site distal to the primary splice donor site.
Transmission of HIV-1 by the mucosal route in female chimpanzees.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 9. Unique Identifier : AIDSLINE PRIM11/94191685; Girard M; Rimsky L; Mahoney J; Muchmore E; Weinhold K; Fultz P; Institut Pasteur, Paris, France.; Adult female chimpanzees at the pre-ovulatory phase of their cycles were inoculated by the genital route with cryopreserved peripheral blood mononuclear cells (PBMC) from an HIV-1 LAI-infected chimpanzee. The titer of the inoculum, determined by end-point dilution and coculture with human or chimpanzee PBMC, was 30 in
Nucleotide sequence analysis of an HIV-2 isolate (EHO) that establishes persistent and pathogenic infection in pig-tailed macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 90. Unique Identifier : AIDSLINE PRIM11/94191686; Misher L; Grant R; Morton WR; McClure J; Hu SL; Washington Regional Primate Research Center, University of; Washington, Seattle 98195.; We previously reported that HIV-2 EHO infects pig-tailed macaques (M. nemestrina) and causes an AIDS-like disease in about 50% of the infected animals (also see McClure et al., this volume). We have now determined the complete nucleotide sequence of the env-nef-LTR region of this isolate. Comparison of the deduced ami
Correlation of organ pathology and distribution of SIV detected by in-situ hybridization during SIVmac251/32H infection of Macaca mulatta.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 91. Unique Identifier : AIDSLINE PRIM11/94191687; Muller JG; Czub S; Rethwilm A; Muller-Hermelink HK; Institute of Pathology, University of Wurzburg, Germany.; The organ distribution of SIVmac251-32H was investigated by in-situ Hybridization during the time-course of the infection. Paraffin embedded tissues of the thymus, lymph nodes (axillary, mediastinal, mesenterial, inguinal, and other regions), the spleen, lung and other tissues were hybridized with a gag-specific 570 b
Simian AIDS type D serogroup 2 retrovirus: polymerase chain reaction (PCR) detection of proviral DNA from distinct immune cell subpopulations within virus-infected macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 92. Unique Identifier : AIDSLINE PRIM11/94191688; Pilcher KY; Pangares N; Shiigi SM; Malley A; Axthelm MK; Machida CA; Division of Neuroscience, Oregon Regional Primate Research; Center, Beaverton 97006.; Most cases of Simian Acquired Immunodeficiency Syndrome (SAIDS)-associated morbidity and mortality in biomedical research colonies of Asian macaques are caused by Type D simian retrovirus (SRV) infection. Type D serogroup 2 retroviruses have been associated with severe immunodeficiency and retroperitoneal fibromatosis
In vitro and in vivo characteristics of SIVsmmPBj molecular clones.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 93. Unique Identifier : AIDSLINE PRIM11/94191689; Saucier MM; Novembre FJ; Hirsch VM; Goldstein S; Johnson PR; McClure HM; Yerkes Regional Primate Research Center, Emory University,; Atlanta, GA.; The acutely lethal syndrome induced in macaques by SIVsmmPBj (PBj) progresses rapidly with animals succumbing to infection by 14 days after inoculation. Our studies have been focused on identifying pathogenic determinants of PBj through the use of molecular clones and chimeras of PBj. In addition to investigating the
Viral proteins required for specific lentivirus RNA encapsidation.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 94. Unique Identifier : AIDSLINE PRIM11/94191690; Schwartz M; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin,; Madison 53706.; We have taken several approaches to identify and characterize the transacting factors that facilitate lentivirus RNA encapsidation. We constructed lentivirus expression constructs that express subsets of the viral genes, quantified virus particle production, and measured the relative efficiency of RNA packaging. Our a
SIV infection of intestinal lymphoid tissues and clinical malabsorption in rhesus macaques (Macaca mulatta).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 96. Unique Identifier : AIDSLINE PRIM11/94191691; Stone J; Heise C; Miller C; Dandekar S; Department of Internal Medicine, University of California, Davis.; The objectives of this study were to assess prospectively the association between SIV infection, histopathologic changes, jejunal bacterial and protozoal flora, clinical malabsorption and nutritional status. We prospectively studied 12 juvenile rhesus macaques (9 SIV infected and 3 controls). Samples were taken preino
Molecular and biologic analysis of quasispecies during evolution of virulent SIVsmmPBj14.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 97. Unique Identifier : AIDSLINE PRIM11/94191692; Tao B; Fultz PN; Department of Microbiology, University of Alabama at Birmingham; 35294.; SIVsmmPBj14, an acutely lethal virus, evolved during 14 months of infection of pig-tailed macaque PBj with SIVsmm9. In addition to inducing disease and death within 1 week, rather than causing an AIDS-like disease, SIV-PBj14 differs from its parent virus, SIVsmm9, in eight in vitro biologic properties. Furthermore, ex
Development of a T cell lymphoma in Macaca fascicularis acutely infected with SIVmac251/32H.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 98. Unique Identifier : AIDSLINE PRIM11/94191693; Titti F; Maggiorella T; Monardo; Koanga-Mogtomo ML; Sernicola L; Corrias F; Panzini GL; Borsetti A; Baroncelli S; Geraci A; et al; Lab. of Virology, Istituto Superiore Sanita, Rome, Italy.; An apparently healthy five year old male Macaca fascicularis (Mf) was experimentally infected i.v. with 10-20 MID50 of SIVmac251/32H. The monkey died 3 months after infection. SIV genome was detected in PBMC by PCR-DNA and the virus was rescued from PBMC cocultivated with CEMx174 cells. However, no detectable anti-SIV
Sequence analysis of the SIVsmm Nef gene in naturally and experimentally infected sooty mangabey monkeys and macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 99. Unique Identifier : AIDSLINE PRIM11/94191694; Villinger F; Lauro S; Mayne A; Folks TM; Ansari AA; Dept of Pathology, Emory University Sch. of Medicine, Atlanta,; GA.; Our laboratory has analysed a total of 29 SIV Nef genes cloned ex vivo from naturally infected mangabeys and from mangabeys and macaques experimentally infected with SIVsmm. Sequence analysis of 21 Nef clones derived from 7 asymptomatic naturally infected mangabeys revealed the presence of 2 families of SIV Nef. Seque
Does peripheral blood T-lymphocyte population distribution in sarcoidosis provide a prognostic clue?: Sarcoidosis. 1991 Sep;8(2):129-33. Unique Identifier : AIDSLINE MED/94196126; Desrues B; Delaval P; Genetet N; Pencole C; Merdrignac G; Dassonville J; L'Huillier JP; Bourguet P; Kernec J; Service de Pneumologie, Hopital Pontchaillou, Centre Hospitalier; Regional et Universitaire, Rennes, France.; In its pulmonary form, sarcoidosis generally resolves spontaneously, but it may lead to fibrosis of the lung. The clinical, radiological and functional tests, as well as activity markers such as the serum angiotensin converting enzyme, intrathoracic uptake of 67Gallium and the cytological data provided by bronchoalveo
Semiquantitative PCR in the diagnosis of HIV infection: correlation to clinical stage and serological status.: Boll Ist Sieroter Milan. 1991-92;70(1-2):403-7. Unique Identifier : AIDSLINE MED/94206477; De Socio GV; Falcinelli C; Francisci D; Pauluzzi S; Cosmi EV; Anceschi MM; II Institute of Obstetrics and Gynecology, University La; Sapienza, Rome, Italy.; Authors utilized the polymerase chain reaction (PCR) technique to detect the presence of HIV DNA in 31 subjects (12 seropositive patients, 4 seronegative, at risk persons and 15 seronegative, not at risk controls). PCR was highly sensitive (enabling the detection of as few as 10 proviral genomes) and specific. By comp
[Chemotaxis deficiency in patients with HIV infection]: Boll Ist Sieroter Milan. 1991-92;70(1-2):433-7. Unique Identifier : AIDSLINE MED/94206479; Ciaffoni S; Roata C; Turrini A; Gandini A; Crocco I; Mazzi R; Malena M; Luzzati R; Aprili G; Istituto di Malattie Infettive, Verona.; Increased susceptibility to bacterial recurrent infection is characteristically associated with impaired B cells function but also with a defective PMN function. We studied PMN CT in 15 HIV positive drug addicts patients with persistent generalized lymphoadenopathy (PGL), in 15 symptom free HIV negative drug addicts (
Association of non-Hodgkin's lymphoma and Kaposi's sarcoma in a patient with HIV infection: case report.: Boll Ist Sieroter Milan. 1991-92;70(1-2):453-5. Unique Identifier : AIDSLINE MED/94206483; Verani DA; Sezione Malattie Infettive, Ospedale degli Infermi, Biella.; We describe a case of an HIV-antibody positive male intravenous drug abuser who suffered from a low grade NHL associated with Kaposi s sarcoma. Both the grade of the NHL and the Kaposi s sarcoma are relatively rare in a patient like ours as the former are usually high grade NHLs and the latter is more common in homose
[Determination of HIV-RNA using in situ hybridization on myocardial tissue. Role of HIV in cardiomyopathy in AIDS]: Boll Ist Sieroter Milan. 1991-92;70(1-2):457-65. Unique Identifier : AIDSLINE MED/94206484; Mencarini P; Tamburrini E; Antinori A; Zannoni G; De Luca A; Capelli A; Ortona L; Istituto di Clinica delle Malattie Infettive, Universita; Cattolica S. Cuore, Roma.; Aim of this study was to evaluate the presence of HIV-1 and CMV genomic sequences in myocardial tissue from autopsy of AIDS patients by in situ hybridization technique and to make a correlation with clinical and/or pathological signs of myocarditis. Seven patien
[Respiratory complications in 44 patients with acquired immunodeficiency syndrome]: Boll Ist Sieroter Milan. 1991-92;70(1-2):487-93. Unique Identifier : AIDSLINE MED/94206489; Negri C; Saracco A; Tambussi G; Ruggieri A; Lazzarin A; Clinica delle Malattie Infettive, Ospedale L. Sacco, Universita; di Milano.; Observation was carried out of 44 patients affected with pulmonary pathology during the course of AIDS, each of whom presented a severe respiratory insufficiency, admitted to the Clinic of Infectious Diseases between May 1987 and March 1989. In the patients suffering from their first respiratory infection, a lower mor
HTLV-I and HIV-I antibody frequency in thalassemics and drug addicts in southeast Sicily.: Boll Ist Sieroter Milan. 1991-92;70(1-2):531-4. Unique Identifier : AIDSLINE MED/94206495; Gulisano G; Ciccia M; Ienna M; Cipolla A; Mauro L; Cattedra di Clinica delle Malattie Tropicale e Sub-Tropicali,; Universita degli Studi di Catania.; HTLV-I (Human T-Lymphotropic Virus Type 1) and HIV-1 (Human Immunodeficiency Virus Type 1) antibodies have been investigated in 702 sera samples from: 259 drug addicts nerve screened for HIV-1 (Group I), 43 drug addicts already identified as HIV-1 seropositive (Group II), 222 thalassemics (Group III) and 178 occasiona
[Levels of interleukin-4 (IL-4) in lymphocyte cultures of subjects with HIV-1 infection]: Boll Ist Sieroter Milan. 1991-92;70(1-2):471-4. Unique Identifier : AIDSLINE MED/94206486; Perrella O; Liguori G; Precchia E; Soscia E; Guarnaccia D; Caruso I; Marinelli P; Finelli L; Tartaglia G; 3rd Dpt. (Sez. 1/2), Hospital D. Cotugno, Naples.; The authors report IL-4 levels in peripheral blood mononuclear cells (PBMC), stimulated with MoAb anti-CD3, in subjects with HIV-1 infection, classified according to the criteria of Centers for Disease Control (CDC) in various stages. The results in vitro have indicate that PBMC IL-4 levels were in normal range also i
AIDS and infection control: experiences, attitudes, knowledge and perception of occupational hazards among Nigerian dentists.: Afr Dent J. 1992;6:1-7. Unique Identifier : AIDSLINE MED/94197883; Sote EO; Department of Child Dental Health, College of Medicine,; University of Lagos, Nigeria.; A questionnaire survey of 79 Nigerian dentists aged 21-60 years was carried out to evaluate their experiences, attitudes, knowledge, and infection control practices in relation to HIV infection. Their perceptions of various occupational hazards were also probed. 84.4% of them held the view that HIV-infected/AIDS patie
The role and responsibilities of oral health personnel in the control and prevention of HIV infection/AIDS in Africa [editorial]: Afr Dent J. 1992;6:1p.. Unique Identifier : AIDSLINE MED/94197884; Okoisor FE
[AIDS and lymphoma of the ear]: Rev Laryngol Otol Rhinol (Bord). 1992;113(3):201-4. Unique Identifier : AIDSLINE MED/94204413; Ouchchane M; Portmann D; Doutre MS; Brottier-Mancini E; C.H.U. Pellegrin Tripode, Clinique ORL, Bordeaux, France.; The authors describe the circumstances for detection of an AIDS lymphomatous complication revealed by an otological picture in one patient. The lymphomatous pathology not related to HIV is reviewed. The particularity of these lymphomas, when they are related to HIV, is their frequent initial extra-ganglionic location,
[Hearing aids and AIDS: apropos of a case]: Rev Laryngol Otol Rhinol (Bord). 1992;113(4):375-6. Unique Identifier : AIDSLINE MED/94204435; Sanguy C; Aids carriers must be fitted with hearing aids early due to their life expectancy. Hearing aids of which the electro-acoustic specificities make it possible to lessen the successive aggravations must be foreseen.
The retroviruses: classification and molecular biology.: Baillieres Clin Neurol. 1992 Apr;1(1):1-21. Unique Identifier : AIDSLINE MED/94207474; Shaunak S; Weber JN; Department of Medicine, Royal Postgraduate Medical School,; Hammersmith Hospital, London, UK.
Central nervous system opportunistic infections in HIV disease: clinical aspects.: Baillieres Clin Neurol. 1992 Apr;1(1):103-54. Unique Identifier : AIDSLINE MED/94207475; Guiloff RJ; Tan SV; Westminster Hospital, London, UK.; Nervous system opportunistic infections are seen in about one fifth of AIDS cases and account for over 40% of the patients with neurological manifestations. Serious infections are seen in severely immunosuppressed patients, usually with CD4 counts of 200 ml-1 or less. The commonest is
Cognitive impairment and dementia in HIV-1 infection.: Baillieres Clin Neurol. 1992 Apr;1(1):155-74. Unique Identifier : AIDSLINE MED/94207476; Burgess A; Riccio M; Charing Cross and Westminster Medical School, Westminster; Hospital, London, UK.
Other neurological diseases in HIV-1 infection: clinical aspects.: Baillieres Clin Neurol. 1992 Apr;1(1):175-209. Unique Identifier : AIDSLINE MED/94207477; Guiloff RJ; Fuller GN; Westminster Hospital, London, UK.; HIV-1-related neurological diseases, excluding opportunistic infections and HIV encephalitis, are considered here. Most occur in severely immunosuppressed patients, with CD4 counts of under 200 x 10(6) l-1. Primary brain lymphoma and metastases from systemic non-Hodgkin s lymphoma ,
Neuropathology of HIV-1 and HTLV-1 infection.: Baillieres Clin Neurol. 1992 Apr;1(1):211-38. Unique Identifier : AIDSLINE MED/94207478; Scaravilli F; Department of Neuropathology, National Hospital for Neurology and; Neurosurgery, London, UK.
The immunology of retrovirus disease.: Baillieres Clin Neurol. 1992 Apr;1(1):23-40. Unique Identifier : AIDSLINE MED/94207479; Dalgleish AG; St George's Hospital, London, UK.
Therapeutic aspects of retroviral disease.: Baillieres Clin Neurol. 1992 Apr;1(1):239-57. Unique Identifier : AIDSLINE MED/94207480; Peto T; John Radcliffe Hospital, Headington, Oxford, UK.; Retroviruses of the nervous system cause HTLV-1-associated myelopathy and HIV-associated diseases. The treatment of HTLV-1 disease is essentially conservative; there is no effective drug treatment and therefore patients should be simply supported and reassured. If appropriate, other members of the family should be tes
Neurological aspects of lentiviral infections in animals.: Baillieres Clin Neurol. 1992 Apr;1(1):41-59. Unique Identifier : AIDSLINE MED/94207481; Kennedy PG; Department of Neurology, University of Glasgow, UK.
HTLV-1 and neurological disease.: Baillieres Clin Neurol. 1992 Apr;1(1):61-81. Unique Identifier : AIDSLINE MED/94207482; Cruickshank JK; Corbin DO; Bucher B; Vernant JC; Centre for Clinical Epidemiology, University of Manchester; Medical School, UK.
HIV-1 and HIV-2: overview of disease spectrum.: Baillieres Clin Neurol. 1992 Apr;1(1):83-101. Unique Identifier : AIDSLINE MED/94207483; Lever AM; Dept of Medicine, University of Cambridge, Eddenbrookes Hospital,; UK.; This overview has attempted to cover the more common aspects of the clinical presentations of HIV infection and the differential diagnoses. These can only be generalizations as presentations differ dramatically from patient to patient. It is also important to be aware that in an individual the disease is continually e
Studies to define viral cofactors for human immunodeficiency virus.: Infect Agents Dis. 1992 Oct;1(5):237-44. Unique Identifier : AIDSLINE MED/94207551; Griffiths PD; Division of Communicable Diseases, Royal Free Hospital School of; Medicine, London, United Kingdom.; Results from molecular biologic, cell biologic and animal experiments show that HIV replication can be driven by a variety of other viruses. If such interactions took place in vivo, then they could help to explain some of the complex pathogenesis of AIDS. The problems incurred in attempting to address this question in
Risk of hepatitis B and human immunodeficiency virus transmission to a patient from an infected surgeon due to percutaneous injury during an invasive procedure: estimates based on a model.: Infect Agents Dis. 1992 Oct;1(5):263-9. Unique Identifier : AIDSLINE MED/94207554; Bell DM; Shapiro CN; Culver DH; Martone WJ; Curran JW; Hughes JM; Hospital Infections Program, National Center for Infectious; Diseases, Centers for Disease Control, Atlanta, Georgia 30333.; The objective was to estimate the probability of sporadic hepatitis B virus (HBV) and human immunodeficiency virus (HIV) transmission to a patient from an infected surgeon due to percutaneous injury during an invasive procedure. Risk was estimated based on a model involving three probabilities: A, the probability that
Prophylaxis and therapy for Pneumocystis pneumonia--where are we?: Infect Agents Dis. 1992 Oct;1(5):270-8. Unique Identifier : AIDSLINE MED/94207555; Masur H; Critical Care Medicine Department, National Institutes of Health,; Bethesda, Maryland 20892.; The armamentarium of drugs to treat and to prevent Pneumocystis pneumonia has expanded substantially over the past decade. In all patient populations trimethoprim-sulfamethoxazole is the preferred regimen for both acute treatment and prophylaxis. Clindamycin-primaquine and atovaquone are both effective agents for acut
Human papillomavirus, human immunodeficiency virus, and cervical cancer: newly recognized associations?: Infect Agents Dis. 1992 Dec;1(6):319-24. Unique Identifier : AIDSLINE MED/94207559; Vernon SD; Icenogle JP; Johnson PR; Reeves WC; Viral Exanthems and Herpesvirus Branch, Centers for Disease; Control, Atlanta, Georgia 30333.; There are now sufficient data to conclude that women infected with human immunodeficiency virus (HIV) have an increased risk of human papillomavirus (HPV) infection and preinvasive stages of cervical cancer. This association is not completely due to immunosuppression. It is likely that HPV pathogenesis is altered in H
Intellectual property issues in a clinical trial: a corporate perspective.: Qual Assur. 1992 Jun;1(3):237-48. Unique Identifier : AIDSLINE MED/94207568; Fersko RS; Connolly MJ; Tanner Propp & Fersko, New York, New York 10016.
[Pediatric AIDS: a report of the first fatal Cuban pediatric case]: Rev Cubana Med Trop. 1992;44(1):44-6. Unique Identifier : AIDSLINE MED/94211981; Gonzalez Nunez I; Capo de Paz V; Rodriguez Barreras ME; Diaz Jidy M; Fraga Castro M; Instituto de Medicina Tropical Pedro Kouri.; The case of a Cuban child with AIDS acquired by perinatal transmission is reported. Thirteen days after birth, the child had chronic diarrhoeas affecting its pondostatural development. It was hospitalized many times due to recurrent respiratory processes, in one of which Pneumocystis carinii was detected. Oral candidi
[Infections and other opportunistic processes in a group of Cuban stage-IV HIV patients]: Rev Cubana Med Trop. 1992;44(1):47-9. Unique Identifier : AIDSLINE MED/94211982; Menendez Capote R; Millan Marcelo JC; Instituto de Medicina Tropical Pedro Kouri.; Forty Cuban patients affected by the human immunodeficiency virus (HIV), belonging to Group IV, assisted during a year at the Pedro Kouri Tropical Medicine Institute, are reported. Pneumocystis carinii, cryptosporidiosis, mucocutaneous herpes simplex, oral candidiasis and multidermatoma herpes zoster were the most com
Lymphoid interstitial pneumonia not associated with HIV infection: role of Epstein-Barr virus.: Mod Pathol. 1992 Sep;5(5):487-91. Unique Identifier : AIDSLINE MED/94218349; Malamou-Mitsi V; Tsai MM; Gal AA; Koss MN; O'Leary TJ; Department of Cellular Pathology, Armed Forces Institute of; Pathology, Washington, DC.; The polymerase chain reaction (PCR) method was used to determine the presence of Epstein-Barr virus sequences in seven cases of pulmonary lymphoid interstitial pneumonia not associated with HIV infection. Evidence of Epstein-Barr virus genome was found in three of six cases in which beta-globin gene, used as an intern
Characterization of the topography of Epstein-Barr virus infection in human immunodeficiency virus-associated lymphoid tissues.: Mod Pathol. 1992 Sep;5(5):559-66. Unique Identifier : AIDSLINE MED/94218363; Arber DA; Shibata D; Chen YY; Weiss LM; Department of Pathology, City of Hope National Medical Center,; Duarte, California.; A highly sensitive in situ hybridization methodology for Epstein-Barr virus (EBV) RNA was used to determine the topography of EBV infection in 16 cases of human immunodeficiency virus-associated lymphoid tissues. Four lymphomas, 11 persistent generalized lymphadenopathy (PGL) lymph nodes, and one lymphoepithelial cyst
[AIDS. Professional risk in dental practice?]: Rev Med Chir Soc Med Nat Iasi. 1992 Jul-Dec;96(3-4):315-8. Unique Identifier : AIDSLINE MED/94218611; Barlean L; Disciplina policlinica stomatologica, Universitatea de; Medicina si Farmacie Iasi.
[Peripheral facial paralysis and HIV infection. 2 case reports]: Rev Med Interne. 1992 Sep-Oct;13(5):354-8. Unique Identifier : AIDSLINE MED/94218551; Doutre MS; Beylot C; Beylot J; Long P; Royer P; Lacoste D; Service de Dermatologie, Hopital Haut-Leveque, Pessac.; Two cases of peripheral facial paralysis in subjects with HIV infection are reported. On the basis of these two cases and data from the literature, the clinical and paraclinical features of this facial nerve lesion are described. The various aetiological hypotheses put forward are discussed, but it is probable that th
Health promotion for Aboriginal communities.: World Health Forum. 1994;15(1):25-8. Unique Identifier : AIDSLINE MED/94190423; Freeman P; University of Papua New Guinea, Boroko.
Community responses to AIDS.: World Health Forum. 1994;15(1):35-8. Unique Identifier : AIDSLINE MED/94190425; Anderson S; Health Care Support Unit, Office of Intervention Development and; Support, Global Programme on AIDS, World Health Organization,; Geneva, Switzerland.; Some examples of care in the community for people with HIV/AIDS are reported from Africa. Members of communities committed to fighting the AIDS epidemic cannot do so alone and should be given every possible help. Inadequate care favours the spread of HIV, as does the stigmatization of people with HIV infection and the
Role of HIV infection in the hematologic manifestations of HIV seropositive subjects.: Crit Rev Oncol Hematol. 1993 Dec;15(3):271-83. Unique Identifier : AIDSLINE MED/94190521; Zauli G; Davis BR; Institute of Human Anatomy, University of Ferrara, Italy.
Antigen detection in neutralization assays: high levels of interfering anti-p24 antibodies in some plasma [letter]: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1173-4. Unique Identifier : AIDSLINE MED/94190621; Mascole JR; Burke DS
Improbability of harmful autoimmune responses resulting from immunization with HIV-1 envelope glycoproteins.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1195-208. Unique Identifier : AIDSLINE MED/94190624; Neurath AR; Strick N; Li YY; Jiang S; Lindsley F. Kimball Research Institute, New York Blood Center,; New York 10021.; Autoimmunity mediated by cross-reactive antibodies, elicited by HIV-1 envelope glycoproteins gp120/gp160, has been postulated to contribute to the pathogenesis of AIDS. Partial amino acid sequence homology between gp120/gp160 and several human host proteins, including MHC antigens and immunoglobulins, has been perceiv
Purification of an Escherichia coli-expressed Nef protein from the human immunodeficiency virus-type 2.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1225-31. Unique Identifier : AIDSLINE MED/94190627; Du Bois GC; Hodge DR; Hanson CA; Samuel KP; Zweig M; Showalter SD; Papas TS; Nucleic Acid and Protein Synthesis Laboratory, Program Resources,; Inc., National Cancer Institute, Frederick Cancer Research and; Development Center, Maryland 21701.; The entire nef gene sequence of HIV-2, NIH-Z strain, has been cloned into the pJL6 expression vector and used for the synthesis of a 23-kDa protein in E. coli. The expressed protein is a fusion between the N-terminal 13 amino acids of the cII gene, 8 amino acids resulting from the ligation procedure, and the 180 amino
Nonaffinity purification of recombinant gp120 for use in AIDS vaccine development.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1233-44. Unique Identifier : AIDSLINE MED/94190628; Scandella CJ; Kilpatrick J; Lidster W; Parker C; Moore JP; Moore GK; Mann KA; Brown P; Coates S; Chapman B; et al; Department of Process Development, Chiron Corporation,; Emeryville, California 94608.; The gene encoding the major envelope glycoprotein of the HIV-SF2 isolate was engineered for the secretion of recombinant gp120 (rgp120SF2) from permanent Chinese hamster ovary (CHO) cell lines. Cellular production methods were scaled up and a method for purification of the secreted glycoprotein was devised. Mild purif
Cellular topoisomerase I activity associated with HIV-1.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1245-50. Unique Identifier : AIDSLINE MED/94190629; Jardine D; Tachedjian G; Locarnini S; Birch C; Virology Department, Fairfield Hospital, Victoria, Australia.; Topoisomerase I activity was detected in detergent-disrupted human immunodeficiency virus type 1 (HIV-1) particles. The enzyme did not require ATP for its conversion of SC DNA to an RC form, had divalent cation requirements similar to those of eukaryotic topoisomerase I, and was significantly inhibited by the specific
Relationship between anti-p24 antibody levels and p24 antigenemia in HIV-infected patients [published erratum appears in AIDS Res Hum Retroviruses 1994 Apr;10(4):431]: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1251-5. Unique Identifier : AIDSLINE MED/94190630; Fenouillet E; Blanes N; Coutellier A; Gluckman JC; CNRS URA 1463, Paris, France.; We studied the influence of HIV p24 antigen immune complexing with anti-p24 antibodies on the assessment of their respective levels in HIV-positive sera. ELISAs were used to evaluate anti-p24 antibody levels and p24 antigenemia, with or without acid dissociation. Observations include the following: (1) p24 antigenemia
An individual with a high prevalence of a tat-defective provirus in peripheral blood.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1265-8. Unique Identifier : AIDSLINE GENBANK/L20412; Sabino E; Cheng-Mayer C; Mayer A; Irwin Memorial Blood Centers, San Francisco, California 94118.; The first exon of tat was sequenced from 23 provirus genomes randomly amplified directly from an HIV-1-infected individual s peripheral blood. Twelve of the 23 sequences constituted a distinct subset of the quasi-species detected. This subset had in common two inactivating mutations in the tat gene. In addition, two o
Susceptibility of human-mouse T cell hybrids to HIV-productive infection.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1269-75. Unique Identifier : AIDSLINE MED/94190633; Ramarli D; Cambiaggi C; De Giuli Morghen C; Tripputi P; Ortolani R; Bolzanelli M; Tridente G; Accolla RS; Istituto di Immunologia e Malattie Infettive, Universita di; Verona, Italy.; Interspecies human x mouse cell hybrids were used to investigate the genetic basis of human permissivity to HTLV-IIIB infection. T cell hybrids between the mouse BW 51.47 T lymphoma line and normal, PHA- IL-2 activated, human peripheral mononuclear cells (PBMCs) were ge
Increased susceptibility of neonatal monocyte/macrophages to HIV-1 infection.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1277-85. Unique Identifier : AIDSLINE MED/94190634; Sperduto AR; Bryson YJ; Chen IS; Department of Pediatrics, UCLA School of Medicine 90024.; The relative susceptibility of neonatal/cord blood monocyte/macrophages to productive infection with human immunodeficiency virus type 1 (HIV-1) was investigated. In addition, the effect of HIV-1 infection of cord blood monocyte/macrophages in various stages of maturation/differentiation as represented by differing ag
Reverse transcription takes place within extracellular HIV-1 virions: potential biological significance.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1287-96. Unique Identifier : AIDSLINE MED/94190635; Zhang H; Zhang Y; Spicer TP; Abbott LZ; Abbott M; Poiesz BJ; Department of Microbiology/Immunology, SUNY Health Science Center; at Syracuse, New York 13210.; Extracellular HIV-1 virions purified from cell culture supernatants have been found to contain viral DNA that is the result of partial reverse transcription within the virus particles. Our data supported these observations and further indicated that the ratio of genomic RNA to viral DNA was approximately 10(3):1 for t
Detecting SIV gp120 and its interaction with soluble CD4 by ELISA.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1297-9. Unique Identifier : AIDSLINE MED/94190636; Moore JP; Sattentau QJ; Aaron Diamond AIDS Research Center, New York, New York 10018.
Acquired immunodeficiency syndrome (AIDS)--data as at 31 December 1993.: Wkly Epidemiol Rec. 1994 Jan 14;69(2):5-6. Unique Identifier : AIDSLINE MED/94190748
The current global situation of the HIV/AIDS pandemic.: Wkly Epidemiol Rec. 1994 Jan 14;69(2):7-8. Unique Identifier : AIDSLINE MED/94190749
[Indolent cutaneous ulcer in a patient with HIV infection]: Enferm Infecc Microbiol Clin. 1993 Dec;11(10):565-6. Unique Identifier : AIDSLINE MED/94191052; Santos J; Marquez M; Rivero A; Unidad de Infecciosos, Hospital Virgen de la Victoria, Malaga.
[Pyogenic liver abscess and HIV (letter)]: Enferm Infecc Microbiol Clin. 1993 Dec;11(10):576-7. Unique Identifier : AIDSLINE MED/94191061; de Otero J; Balcells E; Calvo F; Ribera E; Vicens JC; Martinez Vazquez JM
Efficient diagnosis of Pneumocystis carinii pneumonia [editorial]: Int J STD AIDS. 1994 Jan-Feb;5(1):1-7. Unique Identifier : AIDSLINE MED/94191062; Smith DE; In patients with HIV infection the diagnosis of PCP is relatively simple when patients present late, with advanced pneumonia. The diagnosis becomes more difficult when patients present with minimal symptoms, are receiving specific prophylactic therapy or have had previous AIDS-related pulmonary diseases. A number of n
A brighter image for genitourinary medicine clinics.: Int J STD AIDS. 1994 Jan-Feb;5(1):11-2. Unique Identifier : AIDSLINE MED/94191063; FitzGerald M; Goldsmith M; Belfield T; Hayton P; Musgrove Park Hospital, Taunton, Somerset, UK.
HIV/AIDS, advocacy and anti-discrimination legislation--the Australian response.: Int J STD AIDS. 1994 Jan-Feb;5(1):13-7. Unique Identifier : AIDSLINE MED/94191064; Neilsen GA; Young FJ; Sydney Sexual Health Centre, Sydney Hospital, NSW, Australia.; This paper will address the role of mass communication strategies in the reduction of HIV/AIDS discrimination in Australia . It will focus on the interdependence of mass communication and legislation in health promotion campaigns with particular reference to the Disability Discri
Meatoscopy: an important technique for assessing meatal warts in men.: Int J STD AIDS. 1994 Jan-Feb;5(1):18-20. Unique Identifier : AIDSLINE MED/94191065; Thin RN; St Peter's Hospital, London, UK.; A total of 506 meatoscopic examinations showed this is a simple, safe, rapid, well-tolerated, useful procedure to assess the extent of warts at the meatus and in the distal urethra of men. The procedure was performed in 307 patients. Sixty-five (52.5%) of 124 men with meatal warts had additional urethral lesions not r
How should an AIDS diagnosis be given? The views of patients.: Int J STD AIDS. 1994 Jan-Feb;5(1):21-4. Unique Identifier : AIDSLINE MED/94191066; Pergami A; Catalan J; Hulme N; Burgess A; Gazzard B; Department of Psychiatry, Charing Cross and Westminster Medical; School, London, UK.; The report aimed at obtaining information about patients experience of how the diagnosis of AIDS was given to them by their doctors, and about patients satisfaction with the consultation. Thirty people with AIDS completed a self-report questionnaire enquiring about their views and satisfaction with the process of co
Demonstration of Epstein-Barr virus DNA in acetowhite lesions of the vulva.: Int J STD AIDS. 1994 Jan-Feb;5(1):25-8. Unique Identifier : AIDSLINE MED/94191067; Voog E; Ricksten A; Lowhagen GB; Ternesten A; Department of Dermatovenereology, Sahlgrenska Hospital,; Gothenburg, Sweden.; Acetowhite lesions in the vulva disclosing koilocytosis have been related to infection by human papilloma virus (HPV). Because of the clinical resemblance of these lesions to oral hairy leukoplakia (OHL), and EBV-manifestation, 23 women with acetowhite koilocytotic lesions in the vulva were examined. The PCR-technique
The impact of lubricants on latex condoms during vaginal intercourse.: Int J STD AIDS. 1994 Jan-Feb;5(1):29-36. Unique Identifier : AIDSLINE MED/94191068; Steiner M; Piedrahita C; Glover L; Joanis C; Spruyt A; Foldesy R; Contraceptive Use and Epidemiology Division, Family Health; International, Research Triangle Park, NC 27709.; The objective was to evaluate the impact of additional lubricant on condom breakage and slippage. Two hundred and sixty-eight couples used 6 new and 6 aged condoms during vaginal intercourse and were instructed to use 2 of each type with either water-based lubricant, oil-based lubricant or no additional lubricant. The
Heterosexual partnership characteristics of university women.: Int J STD AIDS. 1994 Jan-Feb;5(1):37-40. Unique Identifier : AIDSLINE MED/94191069; Lindblade K; Foxman B; Koopman JS; Department of Epidemiology, University of Michigan School of; Public Health, Ann Arbor 48109-2029.; In order to assess the individual risk of acquiring sexually transmitted diseases (STDs), both characteristics of the partnership and the individual should be considered. Partnership characteristics have been used as risk markers for STD transmission but their distribution has not been well described. Using a self-adm
Age-related increase in sexual behaviours and decrease in regular condom use among adolescents in Australia.: Int J STD AIDS. 1994 Jan-Feb;5(1):41-7. Unique Identifier : AIDSLINE MED/94191070; Dunne MP; Donald M; Lucke J; Nilsson R; Ballard R; Raphael B; National Centre for HIV Social Research, University of; Queensland, Royal Brisbane Hospital, Herston, Australia.; The prevalence of sexual behaviours was estimated from a survey of 3854 Australian secondary school students. Self-reported prevalence of intercourse increased from 9.9% (age 13 years or less) to 23.9% (age 15) and 51.2% at age 17 and over. Among 932 sexually experienced youth in the final 3 years of secondary school,
Human immunodeficiency virus and Treponema pallidum infections in Nigerian patients with leprosy.: Int J STD AIDS. 1994 Jan-Feb;5(1):48-51. Unique Identifier : AIDSLINE MED/94191071; Nwosu CM; Nwosu SN; Okoye KC; Department of Medicine, College of Health Sciences, Nnamdi; Azikiwe University, Nnewi-Nigeria.; Fifty-one patients were selected from 4 leprosaria in eastern Nigeria and were examined for evidence of syphilis. They were screened serologically for treponemal and human immunodeficiency virus (HIV) infections. Information about their sexual behaviour and demographic data were o
The determination of amines in the vaginal secretions of women in health and disease.: Int J STD AIDS. 1994 Jan-Feb;5(1):52-5. Unique Identifier : AIDSLINE MED/94191072; Jones BM; al-Fattani M; Gooch H; Department of Experimental and Clinical Microbiology, University; of Sheffield Medical School, UK.; The presence of amines in vaginal fluid is thought to be an important contributory factor in the pathogenesis of bacterial vaginosis (BV). As part of on-going work investigating the aetiology of this infection, two separate studies were performed in which gas chromatography was used to measure and compare the amines p
Experience of HIV prevention interventions among female sex workers in Delhi, India.: Int J STD AIDS. 1994 Jan-Feb;5(1):56-7. Unique Identifier : AIDSLINE MED/94191073; Singh YN; Malaviya AN; Department of Medicine, All India Institute of Medical Sciences,; New Delhi.; This paper describes the effect of HIV prevention intervention among female sex workers in Delhi. Over a 2-year period we found a marked increase in condom use with little increase in HIV seroprevalence. The prevalence of HIV infection did not increase during the study period (1 positive among 701 in 1988 vs 1 positiv
Recurrent bullous balanitis: an unusual presentation of balanitis xerotica obliterans.: Int J STD AIDS. 1994 Jan-Feb;5(1):58-9. Unique Identifier : AIDSLINE MED/94191074; Estcourt CS; Higgins SP; Goorney BP; Department of Genitourinary Medicine, Manchester Royal Infirmary,; UK.
Treatment of AIDS-associated oral hairy leukoplakia with cryotherapy.: Int J STD AIDS. 1994 Jan-Feb;5(1):60-2. Unique Identifier : AIDSLINE MED/94191075; Goh BT; Lau RK; Ambrose King Centre, Royal London Hospital, Whitechapel, UK.
Disseminated aspergillosis in the acquired immunodeficiency syndrome.: Int J STD AIDS. 1994 Jan-Feb;5(1):63-6. Unique Identifier : AIDSLINE MED/94191076; Singh G; Wijesurendra CS; Green JT; Department of Genitourinary Medicine, Cardiff Royal Infirmary,; UK.; The relationship of disseminated aspergillosis with human immunodeficiency virus (HIV) infection is unclear. In the initial case definition of acquired immunodeficiency syndrome (AIDS) developed by the Centres for Disease Control (CDC), Atlanta, aspergillosis was included as an AIDS-defining opportunistic infection. I
Rupial syphilides in a single male.: Int J STD AIDS. 1994 Jan-Feb;5(1):67-8. Unique Identifier : AIDSLINE MED/94191077; Williams J; Veluchamy V; Sundararaj AS; Government Rajaji Hospital, Madurai, India.
An audit of the value of microscopy of gram-stained and wet film preparations for the diagnosis of bacterial vaginosis in a department of genitourinary medicine.: Int J STD AIDS. 1994 Jan-Feb;5(1):69-70. Unique Identifier : AIDSLINE MED/94191078; Thompson C; McCabe K; Department of Genitourinary Medicine, Victoria Hospital,; Kirkcaldy, Scotland.
Ulcerative colitis and balanoposthitis [letter]: Int J STD AIDS. 1994 Jan-Feb;5(1):72-3. Unique Identifier : AIDSLINE MED/94191080; Lyttle PH
The role of aerosol pentamidine prophylaxis [letter; comment]: Int J STD AIDS. 1994 Jan-Feb;5(1):73. Unique Identifier : AIDSLINE MED/94191081; Reynolds MT; Monteiro E; Waugh MA
Contact tracing of patients with pelvic inflammatory disease [letter]: Int J STD AIDS. 1994 Jan-Feb;5(1):73-4. Unique Identifier : AIDSLINE MED/94191082; Markos AR
Treatment of anorectal manifestations of AIDS: past and present [editorial]: Int J STD AIDS. 1994 Jan-Feb;5(1):8-10. Unique Identifier : AIDSLINE MED/94191083; Schmitt SL; Wexner SD
Qualitative and quantitative studies of cytokines synthesized and secreted by non-human primate peripheral blood mononuclear cells.: Cytokine. 1993 Sep;5(5):469-79. Unique Identifier : AIDSLINE MED/94191164; Villinger F; Hunt D; Mayne A; Vuchetich M; Findley H; Ansari AA; Department of Pathology, Emory University School of Medicine,; Atlanta, GA 30322.; Non-human primates are being utilized in a variety of pre-clinical studies, including those involved with mechanisms of organ transplant rejection and those being used as models to test the efficacy of vaccines against a variety of infectious diseases, most notably AIDS. These studies clearly involve immunological eff
Chromosomal translocations in leukaemia.: Semin Cancer Biol. 1993 Dec;4(6):333-40. Unique Identifier : AIDSLINE MED/94191180; Gauwerky CE; Croce CM; Jefferson Cancer Institute, Thomas Jefferson University,; Philadelphia, PA 19107.; Many haematologic malignancies carry characteristic chromosomal translocations, which are thought to play an important role in the pathogenesis of these tumours. The t(8; 14) translocation in Burkitt s lymphoma was one of the first characterized at the molecular level. In this translocation the c-myc oncogene at chrom
Multiple cis-acting elements in the human immunodeficiency virus type 2 enhancer mediate the response to T-cell receptor stimulation by antigen in a T-cell hybridoma line.: Blood. 1994 Apr 1;83(7):1839-46. Unique Identifier : AIDSLINE MED/94191249; Hannibal MC; Markovitz DM; Nabel GJ; Howard Hughes Medical Institute, Department of Internal Medicine,; University of Michigan Medical Center, Ann Arbor 48109-0650.; Transcription directed by the human immunodeficiency virus type 2 long terminal repeat (HIV-2 LTR) responds to T-cell antigen receptor signaling. Agents that stimulate T-cell signaling pathways activated by the antigen receptor, such as phorbol ester, plant lectin, or anti-CD3 antibody treatment, have been shown to in
Pneumonia and pneumococcal immunization in human immunodeficiency virus-seropositive hemophiliacs [letter]: Blood. 1994 Apr 1;83(7):2005. Unique Identifier : AIDSLINE MED/94191270; Lederman MM; Kroner B; Kiger K; Goedert JJ
A transmission model for HIV with application to the Australian epidemic.: Math Biosci. 1994 Feb;119(2):205-24. Unique Identifier : AIDSLINE MED/94191306; Becker NG; Egerton LR; Department of Statistics, La Trobe University, Bundoora VIC,; Australia.; An age-specific transmission model is proposed to describe the spread of HIV in a homosexual population. The model incorporates developments in the treatment of patients and the change in the surveillance definition of AIDS. The model is applied to the Australian epidemic with the aim of determining the extent of beha
[Risks of infection caused by blood and blood products with reference to the so-called AIDS scandal (editorial)]: Infusionsther Transfusionsmed. 1993 Dec;20(6):286-90. Unique Identifier : AIDSLINE MED/94191347; Kretschmer V
[Biotest position on HIV-1 seroconversions in 1990 in 11 patients, treated with beta-propiolactone/uv virus inactivated PPSB (letter)]: Infusionsther Transfusionsmed. 1993 Dec;20(6):344-6. Unique Identifier : AIDSLINE MED/94191354; Pustoslemsek P; Kloft M; Kotitschke R
[AIDS and tuberculosis. Epidemiologic aspects. Etiopathogenic correlations]: Pneumoftiziologia. 1993 Jan-Jun;42(1-2):29-35. Unique Identifier : AIDSLINE MED/94191371; Marta D; Institutul de Pneumoftiziologie, Marius Nasta, Bucuresti.
HIV infection in Uganda [letter; comment]: BMJ. 1994 Mar 19;308(6931):789. Unique Identifier : AIDSLINE MED/94191470; Bantebya G; Konings E
Women's reproductive health. Women left destitute by AIDS [letter; comment]: BMJ. 1994 Mar 19;308(6931):789-90. Unique Identifier : AIDSLINE MED/94191472; Berger A
Study of the retinal fiber layer in patients with acquired immunodeficiency syndrome [see comments]: Ger J Ophthalmol. 1994 Jan;3(1):1-4. Unique Identifier : AIDSLINE MED/94191505; Honrubia FM; Ferrer E; Torron C; Gonzalez I; Ophthalmology Service, Miguel Servet Hospital, Zaragoza, Spain.; A study using the monochromatic photography technique to examine the retina of a group of patients with human immunodeficiency virus (HIV) infections in different degrees of evolution and with no history of opportunistic retinal infection revealed the existence of lesions on the level of the retinal nerve fiber layer.
Retinal detachment in patients with acquired immunodeficiency syndrome.: Ger J Ophthalmol. 1994 Jan;3(1):9-14. Unique Identifier : AIDSLINE MED/94191517; Geier SA; Klauss V; Bogner JR; Schmidt-Kittler H; Sadri I; Goebel FD; Universitats-Augenklinik, Munchen, Germany.; Cytomegalovirus retinopathy is the most frequent opportunistic infection of the eye in patients with acquired immunodeficiency syndrome (AIDS). We studied 71 patients with cytomegalovirus retinopathy (n = 69) or acute retinal necrosis (n = 2) with respect to the frequency and manag
Service utilization among older people with AIDS: implications for case management.: J Case Manag. 1993 Winter;2(4):119-24. Unique Identifier : AIDSLINE MED/94191545; Emlet CA; People over 50 years of age have consistently comprised 10% of all cases diagnosed with AIDS in the United States . Older people with AIDS have been found to differ both in the clinical course of the disease as well as in their need for services. A comparison of 49 patients, 10 of whom
Predictive statistics and artificial intelligence in the U.S. National Cancer Institute's Drug Discovery Program for Cancer and AIDS.: Stem Cells (Dayt). 1994 Jan;12(1):13-22. Unique Identifier : AIDSLINE MED/94191554; Weinstein JN; Myers T; Buolamwini J; Raghavan K; van Osdol W; Licht J; Viswanadhan VN; Kohn KW; Rubinstein LV; Koutsoukos AD; et al; Laboratory of Molecular Pharmacology, National Cancer Institute; (NCI), Bethesda, Maryland.; The National Cancer Institute s drug discovery program screens more than 20,000 chemical compounds and natural products a year for activity against a panel of 60 tumor cell lines in vitro. The result is an information-rich database of patterns that form the basis for what we term an information-intensive approach to t
[Current clinical aspects of AIDS]: Bull Mem Acad R Med Belg. 1993;148(5-6):234-9; discussion 240-1. Unique Identifier : AIDSLINE MED/94191572; Clumeck N; Departement de Medecine interne de l'Hopital Saint-Pierre,; Universite libre de Bruxelles.; Our knowledge of the natural history of VIH infection has considerably increased during the last years. We know now that clinical evolution will depend of host factors as well as of viral characteristics. Among the host factors, the early specific cytotoxic response to VIH components plays a major role. Phenotypic var
Dental implants and human immunodeficiency virus disease [editorial]: Implant Dent. 1993 Fall;2(3):149-50. Unique Identifier : AIDSLINE MED/94191583; Glick M; Abel SN
Managing early HIV infection. Agency for Health Care Policy and Research.: Clin Pract Guidel Quick Ref Guide Clin. 1994 Jan;(7):1-37. Unique Identifier : AIDSLINE MED/94191714; el-Sadr W; Oleske JM; Agins BD; This Quick Reference Guide for Clinicians contains highlights from the Clinical Practice Guideline on Evaluation and Management of Early HIV Infection, which was developed by a private-sector panel of health care providers and consumers. Selected aspects of evaluating and managing patients, both adults and children, w
The psychological impact of infertility: a comparison with patients with other medical conditions.: J Psychosom Obstet Gynaecol. 1993;14 Suppl:45-52. Unique Identifier : AIDSLINE MED/94191761; Domar AD; Zuttermeister PC; Friedman R; Division of Behavioral Medicine, New England Deaconess Hospital,; Harvard Medical School, Boston, MA 02215.; To compare the psychological symptoms of infertile women with patients with other chronic medical conditions, subjects completed the Symptom Checklist-90 (Revised) (SCL-90R), a standardized, validated and widely used psychological questionnaire, prior to enrolling in a group behavioral treatment program. All subjects
The changing of the guard [editorial]: Arch Pediatr Adolesc Med. 1994 Jan;148(1):19-22. Unique Identifier : AIDSLINE MED/94191778; Heagarty MC
A search for persistent measles, mumps, and rubella vaccine virus in children with human immunodeficiency virus type 1 infection.: Arch Pediatr Adolesc Med. 1994 Jan;148(1):57-60. Unique Identifier : AIDSLINE MED/94191786; Frenkel LM; Nielsen K; Garakian A; Cherry JD; Department of Pediatrics, UCLA.; OBJECTIVE: To determine whether live measles, mumps, and rubella vaccine viruses persist after immunization of immunocompromised children with human immunodeficiency virus type 1 infection. METHODS: Ten children with symptomatic human immunodeficiency virus type 1 infection who received measles, mumps, and rubella imm
Pulmonary Kaposi's sarcoma revealed by a solitary nodule in a patient with acquired immunodeficiency syndrome.: Am J Respir Crit Care Med. 1994 Apr;149(4 Pt 1):1041-3. Unique Identifier : AIDSLINE MED/94191815; Roux FJ; Bancal C; Dombret MC; Bouvet E; Sautet A; Murciano G; Aubier M; Service de Pneumologie, Hopital Bichat, Paris, France.; Kaposi s sarcoma is very common in patients with AIDS. Usually, skin lesions are associated with various visceral involvements. A homosexual patient with AIDS presented with cough and dyspnea, which were followed months later by hemoptysis. He had no skin lesions or endobronchial Kaposi s sarcoma at any time. His ches
The balance of power between HIV and the immune system.: Trends Microbiol. 1993 Apr;1(1):9-13. Unique Identifier : AIDSLINE MED/94191962; McLean AR; Zoology Dept, University of Oxford, UK.; There are several theories of the pathogenesis of HIV that attempt to explain the long and variable delay between infection and disease. Here, each theory is reviewed within the context of a simple mathematical model of the interactions between HIV and the immune system. From this model, a theoretical index of progres
The class II MHC and HIV-1 binding surfaces of CD4.: Trends Microbiol. 1993 Jul;1(4):119-20; discussion 120-1. Unique Identifier : AIDSLINE MED/94191972; Eiden LE; Lifson JD; NIMH, National Institutes of Health, Bethesda, MD 20892.
HTLV-1 Tax: regulation of gene expression and disease.: Trends Microbiol. 1993 Jul;1(4):131-5. Unique Identifier : AIDSLINE MED/94191975; Yoshida M; Dept of Cellular and Molecular Biology, University of Tokyo,; Japan.; The human T cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes adult T cell leukemia and the neurological disorder tropical spastic paraparesis. Pathology apparently results from the activities of the Tax protein, which trans-activates the expression of viral and cellular genes by binding to various enhan
[Effect of arginine supplementation on T-lymphocyte function in burn patients]: Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa Chih. 1993 Sep;9(5):368-71, 398. Unique Identifier : AIDSLINE MED/94192065; Lu SL; Burn Unit, Rui Jin Hospital, Shanghai Second Medical University.; It is well accepted that nutritional support improves the immunologic functions in burn patients. Arginine has been demonstrated to have tissue--specific properties which influence certain components of the immune system. A series of experiments were carried out in this study, in order to evaluate the immune effect of
A serological survey for bovine immunodeficiency-like virus in Ontario dairy cattle and associations between test results, production records and management practices.: Can J Vet Res. 1994 Jan;58(1):36-41. Unique Identifier : AIDSLINE MED/94192109; McNab WB; Jacobs RM; Smith HE; Animal and Plant Health Directorate, Agriculture Canada, Nepean,; Ontario.; A chemiluminescence Western blot analysis (WBA) for detecting antibovine immunodeficiency-like virus (BIV) antibodies, had good repeatability. The test was subsequently applied to a bank of serum samples from 928 adult cows from 265 herds in Ontario; the number of cows sampled within each herd ranged from 1 to 13. The
Laboratory testing in patients with morbilliform viral eruptions.: Dermatol Clin. 1994 Jan;12(1):69-82. Unique Identifier : AIDSLINE MED/94192266; Boyd AS; Department of Dermatology, Vanderbilt University, School of; Medicine, Nashville, Tennessee.; The explosion of immunologic testing capabilities over the past 20 years has enabled clinicians to accurately diagnose many conditions that previously were very difficult to identify solely on a clinical basis. Among these disorders are the viral exanthems. Infections with some of these viruses are of relatively littl
Testing for syphilis.: Dermatol Clin. 1994 Jan;12(1):9-17. Unique Identifier : AIDSLINE MED/94192268; Johnson PC; Farnie MA; Division of General Medicine, University of Texas-Houston Medical; School.; Syphilis remains an important public health problem of growing proportions despite effective means of prevention and therapy. Clinical staging is difficult. The diagnosis is complicated by the lack of an easy culture method. History, clinical findings, and the detection of spirochetes in tissue serve as the basis for
Staging of lymphoma in adults.: Clin Radiol. 1994 Mar;49(3):149-61. Unique Identifier : AIDSLINE MED/94192286; Sandrasegaran K; Robinson PJ; Selby P; Department of Radiology, St James's University Hospital, Leeds.
Public knowledge/perceptions about AIDS transmission: concerns about use of dental services.: Community Dent Oral Epidemiol. 1994 Feb;22(1):52-5. Unique Identifier : AIDSLINE MED/94192328; Grace EG; Cohen LA; Ward MA; Department of Oral Health Care Delivery, Baltimore College of; Dental Surgery, Dental School, University of Maryland.; This telephone survey of 739 adults living in the State of Maryland (response rate 68.9%) examined the association between public perceptions and knowledge about the routes of transmission of AIDS, and concerns about contracting AIDS in a dental office and attitudes toward confidentiality of AIDS infected dentists and
Anti-CD3 and -CD4 monoclonal antibody in the treatment of steroid-resistant renal allograft rejection.: Chin Med J (Engl). 1993 Nov;106(11):821-4. Unique Identifier : AIDSLINE MED/94192386; Wang XH; Xie T; Department of Urology, First People's Hospital, Shanghai.; Between November 1987 and October 1991, 40 consecutive cadaveric renal recipients immunosuppressed with cyclosporine (CsA) who developed renal allograft rejection were treated with domestically prepared muromonab CD3 (Wu 338) and CD4 (Wu167). CD3 and CD4 monoclonal antibodies (McAb) as rescue treatment (n = 34) succes
[The rational diagnosis of HIV infection]: Dtsch Med Wochenschr. 1994 Mar 25;119(12):425-8. Unique Identifier : AIDSLINE MED/94192456; Gurtler L; Max-von-Pettenkofer-Institut fur Medizinische Mikrobiologie und; Hygiene, Universitat Munchen.
Lung cavitation associated with Pneumocystis carinii infection in the acquired immunodeficiency syndrome: a report of six cases and review of the literature.: Eur Respir J. 1994 Jan;7(1):134-9. Unique Identifier : AIDSLINE MED/94192762; Ferre C; Baguena F; Podzamczer D; Sanchez C; Viladrich PF; Garau J; Gudiol F; Infectious Diseases Service, Hospital de Bellvitge, Universitat; de Barcelona, Spain.; Lung cavitation in patients with the acquired immune deficiency syndrome (AIDS) and Pneumocystis carinii pneumonia (PCP) has mainly been reported as single case studies. Among 160 episodes of PCP seen in a 1,000 bed teaching hospital and a 600 bed teaching hospital from 1985-1992, we found six cases presenting with lu
Increased gamma/delta-positive T-cells in blood and bronchoalveolar lavage of patients with sarcoidosis and hypersensitivity pneumonitis.: Eur Respir J. 1994 Jan;7(1):140-7. Unique Identifier : AIDSLINE MED/94192763; Raulf M; Liebers V; Steppert C; Baur X; Berufsgenossenschaftliches Forschungsinstitut fur Arbeitsmedizin; (BGFA), Institut an der Ruhr-Universitat Bochum, Germany.; A small population of T-cells does not express the conventional T-cell receptor (TCR), characterized by the alpha and beta polypeptide chains (alpha/beta TCR) but two polypeptides termed gamma and delta (gamma/delta TCR). Changes in gamma/delta TCR expression may be relevant as the cause or consequence of several dise
Differential response of NF-kappa B1 p105 and NF-kappa B2 p100 to HTLV-I encoded Tax.: FEBS Lett. 1994 Apr 4;342(2):115-8. Unique Identifier : AIDSLINE MED/94192814; Watanabe M; Muramatsu M; Tsuboi A; Arai K; Department of Molecular and Developmental Biology, University of; Tokyo, Japan.; In a previous study we found that HTLV-I encoded Tax transactivator, which binds to NF-kappa B1 p105, suppresses p105-mediated I kappa B activity, thereby allowing entry of NF-kappa B p65 (RelA) and p50 into the nucleus. In the present report, we compared the effect of Tax on NF-kappa B2 p100, which also binds to Tax,
[Knowledge about and attitude to HIV/AIDS among dentists and dental assistants in Budapest, November 1992]: Fogorv Sz. 1994 Jan;87(1):15-21. Unique Identifier : AIDSLINE MED/94192837; Simon T; Tanner K; Semmelweis Orvostudomanyi Egyetem, Orvostorteneti es; Tarsadalomorvostani Intezet, Budapest.; 118 Dentists and 115 Dental Nurses opinion was evaluated about their knowledges and attitudes to HIV/AIDS problem in Budapest ( Hungary ) 1992 November. The frequency of false knowledges about the transmission was 5-10%. More than 70%
[Esophageal mycosis during primary human immunodeficiency virus infection (letter)]: Gastroenterol Clin Biol. 1993;17(11):868. Unique Identifier : AIDSLINE MED/94192921; Thevenot T; Colardelle P; Chochon M; Andrieu J
Lactobacillus casei endocarditis in an intravenous heroin drug addict: a case report.: Funct Neurol. 1993 Sep-Oct;8(5):355-7. Unique Identifier : AIDSLINE MED/94193039; Verani DA; Carretto E; Bono L; Moggio G; Marone P; Section of Infectious Diseases, Hospital of the Infirm, Biella,; Italy.; A 24-year-old HIV negative unemployed intravenous heroin addict with teeth in poor condition was admitted to hospital with left hemiparesis; CT scan of the brain revealed a hypodense area in the right parietal region. He was apyrexial with marked leukocytosis and raised ESR, had an aortic diastolic murmur and an echoc
[Avoiding risks of unnecessary blood transfusion in surgical patients]: Harefuah. 1994 Jan 16;126(2):98-102. Unique Identifier : AIDSLINE MED/94193073; Assalia A; Schein M; Rosenberg B; Hashmonai M
Laterocervical lymphadenitis caused by Pneumocystis carinii in a patient with AIDS.: Histopathology. 1994 Jan;24(1):91-3. Unique Identifier : AIDSLINE MED/94193161; Ramponi A; Angeli G; Rizzo GM; Monga G; Divisione di Anatomia Patologica, Faculta di Medicina e; Chirurgia, Sede di Novara, Universita di Torino, Italy.
[New developments in antiviral chemotherapy]: Immun Infekt. 1993 Dec;21(6):171-6. Unique Identifier : AIDSLINE MED/94193194; Doerr HW; Preiser W; Weber B; Institut fur Medizinische Virologie, Zentrum der Hygiene,; Klinikum der Universitat Frankfurt/Main.
Epidermal Langerhans cells and HIV-1 infection.: Immunol Lett. 1993 Dec;39(1):33-7. Unique Identifier : AIDSLINE MED/94193202; Dezutter-Dambuyant C; Schmitt D; INSERM U 346 Peau Humanine et Immunite, Clinique; Dermato-Venerologique, Hop. Edouard Herriot, Lyon, France.; Originating from the bone marrow, Langerhans cells migrate into the peripheral epithelia (skin, mucous membranes) and play a key role in the immune surveillance system against foreign antigens. They act as antigen-presenting cells through a specific cooperation with CD4+ lymphocytes after migration to the proximal lym
Early events in the experimental interstitial lung disease induced in sheep by the Visna-maedi virus.: Immunol Lett. 1993 Dec;39(1):39-43. Unique Identifier : AIDSLINE MED/94193203; Cadore JL; Guiguen F; Cordier G; Loire R; Lyon M; Chastang J; Greenland T; Court-Fortune I; Revel D; Mornex JF; Laboratoire de Recherche sur les Lentivirus des Petits Ruminants,; INRA, France.; Visna-maedi virus is a lentivirus closely related to the human immunodeficiency virus type I (HIV-I). During spontaneous infection of sheep by Visna-maedi virus an interstitial lung disease is observed. It is characterized by an alveolitis, peribronchovascular lymphoid nodules, alveolar wall thickening and myomatosis.
Complement dependent cytotoxicity of sensory ganglion neurons mediated by the gp120 glycoprotein of HIV-1.: Immunol Invest. 1994 Jan;23(1):47-52. Unique Identifier : AIDSLINE MED/94193216; Apostolski S; McAlarney T; Hays AP; Latov N; Department of Neurology and Pathology, College of Physicians and; Surgeons of Columbia University, New York, N.Y. 10032.; Patients infected with HIV-1 frequently have a sensory neuropathy, but the cause is unknown. We found that the gp120 glycoprotein of HIV-1 bound to the surface of cultured rat dorsal root ganglia (DRG) neurons, and activated the complement cascade to lyse the neuronal cells. Cytotoxicity was measured by a 51Cr-release
HIV testing policies--an overview.: Indian J Med Res. 1993 Nov;97:219-22. Unique Identifier : AIDSLINE MED/94193218; Narain JP; Pattanayak S; Shah NK; South-East Asia Regional Office of the World Health Organization,; New Delhi.
Proposed national HIV testing policy.: Indian J Med Res. 1993 Nov;97:223-4. Unique Identifier : AIDSLINE MED/94193219; Lal S; Thakur BB; National AIDS Control Organization, New Delhi.
The management of HIV infection in India.: Indian J Med Res. 1993 Nov;97:225-6. Unique Identifier : AIDSLINE MED/94193220; Mathan VI; Department of Gastroenterology & Medical Superintendent,; Christian Medical College & Hospital, Vellore.
Prevalence of HIV infection in pregnant women in Vellore region.: Indian J Med Res. 1993 Nov;97:227-30. Unique Identifier : AIDSLINE MED/94193221; John TJ; Bhushan N; Babu PG; Seshadri L; Balasubramanium N; Jasper P; Department of Microbiology, National AIDS Reference &; Surveillance Centre, Vellore.; All pregnant women attending the antenatal clinic of a large hospital in Vellore, India (Christian Medical College Hospital) were screened for HIV infection between October 1987 and June 1992. A total of 36,953 blood samples were thus screened and 20 infected women were identified. a
HIV screening & risk behaviour in psychoactive substance users.: Indian J Med Res. 1993 Nov;97:231-3. Unique Identifier : AIDSLINE MED/94193222; Malhotra A; Balaji M; Basu D; Mattoo SK; Varma VK; Sehgal S; Department of Psychiatry, Postgraduate Institute of Medical; Education & Research, Chandigarh.; Patients admitted to the Drug De-addiction and Treatment Centre, Postgraduate Institute of Medical Education & Research, Chandigarh, were screened for HIV antibodies. Out of 116 patients, 45 (39%) were injecting drug users (IDUs), 29 (25%) were other drug users and 42 (36%) were primary users of alcohol. One IDU wa
Counselling services for HIV: need of the hour [editorial]: Indian J Public Health. 1993 Jan-Mar;37(1):1-2. Unique Identifier : AIDSLINE MED/94193261; Bansal RD; Kannan AT
A study on the impact of awareness programme imparted to in-service nursing staff on their knowledge regarding AIDS.: Indian J Public Health. 1993 Jan-Mar;37(1):23-5. Unique Identifier : AIDSLINE MED/94193264; Dutta C; MCH, Calcutta.; One hundred five In-service nursing personnel of West Bengal Health Service, who completed a two day s orientation training programme on AIDS were subjected to Pre and Post-training assessment of their knowledge relating to AIDS by the same written questionnaire. Significant improvement in percentage of subjects (from
Root canal treatment on patients with HIV infection.: Int Endod J. 1993 Nov;26(6):369-71. Unique Identifier : AIDSLINE MED/94193285; Cooper H; Surgery V, University College and Middlesex Hospital, London, UK.; Patients attending a dedicated dental clinic during the previous 24 months were assessed for the success of root canal treatment. Two groups, totalling 48 patients, had root canal treatment to 57 teeth performed by one operator. All treatment was carried out without antibiotic prophylaxis over two or more appointments
Drug dependence treatment within the Department of Veterans Affairs: emerging issues.: Int J Addict. 1994 Jan;29(1):53-69. Unique Identifier : AIDSLINE MED/94193307; Walker RD; Howard MO; Suchinsky R; Kaple J; Anderson B; Addictions Treatment Center, Seattle Veterans Affairs Medical; Center, Washington 98108.; The Department of Veterans Affairs is the largest provider of drug dependence treatment services in the United States . However, a national evaluation of primarily drug-dependent veterans has never been reported. Findings from the Drug Abuse Treatment Services Evaluation Project, a thre
Illicit drug injectors in three Texas cities.: Int J Addict. 1994 Jan;29(2):179-94. Unique Identifier : AIDSLINE MED/94193312; Maddux JF; Vogtsberger KN; Prihoda TJ; Desmond DP; Watson DD; Williams ML; Department of Psychiatry, University of Texas Health Science; Center at San Antonio 78284-7792.; In three Texas cities illicit drug injectors not in treatment were located by outreach and interviewed with a standard questionnaire. In all the cities the drug injectors were predominantly undereducated and unemployed young men from minority groups. In Dallas and Houston most were Black, while in San Antonio most wer
Sex differences in self-report of physical health by injection drug users.: Int J Addict. 1994 Jan;29(2):275-83. Unique Identifier : AIDSLINE MED/94193317; Singh BK; Koman JJ 3rd; Williams JS; Catan VM; Souply KL; National Opinion Research Center, Washington, D.C.; Through heterosexual contact, injection drug users (IDUs) put others at risk of contracting Human Immunodeficiency Virus (HIV) disease. Self-report of health was compared among IDUs in Laredo, Texas, San Diego, California, and San Juan, Puerto Rico , and in a subsample which con
HIV-1 infection as a risk factor for the development of tuberculosis: a case-control study in Tanzania.: Int J Epidemiol. 1993 Dec;22(6):1159-65. Unique Identifier : AIDSLINE MED/94193338; Van den Broek J; Borgdorff MW; Pakker NG; Chum HJ; Klokke AH; Senkoro KP; Newell JN; National Institute for Medical Research, Mwanza, Tanzania.; A population-based case-control study was carried out in Mwanza Region, Tanzania , to determine the relative and population attributable risk of human immunodeficiency virus type 1 (HIV-1) infection for developing active tuberculosis. Cases were 441 consecutively diagnosed patient
Blood transfusion: the risks and benefits.: Hawaii Med J. 1994 Jan;53(1):20-2. Unique Identifier : AIDSLINE MED/94193402; Frohlich JA; As greater attention is focused on medical and legal risks of the transfusion process, physicians ordering a blood transfusion must advise their patients thoroughly and clearly of the potential risks involved. Physicians must explain clearly to patients that a zero-risk blood supply is impossible to achieve; patients
In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases.: J Biol Chem. 1994 Apr 8;269(14):10691-8. Unique Identifier : AIDSLINE MED/94193770; Salto R; Babe LM; Li J; Rose JR; Yu Z; Burlingame A; De Voss JJ; Sui Z; Ortiz de Montellano P; Craik CS; Department of Pharmaceutical Chemistry, University of California,; San Francisco 94143-0446.; The irreversible inhibition of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) proteases by 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP) and eight haloperidol derivatives has been studied. EPNP specifically inhibits HIV-1 and HIV-2 proteases with a stoichiometry of one EPNP molecule/dimeric enzyme. The si
Expression of v-src in T cells correlates with nuclear expression of NF-kappa B.: J Immunol. 1994 Mar 15;152(6):2710-9. Unique Identifier : AIDSLINE MED/94194029; Eicher DM; Tan TH; Rice NR; O'Shea JJ; Kennedy IC; Leukocyte Cell Biology Section, NCI-FCRDC, Frederick, MD; 21702-1201.; NF-kappa B is a rapidly inducible transcriptional activator that responds to a variety of signals and influences the expression of many genes involved in the immune response. Protein tyrosine kinases transmit signals from cytokine and immune receptors. Very little information exists linking these two important classes
Neutralization of IL-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy.: J Immunol. 1994 Mar 15;152(6):2960-7. Unique Identifier : AIDSLINE MED/94194057; Broaddus VC; Boylan AM; Hoeffel JM; Kim KJ; Sadick M; Chuntharapai A; Hebert CA; Department of Medicine, San Francisco General Hospital, CA 94110.; Although the potent neutrophil chemotaxin, IL-8, is a known product of endotoxin-stimulated cells in vitro, the contribution of IL-8 to neutrophil recruitment in Gram-negative endotoxin inflammation in vivo is unknown. To determine whether neutralization of IL-8 would decrease endotoxin-induced neutrophil influx, we g
Immunogenic and antigenic properties of an HIV-1 gp120-derived multiple chain peptide.: J Immunol. 1994 Apr 15;152(8):4139-48. Unique Identifier : AIDSLINE MED/94194178; Kelker HC; Schlesinger D; Valentine FT; Department of Medicine, New York University Medical Center, NY; 10016.; An HIV-1 envelope protein gp120-derived monomeric peptide (amino acid residues 419-439) and its homologous multiple chain peptide (MCP) construct were compared for immunogenicity in mice. The Abs stimulated by the MCP recognized epitopes on the MCP that were not present on the homologous monomer. The anti-419-439 MCP
Influence of H-2 class II antigens on the development of murine AIDS.: J Immunol. 1994 Apr 15;152(8):4157-64. Unique Identifier : AIDSLINE MED/94194180; Makino M; Tang Y; Murphy DB; Fredrickson TN; Okada Y; Fujiwara M; Chattopadhyay SK; Mizuochi T; Komuro K; Morse HC 3rd; et al; Laboratory of Immunopathology, National Institute of Allergy and; infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.; Inbred strains of mice differ markedly in their relative susceptibility to the development of lymphoproliferation and immunodeficiency, a syndrome termed mouse AIDS (MAIDS), after infection with the LP-BM5 mixture of murine leukemia viruses (MuLV). The etiologic virus in this mixture is replication defective (BM5def)
Chemically selected subclones of the CEM cell line demonstrate resistance to HIV-1 infection resulting from a selective loss of NF-kappa B DNA binding proteins.: J Immunol. 1994 Apr 15;152(8):4183-91. Unique Identifier : AIDSLINE MED/94194183; Qian J; Bours V; Manischewitz J; Blackburn R; Siebenlist U; Golding H; Laboratory of Retrovirus Research, Food and Drug Administration,; Bethesda, MD 20892.; To delineate cellular genes that are required for optimal HIV-1 infection, CEM cells were subjected to treatment with the chemical mutagen ethylmethanesulfonate (EMS) and subclones were selected based on their increased resistance to HIV-1 infection and reduced syncytium formation, despite relatively normal CD4 expres
Identification of a 68 kd surface antigen of Mycobacterium avium that binds to human macrophages.: J Lab Clin Med. 1994 Apr;123(4):526-35. Unique Identifier : AIDSLINE MED/94194229; Rao SP; Ogata K; Morris SL; Catanzaro A; Department of Medicine, University of California at San Diego.; Infection caused by Mycobacterium avium is the major cause of bacteremia in patients with AIDS. A critical event in the initiation of a variety of bacterial infections is the adherence of bacteria to host cell surfaces, which is often brought about by the interaction of specific molecules on the bacterial surface with
HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro.: J Leukoc Biol. 1994 Apr;55(4):545-51. Unique Identifier : AIDSLINE MED/94194258; Durrbaum-Landmann I; Kaltenhauser E; Flad HD; Ernst M; Forschungsinstitut Borstel, Germany.; We investigated the effect of human immunodeficiency virus type 1 (HIV-1) recombinant gp120 (rec.gp120) on phenotype and function of cultured monocytes. Rec.gp120 significantly reduced the accessory function of monocytes to stimulate autologous lymphocytes with anti-CD3, the Fc receptor-mediated chemiluminescence of m
Human CD4 restores normal T cell development and function in mice deficient in murine CD4.: J Exp Med. 1994 Apr 1;179(4):1233-42. Unique Identifier : AIDSLINE MED/94194279; Law YM; Yeung RS; Mamalaki C; Kioussis D; Mak TW; Flavell RA; Section of Immunobiology, Howard Hughes Medical Institute, School; of Medicine, Yale University, New Haven, Connecticut 06510.; The ability of a human coreceptor to function in mice was investigated by generating human CD4 (hCD4)-expressing transgenic mice on a mouse CD4-deficient (mCD4-/-) background. From developing thymocyte to matured T lymphocyte functions, hCD4 was shown to be physiologically active. By examining the expansion and deleti
Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.: J Exp Med. 1994 Apr 1;179(4):1261-71. Unique Identifier : AIDSLINE GENBANK/Z29614; Kalams SA; Johnson RP; Trocha AK; Dynan MJ; Ngo HS; D'Aquila RT; Kurnick JT; Walker BD; Infectious Disease Unit, Massachusetts General Hospital, Boston.; Human immunodeficiency virus 1 (HIV-1) infection is associated with a vigorous cellular immune response that allows detection of cytotoxic T lymphocyte (CTL) activity using freshly isolated peripheral blood mononuclear cells (PBMC). Although restricting class I antigens and epitopes recognized by HIV-1-specific CTL ha
HIV-inhibitory natural products. 11. Comparative studies of sulfated sterols from marine invertebrates.: J Med Chem. 1994 Mar 18;37(6):793-7. Unique Identifier : AIDSLINE MED/94194491; McKee TC; Cardellina JH 2nd; Riccio R; D'Auria MV; Iorizzi M; Minale L; Moran RA; Gulakowski RJ; McMahon JB; Buckheit RW Jr; et al; Laboratory of Drug Discovery Research and Development, National; Cancer Institute, Frederick, Maryland 21702-1201.; A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values of 3-13 microM agai
Synthesis and biological evaluation of 2',3'-dideoxy-L-pyrimidine nucleosides as potential antiviral agents against human immunodeficiency virus (HIV) and hepatitis B virus (HBV).: J Med Chem. 1994 Mar 18;37(6):798-803. Unique Identifier : AIDSLINE MED/94194492; Lin TS; Luo MZ; Liu MC; Pai SB; Dutschman GE; Cheng YC; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut 06510.; Various 2 ,3 -dideoxy-L-cytidine,2 ,3 -dideoxy-L-uridine, and 3 -deoxy-L-thymidine analogues have been synthesized and evaluated in vitro as potential anti-HIV and anti-HBV agents. Coupling of 1-O-acetyl-5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-L-ribofurano- se (1) with silylated derivatives of 5-fluorocytosine, cyto
Enhanced brain delivery of an anti-HIV nucleoside 2'-F-ara-ddI by xanthine oxidase mediated biotransformation.: J Med Chem. 1994 Mar 18;37(6):821-7. Unique Identifier : AIDSLINE MED/94194496; Shanmuganathan K; Koudriakova T; Nampalli S; Du J; Gallo JM; Schinazi RF; Chu CK; Department of Medicinal Chemistry, College of Pharmacy, UGA,; Athens, Georgia 30602.; In order to enhance the brain delivery of 2 -F-ara-ddI,2 -F-ara-ddP 6 was synthesized and its in vitro and in vivo bioconversion reaction studied. For the study, a new efficient synthetic method for 2 -F-ara-ddP 6 was developed from 5-benzoyl-1,2-O-isopropylidene-3-deoxyribose 1. For in vitro study 2 -F-ara-ddP was in
[Sex education and AIDS prevention]: Kinderarztl Prax. 1993 Dec;61(10):351-4. Unique Identifier : AIDSLINE MED/94194790; Gunther E; Klinik fur Hautkrankheiten/Abt. Andrologie und Sexualmedizin,; Friedrich-Schiller-Universitat Jena.; The well-known deficiencies in sexual education prompt the author to present commendable education programmes by experienced sexual paedagogues. Emancipatory sexual education aims at preparing adolescents for adulthood. Most of the teenagers have other sexual anxieties than an HIV infection. These facts should be util
[Viral hepatitis B and AIDS]: Klin Med (Mosk). 1993;71(6):15-9. Unique Identifier : AIDSLINE MED/94194837; Gavura VV
Statement of the Committee on Infectious Diseases Tennessee Chapter, American Academy of Pediatrics.: J Tenn Med Assoc. 1994 Jan;87(1):21. Unique Identifier : AIDSLINE MED/94194904
State sets new rules for preventing transmission of HIV and HBV viruses.: J Tenn Med Assoc. 1994 Jan;87(1):22. Unique Identifier : AIDSLINE MED/94194905; Grant JH Jr
Threshold conditions for the spread of the HIV infection in age-structured populations of homosexual men.: J Theor Biol. 1994 Jan 7;166(1):9-31. Unique Identifier : AIDSLINE MED/94194962; Hyman JM; Li J; Stanley EA; Theoretical Division, Los Alamos National Laboratory, NM 87545.; The age-structure of a population, and the distribution of sexual behavior according to age, are significant factors determining the spread of the AIDS epidemic. The threshold conditions for age-structured models account for life-history information, and thus differ significantly from their age-independent counterpart
Computer interview for screening blood donors for risk of HIV transmission.: MD Comput. 1994 Jan-Feb;11(1):26-32. Unique Identifier : AIDSLINE MED/94195093; Locke SE; Kowaloff HB; Hoff RG; Safran C; Popovsky MA; Cotton DJ; Finkelstein DM; Page PL; Slack WV; Department of Psychiatry, Beth Israel Hospital, Boston, MA.; To test the ability of a computer-based interview to detect factors related to the risk of the human immunodeficiency virus (HIV) among potential blood donors, and to determine donor reactions to the use of the computer, we compared the rate of detection of HIV-related factors elicited by the computer interview with t
On the mechanism of HIV disease: a hypothesis and the anti-AIDS therapy it suggests.: Med Hypotheses. 1993 Nov;41(5):467-9. Unique Identifier : AIDSLINE MED/94195131; Fuxman YL; A hypothesis is proposed interpreting transformation of the asymptomatic (latent) phase of HIV disease into full-blown AIDS. According to the hypothesis, AIDS in an HIV infected individual is caused by just that HIV strain which fits host s genotype in that way preventing production of the antibody specific to that st
[HIV-p24 antigen test in blood donors: yes or no? (see comments)]: Med Klin. 1994 Jan 15;89(1):25-32, 47. Unique Identifier : AIDSLINE MED/94195148; Caspari G; Gerlich WH; Institut fur Medizinische Virologie, Justus-Liebig-Universitat; Giessen.
[Value of the HIV-p24 antigen test in blood banks (editorial; comment)]: Med Klin. 1994 Jan 15;89(1):41. Unique Identifier : AIDSLINE MED/94195152; Eggers HJ
[Early diagnosis of HIV infections in infants at risk. A partially solved problem (editorial)]: Minerva Pediatr. 1993 Dec;45(12):483-7. Unique Identifier : AIDSLINE MED/94195155; Tovo PA; Palomba E
Recommendations for the prevention and management of Chlamydia trachomatis infections, 1993. Centers for Disease Control and Prevention.: MMWR Morb Mortal Wkly Rep. 1993 Aug 6;42(RR-12):1-39. Unique Identifier : AIDSLINE MED/94195205; In 1985, CDC published Policy Guidelines for Prevention and Control of Chlamydia trachomatis infections. Those guidelines highlighted the prevalence and morbidity of chlamydial infections and stressed the need to include antibiotics effective against chlamydia when treating patients for urethritis, mucopurulent cervic
1993 sexually transmitted diseases treatment guidelines. Centers for Disease Control and Prevention.: MMWR Morb Mortal Wkly Rep. 1993 Sep 24;42(RR-14):1-102. Unique Identifier : AIDSLINE MED/94195207; These guidelines for the treatment of patients with sexually transmitted diseases (STDs) were developed by staff members of CDC after consultation with a group of invited experts who met in Atlanta on January 19-21, 1993. Included are new recommendations for single-dose oral therapy for gonococcal infections, chlamydi
[Study of anti-HIV activity of azidothymidine and fluorothymidine 5'-phosphonates]: Mol Biol (Mosk). 1994 Jan-Feb;28(1):137-42. Unique Identifier : AIDSLINE MED/94195288; Mamaeva OA; Pliasunova OA; Pokrovskii AG; Diatkina NB; Arzumanova AA; It was established that 5 -phosphonates of 3 -azido-2 ,3 -dideoxythymidine ( AZT ) inhibit HIV reproduction in the MT-4 cell line as well as AZT. However, the viability of HIV-infected MT-4 cells after treatment with phosphonates was considerable higher
[Ribonucleoside and 2'-deoxyribonucleoside 5'-phosphonates: synthesis and antiviral activity]: Mol Biol (Mosk). 1994 Jan-Feb;28(1):224-32. Unique Identifier : AIDSLINE MED/94195300; Shirokova EA; Ias'ko MV; Shipitsyn AV; Kraevskii AA; Ostrander M; O'Hara B; Baron P; Maclow K; Polsky B; Groups of 5 -phosphonates of natural 2 -deoxynucleosides and ribonucleosides were synthesized by condensation of 3 -acetylated 2 -deoxynucleosides or 2 ,3 -substituted (2 ,3 -O-isopropylidene, 2 ,3 -O-methoxymethylene, or 2 ,3 -O-ethoxymethylene) ribonucleosides. As condensing agents, either N,N -dicyclohexylcarbodiim
Optimal conditions for detection of human immunodeficiency virus type 1 DNA by polymerase chain reaction with nested primers.: Mol Cell Probes. 1993 Dec;7(6):431-7. Unique Identifier : AIDSLINE GENBANK/KO2007; Zazzi M; Romano L; Peruzzi F; Toneatto S; De Milito A; Botta G; Valensin PE; Department of Molecular Biology, University of Siena, Italy.; An assessment of optimal conditions for nested primer amplification of low copy number target DNA sequences was made using a human immunodeficiency virus type 1 (HIV-1) model. In this polymerase chain reaction (PCR) strategy, an outer primer pair is first used to amplify the target sequence and a fraction of the ampli
Transmission of HIV-1 from one child to another [letter; comment]: N Engl J Med. 1994 May 5;330(18):1313; discussion 1314. Unique Identifier : AIDSLINE MED/94195355; Alimenti A; Levy J
Transmission of HIV-1 from one child to another [letter; comment]: N Engl J Med. 1994 May 5;330(18):1313; discussion 1314. Unique Identifier : AIDSLINE MED/94195356; Fremont-Smith K
Transmission of HIV-1 from one child to another [letter; comment]: N Engl J Med. 1994 May 5;330(18):1314. Unique Identifier : AIDSLINE MED/94195358; Friedland GH
Correlation of nonspecific antiviral activity with the ability to isolate infectious HIV-1 from saliva [letter]: N Engl J Med. 1994 May 5;330(18):1314-5. Unique Identifier : AIDSLINE MED/94195359; Coppenhaver DH; Sriyuktasuth-Woo P; Baron S; Barr CE; Qureshi MN
Rifabutin prophylaxis and uveitis [letter; comment]: N Engl J Med. 1994 May 5;330(18):1315-6. Unique Identifier : AIDSLINE MED/94195360; Fuller JD; Stanfield LE; Craven DE
HIV in Zambia: myth or monster?: Nature. 1994 Mar 17;368(6468):183-4. Unique Identifier : AIDSLINE MED/94195381; Godfrey-Faussett P; Baggaley R; Scott G; Sichone M; Department of Medicine, University Teaching Hospital, Lusaka,; Zambia.; Despite attempts by a few journalists to portray the spread of AIDS in African countries as fictitious, the situation in Zambia shows that such views are completely misguided.
Multi-target PCR analysis by capillary electrophoresis and laser-induced fluorescence.: Nature. 1994 Mar 17;368(6468):269-71. Unique Identifier : AIDSLINE MED/94195401; Lu W; Han DS; Yuan J; Andrieu JM; Laboratory of Tumor Immunology, Hopital Laennec, Universite de; Paris V, France.; Quantitative analysis of polymerase chain reaction (PCR) amplified HIV-1 DNA or cDNA fragments is attained using an automated system that combines capillary-gel electrophoresis (CGE) for high-efficiency separation and laser-induced fluorescence (LIF) for high-sensitivity detection. This system enables the detection of
Newspaper revives anti-HIV claims [news]: Nature. 1994 Apr 14;368(6472):577. Unique Identifier : AIDSLINE MED/94195405
Study confirms AZT's lack of prophylactic effect [new]: Nature. 1994 Apr 14;368(6472):577. Unique Identifier : AIDSLINE MED/94195406; Maddox J
Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues.: Neurology. 1994 Mar;44(3 Pt 1):474-81. Unique Identifier : AIDSLINE MED/94195501; Saito Y; Sharer LR; Epstein LG; Michaels J; Mintz M; Louder M; Golding K; Cvetkovich TA; Blumberg BM; Department of Neurology, University of Rochester Medical Center,; NY 14642.; In previous studies, using polymerase chain reaction amplification of HIV-1 genes directly from pathologic tissues of children who died with AIDS encephalopathy, we showed that the reading frame of the HIV-1 regulatory nef gene is open, suggesting that the nef protein was expressed. We now show, using immunocytochemis
HIV-1 infection of subcortical astrocytes in the pediatric central nervous system.: Neurology. 1994 Mar;44(3 Pt 1):481-7. Unique Identifier : AIDSLINE MED/94195502; Tornatore C; Chandra R; Berger JR; Major EO; Section on Molecular Therapeutics, National Institute of; Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, MD 20892.; Early reports of pediatric HIV-1-associated neuropathology described the presence of viral particles in some astrocytes, implicating direct infection of the immature nervous system as a contributing factor to the observed neuropathology. Several recent reports suggest that in those astrocytes infected with HIV-1, the
Cytomegalovirus encephalitis in acquired immunodeficiency syndrome (AIDS).: Neurology. 1994 Mar;44(3 Pt 1):507-14. Unique Identifier : AIDSLINE MED/94195506; Holland NR; Power C; Mathews VP; Glass JD; Forman M; McArthur JC; Department of Neurology, Johns Hopkins University, Baltimore, MD; 21287-7609.; Cytomegalovirus encephalitis (CMVE) is frequently diagnosed only at postmortem because its specific clinical features have not been fully identified. We have described the clinical, radiologic, and laboratory features of CMVE in a retrospective review of 14 autopsy-confirmed cases of CMVE and compared them with a cont
Lack of anti-Coxiella burnetii seropositivity in patients with HTLV-I-associated myelopathy.: Neurology. 1994 Mar;44(3 Pt 1):571. Unique Identifier : AIDSLINE MED/94195524; Ijichi S; Yuasa Y; Kubota R; Yoshiie K; Niina K; Oda H; Osame M; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.
HIV myelopathy [letter; comment]: Neurology. 1994 Mar;44(3 Pt 1):578-9. Unique Identifier : AIDSLINE MED/94195529; Fuchs D; Murr C; Reibnegger G; Wachter H
Education of children with human immunodeficiency virus infection: guidelines for families, health care and education personnel. Infection and Immunisation Committee of the New Zealand Paediatric Society.: N Z Med J. 1994 Apr 13;107(975):124-6. Unique Identifier : AIDSLINE MED/94195545
HTLV1 related cutaneous T cell lymphoma [letter]: N Z Med J. 1994 Apr 13;107(975):139. Unique Identifier : AIDSLINE MED/94195560; Romeril KR; Taylor B; Rae P
Population migration and the spread of types 1 and 2 human immunodeficiency viruses.: Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2407-14. Unique Identifier : AIDSLINE MED/94195754; Quinn TC; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD.; Over 14 million people are estimated to be infected with the human immunodeficiency viruses (HIV), with nearly three-fourths of the infected persons residing in developing countries. One factor responsible for dissemination of both HIV-1 and HIV-2 worldwide was the intense migration of individuals, from rural to urban
Evolution of drug-resistant tuberculosis: a tale of two species.: Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2428-9. Unique Identifier : AIDSLINE MED/94195757; Iseman MD; University of Colorado School of Medicine, Denver, CO.; The history of the disease tuberculosis is briefly discussed. Now human societal failures have potentiated the evolution of drug-resistant strains of the tubercle bacillus in the United States and around the world. Until recently, this evolutionary change largely posed a threat to the
Effect of changes in human ecology and behavior on patterns of sexually transmitted diseases, including human immunodeficiency virus infection.: Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2430-5. Unique Identifier : AIDSLINE MED/94195758; Wasserheit JN; Division of STD/HIV Prevention, National Center for Prevention; Services, Centers for Disease Control and Prevention, Atlanta, GA; 30333.; The last 20 years have witnessed six striking changes in patterns of sexually transmitted diseases (STDs): emergence of new STD organisms and etiologies, reemergence of old STDs, shifts in the populations in which STDs are concentrated, shifts in the etiological spectra of STD syndromes, alterations in the incidence o
Vaccines for bacterial sexually transmitted infections: a realistic goal?: Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2456-63. Unique Identifier : AIDSLINE MED/94195762; Sparling PF; Elkins C; Wyrick PB; Cohen MS; Department of Medicine, University of North Carolina, School of; Medicine, Chapel Hill 27599-7005.; Bacterial infections of the genital tract (gonorrhea, chlamydia, chancroid, syphilis) are common and cause significant morbidity. Their importance is heightened by recent appreciation of their roles in facilitation of transmission of the human immunodeficiency virus (HIV). Each is capable of causing repeated infection
[Qualified inpatient acute treatment of drug dependent patients in North Rhine Westphalia]: Psychiatr Prax. 1994 Jan;21(1):13-8. Unique Identifier : AIDSLINE MED/94195884; Kuhlmann T; Hasse HE; Sawalies D; Psychosomatische Klinik Bergisch Gladbach.; Qualified concepts of clinical treatment of drug addicts in the Federal Republic of Germany have been put into practice to a large extent only in terms of abstinence oriented long term therapy (in the FRG called disuse therapy). Specialized and differentiated offers of clinical ac
[Substitution as a possibility for the treatment of opiate dependent patients]: Psychiatr Prax. 1994 Jan;21(1):7-9. Unique Identifier : AIDSLINE MED/94195891; von Bardeleben U; Petitjean S; Stohler R; Natsch C; Ladewig D; PUK Basel.; The treatment of patients who are dependent on opiates has definitely been including drug substitution besides withdrawal and weaning in the Swiss urban community (Kanton) of Basel City since 1980. After a significant increase of treatments in 1987 in connection with the spread of HIV infections, more than 800 patient
Low doses of neutrons induce changes in gene expression.: Radiat Res. 1994 Apr;138(1 Suppl):S56-9. Unique Identifier : AIDSLINE MED/94195975; Woloschak GE; Chang-Liu CM; Panozzo J; Libertin CR; Center for Mechanistic Biology and Biotechnology, Argonne; National Laboratory, Illinois 60439-4833.; Studies were designed to identify genes induced in fibroblasts after exposure to low-dose neutron radiation but not after gamma rays. Our past work had shown similar modulation of transcripts for alpha-tubulin, beta- and gamma-actins, ornithine decarboxylase and interleukin 1 after exposure to either neutrons or gamma
HIV disease in Africa [editorial]: Rev Soc Bras Med Trop. 1993 Jul-Sep;26(3):135-9. Unique Identifier : AIDSLINE MED/94196033; Gilks CF
[AIDS--an ethical-political focus]: Rev Soc Bras Med Trop. 1993 Jul-Sep;26(3):187-92. Unique Identifier : AIDSLINE MED/94196041; de Franca GV; Universidade Federal da Paraiba, Jaao Pessoa, PB.
Differential diagnosis of progressive spastic paraparesis.: Semin Neurol. 1993 Dec;13(4):319-21. Unique Identifier : AIDSLINE MED/94196175; Younger DS; Department of Neurology, Columbia-Presbyterian Medical Center,; College of Physicians and Surgeons, Columbia University, New; York, New York 10032.
[HIV detection at the beginning of pregnancy. Is it useful, is it necessary?]: Rev Prat. 1993 Nov 1;43(17):2227-9. Unique Identifier : AIDSLINE MED/94196238; Henrion R; Groupe hospitalier Cochin, clinique universitaire Port-Royal,; Paris.
HIV-1 inhibits Leishmania-induced cell proliferation but not production of interleukin-6 and tumour necrosis factor alpha.: Scand J Immunol. 1994 Apr;39(4):380-6. Unique Identifier : AIDSLINE MED/94196298; Wolday D; Akuffo H; Britton S; Hathaway A; Sander B; Department of Medical Microbiology and Parasitology, Addis Ababa; University, Faculty of Medicine, Ethiopia.; The immune response of normal human peripheral blood mononuclear cells (PBMC) after stimulation with human immunodeficiency virus-1 (HIV-1) antigens plus Leishmania donovani promastigotes in vitro was investigated. HIV-1-antigen stimulation of PBMC did not induce the intracellular accumulation of interleukin-6 (IL-6),
Socio-geographical patterns of HIV-1 transmission in Kagera Region, Tanzania.: Soc Sci Med. 1994 Jan;38(1):129-34. Unique Identifier : AIDSLINE MED/94196408; Killewo J; Dahlgren L; Sandstrom A; Department of Epidemiology and Biostatistics, Muhimbili; University College of Health Sciences, Dar es Salaam, Tanzania.; A population-based study on the prevalence of HIV-1 infection in the Kagera region was performed in 1987. The study was based on a multistage cluster sampling technique covering the age-group 15-54 years. The study showed considerable variation of prevalence of HIV-1 infection in the areas studied. A total of 2475 adu
Knowledge and meaning: the AIDS education campaign in rural northeast Thailand.: Soc Sci Med. 1994 Jan;38(1):135-46. Unique Identifier : AIDSLINE MED/94196409; Lyttleton C; Department of Anthropology, Sydney University, NSW, Australia.; Nearly 80% of Thailand s population live in the rural sector. To date, these villages have been subject to top-down dissemination of HIV/AIDS education information via the mass media and bureaucratic networks. This report details an ethnographic enquiry into the impact education campaigns are having in one village in
Growth models and the HIV epidemic in Finland.: Soc Sci Med. 1994 Jan;38(1):179-85. Unique Identifier : AIDSLINE MED/94196415; Loytonen M; Department of Geography, University of Helsinki, Finland.; Today, we know a lot about HIV and AIDS, yet too little to be able to stop the pandemic by a vaccination or by medication. Until that day is at hand, the only means of controlling the pandemic is by information--information about the diffusion of the virus, about risk behaviour, about safe sex, and about social respon
The relevance of drug injectors' social and risk networks for understanding and preventing HIV infection.: Soc Sci Med. 1994 Jan;38(1):67-78. Unique Identifier : AIDSLINE MED/94196423; Neaigus A; Friedman SR; Curtis R; Des Jarlais DC; Furst RT; Jose B; Mota P; Stepherson B; Sufian M; Ward T; et al; National Development and Research Institutes, Inc., New York City; 10013.; Focusing on the social environment as well as the individual should both enhance our understanding of HIV transmission and assist in the development of more effective prevention programs. Networks are an important aspect of drug injectors social environment. We distinguish between (1) risk networks (the people among
Social networks and infectious disease: the Colorado Springs Study.: Soc Sci Med. 1994 Jan;38(1):79-88. Unique Identifier : AIDSLINE MED/94196424; Klovdahl AS; Potterat JJ; Woodhouse DE; Muth JB; Muth SQ; Darrow WW; Australian National University, Canberra.; The social network paradigm provides a set of concepts and methods useful for studying the structure of a population through which infectious agents transmitted during close personal contact spread, and an opportunity to develop improved disease control programs. The research discussed was a first attempt to use a soc
Epidemiologic comparison of human T-lymphotropic virus type I-infected blood donors from endemic and nonendemic regions over a 3-year period.: Transfusion. 1994 Mar;34(3):198-201. Unique Identifier : AIDSLINE MED/94196615; Massari V; Elghouzzi MH; Agis F; Rannou C; Gordien E; Costagliola D; Lefrere JJ; Faculte de Medecine Saint-Antoine, Institut National de; Transfusion Sanguine, Paris, France.; BACKGROUND: Screening for human T-lymphotropic virus type I (HTLV-I) infection became systematic in 1989 in the French West Indies for blood from all donors and in France for blood from natives of endemic areas; in 1990, it was extended to blood from donors with at-risk sex partner
Fatal disseminated intravascular coagulation and pulmonary thrombosis following blood transfusion in a patient with severe autoimmune hemolytic anemia and human immunodeficiency virus infection.: Transfusion. 1994 Mar;34(3):248-52. Unique Identifier : AIDSLINE MED/94196624; Bilgrami S; Cable R; Pisciotto P; Rowland F; Greenberg B; Division of Hematology-Oncology, University of Connecticut Health; Center, Farmington.; BACKGROUND: Autoimmune hemolytic anemia (AIHA) has rarely been reported in association with human immunodeficiency (HIV) infection and never as a presenting manifestation. Similarly, disseminated intravascular coagulation (DIC) is a very infrequent complication of HIV infection. CASE REPORT: An unusual patient is desc
Evaluation of different supplementary assays for the confirmation of HIV-1 and HIV-2 infections [letter]: Vox Sang. 1994;66(1):82-3. Unique Identifier : AIDSLINE MED/94196743; Soriano V; Gutierrez M; Heredia A; Bravo R; Hewlett I; Gonzalez-Lahoz J
Economic donor screening for anti-HIV in the developing world [letter] [see comments]: Vox Sang. 1994;66(1):88. Unique Identifier : AIDSLINE MED/94196746; Mortimer PP; Parry JV
[What is the future of antiviral therapy of HIV-infected patients? Reports of results of antiretroviral therapy studies at the IX. World Congress on AIDS in Berlin]: Z Arztl Fortbild (Jena). 1993 Dec 12;87(12):925-6. Unique Identifier : AIDSLINE MED/94196758; Baumgarten R; II. Innere Abteilung/Infektion, Krankenhaus Prenzlauer Berg.
Cytotoxic T lymphocyte response in mice induced by a recombinant BCG vaccination which produces an extracellular alpha antigen that fused with the human immunodeficiency virus type 1 envelope immunodominant domain in the V3 loop.: Vaccine. 1994 Feb;12(2):153-8. Unique Identifier : AIDSLINE MED/94196861; Kameoka M; Nishino Y; Matsuo K; Ohara N; Kimura T; Yamazaki A; Yamada T; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.; The host immune response of cell-mediated immunity, particularly that of cytotoxic T lymphocytes (CTLs), is a major immune defence mechanism which may provide resistance to a human immunodeficiency virus type 1 (HIV-1) spread leading to acquired immune deficiency syndrome (AIDS). To prevent the accompanying activity o
Vertically transmitted HIV infection: how representative are data from a voluntary registry? Pediatric AIDS Group of Switzerland (PAGS).: Soz Praventivmed. 1994;39(1):39-40. Unique Identifier : AIDSLINE MED/94196881; Kind C; Neonatologie, Frauenklinik, Kantonsspital, St. Gallen.
Predominantly gastrointestinal symptoms and signs in 11 consecutive AIDS patients with gastrointestinal lymphoma: a multicenter, multiyear study including 763 HIV-seropositive patients.: Am J Gastroenterol. 1994 Apr;89(4):545-9. Unique Identifier : AIDSLINE MED/94197157; Cappell MS; Botros N; Department of Medicine, UMDNJ-Robert Wood Johnson Medical School,; New Brunswick.; OBJECTIVES: Gastrointestinal lymphoma is a distinct subgroup of lymphoma in HIV-seronegative patients. This study analyzes whether gastrointestinal lymphoma similarly forms a distinct clinical subgroup in HIV-seropositive patients. METHODS: Case control study of medical records of 763 human immunodeficiency virus-sero
Idiopathic anorectal ulceration in patients with human immunodeficiency virus infection.: Am J Gastroenterol. 1994 Apr;89(4):599-604. Unique Identifier : AIDSLINE MED/94197166; Wilcox CM; Schwartz DA; Department of Medicine, Emory University School of Medicine,; Atlanta, Georgia.; Opportunistic infections and neoplasms of the anorectum have been reported in patients with human immunodeficiency virus (HIV) infection. More recently, idiopathic ulcerative lesions of the colon and rectum have been described. At our center over a 3-yr period, four patients were identified with ulcerative lesions of
Microsporidia in HIV diarrhea: present but pathogenic?: Am J Gastroenterol. 1994 Apr;89(4):636-8. Unique Identifier : AIDSLINE MED/94197178; Simon D; Bronx Municipal Hospital Center, Albert Einstein College of; Medicine, NY.
Depressive distress among homosexually active African American men and women.: Am J Psychiatry. 1994 Apr;151(4):524-9. Unique Identifier : AIDSLINE MED/94197254; Cochran SD; Mays VM; California State University, Northridge.; OBJECTIVE: Although early surveys of psychological adjustment among gay men and lesbians suggest only minor and not clinically relevant differences from heterosexual populations, concerns about psychiatric morbidity associated with HIV infection have renewed interest in the prevalence of psychological distress in this
Policy guideline on clean needle and syringe exchange.: Am J Psychiatry. 1994 Apr;151(4):631. Unique Identifier : AIDSLINE MED/94197292
Position statement on HIV infection and psychiatric hospitalization of children and adolescents.: Am J Psychiatry. 1994 Apr;151(4):631. Unique Identifier : AIDSLINE MED/94197293
Pathology of patients with Chagas' disease and acquired immunodeficiency syndrome.: Am J Trop Med Hyg. 1994 Mar;50(3):261-8. Unique Identifier : AIDSLINE MED/94197294; Rocha A; de Meneses AC; da Silva AM; Ferreira MS; Nishioka SA; Burgarelli MK; Almeida E; Turcato Junior G; Metz K; Lopes ER; Centro de Ciencias Biomedicas, Universidade Federal de; Uberlandia, Minas Gerais, Brazil.; The main pathologic findings in 23 patients with acquired immunodeficiency syndrome (AIDS) and Chagas disease are reviewed; five are from our own experience and 18 from the literature. The presence of Trypanosoma cruzi parasites and/or T. cruzi antibodies in blood and cerebrospinal fluid was recorded and computerized
Nurses' knowledge, attitudes about HIV, AIDS. A replication study.: AORN J. 1994 Feb;59(2):450-66. Unique Identifier : AIDSLINE MED/94197418; Reeder JM; Hamblet JL; Killen AR; King CA; Uruburu A; Nursing Research Service, Walter Reed Army Medical Center,; Washington, DC.; The AIDS epidemic is now in its second decade and shows no sign of relenting. Unfortunately, however, the AORN study shows that perioperative nurses knowledge regarding HIV and AIDS is not adequate to enable them to provide patient care while maintaining safe practices. Focused educational programs should be made ava
HIV patients have good surgery outcomes [news]: AORN J. 1994 Feb;59(2):530. Unique Identifier : AIDSLINE MED/94197427
Blood contact during open heart operations: reducing the risk [letter]: Ann Thorac Surg. 1994 Mar;57(3):785-6. Unique Identifier : AIDSLINE MED/94197504; Noera G
Evidence of intraprison spread of HIV infection.: Arch Intern Med. 1994 Apr 11;154(7):793-5. Unique Identifier : AIDSLINE MED/94197515; Mutter RC; Grimes RM; Labarthe D; State of Florida Correctional Medical Authority, Tallahassee.; BACKGROUND: Individuals entering prison are known to have high rates of human immunodeficiency virus (HIV) infection, and inmates are known to engage in high-risk behavior. This suggests the potential for intraprison spread of HIV infection, but this has not been documented. METHODS: All prisoners (N = 556) in the Flo
HTLV-1 and myelopathy in Salvador (northeastern Brazil): a case control study.: Arq Neuropsiquiatr. 1993 Dec;51(4):447-51. Unique Identifier : AIDSLINE MED/94197580; Lessa I; Moraes D; Moura L; Melo A; Department of Preventive Medicine, Federal University of Bahia; (UFBA), Salvador, Brasil.; The principal aim of the study was to determine the degree of association between cerebrospinal fluid (CSF) that is positive for HTLV-1 and myelopathy in Salvador, Brazil . From the same hospital, twenty-eight cases of myelopathy and twenty-eight cases showing no neurological disord
Involuntary movements and AIDS: report of seven cases and review of the literature.: Arq Neuropsiquiatr. 1993 Dec;51(4):491-7. Unique Identifier : AIDSLINE MED/94197587; De Mattos JP; Rosso AL; Correa RB; Novis S; Servico de Neurologia, Hospital Universitario Clementino Fraga; Filho, (HUCFF). Universidade Federal do Rio de Janeiro (UFRJ),; Brasil.; We studied 1086 AIDS patients in the last six years. Of these 389 (35.82%) had neurological manifestation and 7 (1.8%) male patients had abnormal involuntary movements (parkinsonism in 3, hemichorea-hemiballism in 2, spinal myoclonus in 1 and rubral tremor in another). All patients were men, 5 white and 2 black. Four
Anal lymphoma presenting as a perianal abscess.: Aust N Z J Surg. 1994 Apr;64(4):279-81. Unique Identifier : AIDSLINE MED/94197624; Porter AJ; Meagher AP; Sweeney JL; Department of Colorectal Surgery, Royal Adelaide Hospital,; Australia.; A case of perianal abscess secondary to anal lymphoma affecting a human immunodeficiency virus negative patient is presented. Causes of perianal abscess other than anal glandular infection are important, although the proportion of abscesses reported to be secondary to these other causes is found to vary widely in the
New evidence for involvement of retroviruses in Sjogren's syndrome and other autoimmune diseases [editorial]: Arthritis Rheum. 1994 Apr;37(4):465-9. Unique Identifier : AIDSLINE MED/94197778; Garry RF
Expression of sequences homologous to HTLV-I tax gene in the labial salivary glands of Japanese patients with Sjogren's syndrome.: Arthritis Rheum. 1994 Apr;37(4):545-50. Unique Identifier : AIDSLINE MED/94197788; Sumida T; Yonaha F; Maeda T; Kita Y; Iwamoto I; Koike T; Yoshida S; Second Department of Internal Medicine, School of Medicine, Chiba; University, Japan.; OBJECTIVE. To address the question of whether the human T cell leukemia virus type I (HTLV-I) gene is associated with the etiology of Sjogren s syndrome (SS). METHODS. RNA expression of HTLV-I gag, pol, env, and tax genes in labial salivary glands (LSGs) from SS patients who were seronegative for antibodies to HTLV-I
Determination of the blood lactate:pyruvate ratio as a noninvasive test for the diagnosis of zidovudine myopathy.: Arthritis Rheum. 1994 Apr;37(4):583-6. Unique Identifier : AIDSLINE MED/94197794; Chariot P; Monnet I; Mouchet M; Rohr M; Lefaucheur JP; Dubreuil-Lemaire ML; Chousterman M; Gherardi R; Departement de Pathologie (Neuropathologie), Hopital Henri; Mondor, Creteil, France.; OBJECTIVE. To evaluate the use of the lactate: pyruvate ratio as a test for the detection of zidovudine myopathy. METHODS. Twenty consecutive human immunodeficiency virus-infected patients with muscle involvement and 20 without muscle involvement were studied prospectively. Blood lactate and pyruvate levels and serum
HIV educational interventions with low risk groups.: AAOHN J. 1994 Mar;42(3):138-40. Unique Identifier : AIDSLINE MED/94197850; Hogan MM
Effects of preactivated MC540 in the treatment of lymphocytic plasmacytic stomatitis in feline leukemia virus and feline immunodeficiency virus positive cats.: J Vet Dent. 1993 Mar;10(1):9-13. Unique Identifier : AIDSLINE MED/94197954; Wiggs RB; Lobprise HB; Matthews JL; Gulliya KS; Department of Physiology, Baylor College of Dentistry, Dallas,; Texas.; Photoactive compounds and drugs are used therapeutically as antibacterial, antiviral and antitumor agents. This report examines the use of a photoactive compound, preactivated merocyanine 540 (pMC540), in the treatment of stomatitis in two cats that are both feline immunodeficiency virus (FIV) positive. One of the cat
Zidovudine pharmacokinetics in zidovudine-induced bone marrow toxicity.: Br J Clin Pharmacol. 1994 Jan;37(1):7-12. Unique Identifier : AIDSLINE MED/94198124; Barry M; Howe JL; Back DJ; Swart AM; Breckenridge AM; Weller IV; Beeching N; Nye F; Department of Pharmacology and Therapeutics, University of; Liverpool.; 1. The major adverse effect of zidovudine (ZDV) is haematological toxicity which results in anaemia and granulocytopenia. The aim of the present study was to investigate if HIV-positive patients developing erythroid aplasia/hypoplasia are exposed to higher plasma concentrations of ZDV owing to impaired hepatic metabol
The UK's AIDS rate [news]: Nurs Stand. 1994 Jan 26-Feb 1;8(18):10. Unique Identifier : AIDSLINE MED/94198145
Psychosocial care of HIV-positive people.: Nurs Stand. 1994 Jan 26-Feb 1;8(18):37-40. Unique Identifier : AIDSLINE MED/94198150; Carlisle C; HIV-positive people continue to be faced with an array of social and personal prejudices, most of which are based on ignorance and fear. The author explores how such attitudes affect HIV-positive people, and offers advice to nurses on how they can help to establish more constructive relationships with these patients.
Epidermal Langerhans cells, HIV-1 infection and psoriasis.: Br J Dermatol. 1994 Mar;130(3):307-11. Unique Identifier : AIDSLINE MED/94198175; Zemelman V; Van Neer F; Roberts N; Patel P; Langtry J; Staughton RC; Skin and Therapeutics Research Laboratory, Chelsea and; Westminster Hospital, London, U.K.; Langerhans cells (LCs) subserve an important antigen-presenting function in the skin immune system. They bear CD4 receptors, which make them potential targets for infection with the human immunodeficiency virus (HIV-1). The observation of reduced numbers of LCs in the skin of patients with the acquired immunodeficienc
[Mechanism of transcriptional activation by HTLV-1 Tax]: Hum Cell. 1993 Dec;6(4):266-72. Unique Identifier : AIDSLINE MED/94198212; Fujisawa J; Hirai H; Suzuki T; Yoshida M; Department of Cellular and Molecular Biology, University of; Tokyo, Japan.; A trans-activator protein Tax of HTLV-1 activates the transcription of various cellular genes as well as viral promoter through the multiple enhancer elements and leads cells to the transformation. Tax protein interacts to enhancer DNA elements by associating with cellular enhancer binding proteins such as CREB, NF-ka
Retroviruses--a clue to autoimmunity? [editorial; comment]: Br J Ophthalmol. 1994 Mar;78(3):161-2. Unique Identifier : AIDSLINE MED/94198239; Towler H
Human T lymphotropic virus type 1 uveitis after Graves' disease [see comments]: Br J Ophthalmol. 1994 Mar;78(3):163-6. Unique Identifier : AIDSLINE MED/94198241; Yamaguchi K; Mochizuki M; Watanabe T; Yoshimura K; Shirao M; Araki S; Miyata N; Mori S; Kiyokawa T; Takatsuki K; Blood Transfusion Service, Kumamoto University Medical School,; Japan.; A distinct clinical entity of uveitis associated with human T lymphotropic virus type 1 (HTLV-I) has been reported previously. During the period between January 1989 and April 1992, 93 patients were observed with HTLV-I uveitis and a significant correlation was found between Graves disease and HTLV-I uveitis. Sixteen
Time-course detection of HIV-1 proviral DNA and genomic RNA by polymerase chain reaction in sera from seropositive and seronegative hemophiliacs treated with clotting factor concentrates.: Int J Hematol. 1993 Oct;58(3):225-32. Unique Identifier : AIDSLINE MED/94198435; Morita T; Kawabata H; Yanagihara Y; Horikoshi Y; Mimaya J; Laboratory of Environmental Microbiology, Graduate School of; Nutritional and Environmental Sciences, University of Shizuoka,; Japan.; The detection of HIV-1 proviral DNA and genomic RNA was performed by polymerase chain reaction (PCR) in hemophiliacs treated with non-heated clotting factor concentrates. Reamplification with double PCR was performed on those samples that were negative for single PCR. Primer pairs of the gag, env, and pol regions were
Self-report of symptoms and neuropsychological performance in asymptomatic HIV-positive individuals.: J Neuropsychiatry Clin Neurosci. 1994 Winter;6(1):43-9. Unique Identifier : AIDSLINE MED/94198582; Beason-Hazen S; Nasrallah HA; Bornstein RA; Department of Psychiatry, Ohio State University, Columbus 43210.; This study examined the relationship between subjective complaints and neuropsychological performance in 133 HIV-positive asymptomatic and 80 HIV-negative gay or bisexual men. Presence and duration of self-reported symptoms were most strongly related to measures of information processing and reaction time. These relat
Homophobia among doctors [see comments]: BMJ. 1994 Feb 26;308(6928):586-7. Unique Identifier : AIDSLINE MED/94198673; Rose L; Foundation for AIDS Counselling, Treatment and Support, London.; Homophobia creates stress for gay men and women. An interview study of 28 doctors, 20 gay and eight non-gay, was performed to assess whether homophobia is strong among the medical profession, the stress it causes, and whether the advent of AIDS and HIV infection has increased the stress. The doctors, recruited by word
Zidovudine could cut transmission of HIV by mothers [news]: BMJ. 1994 Mar 5;308(6929):614. Unique Identifier : AIDSLINE MED/94198698; Roberts J
Gulf states test foreigners for AIDS [news]: BMJ. 1994 Mar 5;308(6929):617. Unique Identifier : AIDSLINE MED/94198699; Kandela P
Prevalence of HIV infection in patients attending an inner city accident and emergency department [see comments]: BMJ. 1994 Mar 5;308(6929):636. Unique Identifier : AIDSLINE MED/94198705; Poznansky MC; Torkington J; Turner G; Bankes MJ; Parry JV; Connell JA; Touquet R; Weber J; Department of Accident and Emergency Medicine, St Mary's; Hospital, London.
HIV risk-taking behaviour among amphetamine users in Sydney, Australia.: Addiction. 1994 Jan;89(1):79-85. Unique Identifier : AIDSLINE MED/94198745; Hando J; Hall W; National Drug and Alcohol Research Centre, University of New; South Wales, Kensington, Australia.; A survey was undertaken of needle-sharing and sexually risky behaviour among 231 Australian amphetamine users, half of whom usually injected amphetamine. The prevalence of risky needle use and sexual behaviour was similar to that observed in recent Australian surveys of opioid injectors. About a third of those who had
Gender differences in needle sharing behaviour patterns [letter; comment]: Addiction. 1994 Jan;89(1):96-7. Unique Identifier : AIDSLINE MED/94198749; Smyth B; Keenan E; Dorman A; O'Connor JJ
Do female injectors under-utilize needle exchanges? [letter; comment]: Addiction. 1994 Jan;89(1):97-8. Unique Identifier : AIDSLINE MED/94198750; Elliott L; Gruer L; Farrow K; Cameron J
Three cluster outbreaks of tuberculosis in British Columbia.: Can Commun Dis Rep. 1994 Jan 15;20(1):1-3. Unique Identifier : AIDSLINE MED/94198793; FitzGerald JM; Division of TB Control, BC Centre for Disease Control, Ministry; of Health, Vancouver.
Control of tuberculosis transmission in health care settings. A joint statement of the WHO tuberculosis programme and the International Union Against Tuberculosis and Lung Disease (IUATLD).: Can Commun Dis Rep. 1994 Jan 15;20(1):3-5. Unique Identifier : AIDSLINE MED/94198794
Providing health services for the homeless: a stitch in time.: Bull N Y Acad Med. 1993 Winter;70(3):146-70. Unique Identifier : AIDSLINE MED/94198851; Brickner PW; McAdam JM; Torres RA; Vicic WJ; Conanan BA; Detrano T; Piantieri O; Scanlan B; Scharer LK; Department of Community Medicine, St. Vincent's Hospital, New; York, NY 10011.
Fire and ice [editorial]: Arch Pediatr Adolesc Med. 1994 Apr;148(4):347-8. Unique Identifier : AIDSLINE MED/94198972; Joffe A
Cytomegalovirus and latency: an overview.: Virchows Arch B Cell Pathol Incl Mol Pathol. 1993;64(6):325-33. Unique Identifier : AIDSLINE MED/94198993; Bruggeman CA; Department of Medical Microbiology, University of; Limburg/University Hospital, The Netherlands.; Cytomegalovirus ( CMV ) is a member of the herpes virus group. Infection results in a variety of disorders which depend largely on the immune status of the host. A well known property of CMV is that after primary infection the virus persists in the body of the hos
Mood and psychiatric disturbance in HIV and AIDS: changes over time.: Br J Psychiatry. 1993 May;162:604-10. Unique Identifier : AIDSLINE MED/94199261; Fell M; Newman S; Herns M; Durrance P; Manji H; Connolly S; McAllister R; Weller I; Harrison M; Department of Academic Psychiatry, University College and; Middlesex School of Medicine, Middlesex Hospital, London.; A sample of 26 HIV seronegative, 59 HIV seropositive asymptomatic and 7 HIV seropositive symptomatic homosexual and bisexual men were assessed over two visits, a mean of 11 months apart, using the BDI, STAI, and CIS. Significant differences emerged between the symptomatic group and the other two groups. Past psychiatr
Kaposi's sarcoma of the testis.: Br J Urol. 1993 Jul;72(1):116-7. Unique Identifier : AIDSLINE MED/94199315; Kneale BJ; Bishop NL; Britton JP; Department of Medicine, Sussex County Hospital, Brighton.
Alcohol, AIDS and immunity.: Br Med Bull. 1994 Jan;50(1):115-23. Unique Identifier : AIDSLINE MED/94199349; McManus TJ; Weatherburn P; Department of Genito-Urinary Medicine, King's Health Care,; London.; In order to understand the potential impact of alcohol consumption on the course of the HIV/AIDS pandemic we examine at least 3 very different debates. In an attempt to summarise these debates we assess the impact of alcohol consumption on numerous aspects of HIV infection, including the relationship between alcohol u
Alcohol misuse as challenge to medical education: a belated remedy.: Br Med Bull. 1994 Jan;50(1):164-70. Unique Identifier : AIDSLINE MED/94199353; Glass-Crome IB; National Addiction Centre, Institute of Psychiatry, University of; London, UK.; Substance misuse contributes directly or indirectly to each of the 5 key targets outlined in the Health of the Nation strategy: coronary heart disease and stroke, cancers, mental illness, HIV/AIDS and accidents. More specifically, the risk factor targets include a 30% reduction in the prevalence of cigarette smoking t
[Role of surgical visceral manifestations in the natural history of the acquired immunodeficiency syndrome in adults]: Bull Acad Natl Med. 1993 Oct;177(7):1165-82; discussion 1183-4. Unique Identifier : AIDSLINE MED/94199435; Arsac M; Universite Paris V.; The surgical effects of AIDS in adults are rather frequent. On the basis of 74 cases, from 1985 to 1992, that we have studied clinically, by imaging procedures, biology, previous and long term follow-up, we have tried to set up the place of these effects in the natural history of the disease. The infectious complicati
[Modes of management of people infected with human immunodeficiency virus (HIV)]: Bull Acad Natl Med. 1993 Oct;177(7):1187-200. Unique Identifier : AIDSLINE MED/94199436; Frottier J
[AIDS and drug addiction in the prison environment]: Bull Acad Natl Med. 1993 Oct;177(7):1275-83. Unique Identifier : AIDSLINE MED/94199442; Gentilini M; Chieze F
Risk of HTLV-I infection in Japanese women who are last in birth order [letter]: Cancer Lett. 1994 Jan 30;76(2-3):191-5. Unique Identifier : AIDSLINE MED/94199533; Umemoto M; Take H; Kusuhara K; Kuraya K; The percentage of last-born women among pregnant women who were seropositive for human T-lymphotropic virus type I (HTLV-I) significantly exceeded that among HTLV-I seronegative women (119/258 (46.1%): 89/251 (35.4%); P
Keratoconjunctivitis sicca in female patients infected with human immunodeficiency virus.: CLAO J. 1994 Jan;20(1):49-51. Unique Identifier : AIDSLINE MED/94199778; Lucca JA; Kung JS; Farris RL; Department of Ophthalmology, Columbia University, New York, NY.; We recently reported keratoconjunctivitis sicca (KCS) occurring as a single entity in approximately 20% of male patients testing positive for human immunodeficiency virus (HIV). In a subsequent study of HIV-positive females (n = 59; age range: 23 to 42 years), ten were found to have clinical signs and symptoms of KCS.
Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID).: Clin Exp Immunol. 1994 Apr;96(1):48-53. Unique Identifier : AIDSLINE MED/94199887; Stagg AJ; Funauchi M; Knight SC; Webster AD; Farrant J; Antigen Presentation Group, Clinical Research Centre, Harrow, UK.; Antigen-driven responses by T cells from patients with CVID and normal subjects have been assessed. Low-density cells enriched for antigen-presenting dendritic cells were cultured with T cells using a 20-microliters hanging drop system. T cells from all subgroups of CVID patients showed markedly reduced responses to t
Increased levels of interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) mRNA expressing blood mononuclear cells in human HIV infection.: Clin Exp Immunol. 1994 Apr;96(1):59-63. Unique Identifier : AIDSLINE MED/94199889; Navikas V; Link J; Wahren B; Persson C; Link H; Department of Neurology, Huddinge Hospital, Stockholm, Sweden.; Evidence has been presented for the involvement of IFN-gamma, IL-4 and TGF-beta in AIDS. Measured plasma levels may, however, poorly reflect in vivo production, since cytokines act auto- and paracrinally and have very short half life in plasma. In situ hybridization with complementary DNA oligonucleotide probes was us
The significance of the pre-challenge immune status of mice for development of retrovirus-induced immunodeficiency syndrome (MAIDS).: Clin Exp Immunol. 1994 Apr;96(1):64-8. Unique Identifier : AIDSLINE MED/94199890; Pavlovitch JH; Rizk-Rabin M; Picard F; Marussig M; Halbreich A; CNRS URA 583, Hopital Necker, Paris, France.; The effects of vaccination with RNA-free viral pseudoparticles, preinfection with non-pathogenic ecotropic virus, and induction of tolerance to viral proteins in newborns on the outcome of murine immunodeficiency syndrome (MAIDS) were studied. The parameters used to follow disease progression were: lymphopenia, circul
The HIV mental health spectrum.: Community Ment Health J. 1994 Feb;30(1):75-89; discussion 91-4. Unique Identifier : AIDSLINE MED/94199950; Knox MD; Davis M; Friedrich MA; Department of Community Mental Health, University of South; Florida, Tampa 33612-3899.; The growing mental health needs that are related to HIV are immense and diverse. The HIV mental health spectrum is a model that identifies and characterizes populations in need of HIV-related services which can be offered by Community Mental Health Centers. The spectrum describes the specialized service requirements f
The oral effects of AIDS.: Dent Teamwork. 1993 Jul-Aug;6(4):16-21. Unique Identifier : AIDSLINE MED/94200106; Chiodo GT; Rosenstein DI; Dept. of Public Health Dentistry, Oregon Health Sciences; University School of Dentistry.
The occurrence of enzootic bovine leukosis (EBL) in Namibia--an epidemiological study.: DTW Dtsch Tierarztl Wochenschr. 1994 Feb;101(2):66-7. Unique Identifier : AIDSLINE MED/94200150; Kaura HT; Hubschle OJ; Central Veterinary Laboratory, Windhoek, Namibia.; A seroepidemiological survey for antibodies to bovine leukemia virus (BLV) (synonymous with bovine C-type and bovine leukosis virus) in cattle in Namibia was performed. A BLV glycoprotein antigen was used in an enzyme-linked immunosorbent assay (ELISA). In 410 (12.3%) out of a tot
Engagement of the CD4 receptor inhibits the interleukin-2-dependent proliferation of human T cells transformed by Herpesvirus saimiri [published erratum appears in Eur J Immunol 1994 Jul;24(7):1727]: Eur J Immunol. 1994 Apr;24(4):843-50. Unique Identifier : AIDSLINE MED/94200220; Broker BM; Tsygankov AY; Fickenscher H; Chitaev NA; Muller-Fleckenstein I; Fleckenstein B; Bolen JB; Emmrich F; Schulze-Koops H; Department of Molecular Biology, Bristol-Myers Squibb; Pharmaceutical Research Institute, Princeton.; Infection with Herpesvirus saimiri, a tumor virus of non-human primates, transformed human CD4+ T cell clones to permanent interleukin (IL)-2-dependent growth without need for restimulation with antigen and accessory cells. The IL-2-dependent proliferation of these cells was dramatically inhibited by soluble anti-CD4
A fungal metabolite which inhibits the interaction of CD4 with major histocompatibility complex-encoded class II molecules.: Eur J Immunol. 1994 Apr;24(4):991-8. Unique Identifier : AIDSLINE MED/94200241; Gammon G; Chandler G; Depledge P; Elcock C; Wrigley S; Moore J; Cammarota G; Sinigaglia F; Moore M; Department of Molecular Sciences, Xenova Ltd, Slough, Berks, GB.; CD4, a cell-surface glycoprotein expressed on a subpopulation of T cells, is the receptor for class II molecules of the major histocompatibility complex (MHC II) and a receptor for the envelope glycoprotein (gp 120) of human immunodeficiency virus-1 (HIV-1). Screening of microbial metabolites for CD4-binding activity
The diagnosis of toxoplasmosis using IgG avidity.: Epidemiol Infect. 1994 Apr;112(2):399-408. Unique Identifier : AIDSLINE MED/94200304; Holliman RE; Raymond R; Renton N; Johnson JD; PHLS Toxoplasma Reference Unit, St George's Hospital, London.; Current methods to establish the duration of toxoplasma infection in pregnant women and for the diagnosis of toxoplasmosis in the neonate or HIV infected patient have significant limitations. We assessed the precision of a commercial ELISA for the detection of toxoplasma specific IgG and adapted the assay to measure a
Risk factors for severe disease due to Toxoplasma gondii in HIV-positive patients.: Eur J Epidemiol. 1993 Nov;9(6):633-7. Unique Identifier : AIDSLINE MED/94200365; Stellbrink HJ; Fuhrer-Burow R; Raedler A; Albrecht H; Fenske S; Medizinische Klinik, Universitatskrankenhaus Eppendorf, Hamburg,; Federal Republic of Germany.; The objective of this study was to assess the risk of toxoplasmosis in HIV-positive subjects as a basis for primary prophylaxis. A retrospective chart review of 400 consecutive patients was carried out and clinical and laboratory markers at first presentation and follow-up data on the occurrence of toxoplasmosis were
An emerging opportunistic infection in HIV patients: a retrospective analysis of 11 cases of pulmonary aspergillosis.: Eur J Epidemiol. 1993 Nov;9(6):638-44. Unique Identifier : AIDSLINE MED/94200366; Tumbarello M; Ventura G; Caldarola G; Morace G; Cauda R; Ortona L; Istituto di Clinica Malattie Infettive Universita Cattolica S.; Cuore, Largo A. Gemelli, Rome, Italy.; Invasive pulmonary aspergillosis usually occurs in patients with severe granulocytopenia or defects of cell-mediated immunity secondary to cytotoxic chemotherapy or high-dose corticosteroids, but it is an unusual opportunistic infection in patients with AIDS. Eleven cases of Aspergillus pulmonary disease were diagnose
Declining prevalence of HIV infection among injecting drug users entering drug treatment in Italy: 1990-1991.: Eur J Epidemiol. 1993 Nov;9(6):663-6. Unique Identifier : AIDSLINE MED/94200370; Rezza G; De Rose A; Dorrucci M; Arpino C; Serafin I; AIDS Unit, Istituto Superiore di Sanita, Rome, Italy.; Two surveys were conducted in 1990 and 1991 in order to estimate the prevalence of HIV infection among injecting drug users attending drug treatment centers throughout Italy . Among the 35,073 IDUs attending these facilities in 1990, 32.1% were HIV-positive. In 1991, 29.7% of 41,794
Responding to inquisitive patients.: Dent Econ. 1993 Nov;83(11):27-8, 30, 32. Unique Identifier : AIDSLINE MED/94200454; Westman RP
[Management of AIDS patients in general practice. Confidentiality--alternative therapy]: Fortschr Med. 1994 Feb 10;112(4):18, 20. Unique Identifier : AIDSLINE MED/94200721; Roth R
Systemic lymphadenopathic histology in human immunodeficiency virus-1-seropositive drug addicts without apparent acquired immunodeficiency syndrome.: Hum Pathol. 1994 Mar;25(3):248-56. Unique Identifier : AIDSLINE MED/94200785; Burke AP; Anderson D; Mannan P; Ribas JL; Liang YH; Smialek J; Virmani R; Department of Cardiovascular Pathology, Armed Forces Institute of; Pathology, Washington, DC.; We examined lymph nodes from multiple sites in 50 individuals infected with human immunodeficiency virus (HIV-1) who died accidentally of drug overdoses and in whom there was no evidence of opportunistic infection. The size, histologic pattern, presence of Warthin-Finkeldey-type giant cells, and estimation of CD4 cell
3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity.: J Antibiot (Tokyo). 1994 Feb;47(2):136-42. Unique Identifier : AIDSLINE MED/94201091; Roggo BE; Petersen F; Delmendo R; Jenny HB; Peter HH; Roesel J; Biotechnology Research Laboratories, CIBA-GEIGY Limited, Basel,; Switzerland.; In the course of a screening program for HIV-1 protease inhibiting activity, six new homologues of 3-alkanoyl-5-hydroxymethyl tetronic acids (1 approximately 6) and the known natural product resistomycin (7) were isolated from cultures of the Actinomycete strain DSM 7357. The substituted tetronic acids belong to a rec
3-Alkanoyl-5-hydroxymethyl tetronic acid homologues: new inhibitors of HIV-1 protease. II. Structure determination.: J Antibiot (Tokyo). 1994 Feb;47(2):143-7. Unique Identifier : AIDSLINE MED/94201092; Roggo BE; Hug P; Moss S; Raschdorf F; Peter HH; Biotechnology Research Laboratories, CIBA-GEIGY Limited, Basel,; Switzerland.
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy [see comments]: J Bone Joint Surg Am. 1994 Apr;76(4):482-8. Unique Identifier : AIDSLINE MED/94201208; Rivard GE; Girard M; Belanger R; Jutras M; Guay JP; Marton D; Department of Pediatrics, Hopital Sainte-Justine, Montreal,; Quebec, Canada.; Between 1977 and 1992, we performed ninety-two synoviortheses (destruction of synovial tissue by intra-articular injection of a radioactive agent) on forty-eight patients who had a severe congenital disorder of hemostasis and chronic hemophilic synovitis that was resistant to conventional treatment. Colloidal 32P chro
Blood use in the burn unit: a possible role for erythropoietin.: J Burn Care Rehabil. 1994 Jan-Feb;15(1):37-41. Unique Identifier : AIDSLINE MED/94201234; Poletes GP; Miller SF; Finley RK; Lincks J; Department of Surgery, Wright State University School of; Medicine, Dayton, OH.; Recently, several of our patients have raised questions concerning the safety of blood transfusions and especially the transmission of human immunodeficiency virus infection. We have noticed a growing reluctance of patients to receive blood transfusions. This prompted us to review the use of blood in our burn unit for
Determination of 3'-amino-3'-deoxythymidine, a cytotoxic metabolite of 3'-azido-3'-deoxythymidine, in human plasma by ion-pair high-performance liquid chromatography.: J Chromatogr. 1993 Dec 22;622(2):235-42. Unique Identifier : AIDSLINE MED/94201280; Burger DM; Rosing H; Koopman FJ; Mennhorst PL; Mulder JW; Bult A; Beijnen JH; Department of Pharmacy, Slotervaart Hospital, Amsterdam,; Netherlands.; A sensitive high-performance liquid chromatographic assay has been developed to determine the levels of 3 -amino-3 -deoxythymidine (AMT), a cytotoxic metabolite of 3 -azido-3 -deoxy-thymidine ( AZT , zidovudine), in human plasma. The sample pretreatment
Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: application to acute retroviral infection.: J Clin Microbiol. 1994 Feb;32(2):292-300. Unique Identifier : AIDSLINE MED/94201349; Mulder J; McKinney N; Christopherson C; Sninsky J; Greenfield L; Kwok S; Department of Infectious Diseases, Roche Molecular Systems, Inc.,; Alameda, California 94501.; A method for quantitating human immunodeficiency virus type 1 plasma viremia may be useful in monitoring disease progression and the responsiveness of patients to a therapeutic regimen or vaccine. A quantitative assay for viral RNA in plasma or sera that differs in several aspects from those reported previously was de
Correlation between antibiotic resistance, phage-like particle presence, and virulence in Rhodococcus equi human isolates.: J Clin Microbiol. 1994 Feb;32(2):377-83. Unique Identifier : AIDSLINE MED/94201361; Nordmann P; Keller M; Espinasse F; Ronco E; Service de Microbiologie, Hopital Raymond Poincare, Faculte de; Medecine Paris-Ouest, Universite Paris 5, Garches, France.; Rhodococcus equi is a gram-positive coccobacillus that appears to be emerging as a pulmonary pathogen in AIDS patients. In four human clinical isolates, two antibiotic resistance phenotypes were found to coexist: one beta-lactam resistant and the other beta-lactam susceptible. In vitro, beta-lactam-resistant mutants w
Diagnosis of human immunodeficiency virus (HIV) infection: multicenter evaluation of a newly developed anti-HIV 1 and 2 enzyme immunoassay.: J Clin Microbiol. 1994 Feb;32(2):403-6. Unique Identifier : AIDSLINE MED/94201366; Hess G; Avillez F; Lourenco MH; D'Agostino F; Cambie G; Piot P; Vercauteren G; Michl U; Melchior W; Bayer H; Medizinische Klinik und Poliklinik, Klinikum der; Johannes-Gutenberg-Universitat, Mainz, Germany.; A new anti-human immunodeficiency virus type 1 and 2 (anti-HIV 1 and 2) test is described. It uses recombinant p24 and peptides covering gp32, gp41, and gp120 to identify HIV-1 and HIV-2 infections. This test has been shown to be specific (99.5%) and sensitive (99.8%). In this respect, the assay was equal or superior
Virulence of Rhodococcus equi isolates from patients with and without AIDS.: J Clin Microbiol. 1994 Feb;32(2):457-60. Unique Identifier : AIDSLINE MED/94201375; Takai S; Sasaki Y; Ikeda T; Uchida Y; Tsubaki S; Sekizaki T; Department of Animal Hygiene, School of Veterinary Medicine and; Animal Sciences, Kitasato University, Aomori, Japan.; Rhodococcus equi is an emerging opportunistic pathogen of human immunodeficiency virus-infected patients. Thirty-nine isolates of R. equi from immunocompromised patients with and without AIDS were analyzed for the presence of virulence plasmid DNA, expression of 15- to 17-kDa antigens, and their pathogenicities in mic
Loofah sponges as reservoirs and vehicles in the transmission of potentially pathogenic bacterial species to human skin.: J Clin Microbiol. 1994 Feb;32(2):469-72. Unique Identifier : AIDSLINE MED/94201378; Bottone EJ; Perez AA 2nd; Oeser JL; Clinical Microbiology Laboratories, Mount Sinai Hospital, New; York, New York 10029.; Loofah sponges are natural products used as exfoliative beauty aids. As a consequence of tracing a case of Pseudomonas aeruginosa folliculitis to a contaminated loofah sponge, we assessed the role of loofah sponges in supporting the growth of a wide variety of bacterial species. Our data show growth enhancement of ste
Microplate-based DNA hybridization assays for detection of human retroviral gene sequences.: J Clin Microbiol. 1994 Feb;32(2):547-50. Unique Identifier : AIDSLINE MED/94201396; Dyster LM; Abbott L; Bryz-Gornia V; Poiesz BJ; Papsidero LD; Cellular Products, Inc., Buffalo, New York 14202.; Nonisotopic, microwell-based DNA hybridization assays for the specific detection of human immunodeficiency virus type 1 (HIV-1) gag, human T-cell lymphotropic virus type I (HTLV-I) pol, and HTLV-II pol DNA sequences were evaluated. The performances of these detection kits (Gene Detective enzyme oligonucleotide assays;
Survival of human immunodeficiency virus in suspension and dried onto surfaces.: J Clin Microbiol. 1994 Feb;32(2):571-4. Unique Identifier : AIDSLINE MED/94201404; van Bueren J; Simpson RA; Jacobs P; Cookson BD; Laboratory of Hospital Infection, Central Public Health; Laboratory, London, England.; Cell-free and cell-associated human immunodeficiency virus cultures suspended in 10% serum remained infectious for several weeks at room temperature. The stability was further increased when cell-associated virus was suspended in neat serum. When dried onto a glass coverslip, virus remained infectious for several days
OSHA--authority over reason.: J Ala Dent Assoc. 1993 Winter;77(1):20-2. Unique Identifier : AIDSLINE MED/94201480; Carter SD
Lymphocyte infiltration and thickness of the nasal mucous membrane in perennial and seasonal allergic rhinitis.: J Allergy Clin Immunol. 1994 Mar;93(3):635-43. Unique Identifier : AIDSLINE MED/94201494; Calderon MA; Lozewicz S; Prior A; Jordan S; Trigg CJ; Davies RJ; Department of Respiratory Medicine and Allergy, St. Bartholomew's; Hospital, London, England.; We have used immunocytochemical techniques to study infiltration by lymphocytes in biopsy specimens of the nasal mucosal membrane in 24 atopic patients and 10 normal volunteers. Twelve patients had perennial rhinitis and 12 had seasonal allergic rhinitis (SR) to grass pollen. Biopsy specimens were taken both in and ou
Superinduction of mitogen-stimulated interferon-gamma production and other lymphokines by Sendai virus.: J Interferon Res. 1993 Dec;13(6):407-12. Unique Identifier : AIDSLINE MED/94201585; Costas MA; Mella D; Criscuolo M; Diaz A; Finkielman S; Nahmod VE; Arzt E; Instituto de Investigaciones Medicas, Facultad de Medicina,; Universidad de Buenos Aires, Argentina.; We observed that Sendai virus preinduction of peripheral blood mononuclear cells and subsequent mitogenic stimulation resulted in: (i) Superproduction of interferon-gamma, (IFN-gamma) (ii) an increase in interleukin-2 ( IL-2 ) synthesis that correlates with DNA synthesis
Vitamin E supplementation modulates cytokine production by thymocytes during murine AIDS.: Immunol Res. 1993;12(4):358-66. Unique Identifier : AIDSLINE MED/94201611; Wang Y; Huang DS; Watson RR; Department of Family and Community Medicine, University of; Arizona, Tucson 85724.; Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine AIDS, which is functionally similar to human AIDS. Retrovirus infection targeted the thymus, producing altered T cell differentiation via the dysregulation of thymocyte cytokine production. Human AIDS causes vitamin deficiencies, therefore the ef
HIV-1 infection as a risk factor for leprosy; a case-control study in Tanzania [see comments]: Int J Lepr Other Mycobact Dis. 1993 Dec;61(4):556-62. Unique Identifier : AIDSLINE MED/94201639; Borgdorff MW; van den Broek J; Chum HJ; Klokke AH; Graf P; Barongo LR; Newell JN; National Institute for Medical Research, Mwanza, Tanzania.; A case-control study was carried out in Tanzania to determine the relative risk of those with HIV-1 infection for getting leprosy. Cases were 93 consecutively diagnosed patients with leprosy aged 15-54 years from the Mwanza Region. Controls were a representative population sample
Infectious diseases in dentistry: answers to ten legal (or illegal?) questions.: J Mass Dent Soc. 1993 Spring;42(2):85-90. Unique Identifier : AIDSLINE MED/94201679; Logan MK
Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy.: J Intern Med. 1994 Apr;235(4):367-71. Unique Identifier : AIDSLINE MED/94201727; Bissuel F; Bruneel F; Habersetzer F; Chassard D; Cotte L; Chevallier M; Bernuau J; Lucet JC; Trepo C; Hepato-gastroenterology Second AIDS Unit, Hotel-Dieu Hospital,; Lyon, France.; We report two cases of fulminant hepatic failure in HIV-1-infected patients treated with didanosine (ddI). Clinical manifestations including vomiting, diarrhoea and dyspnoea were identical in both cases. Biological data mainly revealed hepatic failure and lactic acidosis. Histological examination of liver biopsies sho
Genomic variation of human immunodeficiency virus type 1 (HIV-1): molecular analyses of HIV-1 in sequential blood samples and various organs obtained at autopsy.: J Gen Virol. 1994 Apr;75 ( Pt 4): 67-79. Unique Identifier : AIDSLINE +; Ball JK; Holmes EC; Whitwell H; Desselberger U; Regional Virus Laboratory, East Birmingham Hospital, U.K.; Length polymorphisms and partial nucleotide sequences were determined for the hypervariable regions, V1 to V5, of the human immunodeficiency virus type 1 (HIV-1) env gene obtained from proviral DNA of sequential peripheral blood samples, from viral RNA in plasma, and from proviral DNA obtained from different organs of
Analysis of the human immunodeficiency virus type 1 envelope protein interaction with the CD4 host cell receptor.: J Gen Virol. 1994 Apr;75 ( Pt 4):839-47. Unique Identifier : AIDSLINE MED/94201759; Malvoisin E; Wild F; Institut Pasteur de Lyon, France.; A secreted form of human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp160s), expressed in HeLa cells from a vaccinia virus recombinant was analysed by velocity-gradient centrifugation and chemical cross-linking. We showed that gp160s existed predominantly as a dimer, but higher forms corresponding to
Correlation between high level gp160 expression and reduced CD4 biosynthesis in clonal derivatives of human immunodeficiency virus type 1-infected U-937 cells.: J Gen Virol. 1994 Apr;75 ( Pt 4):857-65. Unique Identifier : AIDSLINE MED/94201761; Geleziunas R; Bour S; Wainberg MA; McGill AIDS Centre, Lady Davis Institute-Jewish General Hospital,; Montreal, Canada.; We have compared cytoplasmic CD4 mRNA accumulation, CD4 biosynthesis and steady-state levels of both CD4 protein and mRNA in a variety of clonal derivatives of U-937 cells, chronically infected with human immunodeficiency virus type 1 IIIB (HIV-1), that express various cellular and viral phenotypes. These phenotypes i
The development of a Q-sort behavioral rating procedure for pediatric HIV patients.: J Pediatr Psychol. 1994 Feb;19(1):27-46. Unique Identifier : AIDSLINE MED/94201983; Moss HA; Brouwers P; Wolters PL; Wiener L; Hersh S; Pizzo PA; Pediatric Branch, National Cancer Institute, Bethesda, Maryland.; Developed a Q-sort procedure to assess social, emotional, and motivational behavior associated with central nervous system disease among 180 HIV-infected pediatric patients. These ratings were factor analyzed and scales were derived based on the factor structure. Younger (M age = 1.03 years) patients with HIV-associat
Preadolescents' perceptions of AIDS before and after Earvin Magic Johnson's announcement.: J Pediatr Psychol. 1994 Feb;19(1):3-17; discussion 19-26. Unique Identifier : AIDSLINE MED/94201984; Whalen CK; Henker B; O'Neil R; Hollingshead J; Holman A; Moore B; Department of Psychology and Social Behavior, University of; California, Irvine 92717.; Compared sixth graders AIDS concerns before and after Magic Johnson announced that he tested HIV-positive. Examined perceptions of self/other vulnerability (optimistic bias) using questionnaires (Study A) and interviews (Study B). Also examined AIDS worries mentioned in open-ended interviews (Study C). Studies A and
Adaptive behavior of children with symptomatic HIV infection before and after zidovudine therapy.: J Pediatr Psychol. 1994 Feb;19(1):47-61. Unique Identifier : AIDSLINE MED/94201985; Wolters PL; Brouwers P; Moss HA; Pizzo PA; Pediatric Branch, National Cancer Institute, Bethesda, Maryland; 20892.; Assessed longitudinally the effects of HIV infection and zidovudine on the adaptive behavior of 25 children with symptomatic disease (M age = 5.3 years; range = 1-12; 52% classified as encephalopathic) by parent report using the Vineland Adaptive Behavior Scales. Patients also were evaluated with an age-appropriate in
Clinical issues and therapeutic interventions in the care of pregnant women infected with the human immunodeficiency virus.: J Perinat Neonatal Nurs. 1994 Mar;7(4):13-30. Unique Identifier : AIDSLINE MED/94201998; Shannon M; As the incidence of human immunodeficiency virus (HIV) infection increases in women of reproductive age in the United States , clinical issues and therapeutic interventions specifically addressing the needs of HIV-positive pregnant women will continue to evolve and be incorporated into
Management of infants born to women infected with the human immunodeficiency virus.: J Perinat Neonatal Nurs. 1994 Mar;7(4):79-89. Unique Identifier : AIDSLINE MED/94202003; Benson MS; The numbers of women and children infected with the human immunodeficiency virus (HIV) in the United States are growing rapidly. As these numbers increase, we can expect a strong impact on our health care system and our society as a whole. Research in the area of perinatal HIV is ongoi
[Progressive multifocal leukoencephalopathy localized in the thalamic grey matter in an AIDS-patient]: J Radiol. 1993 Dec;74(12):645-8. Unique Identifier : AIDSLINE MED/94202021; Sarrazin JL; Derosier C; Schill H; Neveux Y; Hor F; Cordoliani YS; Service d'Imagerie medicale, Hopital du Val-de-Grace, Paris.; Involvement of the deep grey matter is unusual in Progressive Multifocal Leukoencephalopathy (PML), which is disease of the white matter. Basal ganglia involvement is usually secondary to extension from lesions of adjacent white matter and easy to recognize. We report a biopsy-proven case of PML in which lesions were
Characteristics of human immunodeficiency virus and chlorpromazine induced antiphospholipid antibodies: effect of beta 2 glycoprotein I on binding to phospholipid.: J Rheumatol. 1994 Jan;21(1):94-9. Unique Identifier : AIDSLINE MED/94202094; Gharavi AE; Sammaritano LR; Wen J; Miyawaki N; Morse JH; Zarrabi MH; Lockshin MD; Antiphospholipid Research Laboratory, New Orleans 70112.; OBJECTIVE. To investigate the nature of the target epitope for human immunodeficiency virus (HIV) and chlorpromazine (CPZ) induced antiphospholipid antibodies (aPL) by evaluating the effect of the aPL cofactor (beta 2 glycoprotein I) on phospholipid binding and to compare this with known binding patterns of infection
New recommendations announced for HIV-infected and HBV-infected health care workers.: J Mich Dent Assoc. 1993 Feb;75(2):28-30. Unique Identifier : AIDSLINE MED/94202191
AIDS and dental office safety--what Michigan's residents really think.: J Mich Dent Assoc. 1993 Apr-May;75(4):26-9. Unique Identifier : AIDSLINE MED/94202195
Patient and dental student responses to a survey about AIDS in the dental setting.: J Mich Dent Assoc. 1993 Apr-May;75(4):30-2, 34, 66. Unique Identifier : AIDSLINE MED/94202196; Thaker HJ; Gobetti JP; Green TG; University of Michigan School of Dentistry.; The purpose of the study was to gain information about patients and dental students attitudes concerning AIDS and dentistry. Opinions of patients and students at a Midwestern dental school were surveyed. The dental students responses were not as consistent as the patient responses. Both groups felt there was a risk
Effect of cardiopulmonary bypass on the specific immunity of the host.: J Tongji Med Univ. 1993;13(4):231-3. Unique Identifier : AIDSLINE MED/94202255; Lu Q; Lan HJ; Cai JJ; Sun ZQ; Institute of cardiovascular disease, Tongji Medical University,; Wuhan.; T cell subsets and immunoglobulin (Ig) were observed sequentially with the OKT monoclonal antibodies rosette test and the rate scattering turbidimetry in 13 patients who underwent open heart surgery under cardiopulmonary bypass (CPB) for rheumatic heart diseases (RHD) and congenital heart diseases (CHD), before and af
Role of the cytoskeleton in cell-to-cell transmission of human immunodeficiency virus.: J Virol. 1994 May;68(5):2898-905. Unique Identifier : AIDSLINE MED/94202275; Pearce-Pratt R; Malamud D; Phillips DM; Population Council, New York, New York 10021.; We previously observed that when human immunodeficiency virus (HIV)-infected T lymphocytes are added to epithelial cells, they adhere, polarize, and secrete virions unidirectionally onto the epithelium. Epithelial cells subsequently take up virus and become productively infected. We report here that colchicine treatme
Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.: J Virol. 1994 May;68(5):2906-14. Unique Identifier : AIDSLINE MED/94202276; Chowers MY; Spina CA; Kwoh TJ; Fitch NJ; Richman DD; Guatelli JC; Department of Medicine, University of California, San Diego.; The replication competence of human immunodeficiency virus type 1 genomes containing mutations in the nef open reading frame was evaluated in continuous cell lines. Mutants that contained a deletion in the nef open reading frame, premature termination codons, or missense mutations in the N-terminal myristoylation sign
Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA.: J Virol. 1994 May;68(5):2986-93. Unique Identifier : AIDSLINE MED/94202285; Nasioulas G; Zolotukhin AS; Tabernero C; Solomin L; Cunningham CP; Pavlakis GN; Felber BK; Human Retrovirus Pathogenesis Group, National Cancer; Institute-Frederick Cancer Research and Development Center,; Maryland 21702-1201.; In the absence of the viral regulatory protein Rev, the human immunodeficiency virus type 1 gag/pol and env mRNAs are inefficiently expressed, since nucleocytoplasmic transport, stability, and polysomal loading are impaired. It has been suggested that splicing is necessary for Rev function and that the low expression
Primary stage of feline immunodeficiency virus infection: viral dissemination and cellular targets.: J Virol. 1994 May;68(5):3080-91. Unique Identifier : AIDSLINE MED/94202295; Beebe AM; Dua N; Faith TG; Moore PF; Pedersen NC; Dandekar S; Department of Internal Medicine, School of Medicine, University; of California, Davis 95616.; The objective of this study was to identify cellular and organ targets of acute feline immunodeficiency virus (FIV) infection in vivo. Tissues of FIV-infected cats were studied at eight time points during the first 3 months after experimental infection. FIV nucleic acids were first detected by in situ hybridization 21
The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef [published erratum appears in J Virol 1994 Jul;68(7):4705]: J Virol. 1994 May;68(5):3092-101. Unique Identifier : AIDSLINE MED/94202296; Anderson SJ; Lenburg M; Landau NR; Garcia JV; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, Tennessee 38101.; Human immunodeficiency virus type 1 Nef down-regulates surface expression of murine and human CD4 but not human CD8. We recently reported that the cytoplasmic domain of CD4 is required for its down-regulation by Nef. Using a chimeric molecule composed of the extracellular and transmembrane domains of human CD8 fused t
Equine infectious anemia virus trans-regulatory protein Rev controls viral mRNA stability, accumulation, and alternative splicing.: J Virol. 1994 May;68(5):3102-11. Unique Identifier : AIDSLINE MED/94202297; Martarano L; Stephens R; Rice N; Derse D; Biological Carcinogenesis and Development Program, PRI/DynCorp,; Frederick, Maryland 21702-1201.; The cis- and trans-acting components of the Rev regulatory pathway employed by equine infectious anemia virus (EIAV) to regulate and coordinate viral gene expression were examined in complementation experiments. Viral protein expression and mRNA expression were compared in cells transiently transfected with wild-type
Extensive envelope heterogeneity of simian immunodeficiency virus in tissues from infected macaques.: J Virol. 1994 May;68(5):3129-37. Unique Identifier : AIDSLINE +; Campbell BJ; Hirsch VM; Immunodeficiency Viruses Section, National Institute of Allergy; and Infectious Diseases, Rockville, Maryland 20852.; The extent of virus genetic variation within tissues and peripheral blood mononuclear cells (PBMC) from two simian immunodeficiency virus (SIV)-infected macaques was analyzed. The products of PCR amplification of two regions, region 1 (SIV V1 region) and region 2 (region corresponding to the human immunodeficiency vir
Identification of human immunodeficiency virus type 1 Gag protein domains essential to membrane binding and particle assembly.: J Virol. 1994 May;68(5):3232-42. Unique Identifier : AIDSLINE MED/94202311; Spearman P; Wang JJ; Vander Heyden N; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110.; Assembly of human immunodeficiency virus type 1 (HIV-1) particles occurs at the plasma membrane of infected cells. Myristylation of HIV-1 Gag precursor polyprotein Pr55Gag is required for stable membrane binding and for assembly of viral particles. We expressed a series of proteins representing major regions of the HI
Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-kappa B and AP-1 in human T cells in vitro after T-cell receptor stimulation.: J Virol. 1994 May;68(5):3243-9. Unique Identifier : AIDSLINE MED/94202312; Bandres JC; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110.; Human immunodeficiency virus type 1 (HIV-1) negative factor (Nef) has been shown to down-regulate the transcription factors NF-kappa B and AP-1 in vitro. To define the mechanism of action of the Nef protein, the signal transduction pathways which may be affected in T cells by constitutive expression of the nef gene we
Second-site long terminal repeat (LTR) revertants of replication-defective human immunodeficiency virus: effects of revertant TATA box motifs on virus infectivity, LTR-directed expression, in vitro RNA synthesis, and binding of basal transcription factors TFIID and TFIIA.: J Virol. 1994 May;68(5):3298-307. Unique Identifier : AIDSLINE MED/94202317; Kashanchi F; Shibata R; Ross EK; Brady JN; Martin MA; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.; Second-site revertants from replication-incompetent molecular clones of human immunodeficiency virus (HIV) contain base substitutions adjacent to the TATA motif. The altered TATA box motifs were analyzed for their effect(s) on virus infectivity, long terminal repeat (LTR)-directed expression in transient transfection
Effects of the Tat basic domain on human immunodeficiency virus type 1 transactivation, using chemically synthesized Tat protein and Tat peptides.: J Virol. 1994 May;68(5):3343-53. Unique Identifier : AIDSLINE MED/94202322; Vives E; Charneau P; van Rietschoten J; Rochat H; Bahraoui E; Laboratoire de Biochimie, Ingenierie des proteines, CNRS,; URA1455, Faculte de Medecine Secteur Nord, Marseille, France.; To study the structure relationship of different Tat domains, the full-length Tat protein Tat1-86, the gene product of the first exon Tat1-72 which retains full activity of the protein, and a panel of shorter peptides mimicking different regions of the primary structure of the Tat protein were chemically synthesized b
The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein.: J Virol. 1994 May;68(5):3374-9. Unique Identifier : AIDSLINE MED/94202326; Yamada T; Yamaoka S; Goto T; Nakai M; Tsujimoto Y; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.; The Tax protein of human T-cell leukemia virus type I activates transcription of cellular and viral genes and can immortalize primary T lymphocytes. We have previously reported that the Tax protein transforms Rat-1 cells. Here we show that Tax-transformed Rat-1 cells detach from plates to undergo apoptotic cell death
Feline immunodeficiency virus can be experimentally transmitted via milk during acute maternal infection.: J Virol. 1994 May;68(5):3380-5. Unique Identifier : AIDSLINE MED/94202327; Sellon RK; Jordan HL; Kennedy-Stoskopf S; Tompkins MB; Tompkins WA; Department of Microbiology, Pathology, and Parasitology, College; of Veterinary Medicine, North Carolina State University, Raleigh; 27606.; Postnatal transmission of feline immunodeficiency virus (FIV) in neonates nursed by acutely infected mothers and infection resulting from oral inoculation of kittens with FIV were evaluated. Ten of 16 kittens nursed by four queens with FIV infection established immediately postpartum developed FIV infection. Five of 1
Evolution of the human immunodeficiency virus type 2 envelope gene in preimmunized and persistently infected rhesus macaques.: J Virol. 1994 May;68(5):3415-20. Unique Identifier : AIDSLINE GENBANK/S69447; Bayon-Auboyer MH; Boussin FD; Vogt G; Le Grand R; Vaslin B; Nicol-Jourdain I; Dormont D; Laboratoire de Neuropathologie Experimentale et Neurovirologie,; Commissariat a l'Energie Atomique, Fontenay-aux-Roses, France.; The V3 and V4 domains of human immunodeficiency virus type 2 (HIV-2) env genes from 14 rhesus macaques experimentally infected by HIV-2 SBL6669/H5 were sequenced. No variation was observed in viral sequences from sera and from uncultured peripheral blood mononuclear cells during primary infection. The first mutations
Distribution of mouse mammary tumor virus in Asian wild mice.: J Virol. 1994 May;68(5):3437-42. Unique Identifier : AIDSLINE MED/94202336; Imai S; Okumoto M; Iwai M; Haga S; Mori N; Miyashita N; Moriwaki K; Hilgers J; Sarkar NH; Department of Pathology, Nara Medical University, Japan.; Several groups of wild mice (Mus musculus) were captured from eight different locations in Asia and bred for several generations in a facility free of any laboratory strains of mice carrying mouse mammary tumor virus (MMTV). The distribution of endogenous MMTV proviral sequences in the liver tissues of these mice was
The open reading frame I (ORF I)/ORF II part of the human T-cell leukemia virus type I X region is dispensable for p40tax, p27rex, or envelope expression.: J Virol. 1994 May;68(5):3448-51. Unique Identifier : AIDSLINE MED/94202338; Roithmann S; Pique C; Le Cesne A; Delamarre L; Pham D; Tursz T; Dokhelar MC; CNRS Unite de Recherche Associee 1156, Institut Gustave Roussy,; Villejuif, France.; The X region of the human T-cell leukemia virus type I contains the second coding exon of the tax and rex regulatory proteins (open reading frame IV [ORF IV] and ORF III, respectively), as well as coding regions for more recently described proteins, p30II (or the tof protein) and p13II in ORF II and the putative rof p
AIDS research coordination abetted [news]: JAMA. 1994 Apr 13;271(14):1061. Unique Identifier : AIDSLINE MED/94202365; Cotton P
Comparison of long-term prognosis of patients with AIDS treated and not treated with zidovudine. AIDS in Europe Study Group [see comments]: JAMA. 1994 Apr 13;271(14):1088-92. Unique Identifier : AIDSLINE MED/94202382; Lundgren JD; Phillips AN; Pedersen C; Clumeck N; Gatell JM; Johnson AM; Ledergerber B; Vella S; Nielsen JO; Department of Infectious Diseases, Hvidovre Hospital, Copenhagen,; Denmark.; OBJECTIVE--To determine the association between elapsed time since starting zidovudine and survival in patients with acquired immunodeficiency syndrome (AIDS). DESIGN--Inception cohort and observational study of patients treated and not treated with zidovudine. SETTING--Fifty-one centers in 17 European countries. PATI
Effectiveness of zidovudine in treatment of advanced HIV infection [editorial; comment]: JAMA. 1994 Apr 13;271(14):1121-2. Unique Identifier : AIDSLINE MED/94202389; Phair JP
HIV testing: AMA code of ethics [letter; comment]: JAMA. 1994 Apr 20;271(15):1160. Unique Identifier : AIDSLINE MED/94202404; Glasson J; Orentlicher D
[Opportunistic infection]: Nippon Rinsho. 1994 Feb;Suppl 3:260-3. Unique Identifier : AIDSLINE MED/94202507; Higashiyama Y; Taira K; Koga H; Second Department of Internal Medicine, Nagasaki University; School of Medicine.
Autoptic findings in HIV-1 positive children.: Klin Padiatr. 1994 Jan-Feb;206(1):45-9. Unique Identifier : AIDSLINE MED/94202853; Masini T; Chinaglia D; Ghidoni P; Gullotta F; Institute of Pathology, University of Milan, Italy.; The growing incidence of AIDS in children and newborns has been related to increasing incidence of AIDS in women. Case records were composed by 14 children with death occurring at different ages--from 1 hour to 12 years--and 1 female fetus, all with serological confirmation of AIDS. Brain and internal organs samples w
HIV infection/AIDS: a clinician's perspective.: J Tenn Dent Assoc. 1993 Jul;73(3):11-5. Unique Identifier : AIDSLINE MED/94202883; Raybould TP; Adult Special Patient Care Program, University of Kentucky; College of Dentistry.; HIV infection and AIDS presents complex issues for all mankind. With every day that passes, 5000 more people worldwide become infected with the virus. Young people and adults alike need frank and clear information regarding how to protect themselves and others. Even though the vast majority of HIV infections are sprea
Risk communication in dental practice: responding assertively to AIDS, fear and infection control.: J Tenn Dent Assoc. 1993 Jul;73(3):16-8, 65. Unique Identifier : AIDSLINE MED/94202884; Horowitz LG; There is great value in applying the science of risk communication in contemporary dental practice. Dental professionals can respond most assertively to anxious patients by developing active listening skills while engaging patients negative beliefs and attitudes regarding dental care in the age of AIDS. This paper ad
Transient adult T-cell leukemia/lymphoma picture during varicella infection in an HTLV-1 carrier.: Leukemia. 1994 Apr;8(4):682-7. Unique Identifier : AIDSLINE MED/94202922; D'Incan M; Combemale P; Verrier B; Garin D; Audoly G; Brunot J; Desgranges C; Flechaire A; Unit of Research on Hepatitis, AIDS and Human Retroviruses, Lyon,; France.; HTLV-1 (human T-lymphotropic virus type 1) is associated with tropical spastic paraparesis, adult T-cell lymphoma (ATL), and also with opportunistic infections. The risk for developing ATL in HTLV-1 healthy carriers is low, between 1 and 4%. Nothing is known about the events promoting the evolution from the healthy ca
Retroviruses and cancer: US-Japan clinico-epidemiological experiences held under the auspices of the US-Japan bilateral agreement.: Leukemia. 1994 Apr;8(4):694-704. Unique Identifier : AIDSLINE MED/94202924
An enhanced surveillance program for adult T-cell leukemia in central Brooklyn.: Leukemia. 1994 Apr;8 Suppl 1:S111-5. Unique Identifier : AIDSLINE MED/94202931; Welles SL; Levine PH; Joseph EM; Goberdhan LJ; Lee S; Miotti A; Cervantes J; Bertoni M; Jaffe E; Dosik H; Department of Biostatistics, Harvard School of Public Health,; Boston, MA.; The Brooklyn Adult T-cell Leukemia/Lymphoma (ATL) study was developed to estimate the incidence of the human T-cell lymphotropic virus type I (HTLV-I)-associated ATL in the Crown Heights/Bedford Stuyvesant community. This central Brooklyn black community is an area which has already been shown in earlier reports to be
Mutational analysis of the HIV-1 Vpu protein.: Leukemia. 1994 Apr;8 Suppl 1:S156-62. Unique Identifier : AIDSLINE MED/94202942; Friborg J; Yao XJ; Boisvert F; Garzon S; Cohen EA; Departement de Microbiologie et Immunologie, Faculte de Medecine,; Universite de Montreal, Quebec, Canada.; The human immunodeficiency virus type-1 (HIV-1) encoded Vpu protein facilitates the release of budding virions from the surface of infected cells and delays the rate of syncytium formation of the virus. Furthermore, Vpu induces rapid degradation of nascent CD4 molecules that are retained in the endoplasmic reticulum b
Neonatal HIV-1 thymic infection.: Leukemia. 1994 Apr;8 Suppl 1:S163-5. Unique Identifier : AIDSLINE MED/94202943; Rosenzweig M; Bunting EM; Gaulton GN; Department of Pathology and Laboratory Medicine, School of; Medicine, University of Pennsylvania, Philadelphia 19104.; The thymus is the primary site of T cell ontogeny and selection during fetal and neonatal development. Previous studies have established that the thymus is also a site of HIV-1 infection, as early as the first trimester of pregnancy. Alteration of the thymocyte maturation process by HIV-1 could impact on the periphera
Virus induction of NF-kappa B/Rel proteins and type I interferon gene expression in myelomonoblastic cells.: Leukemia. 1994 Apr;8 Suppl 1:S170-4. Unique Identifier : AIDSLINE MED/94202945; Roulston A; Conti L; McKiel V; Wainberg MA; Hiscott J; Abe Stern Cancer Research Laboratory, Lady Davis Institute for; Medical Research, Sir Mortimer B. Davis Jewish General Hospital,; Montreal, Quebec, Canada.; The correlation between virus induced NF-kappa B DNA binding activity and interferon gene expression was examined in the myelomonoblastic PLB-985 cell line. Previous studies have shown that chronic HIV-1 infection of PLB-985 cells (PLB-IIIB) leads to the selection of cells with a more differentiated monocytic phenotyp
Long-term persistence of AZT-resistance mutations in the plasma HIV-1 of patients removed from AZT therapy.: Leukemia. 1994 Apr;8 Suppl 1:S179-82. Unique Identifier : AIDSLINE MED/94202947; Smith MS; Koerber KL; Pagano JS; University of North Carolina Lineberger Comprehensive Cancer; Center, Chapel Hill.; Zidovudine (3 -azido-2 ,3 -dideoxythymidine) resistant isolates of human immunodeficiency virus type I (HIV-1) were previously demonstrated in zidovudine-treated AIDS patients. The genetic linkage of multiple mutations characteristic of zidovudine-resistance as well as dideoxyinosine-resistance were demonstrated by ex
Different effects of breast cancer, HIV-1 infection and chemotherapy on inducible natural immunity.: Leukemia. 1994 Apr;8 Suppl 1:S183-5. Unique Identifier : AIDSLINE MED/94202949; Brenner BG; Vo C; Wainberg MA; Lady Davis Institute, Jewish General Hospital, Montreal, Que,; Canada.; Breast cancer chemotherapy and HIV-1 viral infection (AIDS) can result in respective transient or irreversible losses of up to 40-50% of circulating lymphocytes. The relationship of lymphopenia on tumor immunosurveillance and the control of opportunistic infections has yet to be established. The objective of this stud
Phenotype analysis of lymphocytes present in different stages of neoplasia induced by bovine leukemia virus.: Leukemia. 1994 Apr;8 Suppl 1:S206-10. Unique Identifier : AIDSLINE MED/94202955; Chiba T; Ajito T; Okada K; Department of Veterinary Pathology, Faculty of Agriculture, Iwate; University, Morioka, Japan.; Distribution of subpopulations of lymphocytes in the lymph nodes and tumor tissues from cattle with enzootic bovine leukosis (EBL) was examined by immunohistology using a panel of monoclonal antibodies against leukocyte differentiation molecules of bovine leukocytes and tumor-associated antigen (TAA) of EBL. As diseas
Identification of tumor-associated antigen that is expressed on bovine leukemia virus-induced lymphosarcoma cells and expression of its human homologue in human T-cell lymphotrophic virus I-infected cell lines.: Leukemia. 1994 Apr;8 Suppl 1:S231-4. Unique Identifier : AIDSLINE MED/94202962; Aida Y; Amanuma H; Okada K; Tsukuba Life Science Center, Institute of Physical and Chemical; Research (RIKEN), Ibaraki, Japan.; By using the monoclonal antibody (MAb) c143 against tumor-associated antigen that is expressed in tumor cells of cattle with bovine leukemia virus (BLV)-induced enzootic bovine leukosis (EBL), we found a novel bovine MHC class II-related antigen which consists of alpha chain (36-37 kDa) and beta chain (32 and 34 kDa).
Mechanism of transcriptional activation of viral and cellular genes by oncogenic protein of HTLV-1.: Leukemia. 1994 Apr;8 Suppl 1:S51-3. Unique Identifier : AIDSLINE MED/94202968; Yoshida M; Department of Cellular and Molecular Biology, University of; Tokyo, Japan.; Regulatory protein Tax of human T cell leukemia virus type 1 (HTLV-1) positively regulates the transcription of its own genome and specific cellular genes, and contributes to the pathogenicity in ATL, HAM/TSP and other associated diseases. The one mechanism of the transcriptional activation includes binding of Tax pro
Cytotoxic T cell response and expression of the target antigen in HTLV-I infection.: Leukemia. 1994 Apr;8 Suppl 1:S54-9. Unique Identifier : AIDSLINE MED/94202969; Kannagi M; Matsushita S; Shida H; Harada S; Department of Biodefence and Medical Virology, Kumamoto; University School of Medicine, Japan.; The cytotoxic T cell response of peripheral blood mononuclear cells (PBMC) to in vitro stimulation with human T cell leukemia virus type I (HTLV-I) was compared among HTLV-I-infected individuals with various clinical conditions. Induction of HTLV-I-specific cytotoxic T lymphocytes (CTL) was observed in 57% of asymptom
Recognition by human sera of a variable region of the surface glycoprotein of HTLV-I.: Leukemia. 1994 Apr;8 Suppl 1:S65-7. Unique Identifier : AIDSLINE MED/94202971; Edouard E; Londos-Gagliardi D; Busetta B; Geoffre S; Dalbon P; Moreau JP; Guillemain B; INSERM, Unite 328, Fondation Bergonie, Bordeaux, France.; The region comprised between the amino acids 175 and 199 of the HTLV-I envelope surface glycoprotein is one of the immunodominant domains of this molecule. In this region, which is well recognized by sera from HTLV-I infected patients, a substitution of the proline at position 192 by a serine has been described in som
Intervention of maternal transmission of HTLV-1 in Nagasaki, Japan.: Leukemia. 1994 Apr;8 Suppl 1:S68-70. Unique Identifier : AIDSLINE MED/94202972; Hino S; Katamine S; Kawase K; Miyamoto T; Doi H; Tsuji Y; Yamabe T; Faculty of Medicine, Tottori University, Yonago, Japan.; Seroepidemiological and laboratory virological evidences strongly suggested that endemicity of HTLV-1 in Nagasaki Japan depends on maternal infant infections via breast milk. The most obvious way to prove this concept was an intervention study with refraining from breast-feeding by
Interactions between HTLV-I Tax and NF-kappa B/Rel proteins in T cells.: Leukemia. 1994 Apr;8 Suppl 1:S71-6. Unique Identifier : AIDSLINE MED/94202974; Lacoste J; Lanoix J; Pepin N; Hiscott J; Abe Stern Cancer Research Laboratory, Lady Davis Institute for; Medical Research, Sir Mortimer B. Davis-Jewish General Hospital,; Montreal, Quebec, Canada.; Members of the NF-kappa B/Rel family of transcription factors are involved in the transcriptional regulation of numerous polypeptides important to the immune response and cellular growth. Several genes regulated in part by NF-kappa B/Rel such as interleukin 2, IL-2 rec
Some epidemiological features of the human T-cell lymphotropic virus type I (HTLV-I) and ATL in Nigerians.: Leukemia. 1994 Apr;8 Suppl 1:S77-82. Unique Identifier : AIDSLINE MED/94202975; Williams CK; Dada A; Blattner WA; Allan Blair Memorial Clinic, Saskatchewan Cancer Foundation,; Regina, Canada.; With a seroprevalence rate (SPR) of 6%-10% among healthy adult blood donors (ABD), Nigeria and other African locales represent an endemic zone for HTLV-I. We studied SPR in patients with leukaemia, lymphomas, solid tumours, and chronic disorders, as well as in groups of men and wo
Identification of HTLV-I 21 bp repeat-specific DNA-protein complexes.: Leukemia. 1994 Apr;8 Suppl 1:S83-7. Unique Identifier : AIDSLINE MED/94202976; Tillmann M; Wigdahl B; Department of Microbiology and Immunology, Pennsylvania State; University College of Medicine, Hershey 17033.; The human T cell lymphotropic virus type 1 (HTLV-I)-encoded protein, Tax, is capable of transcriptionally trans-activating HTLV-I by interacting with specific sequences in the HTLV-I long terminal repeat (LTR) which comprise an inducible enhancer containing three imperfect tandem repeats of a 21 bp sequence. Evidence
Human T-lymphotropic virus type I uveitis.: Leukemia. 1994 Apr;8 Suppl 1:S88-90. Unique Identifier : AIDSLINE MED/94202977; Yamaguchi K; Mochizuki M; Watanabe T; Miyata N; Tajima K; Mori S; Takatsuki K; Department of Internal Medicine, Kumamoto University School of; Medicine, Japan.; In addition to adult T-cell leukemia (ATL) and chronic myelopathy (HAM/TSP), our current study indicates that human T lymphotropic virus type I (HTLV-I) is a causative agent for a specific type of uveitis with unknown etiology (idiopathic uveitis). The present paper describes the seroepidemiological, clinical, and mol
Comparative analysis of the T cell receptor V beta repertoire in various lymphoid tissues from HIV-infected patients: evidence for an HIV-associated superantigen.: Leukemia. 1994 Apr;8 Suppl 1:S95-7. Unique Identifier : AIDSLINE MED/94202979; Soudeyns H; Routy JP; Sekaly RP; Laboratoire d'Immunologie, Institut de Recherches Cliniques de; Montreal, Quebec, Canada.; The search to identify HIV-associated molecules with superantigenic properties has focussed on demonstration of T cell receptor V beta subset-specific perturbations in HIV-infected patients. In this report, the V beta repertoire of two HIV patients was studied in lymph nodes, where HIV-1 replication is the most intens
An architecture for knowledge-based construction of decision models.: Med Decis Making. 1994 Jan-Mar;14(1):27-39. Unique Identifier : AIDSLINE MED/94203024; Sonnenberg FA; Hagerty CG; Kulikowski CA; Department of Medicine, UMDNJ Robert Wood Johnson Medical School,; New Brunswick.; Clinical application of decision analysis has been limited by unfamiliarity of clinicians with the technique, large data requirements, and the length of time needed to construct models. In order to make decision modeling more accessible to clinicians, the authors developed a computer program to construct decision mode
Nurses' fear of contagion: a functional-measurement analysis.: Med Decis Making. 1994 Jan-Mar;14(1):40-5. Unique Identifier : AIDSLINE MED/94203025; Rundall CS; Weiss DJ; Department of Psychology, California State University, Los; Angeles 90032.; The amounts of fear of contagion aroused in nurses by 15 unnamed diseases were examined. The diseases were chosen to allow factorial arrangement according to their degrees of transmissibility and the severities of their prognoses. Concern about contagion was hypothesized to increase as transmissibility increased and a
Fungal sinusitis in patients with AIDS: report of 4 cases and review of the literature.: Medicine (Baltimore). 1994 Mar;73(2):69-78. Unique Identifier : AIDSLINE MED/94203043; Meyer RD; Gaultier CR; Yamashita JT; Babapour R; Pitchon HE; Wolfe PR; Division of Infectious Diseases, Cedars-Sinai Research Institute,; UCLA School of Medicine, Los Angeles, California.; We report here 3 cases of aspergillus sinusitis in patients with AIDS and the 1st fully described case, to our knowledge, of sinusitis associated with Pseudallescheria boydii in a patient with AIDS. We review the microbiology and pathology of fungal sinusitis in patients with AIDS and the morphologic and clinical feat
Kaposi's sarcoma of the bone marrow presenting with fever of unknown origin.: Med Pediatr Oncol. 1994;22(6):410-3. Unique Identifier : AIDSLINE MED/94203091; Levin M; Hertzberg L; Staten Island University Hospital, Sanford R. Nalitt Institute; for Cancer and Blood Related Diseases, NY 10305.; Kaposi s sarcoma (KS) has become more common in the United States with the spread of the Acquired Immunodeficiency Syndrome (AIDS) epidemic. The epidemic form associated with AIDS involves primarily skin and visceral organs. Bone marrow involvement is rare. We present a case of Kaposi
Specificity of antipeptide antibodies produced against V2 and V3 regions of the external envelope of human immunodeficiency virus type 2.: Mol Immunol. 1994 Apr;31(5):361-9. Unique Identifier : AIDSLINE MED/94203208; Babas T; Benichou S; Guetard D; Montagnier L; Bahraoui E; CNRS URA 1455, Laboratoire de Biochimie, Faculte de Medecine; Nord, Marseille, France.; The V2 region of simian immunodeficiency virus (SIV) and V3 region of human immunodeficiency virus type 1 (HIV-1) have been reported to be neutralization epitopes. We analysed the corresponding regions in HIV-2. Synthetic peptides modeling the V2 (aa 149-168) and V3 (CV3: aa 298-315 and NV3: aa 306-324) regions of the
Haemophiliacs seek charges in AIDS scandal [news]: Nature. 1994 Apr 21;368(6473):680. Unique Identifier : AIDSLINE MED/94203273; Swinbanks D
[Does latent HIV-infection exist?]: Ned Tijdschr Geneeskd. 1994 Apr 2;138(14):699-701. Unique Identifier : AIDSLINE MED/94203312; Romijn JA; Danner SA; Sauerwein HP; Academisch Medisch Centrum, afd. Interne Geneeskunde, Amsterdam.
[Acetylcysteine: a promising antioxidant for cardiorespiratory disorders]: Ned Tijdschr Geneeskd. 1994 Apr 2;138(14):701-5. Unique Identifier : AIDSLINE MED/94203313; Spapen H; Zhang H; Gillet R; De Wit N; Huyghens L; Academisch Ziekenhuis Vrije Universiteit, afd. Intensieve Zorgen,; Brussel, Belgie.
AIDS: advocacy & activism: we need money and services now!: Nurs Health Care. 1994 Jan;15(1):6. Unique Identifier : AIDSLINE MED/94203484; Fedor M
How to share unit equipment safely.: Nursing. 1994 Apr;24(4):18. Unique Identifier : AIDSLINE MED/94203517; Sheldon JE
Euthanasia: in support of patients [letter]: Nursing. 1994 Apr;24(4):4. Unique Identifier : AIDSLINE MED/94203527; Hlavaty KM
H.I.V. disease. Nursing attitudes [news]: Nursing. 1994 Apr;24(4):9. Unique Identifier : AIDSLINE MED/94203539
AIDS update [news]: Occup Health (Lond). 1993 Oct;45(10):325. Unique Identifier : AIDSLINE MED/94203554
Seafarers' HIV/AIDS education package [news]: Occup Health (Lond). 1993 Nov;45(11):354. Unique Identifier : AIDSLINE MED/94203560
HIV in perspective.: Occup Health (Lond). 1993 Nov;45(11):377-8. Unique Identifier : AIDSLINE MED/94203565; Goldman L
Did Dr. Acer murder his patients? [editorial]: Oral Health. 1993 Sep;83(9):3. Unique Identifier : AIDSLINE MED/94203649; Lang R; University of Toronto.
Molecular cloning of a recombinant retrovirus carrying a mutated envAKR-mycMH2 fusion gene immortalizing cells of the monocytic-macrophage lineage.: Oncogene. 1994 May;9(5):1473-7. Unique Identifier : AIDSLINE GENBANK/Z26309; Sassano M; Granucci F; Seveso M; Marconi G; Foti M; Ricciardi-Castagnoli P; CNR Center of Cytopharmacology, University of Milan, Italy.; The VN-11 recombinant retroviruses, originally generated by co-transfection of the avian MH2 and AKRv viral genomes, were molecularly cloned from an infected mouse cell line named N11. The analysis of the proviral genome sequence from one of these recombinants showed a possible envAKR-mycMH2 fusion. Point mutations we
Intermolecular disintegration and intramolecular strand transfer activities of wild-type and mutant HIV-1 integrase.: Nucleic Acids Res. 1994 Mar 25;22(6):1037-43. Unique Identifier : AIDSLINE MED/94203787; Mazumder A; Engelman A; Craigie R; Fesen M; Pommier Y; Laboratory of Molecular Pharmacology, NCI, Rockville, MD 20892.; We report the activities of HIV integrase protein on a novel DNA substrate, consisting of a pair of gapped duplex molecules. Integrase catalyzed an intermolecular disintegration reaction that requires positioning of a pair of the gapped duplexes in a configuration that resembles the intgration intermediate. However, t
Mutagenesis of the hairpin ribozyme.: Nucleic Acids Res. 1994 Mar 25;22(6):1096-100. Unique Identifier : AIDSLINE MED/94203795; Anderson P; Monforte J; Tritz R; Nesbitt S; Hearst J; Hampel A; Department of Biological Sciences, Northern Illinois University,; DeKalb 60115.; Extensive in vitro mutagenesis studies have been performed on the hairpin ribozyme and substrate in an effort to refine the overall secondary structure of the molecule and provide further insight into what elements are essential for activity. A secondary structure consisting of four helices and five loop regions remai
Endogenous viral complexes with long RNA cosediment with the agent of Creutzfeldt-Jakob disease.: Nucleic Acids Res. 1994 Mar 25;22(6):1101-7. Unique Identifier : AIDSLINE MED/94203796; Akowitz A; Sklaviadis T; Manuelidis L; Yale Medical School, New Haven, CT 06510.; A class of viruslike agents that induces Creutzfeldt-Jakob Disease (CJD) and scrapie remains undefined at the molecular level. Several investigators believe this infectious agent is constituted by a single host protein or prion , and have emphasized data that would seem to exclude the presence of any viral nucleic ac
A novel assay for the DNA strand-transfer reaction of HIV-1 integrase.: Nucleic Acids Res. 1994 Mar 25;22(6):1121-2. Unique Identifier : AIDSLINE MED/94203801; Hazuda DJ; Hastings JC; Wolfe AL; Emini EA; Department of Antiviral Research, Merck Research Laboratories,; West Point, PA 19486.
A wide body.: Nurs Times. 1994 Mar 9-15;90(10):45. Unique Identifier : AIDSLINE MED/94203840; Hempel S
Anger mounts over HIV disclosures [news]: Nurs Times. 1994 Mar 9-15;90(10):7. Unique Identifier : AIDSLINE MED/94203846; Cassidy J
Homosexual men's views on visiting GPs.: Nurs Times. 1994 Mar 2-8;90(9):10-1. Unique Identifier : AIDSLINE MED/94203848
Stately union.: Nurs Times. 1994 Mar 2-8;90(9):43. Unique Identifier : AIDSLINE MED/94203856; Cohen P
Concern over HIV disclosure rules [news]: Nurs Times. 1994 Mar 2-8;90(9):6. Unique Identifier : AIDSLINE MED/94203860; Cassidy J
Update on AIDS and sexual behavior of college students: seven years later.: Psychol Rep. 1994 Feb;74(1):208-10. Unique Identifier : AIDSLINE MED/94204110; Simkins LD; Department of Psychology, University of Missouri-Kansas City; 64110-2499.; This survey of 54 single, sexually active college students indicated that there has been a significant increase in concern about AIDS compared to a survey on a similar sample in 1985. A majority of this sample have been involved in monogamous relationships during the past year and 35% have had the AIDS test on which n
Comparison of Indonesian and American college students' attitudes toward homosexuality.: Psychol Rep. 1994 Feb;74(1):227-37. Unique Identifier : AIDSLINE MED/94204113; Kyes KB; Tumbelaka L; Wake Forest University.; Indonesian and U.S. college students were compared to assess whether an interaction of sex of subject by sex of target on attitudes toward homosexuals would be replicated cross-culturally. The Indonesian sample was expected to hold more traditional attitudes toward women s gender-role behavior which was expected to ov
Internal consistency and stability of the Attitudes Toward AIDS Scale-High School Version.: Psychol Rep. 1994 Feb;74(1):329-30. Unique Identifier : AIDSLINE MED/94204126; Goh DS; Graduate Program in School Psychology, Queens College/CUNY,; Flushing 11367.; Reliabilities of the Attitudes Toward AIDS Scale-High School Version were estimated for a sample of 170 adolescents. Cronbach alpha of .79 and a stability coefficient of .84 were obtained.
Computer-administered visual analogue mood scales: rapid and valid assessment of mood in HIV positive individuals.: Psychol Rep. 1994 Feb;74(1):39-42. Unique Identifier : AIDSLINE MED/94204130; Maruff P; Wood S; Currie J; McArthur-Jackson C; Malone V; Benson E; Neurophysiology and Neurovisual Research Unit, Mental Health; Research Institute of Victoria, Parkville, Australia.; Studies of cognition in patients with the human immunodeficiency virus must take into account the effects of mood. Standardised mood-rating questionnaires are oftentimes consuming and fatiguing for such patients and so may be omitted from experiments. Visual analogue rating scales for affective state are rapidly admin
The AIDS prevention magic show: avoiding the tragic with magic.: Public Health Rep. 1994 Mar-Apr;109(2):162-7. Unique Identifier : AIDSLINE MED/94204164; Lustig SL; Rush Medical College, Chicago, IL 60612.; Teenagers are a crucial target group for interventions concerning acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV). Experimenting with their burgeoning sexuality and increased ability to obtain drugs, they are prime candidates for AIDS prevention and education strategies. The interventi
Applications of data from the CDC Family of Surveys.: Public Health Rep. 1994 Mar-Apr;109(2):204-11. Unique Identifier : AIDSLINE MED/94204168; Onorato IM; Gwinn M; Dondero TJ Jr; Public Health Service, Centers for Disease Control and Prevention; (CDC), Atlanta, GA 30333.; The CDC Family of Surveys is a national serologic surveillance system set up to characterize the extent of human immunodeficiency virus (HIV) infection in the United States . The now Centers for Disease Control and Prevention (CDC) and participating State and local health departments be
Admissions of injection drug users to drug abuse treatment following HIV counseling and testing.: Public Health Rep. 1994 Mar-Apr;109(2):212-8. Unique Identifier : AIDSLINE MED/94204169; McCusker J; Willis G; McDonald M; Lewis BF; Sereti SM; Feldman ZT; University of Massachusetts, School of Public Health, Amherst; 01003.; The outcomes of counseling and testing programs related to human immunodeficiency virus (HIV) infection and risk of infection among injection drug users (IDUs) are not well known or understood. A counseling and testing outcome of potential public health importance is attaining admission to drug abuse treatment by thos
NICHD funds studies of contraceptive vaccines [news]: Public Health Rep. 1994 Mar-Apr;109(2):302-3. Unique Identifier : AIDSLINE MED/94204181
HRSA awards cities $160 million in Ryan White AIDS grants [news]: Public Health Rep. 1994 Mar-Apr;109(2):304. Unique Identifier : AIDSLINE MED/94204182
NLM offers free access to electronic AIDS data [news]: Public Health Rep. 1994 Mar-Apr;109(2):305. Unique Identifier : AIDSLINE MED/94204183
Liposomal amphotericin B (AmBisome) in Mediterranean visceral leishmaniasis: a multi-centre trial.: Q J Med. 1994 Feb;87(2):75-81. Unique Identifier : AIDSLINE MED/94204189; Davidson RN; Di Martino L; Gradoni L; Giacchino R; Russo R; Gaeta GB; Pempinello R; Scott S; Raimondi F; Cascio A; et al; St Mary's Hospital Medical School, Dept of Infectious and; Tropical Diseases, Lister Unit, Northwick Park Hospital, Harrow,; UK.; Thirty-one patients with visceral leishmaniasis (VL) caused by Leishmania infantum received liposomal amphotericin B (AmBisome) in a multi-centre study. Ten immunocompetent patients (six children) received 1-1.38 mg/kg/day for 21 days, and ten (nine children) received 3 mg/kg/day for 10 days. All were cured without si
Spectrum of pulmonary nontuberculous mycobacterial infection.: Radiology. 1994 May;191(2):343-50. Unique Identifier : AIDSLINE MED/94204202; Miller WT Jr; Department of Diagnostic Radiology, Hospital of the University of; Pennsylvania, Philadelphia 19104.; PURPOSE: To organize pulmonary nontuberculous mycobacterial (NTMB) infections into a classification system based on clinical and radiographic features. MATERIALS AND METHODS: Scientific literature was reviewed and organized into a framework of clinical-radiographic syndromes of NTMB infection. RESULTS: NTMB infection
Cancer of the anal canal: treatment with chemotherapy and low-dose radiation therapy.: Radiology. 1994 May;191(2):569-72. Unique Identifier : AIDSLINE MED/94204241; Smith DE; Shah KH; Rao AR; Frost DB; Latino F; Anderson PJ; Peddada AV; Kagan AR; Department of Radiation Oncology, Kaiser Permanente Medical; Center, Los Angeles, CA 90027.; PURPOSE: To determine the efficacy of a standardized protocol of chemotherapy and low-dose radiation therapy in treatment of patients with anal canal cancer. MATERIALS AND METHODS: Forty-two consecutive patients with anal canal cancer were treated with 15 fractions of 30-Gy photon beam radiation therapy administered a
[Progressive multifocal leukoencephalopathy in acquired immunodeficiency syndrome]: Rev Clin Esp. 1994 Jan;194(1):13-6. Unique Identifier : AIDSLINE MED/94204309; Clavo Sanchez A; Garcia-Gil D; Sasian Martinez S; Geraldia Lama M; Serrano Gonzalez A; Bascunana Quirell A; Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta; del Mar, Cadiz.; Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection in HIV-infected persons. We present the characteristics of seven cases of PML, which represent 3.1% of our patients with AIDS. In six cases, was the marker disease for AIDS. The most common clinical manifestation was a slowly evolving f
[Intestinal coccidiosis. Parasites dangerous to immunosuppressed patients]: Rev Prat. 1993 Dec 1;43(19):2536-8. Unique Identifier : AIDSLINE MED/94204547; Deluol AM; Hopital Rothschild, laboratoire de microbiologie, Paris.
[Comparison of two ELISA systems for the detection of antibodies against IBR/IPV and against enzootic bovine leukemia virus]: Schweiz Arch Tierheilkd. 1994;136(2):58-67. Unique Identifier : AIDSLINE MED/94204615; Rosskopf M; Staub E; Ackermann M; Institut fur Virologie, Veterinarmedizinische Fakultat,; Universitat Zurich.; Sensitivity and specificity of two ELISA systems for the detection of antibodies to Bovine Herpes-virus 1 (BHV1; IBR/IPV) were tested by using 214 sera of cattle with predetermined history of BHV1 infection and freedom from BHV1 infection, respectively. With these sera as gold-standard, the sensitivity of ELISA1 (Herd
Dilemmas in the prophylaxis of Pneumocystis carinii pneumonia.: South Med J. 1994 Apr;87(4):429-30. Unique Identifier : AIDSLINE MED/94204788; Glatt AE; Division of Infectious Diseases, Catholic Medical Center of; Brooklyn and Queens, Inc, Jamaica, NY 11432.; Pneumocystis carinii pneumonia has been the most common life-threatening opportunistic infection in patients with acquired immunodeficiency syndrome. With a better understanding of the natural history of HIV infection, however, we have come to realize that prophylaxis against P carinii can prevent the majority of such
Follow-up survey of inpatients with AIDS and HIV infection: economic impact on hospitals in North Carolina.: South Med J. 1994 Apr;87(4):446-53. Unique Identifier : AIDSLINE MED/94204792; Campbell LS; Kory WP; Department of Social Medicine, School of Medicine, University of; North Carolina at Chapel Hill.; This study is a 2-year follow-up to a 1987-1988 survey of North Carolina hospitals regarding hospital utilization by patients with acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection. Almost 99% of the state s hospitals participated in the re-survey for the fiscal year 1989-1990.
Outbreaks of syphilis in rural Texas towns, 1991-1992.: South Med J. 1994 Apr;87(4):493-6. Unique Identifier : AIDSLINE MED/94204801; Schulte JM; Ramsey HA; Paffel JM; Roberts MA; Williams RL; Blass CM; Bell CE; Simpson DM; Bureau of HIV and STD Control, Texas Department of Health, Austin; 78756.; Between 1986 and 1990, rates of primary and secondary syphilis increased 134% in rural counties in the South. Reasons for the increases are speculative. During the 14 months ending in October 1992, outbreaks in four eastern Texas counties provided an opportunity to characterize syphilis in rural Texas. We reviewed rec
Hypereosinophilic syndrome associated with HIV infection. Military Medical Consortium for Applied Retroviral Research.: South Med J. 1994 Apr;87(4):525-9. Unique Identifier : AIDSLINE MED/94204808; Drabick JJ; Magill AJ; Smith KJ; Nutman TB; Benson PM; Department of Bacterial Diseases, Walter Reed Army Institute of; Research, Washington, DC 20307-5100.; A hypereosinophilic syndrome associated with dermatitis has been observed rarely in association with HIV infection. We describe the case of a young man with AIDS who came to us with a diffuse cutaneous eruption, fever, angioedema, eosinophilia, and a mildly elevated serum IgE level. No allergic or infectious cause of
Splenic infection simulating lymphoma: an unusual presentation of disseminated Pneumocystis carinii infection.: South Med J. 1994 Apr;87(4):530-6. Unique Identifier : AIDSLINE MED/94204809; Rockley PF; Wilcox CM; Moynihan M; Hewan-Lowe K; Schwartz DA; Department of Medicine, Emory University School of Medicine,; Atlanta, GA 30303.; This report of disseminated pneumocystosis in an HIV-infected patient describes an unusual presentation consisting of splenic disease mimicking lymphoma, absence of typical roentgenographic signs of pulmonary or disseminated pneumocystis, and absence of use of aerosolized pentamidine. Because of these factors, a diagn
Disseminated cryptococcal disease complicating steroid therapy for Pneumocystis carinii pneumonia in a patient with AIDS.: South Med J. 1994 Apr;87(4):537-8. Unique Identifier : AIDSLINE MED/94204810; Bernstein B; Flomenberg P; Letzer D; Department of Medicine, Medical College of Wisconsin, Milwaukee; 53226.; Recent studies have suggested that steroid therapy may reduce the morbidity and mortality of HIV-associated Pneumocystis carinii pneumonia (PCP) in a select population of patients. However, the risks of steroid therapy for this group have not been well defined. We describe the case of a patient admitted with severe PC
Pediatric infection with the human immunodeficiency virus (HIV): head, neck, and oral manifestations.: Spec Care Dentist. 1993 May-Jun;13(3):113-6. Unique Identifier : AIDSLINE MED/94204878; Asher RS; McDowell J; Acs G; Belanger G; Department of Applied Dentistry, University of Colorado School of; Dentistry.; The increasing incidence of HIV infection in the pediatric population is of concern for the practicing dentist. Long incubation periods of the virus, combined with difficulty in detection, results in many undiagnosed cases of prenatal and natal infections with HIV. As a result, many dentists will unknowingly treat HIV
Israeli dentists: a survey of infection control office practices and care of medically compromised patients.: Spec Care Dentist. 1993 May-Jun;13(3):117-21. Unique Identifier : AIDSLINE MED/94204879; Trieger N; Schlesinger N; Kaufman E; Mann J; Department of Dentistry, Albert Einstein College of; Medicine/Montefiore Medical Center, Bronx, NY.; A survey was conducted by interviewing a randomly selected sample of practicing dentists in Israel in 1991. The aim of this study was to evaluate methods of infection control in current use and to learn about the access to care for medically compromised patients. One hundred sevent
Use of bronchoscopy in the diagnosis of infection in the immunocompromised host [editorial]: Thorax. 1994 Jan;49(1):3-7. Unique Identifier : AIDSLINE MED/94204989; Baughman RP
Human visceral leishmaniasis in Alpes-Maritimes, France: epidemiological characteristics for the period 1985-1992.: Trans R Soc Trop Med Hyg. 1994 Jan-Feb;88(1):33-4. Unique Identifier : AIDSLINE MED/94205051; Marty P; Le Fichoux Y; Pratlong F; Gari-Toussaint M; Faculte de Medecine, Universite de Nice-Sophia Antipolis,; France.; In 8 years (1985-1992), 65 cases of human visceral leishmaniasis (HVL) have been diagnosed in the department of Alpes-Maritimes, France , 56 of them having been infected locally. The annual frequency has increased from 3 cases in 1985 to 15 cases in 1992. There is a low rate of paed
Low risk of sexual transmission of hepatitis C virus in Somalia.: Trans R Soc Trop Med Hyg. 1994 Jan-Feb;88(1):55-6. Unique Identifier : AIDSLINE MED/94205062; Watts DM; Corwin AL; Omar MA; Hyams KC; Naval Medical Research Institute, Bethesda, Maryland 20852.; The prevalence in Somalia of antibody to hepatitis C virus (anti-HCV) was determined in a survey of 236 female prostitutes, 80 sexually transmitted disease (STD) clinic patients, 79 male soldiers, and 43 tuberculosis patients. Of 98 (22%) serum samples repeatedly anti-HCV reactive
Reduced efficacy of chemotherapy might accumulate concurrent HTLV-1 infection among strongyloidiasis patients in Okinawa, Japan.: Trans R Soc Trop Med Hyg. 1994 Jan-Feb;88(1):59. Unique Identifier : AIDSLINE MED/94205065; Sato Y; Shiroma Y; Kiyuna S; Toma H; Kobayashi J; Department of Parasitology, School of Medicine, University of the; Ryukyus, Okinawa, Japan.
The seroprevalence of syphilis, toxoplasmosis and hepatitis B in patients in Bahrain infected with human immunodeficiency virus.: Trans R Soc Trop Med Hyg. 1994 Jan-Feb;88(1):60. Unique Identifier : AIDSLINE MED/94205066; Yousif A; Wallace M; Baig B; Department of Pathology, Salmaniya Medical Centre, Manama,; Bahrain.
Clinical isolates of HIV-associated cryptococcosis in Nairobi, Kenya.: Trans R Soc Trop Med Hyg. 1994 Jan-Feb;88(1):85. Unique Identifier : AIDSLINE MED/94205076; Batchelor BI; Brindle RJ; Waiyaki PG; Kenya Medical Research Institute, Nairobi.
[The risk of substitution therapy with blood and blood products]: Z Arztl Fortbild (Jena). 1994 Jan;88(1):3-4. Unique Identifier : AIDSLINE MED/94205213; Baumgarten R; II. Innere Abteilung/Infektion, Krankenhaus Prenzlauer Berg.
[Neuro-AIDS in children]: Zh Nevropatol Psikhiatr Im S S Korsakova. 1993;93(5):3-9. Unique Identifier : AIDSLINE MED/94205293; Badalian LO; Berestov AI; Arkhipova BA; Gvatua TO; The paper analyzes the results of studying nervous diseases in children with HIV infection. A total of 57 children aged 1.5 to 16 years who had different stages of AIDS were examined. HIV-related encephalopathy, encephalopathy with the polyneuropathy syndrome, encephalomyelopolyneuritis, mixed AIDS-related encephalopa
Acquired immunodeficiency syndrome and the Americans with Disabilities Act: a legal duty to treat.: Am J Med. 1994 Mar;96(3):282-8; discussion 289-91. Unique Identifier : AIDSLINE MED/94205631; Halevy A; Brody B; Department of Medicine, Baylor College of Medicine, Houston, TX.; The emergence of the human immunodeficiency virus (HIV) as a serious public health threat has rekindled long dormant debate about individual physicians duty to treat potentially contagious patients. Because of the widely accepted common-law tenet of the no duty [to treat] rule, previous work on a duty to treat focuse
Chagas disease: another cause of cerebral mass in AIDS [letter; comment]: Am J Med. 1994 Mar;96(3):301-2. Unique Identifier : AIDSLINE MED/94205636; del Castillo M; Silva M
Group B streptococcal metastatic endophthalmitis.: Am J Ophthalmol. 1994 Apr 15;117(4):498-500. Unique Identifier : AIDSLINE MED/94205646; Nagelberg HP; Petashnick DE; To KW; Woodcome HA Jr; Department of Ophthalmology, Rhode Island Hospital, Brown; University School of Medicine, Providence 02903.; Reports of invasive Group B Streptococcus infection in adults with underlying medical conditions have been increasing. Ocular infection with this organism is unusual. Metastatic endophthalmitis in adults caused by this organism has been reported rarely and has only been associated with endocarditis. We encountered two
Varicella-zoster virus retinitis as the initial manifestation of the acquired immunodeficiency syndrome [letter]: Am J Ophthalmol. 1994 Apr 15;117(4):536-8. Unique Identifier : AIDSLINE MED/94205656; Friedman SM; Margo CE; Connelly BL
Promoting condom availability in schools [letter; comment]: Am J Public Health. 1994 Apr;84(4):676-7. Unique Identifier : AIDSLINE MED/94205697; Clark MP; Reynolds JH
AIDS-associated Reiter's syndrome [clinical conference]: Ann Allergy. 1994 Apr;72(4):307-16. Unique Identifier : AIDSLINE MED/94205745; Altman EM; Centeno LV; Mahal M; Bielory L; UMDNJ-New Jersey Medical School, Division of Allergy and; Immunology, Newark 07103-2499.; Classically, Reiter s syndrome was defined as a triad of arthritis, urethritis, and conjunctivitis. In 1981, the American Rheumatism Association revised its defining criteria for Reiter s syndrome as an episode of peripheral arthritis of more than 1 month s duration occurring in association with urethritis and/or cerv
Abdominal tuberculosis [see comments]: Ann R Coll Surg Engl. 1994 Mar;76(2):75-9. Unique Identifier : AIDSLINE MED/94205956; Ahmed ME; Hassan MA; Department of Surgery, Faculty of Medicine, University of; Khartoum, Sudan.; The abdomen is involved in 10% to 30% of patients with pulmonary tuberculosis. The diagnosis is not difficult in societies where the disease is common and clinicians are aware of it. While previously rare in Western countries, the incidence is now rising among immigrants, and patients with AIDS. In HIV-infected patien
Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage [see comments]: Ann Neurol. 1994 Apr;35(4):482-7. Unique Identifier : AIDSLINE MED/94206021; Dalakas MC; Leon-Monzon ME; Bernardini I; Gahl WA; Jay CA; Neuromuscular Diseases Section, National Institute of; Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, MD 20892.; The use of zidovudine ( AZT ) for the treatment of acquired immunodeficiency syndrome (AIDS) induces a DNA-depleting mitochondrial myopathy, which is histologically characterized by the presence of muscle fibers with ragged-red-like features, red-rimmed
Progressive multifocal leukoencephalopathy complicating Wiskott-Aldrich syndrome. Report of a case and review of the literature of progressive multifocal leukoencephalopathy with other inherited immunodeficiency states.: Arch Neurol. 1994 Apr;51(4):422-6. Unique Identifier : AIDSLINE MED/94206252; Katz DA; Berger JR; Hamilton B; Major EO; Post MJ; Department of Neurology, University of Miami School of Medicine,; Fla.; OBJECTIVE: To describe the occurrence of progressive multifocal leukoencephalopathy (PML) in association with Wiskott-Aldrich syndrome, an X-linked recessive disorder with impairment of both cellular and humoral immunity. DESIGN: A detailed analysis of this patient s clinical illness, immunologic factors, neuroradiogr
Acute retinal necrosis after chickenpox in a patient with acquired immunodeficiency syndrome [letter]: Arch Ophthalmol. 1993 Dec;111(12):1607-8. Unique Identifier : AIDSLINE MED/94206260; Friedman SM; Mames RN; Sleasman JW; Whitcup SM
[Tuberculosis. Role of fine needle puncture in the current diagnostic approach]: Ann Pathol. 1994;14(1):23-7. Unique Identifier : AIDSLINE MED/94206342; Sudaka A; Cochand-Priollet B; Chedin P; Chagnon S; Raskine L; Bergman JF; Service Central d'Anatomie et Cytologie Pathologiques, Hopital; Lariboisiere, Paris.; Twenty-one fine needle aspiration biopsies were performed with a diagnosis of tuberculosis or granulomatous inflammation. The ages of the patients ranged from 26 to 66 years (mean, 36 years); 16 were men and 5 women. Two of them were positive for the human immunodeficiency virus. In twenty cases, the cytological diagn
Insulin (auto)antibodies from human IDDM cross-react with retroviral antigen p73.: J Autoimmun. 1993 Dec;6(6):787-98. Unique Identifier : AIDSLINE MED/94206426; Hao W; Serreze DV; McCulloch DK; Neifing JL; Palmer JP; Department of Medicine, University of Washington, Seattle.; In NOD mice, endogenous retroviruses including intracisternal type A particles (IAP) are expressed in the pancreatic beta cells. Furthermore, in these mice, insulin autoantibodies (IAA) cross-react with retroviral protein p73 (the IAP gag gene product), suggesting molecular mimicry between insulin and p73. We therefor
Immunization of macaque monkeys with low- and high-dose regimens of SIVmac results in different immune responses [letter; comment]: Immunol Today. 1994 Feb;15(2):90-1. Unique Identifier : AIDSLINE MED/94206441; Dittmer U; Bodemer W; Hunsmann G; Voss G
[Tuberculous retropharyngeal abscess in an HIV patient. Report of a case]: Acta Otorrinolaringol Esp. 1993 Nov-Dec;44(6):467-70. Unique Identifier : AIDSLINE MED/94206596; Melchor Diaz MA; Domingo Carrasco C; Monge Jodra R; Marino Espuelas J; Ontanon Martin M; Servicio de ORL, Hospital 12 de Octubre, Madrid.; The tubercular retropharyngeal abscess is a rare manifestation of this infection, even in the presence of an extensive pulmonary involvement. We present the case of a patient HIV positive with an important compromise of the airway, and a review of the literature.
5'-Azido and 5'-fluoro alpha-nucleosides as analogues of AZT and FLT.: Acta Chem Scand. 1994 Mar;48(3):215-21. Unique Identifier : AIDSLINE MED/94206683; Schmidt L; Pedersen EB; Nielsen C; Department of Chemistry, Odense University, Denmark.; 5-Azido-2,5-dideoxy-beta-D-erythro-pentofuranosyl nucleosides 10 and their corresponding alpha-anomers 11 have been synthesized by condensation of methyl 3-O-acetyl-5-azido-2,5-dideoxy-beta-D-erythro-pentofuranoside (7) with silylated nucleobases followed by deprotection with methanolic ammonia. Reaction of silylated
Global programme on AIDS.: Wkly Epidemiol Rec. 1994 Feb 11;69(6):37-8. Unique Identifier : AIDSLINE MED/94206780
The number of HIV positive people in Scotland [news]: Nurs Stand. 1994 Feb 16-22;8(21):13. Unique Identifier : AIDSLINE MED/94206797
New test may predict progression of HIV [news]: Nurs Stand. 1994 Feb 16-22;8(21):14. Unique Identifier : AIDSLINE MED/94206798
Increased replication in HIV/HSV co-infection [news]: Nurs Stand. 1994 Feb 16-22;8(21):17. Unique Identifier : AIDSLINE MED/94206799
HIV/AIDS. Anonymous testing: legal or illegal?: Nurs Stand. 1994 Feb 16-22;8(21):22-3. Unique Identifier : AIDSLINE MED/94206802; Dimond B
No sex for UK nurses.: Nurs Stand. 1994 Mar 16-22;8(25):48-9. Unique Identifier : AIDSLINE MED/94206832; Dyer M
Triple helix formation with short oligonucleotide-intercalator conjugates matching the HIV-1 U3 LTR end sequence.: Biochemistry. 1994 Apr 12;33(14):4187-96. Unique Identifier : AIDSLINE MED/94206924; Mouscadet JF; Ketterle C; Goulaouic H; Carteau S; Subra F; Le Bret M; Auclair C; Laboratoire de Physicochimie et de Pharmacologie des; Macromolecules Biologiques, Institut Gustave-Roussy, CNRS URA; 147, INSERM, Villejuif, France.; In an attempt to target short purine sequences in view of pharmacological application, we have synthesized three new TFO (triple-helix-forming oligonucleotide) conjugates in which an intercalating oxazolopyridocarbazole (OPC) chromophore is linked by a pentamethylene linker to a 7-mer oligonucleotide matching the poly
[Varicella pneumonia in adults infected by HIV-1. Presentation of 2 cases]: Enferm Infecc Microbiol Clin. 1994 Jan;12(1):26-30. Unique Identifier : AIDSLINE MED/94207053; Sans M; Gatell JM; Rafel M; Mallolas J; Soriano E; Servicio de Enfermedades Infecciosas, Hospital Clinic i; Provincial, Barcelona.; BACKGROUND: Infection by the varicella-zoster virus (VZV) is frequent in patients infected by the HIV-1. Nonetheless, visceral involvement in addition to that of pneumonia is rare, despite the important immune dysfunction found among these patients. METHODS: Varicella pneumonia was diagnosed in 2 patients with HIV-1 i
[Bacteremia caused by Campylobacter jeikeium in 2 AIDS patients without neutropenia]: Enferm Infecc Microbiol Clin. 1994 Jan;12(1):31-3. Unique Identifier : AIDSLINE MED/94207054; Sanchez-Porto A; Vergara de Campos A; Inigo MA; Torres-Tortosa M; Rodriguez-Iglesias M; Unidad de Microbiologia Clinica, Hospital del SAS de La Linea,; Cadiz.; BACKGROUND: Bacteremia by Corynebacterium jeikeium is generally described in patients with a bone marrow transplantation and/or neutropenia. In 1991, the first case of bacteremia by C. jeikeium was described in a patient with AIDS and neutropenia. The aim of this study was to describe 2 cases of bacteremia by C. jeike
[Bacteremia caused by Haemophilus influenzae with special reference to its relation to HIV infection]: Enferm Infecc Microbiol Clin. 1994 Jan;12(1):34-7. Unique Identifier : AIDSLINE MED/94207055; Teira R; Oceja E; Baraia-Etxaburu J; Zubero Z; Munoz J; Cisterna R; Santamaria JM; Seccion de Enfermedades Infecciosas, Hospital de Basurto,; Bilbao.; BACKGROUND: The association between infection by Haemophilus influenzae and infection by the human immunodeficiency virus (HIV) has been clearly demonstrated. However, some characteristics of this association still remain poorly defined. METHODS: The medical records of all adult patients admitted to a general hospital
[Slowly developing cavitated pneumonia in a patient with HIV infection]: Enferm Infecc Microbiol Clin. 1994 Jan;12(1):39-40. Unique Identifier : AIDSLINE MED/94207056; Gomez C; Martinez A; Cano A; Altuna A; Lafuente A; Artero JM; Prieto JM; Martin Luengo F; Servicio de Microbiologia, Hospital General Universitario,; Murcia.
[Hyperkeratotic dermatitis in a patient with HIV infection (letter)]: Enferm Infecc Microbiol Clin. 1994 Jan;12(1):47-8. Unique Identifier : AIDSLINE MED/94207066; Ferrer E; Serrano C; Drobnic L; Moiset I; Jeremias J
A molecular genetic intervention for AIDS--effects of a transdominant negative form of Rev.: Hum Gene Ther. 1994 Jan;5(1):79-92. Unique Identifier : AIDSLINE MED/94207076; Nabel GJ; Fox BA; Post L; Thompson CB; Woffendin C; University of Michigan Medical Center.
[An emerging enteropathogen? (editorial)]: Invest Clin. 1993;34(3):109-11. Unique Identifier : AIDSLINE MED/94207077; Chacin-Bonilla L
[Viral transcription trans-activators]: Biokhimiia. 1994 Feb;59(2):163-92. Unique Identifier : AIDSLINE MED/94207082; Chinenov IuB; The structure and functional peculiarities of a wide range of viral transcriptional transactivators have been considered. Analysis of literature data, concerning with the principles of functioning has made it possible to divide the viral transcriptional transactivators into three major groups: transcriptional transact
[Hospital emergencies coming from a penitentiary center (letter)]: Aten Primaria. 1994 Feb 15;13(2):89. Unique Identifier : AIDSLINE MED/94207104; Garcia Velasco G; Martinez Cordero A
[Geriatric AIDS: 2 new cases (letter)]: Aten Primaria. 1994 Feb 15;13(2):98-9. Unique Identifier : AIDSLINE MED/94207116; Mansilla Bermenjo MJ; Marchan Carranza E; Carbayo Garcia JJ; Moraleda Velasco P
The core group revisited: the effect of partner mixing and migration on the spread of gonorrhea, Chlamydia, and HIV.: Math Biosci. 1994 Mar;120(1):1-23. Unique Identifier : AIDSLINE MED/94207216; Stigum H; Falck W; Magnus P; Department of Epidemiology, National Institute of Public Health,; Oslo, Norway.; A set of differential equations are used to model the spread of sexually transmitted diseases (STDs) in a one-sex population that includes a core group of highly sexually active subjects. The effects of partner mixing between groups and migration to and from the core on the equilibrium number of infected are shown for
Maternally acquired immunity in newborns from women infected by the human immunodeficiency virus.: Acta Paediatr. 1993 Dec;82(12):1034-8. Unique Identifier : AIDSLINE MED/94207229; de Moraes-Pinto MI; Farhat CK; Carbonare SB; Curti SP; Otsubo ME; Lazarotti DS; Campagnoli RC; Carneiro-Sampaio MM; Department of Pediatrics, Escola Paulista de Medicina,; Universidade de Sao Paulo, Brazil.; Maternally acquired immunity was studied in 16 pairs of human immunodeficiency virus (HIV)-seropositive women and their newborns, and was compared to 18 control mother-newborn pairs. The HIV-infected women had higher IgG levels than the control subjects, but no difference was observed between newborn samples, presumab
Inhibition of HIV-1 replication in cultured cells with antisense oligonucleotides encapsulated in immunoliposomes.: Antisense Res Dev. 1993 Winter;3(4):323-38. Unique Identifier : AIDSLINE MED/94207284; Zelphati O; Zon G; Leserman L; Centre d'Immunologie, Institut National de la Sante et de la; Recherche Medicale-Centre National de la Recherche Scientifique; de Marseille-Luminy, France.; Antisense oligonucleotides inhibit HIV replication in vitro, but their activity is limited by their sensitivity to nucleases and low cellular uptake. To see whether these problems could be circumvented, we compared effects of HIV-1 rev and tat gene-specific antisense phosphodiester or phosphorothioate oligonucleotides
Retroviruses and inflammatory myopathies in humans and primates.: Baillieres Clin Neurol. 1993 Nov;2(3):659-91. Unique Identifier : AIDSLINE MED/94207491; Dalakas MC; Neuromuscular Diseases Section, National Institutes of Health,; Bethesda, Maryland 20892.; The human immunodeficiency virus (HIV), the human T cell lymphotropic virus (HTLV-1), the human foamy retrovirus and the simian immunodeficiency viruses have been associated with the development of an inflammatory myopathy in humans and primates. The myopathy caused by HIV and HTLV-1 is not due to direct infection of
Short-sighted evolution and the virulence of pathogenic microorganisms.: Trends Microbiol. 1994 Mar;2(3):76-81. Unique Identifier : AIDSLINE MED/94207662; Levin BR; Bull JJ; Dept of Biology, Emory University, Atlanta, GA 30322.; For some microorganisms, virulence may be an inadvertent consequence of mutation and selection in the parasite population, occurring within a host during the course of an infection. This type of virulence is short-sighted, in that it engenders no advantage to the pathogen beyond the afflicted host. Bacterial meningiti
Yttrium synovectomy in haemophilic arthropathy.: Br J Rheumatol. 1994 Apr;33(4):351-6. Unique Identifier : AIDSLINE MED/94207703; Dawson TM; Ryan PF; Street AM; Robertson PL; Kalff V; Kelly MJ; Cicuttini FM; Department of Rheumatology, Alfred Hospital, Prahran, Melbourne,; Australia.; Between 1987 and 1991 we performed Yttrium-90 (Y-90) silicate radionuclide synovectomies on 40 joints of 20 haemophiliac patients with haemophilic arthropathy. All were male, their mean age was 31 yr and 15 of the 20 (75%) were HIV antibody positive. The number of joint bleeds and amount of factor (VIII and IX) replac
Pyomyositis due to Escherichia coli in a patient infected by HIV [letter]: Br J Rheumatol. 1994 Apr;33(4):404-5. Unique Identifier : AIDSLINE MED/94207714; Vilades C; Garcia-Queralt R; Rivas I; Vidal F; Richart C
AIDS and dentistry [letter; comment] [see comments]: J Can Dent Assoc. 1994 Mar;60(3):177. Unique Identifier : AIDSLINE MED/94207877; Wood MR
Long survival in patients with acquired immune deficiency syndrome-related primary central nervous system lymphoma.: Cancer. 1994 Mar 15;73(6):1728-30. Unique Identifier : AIDSLINE MED/94207950; Chamberlain MC; University of California, Department of Neurosciences, San Diego; 92103.; BACKGROUND. Primary central nervous system lymphoma (PCNSL) is the most common brain tumor occurring in patients with acquired immune deficiency syndrome (AIDS). After diagnosis of PCNSL, the median survival time is 2-5 months with treatment with whole brain irradiation (WBI). METHODS. Four (of approximately 40) patie
Treatment of acquired immunodeficiency syndrome (AIDS)-related cancer.: Cancer Treat Rev. 1994 Apr;20(2):149-72. Unique Identifier : AIDSLINE MED/94207995; Monfardini S; Tirelli U; Vaccher E; Division of Medical Oncology, Centro di Riferimento Oncologico,; Aviano, Italy.
[Application of the time-resolved immunofluorometric assay in the detection of viruses]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1993 Dec;14(6):362-5. Unique Identifier : AIDSLINE MED/94208045; Zuo S; Institute of Microbiology and Epidemiology, Academy of Military; Medical Sciences, Beijing.; Two systems of time-resolved immunofluorometric assay (TR-IFMA), i.e., LKB system detection of viruses. The viruses detected were mainly adenovirus, influenza virus, parainfluenza virus, respiratory syncytial virus rotavirus, hepatitis B virus, human immunodeficiency virus, rubella virus, etc. Compared with methods of
Inhibition of DNA topoisomerase I activity by 2',5'-oligoadenylates and mismatched double-stranded RNA in uninfected and HIV-1-infected H9 cells.: Chem Biol Interact. 1994 Feb;90(2):169-83. Unique Identifier : AIDSLINE MED/94208071; Schroder HC; Kelve M; Schacke H; Pfleiderer W; Charubala R; Suhadolnik RJ; Muller WE; Abteilung Angewandte Molekularbiologie, Johannes; Gutenberg-Universitat, Mainz, Germany.; 2 ,5 -Oligoadenylates (2-5As) inhibit the type I DNA topoisomerase activity both in uninfected and HIV-1-infected human T cell line H9 as well as the purified enzyme (calf thymus). Topoisomerase I activity was determined by measuring the relaxation of negatively supercoiled pBR322 DNA. Inhibition of topoisomerase I by
Diazolidinyl urea: incidence of sensitivity, patterns of cross-reactivity and clinical relevance.: Contact Dermatitis. 1994 Jan;30(1):16-9. Unique Identifier : AIDSLINE MED/94208233; Hectorne KJ; Fransway AF; Department of Dermatology, Mayo Clinic, Rochester, MN 55905.; Diazolidinyl urea (DIAZ) is a formaldehyde-releasing preservative used in cosmetics and personal-care products, which has been identified as a sensitizing agent in contact dermatitis. To determine whether DIAZ sensitization is secondary to formaldehyde release or due to its own allergenic properties, we reviewed 708 c
Specific binding of HIV-1 nucleocapsid protein to PSI RNA in vitro requires N-terminal zinc finger and flanking basic amino acid residues.: EMBO J. 1994 Apr 1;13(7):1525-33. Unique Identifier : AIDSLINE MED/94208520; Dannull J; Surovoy A; Jung G; Moelling K; Max-Planck-Institut fur Molekulare Genetik, Abteilung Schuster,; Germany.; The nucleocapsid (NC) protein of human immunodeficiency virus HIV-1 (NCp7) is responsible for packaging the viral RNA by recognizing a packaging site (PSI) on the viral RNA genome. NCp7 is a molecule of 55 amino acids containing two zinc fingers, with only the first one being highly conserved among retroviruses. The f
Elevated serum thyrotropin [TSH] levels in critically ill patients with acquired immunodeficiency syndrome (AIDS).: Exp Clin Endocrinol. 1993;101(6):346-9. Unique Identifier : AIDSLINE MED/94208636; Peter SA; Ortiz JM; Vergara R; Woodhull Medical and Mental Health Center, Department of Medicine; New York.; STUDY OBJECTIVE: To determine thyrotropin (TSH) reserve in critically ill patients with Acquired Immunodeficiency Syndrome (AIDS). DESIGN: Prospective longitudinal. SETTING: Six hundred (600) bed municipal hospital serving a poor neighborhood in New York City with a high incidence of AIDS mainly from intravenous drug
Cytomegalovirus infection in the pregnant women.: Eur J Obstet Gynecol Reprod Biol. 1993 Dec 15;52(2):139-42. Unique Identifier : AIDSLINE MED/94208698; Consten EC; Brummelkamp WH; Henny CP; Department of Surgery, Academic Hospital, University of; Amsterdam, The Netherlands.; Cytomegaloviruses ( CMV ) commonly infect man but overt disease only occurs in few patients; in the vast majority the infection is subclinical. We report on a HIV-negative pregnant woman. She suffered from a life-threatening ulcerating colitis due to CMV infection
The importance of serial immunoglobulin evaluations in HIV-seropositive haemophiliacs.: Haematologia (Budap). 1993;25(4):271-6. Unique Identifier : AIDSLINE MED/94208776; Mares M; Sartori MT; Zerbinati P; Girolami A; Institute of Medical Semeiotics, University of Padua Medical; School, Padova, Italy.; The aim of our investigation was to evaluate whether the alteration of immunoglobulins (Igs) may be a predictive marker of the evolution of HIV infection in seropositive haemophiliacs. For this purpose two groups of haemophiliac patients (16 seronegative and 21 seropositive) were compared to evaluate the variations of
[Nosocomial infections and infection control committee]: Hokkaido Igaku Zasshi. 1994 Mar;69(2):157-60. Unique Identifier : AIDSLINE MED/94208807; Togashi T; Department of Pediatrics, Hokkaido University School of Medicine,; Sapporo, Japan.; The problems of nosocomial infections include cross infections from the environments to patients in the wards and infections from virus-contaminated bloods into medical staffs by mainly needle stick injury. The infection control committees organized in Hokkaido University Hospital in 1981 for HBV infection, in 1992 fo
Identification of a putative cellular receptor for feline immunodeficiency virus as the feline homologue of CD9.: Immunology. 1994 Feb;81(2):228-33. Unique Identifier : AIDSLINE MED/94208851; Willett BJ; Hosie MJ; Jarrett O; Neil JC; Department of Veterinary Pathology, University of Glasgow; Veterinary School, U.K.; A monoclonal antibody vpg15 has been identified which recognizes a putative cellular receptor for feline immunodeficiency virus (FIV). The antibody immunoprecipitates a single 24,000 MW species from feline cells. The molecular size and pattern of expression of the ligand for the vpg15 antibody displayed similarities t
Selective inhibition of immature CD4-CD8+ thymocyte proliferation, but not differentiation, by the thymus atrophy-inducing compound di-n-butyltin dichloride.: Immunology. 1994 Feb;81(2):261-7. Unique Identifier : AIDSLINE MED/94208856; Pieters RH; Bol M; Ariens T; Punt P; Seinen W; Bloksma N; Penninks AH; Research Institute of Toxicology, Utrecht University, The; Netherlands.; Effects of the thymus atrophy-inducing organotin compound di-n-butyltin dichloride (DBTC) on the differentiation and proliferation of immature rat thymocyte subsets were studied in vivo and in vitro. Incubation of freshly isolated CD4-CD8- or immature CD4-CD8+ (characterized as CD4-CD53-) thymocytes with 10(-7) M DBTC
Tuberculosis: an epidemic in the making [editorial]: Indian J Pathol Microbiol. 1993 Oct;36(4):339-40. Unique Identifier : AIDSLINE MED/94208887; Talib VH; Pandey J; Khurana SK
HIV-1 seropositivity in pulmonary tuberculosis (study of 340 cases from Marathwada).: Indian J Pathol Microbiol. 1993 Oct;36(4):383-8. Unique Identifier : AIDSLINE MED/94208894; Talib SH; Bansal MP; Kamble MM; Department of Medicine, Govt. Medical College & Hospital,; Aurangabad.; An investigative study was carried out in 340 cases of established pulmonary and presumed pleural tuberculosis for co-occurrence of HIV-1 infection in them. Confirmatory screening for HIV-1 was carried out with both ELISA (Vironostika) and Serodia commercial kits in all reactive samples on first screening. In all, 16
Infective dermatitis among patients with ATL in Japan [letter]: Int J Cancer. 1994 Apr 15;57(2):293. Unique Identifier : AIDSLINE MED/94208964; Tsukasaki K; Yamada Y; Ikeda S; Tomonaga M
Papulonecrotic tuberculid secondary to disseminated Mycobacterium avium complex [see comments]: Int J Dermatol. 1994 Feb;33(2):109-12. Unique Identifier : AIDSLINE MED/94208987; Williams JT; Pulitzer DR; DeVillez RL; Department of Pathology, University of Texas Health Science; Center, San Antonio 78284.; BACKGROUND. Papulonecrotic tuberculid is a rarely reported cutaneous reaction to the mycobacterium bacillus. It is most often encountered in association with tuberculosis. The clinical and histologic picture of the entity is a distinctive one, but the etiology of the disease process is uncertain. Therapy directed agai
Maternal immunization to prevent infectious diseases in the neonate or infant.: Int J Technol Assess Health Care. 1994 Winter;10(1):143-53. Unique Identifier : AIDSLINE MED/94209044; Insel RA; Amstey M; Woodin K; Pichichero M; University of Rochester Medical Center.; The approach of providing passive protection to young infants by immunizing pregnant women can bypass the problems of immunological immaturity in the neonate, avoid or delay active immunization of the infant in the first year of life, and prevent transmission of an infection from the mother to the neonate. Optimal vac
Mutational analysis of the substrate binding pockets of the Rous sarcoma virus and human immunodeficiency virus-1 proteases.: J Biol Chem. 1994 Apr 15;269(15):11170-7. Unique Identifier : AIDSLINE MED/94209287; Cameron CE; Ridky TW; Shulenin S; Leis J; Weber IT; Copeland T; Wlodawer A; Burstein H; Bizub-Bender D; Skalka AM; Case Western Reserve University School of Medicine, Cleveland,; Ohio 44106-4935.; Mutations, designed by analysis of the crystal structures of Rous sarcoma virus (RSV) and human immunodeficiency virus type 1 (HIV-1) protease (PR), were introduced into the substrate binding pocket of RSV PR. The mutations substituted nonconserved residues of RSV PR, located within 10 A of the substrate, for those in
A hammerhead ribozyme inhibits the proliferation of an RNA coliphage SP in Escherichia coli.: J Biol Chem. 1994 Apr 15;269(15):11361-6. Unique Identifier : AIDSLINE MED/94209314; Inokuchi Y; Yuyama N; Hirashima A; Nishikawa S; Ohkawa J; Taira K; Department of Biosciences, Teikyo University, Utsunomiya, Japan.; Ribozymes are potentially powerful tools for the suppression of intracellular gene expression. However, the few reports that exist of their activities in bacteria have described mixed success. Chuat and Galibert (Chuat, J.-C., and Galibert, F. (1989) Biochem. Biophys. Res. Commun. 162, 1025-1029) failed to detect any
Dental complications after treating patients with AIDS.: J Am Dent Assoc. 1994 Mar;125(3):296-301. Unique Identifier : AIDSLINE MED/94209523; Glick M; Abel SN; Muzyka BC; DeLorenzo M; Infectious Disease Program, School of Dental Medicine, University; of Pennsylvania, Philadelphia 19140.; Post-procedural complications were assessed for 331 patients with AIDS after a wide range of outpatient dental procedures. Only patients with a CD4+ cell count
[Where in the world is perinatal medicine going? (letter)]: J Gynecol Obstet Biol Reprod (Paris). 1994;23(1):105-7. Unique Identifier : AIDSLINE MED/94209564; Thoulon JM
Suicidality and HIV status in the emergency department [letter]: J Emerg Med. 1993 Nov-Dec;11(6):762-3. Unique Identifier : AIDSLINE MED/94209603; Tueth MJ
Serum IgA-mediated neutralization of HIV type 1.: J Immunol. 1994 May 1;152(9):4642-8. Unique Identifier : AIDSLINE MED/94209687; Burnett PR; VanCott TC; Polonis VR; Redfield RR; Birx DL; U.S. Army Dental Research Detachment, Washington, DC 20307.; The sera of 33 HIV-1-infected individuals, previously shown to neutralize HIV-1MN in vitro, were screened by ELISA for IgA reactivity against rgp120MN and a synthetic V3MN loop peptide. Six were selected for evaluation of the effect of serum IgA from infected individuals on the in vitro infection of susceptible target
Functional and phenotypic change of T cells in murine acquired immune deficiency.: J Immunol. 1994 May 1;152(9):4671-9. Unique Identifier : AIDSLINE MED/94209690; Kanagawa O; Gayama S; Vaupel B; Department of Pathology and Medicine, Washington University; School of Medicine, St. Louis, MO 63110.; Infection of susceptible C57BL/6 mice with defective LP-BM5 murine leukemia virus causes disease termed murine acquired immune deficiency syndrome (MAIDS). The disease is characterized by lymphoadenopathy, hyperimmunoglobulinemia, and immune deficiency in both T and B cell functions. The development of disease require
Role of IMA in prevention and control of AIDS [editorial]: J Indian Med Assoc. 1993 Dec;91(12):308. Unique Identifier : AIDSLINE MED/94209723; Grover NK
National AIDS control programme and generation of awareness in medical profession [editorial]: J Indian Med Assoc. 1993 Dec;91(12):309. Unique Identifier : AIDSLINE MED/94209724; Lal S
AIDS and society.: J Indian Med Assoc. 1993 Dec;91(12):313-4. Unique Identifier : AIDSLINE MED/94209725; Parameshvara V
HIV/AIDS epidemic in Asia: the current situation and strategies for prevention.: J Indian Med Assoc. 1993 Dec;91(12):315-6, 324. Unique Identifier : AIDSLINE MED/94209726; Narain JP; Shah NK; WHO, Regional Office for South-East Asia, New Delhi.
AIDS--glimpses of African experience.: J Indian Med Assoc. 1993 Dec;91(12):317-8. Unique Identifier : AIDSLINE MED/94209727; Banerjee K; Department of Medicine, Calcutta Medical College.
The importance of counselling in the care of persons with HIV infection or AIDS.: J Indian Med Assoc. 1993 Dec;91(12):321-4. Unique Identifier : AIDSLINE MED/94209729; John TJ; Department of Microbiology and Virology, Christian Medical; College and Hospital, Vellore.
Ethical and legal issues and AIDS.: J Indian Med Assoc. 1993 Dec;91(12):325-6. Unique Identifier : AIDSLINE MED/94209730; De Souza EJ; FIAMC Bio-Medical Ethics Centre, Bombay.
Acquired immunodeficiency syndrome and some social problems.: J Indian Med Assoc. 1993 Dec;91(12):327-9, 331. Unique Identifier : AIDSLINE MED/94209731; Dutta GP
HIV testing policy and surveillance.: J Indian Med Assoc. 1993 Dec;91(12):330-1. Unique Identifier : AIDSLINE MED/94209732; Lal S; Salil P; Thakur BB; National AIDS Control Organisation, Ministry of Health and Family; Welfare, New Delhi.
AIDS: a paediatric perspective.: J Indian Med Assoc. 1993 Dec;91(12):332-4, 337. Unique Identifier : AIDSLINE MED/94209733; Chatterjee S; Chatterjee R; Department of Paediatric Medicine, Calcutta National Medical; College.
Infection control in the health care settings.: J Indian Med Assoc. 1993 Dec;91(12):335-7. Unique Identifier : AIDSLINE MED/94209734; Anand VJ; Mahajan V; Department of Surgery, Moulana Azad Medical College, New Delhi.
AIDS today.: J Indian Med Assoc. 1993 Dec;91(12):338-40. Unique Identifier : AIDSLINE MED/94209735; Mukherjee S; Kar M; Department of Medicine, Medical College, Calcutta.
AIDS: perspective and strategy [letter; comment]: J Indian Med Assoc. 1993 Dec;91(12):341. Unique Identifier : AIDSLINE MED/94209736; Srinivasa H
Tuberculosis and HIV infection [letter]: J Indian Med Assoc. 1993 Dec;91(12):341-2. Unique Identifier : AIDSLINE MED/94209737; Avasthi R
AIDS problems [letter; comment]: J Indian Med Assoc. 1993 Dec;91(12):342. Unique Identifier : AIDSLINE MED/94209738; De TS
BK and JC viruses in human immunodeficiency virus type 1-infected persons: prevalence, excretion, viremia, and viral regulatory regions.: J Infect Dis. 1994 Mar;169(3):485-90. Unique Identifier : AIDSLINE MED/94209740; Sundsfjord A; Flaegstad T; Flo R; Spein AR; Pedersen M; Permin H; Julsrud J; Traavik T; Department of Virology, University of Tromso, Norway.; Human polyomavirus BK (BKV) and JC (JCV) infections were examined in persons infected with human immunodeficiency virus type 1 (HIV-1). High frequencies of BKV (24%) and JCV viruria (16%) were detected by polymerase chain reaction (PCR). BKV viruria was not found in an immunocompetent control group, in contrast to a f
Differential immune responsiveness to the immunodominant epitopes of regulatory proteins (tax and rex) in human T cell lymphotropic virus type I-associated myelopathy.: J Infect Dis. 1994 Mar;169(3):496-503. Unique Identifier : AIDSLINE MED/94209742; Lal RB; Giam CZ; Coligan JE; Rudolph DL; Retrovirus Diseases Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30329.; Infection by human T cell lymphotropic virus type I (HTLV-I) is etiologically linked with HTLV-I-associated myelopathy (HAM) or adult T cell leukemia (ATL). To evaluate the contribution of the viral regulatory proteins tax and rex during the development of disease, antibody responses to these proteins were analyzed in
Apparent selection against transmission of zidovudine-resistant human immunodeficiency virus type 1 variants.: J Infect Dis. 1994 Mar;169(3):611-4. Unique Identifier : AIDSLINE MED/94209758; Wahlberg J; Fiore J; Angarano G; Uhlen M; Albert J; Department of Biochemistry and Biotechnology, Royal Institute of; Technology, Stockholm, Sweden.; The sexual transmission of zidovudine-resistant human immunodeficiency virus type 1 (HIV-1) variants was investigated in 5 donor-recipient pairs in which all donors and none of the recipients had received zidovudine treatment. The virus isolates were tested for sensitivity to zidovudine (IC50) in vitro using blood don
Intestinal secretory IgA immune response against human immunodeficiency virus among infected patients with acute and chronic diarrhea.: J Infect Dis. 1994 Mar;169(3):614-7. Unique Identifier : AIDSLINE MED/94209759; Mathewson JJ; Jiang ZD; DuPont HL; Chintu C; Luo N; Zumla A; Center for Infectious Diseases, University of Texas Medical; School/School of Public Health, Houston 77030.; Diarrhea is common in patients infected with the human immunodeficiency virus (HIV) in Africa. There has been speculation that HIV itself may cause some of the enteropathy seen. The intestinal secretory IgA (sIgA) response was used to evaluate HIV intestinal infections in Zambian patients with acute and chronic diarrh
Opportunistic events and p17 expression in the bone marrow of human immunodeficiency virus-infected patients.: J Infect Dis. 1994 Mar;169(3):617-20. Unique Identifier : AIDSLINE MED/94209760; Wiley EL; Nightingale SD; Department of Pathology, University of Texas, Southwestern; Medical Center at Dallas.; Bone marrow biopsies from 114 human immunodeficiency virus (HIV)-infected patients were stained with an anti-p17 monoclonal antibody to detect active HIV replication and associated factors. Immunoreactive p17 was found as virus-like particles in macrophages and dendritic cells and occasionally in megakaryocytes in 62
Immunoglobulin prophylaxis against human T cell lymphotropic virus type II in rabbits.: J Infect Dis. 1994 Mar;169(3):620-3. Unique Identifier : AIDSLINE MED/94209761; Morishita N; Ishii K; Tanaka Y; Sawada T; Hoshino H; Foung SK; Miyoshi I; Department of Medicine, Kochi Medical School, Japan.; Hyperimmune globulins, I-IgG and II-IgG, prepared from healthy persons seropositive for human T cell lymphotropic virus (HTLV) types I and II, respectively, were tested for their prophylactic effect against HTLV-II infection in rabbits. Three groups (A, B, and C) of 3 female rabbits each were used. Group A rabbits wer
Detection of cytomegalovirus in cerebrospinal fluid autopsy specimens from AIDS patients.: J Infect Dis. 1994 Mar;169(3):623-7. Unique Identifier : AIDSLINE MED/94209762; Achim CL; Nagra RM; Wang R; Nelson JA; Wiley CA; Department of Pathology, University of California, San Diego, La; Jolla.; Cytomegalovirus ( CMV ) is a common opportunistic pathogen infecting AIDS patients. Polymerase chain reaction (PCR) and antigen capture ELISA were used to detect CMV in 40 cerebrospinal fluid autopsy specimens from patients with AIDS. CMV DNA was detected by PCR i
Hepatitis B virus activation among central Africans infected with human immunodeficiency virus (HIV) type 1: pre-s2 antigen is predominantly expressed in HIV infection.: J Infect Dis. 1994 Mar;169(3):628-32. Unique Identifier : AIDSLINE MED/94209763; Kashala O; Mubikayi L; Kayembe K; Mukeba P; Essex M; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115.; To evaluate the impact of human immunodeficiency virus (HIV) type 1 on the natural history of hepatitis B virus (HBV) infection, sera from Central Africans with and without antibodies to HIV were examined for HBV markers of ongoing replication, recovery from infection, and reactivation or reinfection. The prevalence o
Possible role of high-titer maternal viremia in perinatal transmission of hepatitis C virus.: J Infect Dis. 1994 Mar;169(3):638-41. Unique Identifier : AIDSLINE MED/94209765; Lin HH; Kao JH; Hsu HY; Ni YH; Yeh SH; Hwang LH; Chang MH; Hwang SC; Chen PJ; Chen DS; Department of Obstetrics and Gynecology, College of Medicine,; National Taiwan University, Taipei, Republic of China.; To study perinatal transmission of hepatitis C virus (HCV), 15 anti-HCV-positive carrier mothers without human immunodeficiency virus coinfection were recruited. At delivery, maternal blood was taken and anti-HCV titer was determined and HCV RNA measured in each serum sample by reverse transcription polymerase chain r
Immunoepidemiologic studies of Strongyloides stercoralis and human T lymphotropic virus type I infections in Jamaica.: J Infect Dis. 1994 Mar;169(3):692-6. Unique Identifier : AIDSLINE MED/94209780; Robinson RD; Lindo JF; Neva FA; Gam AA; Vogel P; Terry SI; Cooper ES; Department of Zoology, University of the West Indies, Kingston,; Jamaica.; Epidemiologic investigations of Strongyloides stercoralis and human T lymphotropic virus type I (HTLV-I) infections were conducted. Of 312 persons contacted, 209 (67%) provided blood and stool samples. Prevalences of S. stercoralis and HTLV-I antibodies were 26.8% and 8.1% (n = 198), respectively, and S. stercoralis l
Secretory IgA antibodies to Cryptosporidium parvum in AIDS patients with chronic cryptosporidiosis.: J Infect Dis. 1994 Mar;169(3):696-9. Unique Identifier : AIDSLINE MED/94209781; Cozon G; Biron F; Jeannin M; Cannella D; Revillard JP; Immunology Laboratory, Institut National de la Sante et de la; Recherche Medicale, Hopital E. Herriot, Lyon, France.; Immune mechanisms that may control Cryptosporidium parvum infection remain unknown. The role of T cell-mediated immunity is suggested by the chronic disease observed in AIDS patients and in athymic or CD4+ T cell-depleted mice. The role of specific antibodies is also unclear. This study sought to determine serum and s
Mononuclear cell subpopulations in human immunodeficiency virus (HIV)-positive versus HIV-negative patients with visceral leishmaniasis [letter]: J Infect Dis. 1994 Mar;169(3):707-8. Unique Identifier : AIDSLINE MED/94209788; Cenini P; Berhe N; Hailu A; Frommel D
Thirteen current anti-HIV-1/HIV-2 enzyme immunoassays: how accurate are they?: J Med Virol. 1994 Feb;42(2):115-8. Unique Identifier : AIDSLINE MED/94209851; McAlpine L; Gandhi J; Parry JV; Mortimer PP; Hepatitis and Retrovirus Laboratory, Central Public Health; Laboratory, Colindale, London, United Kingdom.; The sensitivity and specificity of 13 current anti-HIV-1/HIV-2 screening enzyme immunoassays (EIA) for the detection of anti-HIV in human serum or plasma were investigated by testing against a panel of 454 well-characterised serum or plasma specimens. The panel included specimens confirmed to contain anti-HIV-1 (n = 9
Novel HIV-inhibitory halistanol sulfates F-H from a marine sponge, Pseudoaxinissa digitata.: J Nat Prod. 1994 Jan;57(1):164-7. Unique Identifier : AIDSLINE MED/94209928; Bifulco G; Bruno I; Minale L; Riccio R; Dipartimento di Chimica delle Sostanze Naturali, Universita di; Napoli Federico II, Napoli, Italy.; Three new steroid sulfates 2-4 related to halistanol sulfate [1] were isolated along with the known halistanol sulfate C [5] from the marine sponge Pseudoaxinissa digitata. Halistanol sulfates F [2] and G [3] proved to be cytoprotective against HIV.
Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.: J Nat Prod. 1994 Jan;57(1):42-51. Unique Identifier : AIDSLINE MED/94209934; Hu CQ; Chen K; Shi Q; Kilkuskie RE; Cheng YC; Lee KH; Natural Products Laboratory, School of Pharmacy, University of; North Carolina, Chapel Hill 27599.; An active anti-HIV principle, acacetin-7-O-beta-D-galactopyranoside, has been isolated from Chrysanthemum morifolium. Seven additional flavonoids isolated from this plant, 13 known related flavonoids, and 14 synthetic flavonoids were also evaluated as inhibitors of HIV replication in H9 cells. A known flavone, chrysin
Production of granulocyte-macrophage colony stimulating factor by human T-lymphotropic virus type I-infected human glioma cells.: J Neurol Sci. 1994 Feb;121(2):208-14. Unique Identifier : AIDSLINE MED/94209990; Nishiura Y; Nakamura T; Takino H; Ichinose K; Nagasato K; Ohishi K; Tsujihata M; Nagataki S; First Department of Internal Medicine, Nagasaki University School; of Medicine, Japan.; We investigated the production of granulocyte-macrophage colony stimulating factor (GM-CSF) by human T-lymphotropic virus type I (HTLV-I)-infected human glioma cells (KG-1-C and T98G). When glioma cells were co-cultured with HTLV-I-producing T cell lines (HCT-1 and MT-2), GM-CSF was detected in the culture supernatant
A pathologically distinct new form of HIV associated encephalopathy.: J Neurol Sci. 1994 Feb;121(2):215-21. Unique Identifier : AIDSLINE MED/94209991; von Giesen HJ; Arendt G; Neuen-Jacob E; Prestien K; Jablonowski H; Freund HJ; Department of Neurology, Heinrich-Heine-University Dusseldorf,; Germany.; We present the clinical, morphological and neuropathological findings in a 44-year-old male suffering from the acquired immunodeficiency syndrome (AIDS) (CDC stage IV C2) who presented with rapidly progressive right-side hemiparesis and developed hemianopia and aphasia. Scans showed multiple, not contrast-enhancing, n
IgG, IgM, and IgA response to HIV in infants born to HIV-1 infected mothers. Swiss Neonatal HIV Study Group.: J Acquir Immune Defic Syndr. 1994 May;7(5):421-7. Unique Identifier : AIDSLINE MED/94210365; Schupbach J; Tomasik Z; Jendis J; Boni J; Seger R; Kind C; Swiss National Center for Retroviruses, University of Zurich.; Children born to HIV-1-positive mothers were prospectively tested for HIV-reactive IgG, IgM, and IgA by Western blot, in order to study the children s humoral immune response in the background of passively transferred maternal IgG. In infected infants, a response was first seen at 1-3 months for env-reactive IgM and I
Biphasic in vitro regulation of retroviral replication by CD8+ cells from nonhuman primates.: J Acquir Immune Defic Syndr. 1994 May;7(5):438-46. Unique Identifier : AIDSLINE MED/94210367; Knuchel M; Bednarik DP; Chikkala N; Ansari AA; Department of Pathology, Emory University School of Medicine,; Atlanta, GA.; CD8+ T cells from naturally infected disease-resistant sooty mangabeys (Cercocebus atys) secrete a soluble factor which inhibits the in vitro replication of the simian immunodeficiency virus (SIV). To gain further insight on the mechanism(s) involved, CD8+ effector T cells and target cells from sooty mangabeys were im
Lack of correlation between the number of circulating B cells and the concentration of serum antibodies reactive with the HIV-1 envelope glycoprotein.: J Acquir Immune Defic Syndr. 1994 May;7(5):447-53. Unique Identifier : AIDSLINE MED/94210368; Schwartz DH; Cosentino LM; Shirai A; Conover J; Daniel S; Klinman DM; Laboratory of Retroviral Research, CBER/FDA, Bethesda, MD 20892.; Cells obtained from the peripheral blood of HIV-infected patients and volunteers immunized with HIV-1 vaccines are commonly used to study anti-viral responses, since lymphocytes from the central lymphoid organs are difficult to obtain. Analyses involving PBMC implicitly assume that circulating B cells provide an accur
Intermittent therapy [editorial]: J Acquir Immune Defic Syndr. 1994 May;7(5):454-6. Unique Identifier : AIDSLINE MED/94210369; Volberding PA
Trimethoprim-sulfamethoxazole versus aerosolized pentamidine for primary prophylaxis of Pneumocystis carinii pneumonia: a prospective, randomized, controlled clinical trial. LFPMI Study Group. Ligue Francaise de Prevention des Maladies Infectieuses.: J Acquir Immune Defic Syndr. 1994 May;7(5):457-62. Unique Identifier : AIDSLINE MED/94210370; May T; Beuscart C; Reynes J; Marchou B; Leclercq P; Borsa Lebas F; Saba J; Micoud M; Mouton Y; Canton P; Department of Infectious Diseases, University Hospital Nancy,; France.; The objective was to compare the efficacy and tolerance of monthly aerosolized pentamidine versus trimethoprim-sulfamethoxazole (TMP-SMX) to prevent the first episode of Pneumocystis carinii pneumonia (PCP) in human immunodeficiency virus (HIV)-infected patients. In an open, prospective, randomized multicentric clinic
Liposomal doxorubicin in the treatment of advanced AIDS-related Kaposi sarcoma.: J Acquir Immune Defic Syndr. 1994 May;7(5):463-8. Unique Identifier : AIDSLINE MED/94210371; Bogner JR; Kronawitter U; Rolinski B; Truebenbach K; Goebel FD; Medizinische Poliklinik, Klinikum Innenstadt, University of; Munich, Germany.; Neither single-agent therapy nor any combination treatment has been satisfactory enough to be regarded as standard in systemic advanced Kaposi sarcoma. In an attempt to achieve high efficacy in combination with low toxicity, we used a new liposomal formulation of doxorubicin. Pharmacologic data had established a long
Injected-drug use: complications and costs in the care of hospitalized HIV-infected patients.: J Acquir Immune Defic Syndr. 1994 May;7(5):469-73. Unique Identifier : AIDSLINE MED/94210372; Stein MD; Department of Medicine, Brown University School of Medicine,; Providence, Rhode Island.; The aim of this study was to determine the contribution of injected-drug-use complications to the utilization of inpatient care by persons infected with human immunodeficiency virus (HIV). Retrospective chart review was done of all hospital admissions between January 1, 1991, and December 31, 1991, with outpatient rec
Recombinant human erythropoietin and health-related quality of life of AIDS patients with anemia.: J Acquir Immune Defic Syndr. 1994 May;7(5):474-84. Unique Identifier : AIDSLINE MED/94210373; Revicki DA; Brown RE; Henry DH; McNeill MV; Rios A; Watson T; Battelle Medical Technology Assessment and Policy Research; Center, Washington, D.C.; To evaluate the effect of recombinant human erythropoietin on anemia and health-related quality of life in patients with acquired immunodeficiency syndrome (AIDS), we initiated an observational study with an open-label multicenter treatment protocol that involved multiple academic and community physicians in the
Spread of AIDS in rural America, 1982-1990.: J Acquir Immune Defic Syndr. 1994 May;7(5):485-90. Unique Identifier : AIDSLINE MED/94210374; Lam NS; Liu KB; Department of Geography and Anthropology, Louisiana State; University, Baton Rouge 70803.; Using a national county database, we examine the hypothesis of increasing spread of acquired immune deficiency syndrome (AIDS) in rural America. Data for county-level AIDS caseloads for the period 1982-1990 were obtained by contacting state health officials of individual states. Yearly and cumulative AIDS cases by cou
Interpreting HIV seroprevalence data from a street-based outreach program.: J Acquir Immune Defic Syndr. 1994 May;7(5):491-9. Unique Identifier : AIDSLINE MED/94210375; Iguchi MY; Bux DA; Lidz V; Kushner H; French JF; Platt JJ; Hahnemann University School of Medicine, Department of Mental; Health Sciences, Philadelphia, PA 19102-1102.; A total of 4,375 subjects were recruited through continuous street outreach over 31 months for interviews on HIV-related risk behavior and HIV-antibody testing. Changes over time among sampled subjects with respect to HIV infection and HIV-risk behavior have been examined retrospectively, and significant and consisten
Understanding the dynamics of the HIV epidemic among Italian intravenous drug users: a cross-sectional versus a longitudinal approach.: J Acquir Immune Defic Syndr. 1994 May;7(5):500-3. Unique Identifier : AIDSLINE MED/94210376; Rezza G; Nicolosi A; Zaccarelli M; Sagliocca L; Nespoli M; Gattari P; Spizzichino L; Ippolito G; Lazzarin A; AIDS Unit, Istituto Superiore di Sanita, Rome, Italy.; We studied annual human immunodeficiency virus (HIV) seroprevalence and incidence in a large number of intravenous drug users attending drug treatment centers in three Italian urban areas. We also evaluated risk factors for HIV seropositivity and for HIV seroconversion. The results showed that HIV prevalence and incid
Predictors of unsafe needle practices: injection drug users in Denver.: J Acquir Immune Defic Syndr. 1994 May;7(5):504-8. Unique Identifier : AIDSLINE MED/94210377; Booth RE; Department of Psychiatry, University of Colorado Health Sciences; Center, Denver 80211.; To identify factors associated with unsafe needle hygiene, we studied 378 injection drug users (IDUs) in Denver, Colorado. The sample was drawn from neighborhoods with large concentrations of injectors and crack smokers. Respondents were questioned about their needle hygiene practices during the 30-day period prior to
The distribution of T-cell subsets among HTLV-I carriers in Japan.: J Acquir Immune Defic Syndr. 1994 May;7(5):509-16. Unique Identifier : AIDSLINE MED/94210378; Welles SL; Tachibana N; Okayama A; Murai K; Shioiri S; Sagawa K; Katagiri K; Mueller NE; Department of Epidemiology, Harvard School of Public Health,; Boston, Massachusetts 02115.; Data on T-cell subsets from 89 human T-cell lymphotropic virus-I (HTLV-I) carriers and 25 seronegative people were analyzed to identify differences in T-cell subset values among three subgroups: HTLV-I carriers with abnormal lymphocytes (Ably; n = 24), carriers without Ably (n = 65), and HTLV-I seronegatives (n = 25).
Successful treatment of HIV-related thrombocytopenia with didanosine (ddI) [letter]: J Acquir Immune Defic Syndr. 1994 May;7(5):521-2. Unique Identifier : AIDSLINE MED/94210381; Piketty C; Gilquin J; Kazatchkine MD
Validity of three assays for HIV-1 antibodies in saliva [letter]: J Acquir Immune Defic Syndr. 1994 May;7(5):522-5. Unique Identifier : AIDSLINE MED/94210382; Frerichs RR; Eskes N; Htoon MT
Effects of intravenous drug use and gender on the cost of hospitalization for patients with AIDS [letter; comment]: J Acquir Immune Defic Syndr. 1994 May;7(5):525-6. Unique Identifier : AIDSLINE MED/94210383; Justice A
Homosexual prostitution and the potential spread of HIV in The Netherlands [letter]: J Acquir Immune Defic Syndr. 1994 May;7(5):526-9. Unique Identifier : AIDSLINE MED/94210384; de Graaf R; Vanwesenbeeck I; van Zessen G; Straver CJ; Visser JH
The nurse's interaction with the AIDS patient.: J Pract Nurs. 1994 Mar;44(1):12-3. Unique Identifier : AIDSLINE MED/94210394; Furnish WL
Eye care and AIDS prevention for ophthalmic medical personnel [published erratum appears in J Ophthalmic Nurs Technol 1993 Jul-Aug;12(4):162]: J Ophthalmic Nurs Technol. 1993 May-Jun;12(3):117-21. Unique Identifier : AIDSLINE MED/94210517; Elfervig LS; 1. Clinical nurse specialists should use common sense precautions for infection control in all office procedures to prevent the spread of HIV, especially handwashing and proper disinfection of all instruments. 2. Nurses should be fully informed of the appearance and mechanism of AIDS in ocular manifestations (especial
Otosyphilis: diagnostic and therapeutic update.: J Otolaryngol. 1993 Dec;22(6):401-8. Unique Identifier : AIDSLINE MED/94210586; Linstrom CJ; Gleich LL; Department of Otolaryngology, New York Medical College, Valhalla.; The thorough investigation of patients presenting with sudden or fluctuating hearing loss, ringing or vertigo includes serology to exclude otosyphilis. Treatment of otosyphilis with penicillin and corticosteroids has achieved improvement in hearing, tinnitus and vertigo, but not in all patients. Selecting which patien
Evaluating behavioral interventions: need for randomized controlled trials [letter; comment]: JAMA. 1994 May 4;271(17):1317-8. Unique Identifier : AIDSLINE MED/94210679; Gerber AR; Campbell CH Jr; Dillon BA; Holtgrave DR
Practical epidemiology and biostatistics in research. IV. Putting research into operation.: JPMA J Pak Med Assoc. 1994 Jan;44(1):23-4. Unique Identifier : AIDSLINE MED/94210705; Lobo MA; Qureshi AF; Department of Community Health Sciences, Aga Khan University,; Karachi.
A view of HIV-I infection in Karachi.: JPMA J Pak Med Assoc. 1994 Jan;44(1):8-11. Unique Identifier : AIDSLINE MED/94210707; Kayani N; Sheikh A; Khan A; Mithani C; Khurshid M; Department of Pathology, Aga Khan University Medical Centre,; Karachi.; A prospective study on the prevalence of HIV-I infection in Karachi, Pakistan was conducted over a period of six years (1986-1992). Over 15,000 individual samples and more than 32,000 donor units of individuals residing in Karachi at the time of sample collection were tested for
[Incidence of enteropathogens in patients with human immunodeficiency virus infection (published erratum appears in Med Clin (Barc) 1994 May 21;102(19):759)]: Med Clin (Barc). 1994 Feb 19;102(6):205-8. Unique Identifier : AIDSLINE MED/94210945; Moreno A; Gatell JM; Mensa J; Valls ME; Vila J; Claramonte X; Miro JM; Mallolas J; Zamora L; Lozano L; et al; Servicio de Enfermedades Infecciosas, Hospital Clinic i; Provincial, Barcelona.; BACKGROUND: To establish the incidence of diarrhea and its evolution over time, the causal microorganisms, recurrence and associated mortality in patients with AIDS or severe immunologic alterations (CD4 lymphocytes lower than 0.5 x 10(9)/l). METHODS: A prospective longitudinal study was carried out from 1984 to 1992.
[Infection by the human immunodeficiency virus type 1 in the population of prisoners of Catalonia]: Med Clin (Barc). 1994 Feb 19;102(6):209-12. Unique Identifier : AIDSLINE MED/94210946; Bayas JM; Martin V; Vidal J; Pumarola T; Jimenez de Anta MT; Salleras L; Servicio de Medicina Preventiva, Hospital Clinic i Provincial,; Barcelona.; BACKGROUND: The prison population represents a high risk group for the human immunodeficiency virus type 1 infection. The present study was carried out to know the prevalence of infection in this collective in three penitentiary centers in Catalonia. METHODS: All the subjects who were in or who were admitted to the th
[Syphilitic optic neuritis in 2 patients with HIV infection (letter)]: Med Clin (Barc). 1994 Feb 19;102(6):236. Unique Identifier : AIDSLINE MED/94210953; Baez B; Gato A; Guardiola S; Pontes MJ
[Factors facilitating changes in HIV risk behavior in parenteral drug users (letter)]: Med Clin (Barc). 1994 Feb 19;102(6):237-8. Unique Identifier : AIDSLINE MED/94210956; Peri JM; Solto C; Bayes R
Who chooses to have the HIV antibody test in the antenatal clinic?: Midwifery. 1994 Mar;10(1):44-8. Unique Identifier : AIDSLINE MED/94211157; Meadows J; Jenkinson S; Catalan J; With the increase in human immunodeficiency virus (HIV) seroprevalence amongst antenatal clinic attenders, and given that current medical opinion considers it desirable that a woman is aware of her serostatus, it has been recommended that the HIV test is offered to all women in the antenatal clinic and that its uptake
Zidovudine for the prevention of HIV transmission from mother to infant.: MMWR Morb Mortal Wkly Rep. 1994 Apr 29;43(16):285-7. Unique Identifier : AIDSLINE MED/94211192; Worldwide, perinatal (i.e., mother to infant) transmission accounts for most human immunodeficiency virus (HIV) infections among children; in the United States , of the approximately 7000 infants born to HIV-infected mothers each year, 1000-2000 are HIV-infected. Strategies for reducing
HTLV-1 in acquired adult myopathy [letter; comment]: Muscle Nerve. 1994 May;17(5):559. Unique Identifier : AIDSLINE MED/94211235; Bradley WG
Turbidimetric and visual criteria for determining the in vitro activity of six antifungal agents against Candida spp. and Cryptococcus neoformans.: Mycopathologia. 1993 Oct;124(1):19-25. Unique Identifier : AIDSLINE MED/94211262; Barchiesi F; Del Poeta M; Morbiducci V; Ancarani F; Scalise G; Institute of Infectious Diseases and Public Health, University of; Ancona, Ospedale Umberto I, Ancona, Italy.; The drug concentration which inhibited 50% of growth (IC50), the lowest drug concentration at which growth was less than 30% of that in a positive control well (IC30), the visual minimal inhibitory concentration (MIC), and the minimum fungicidal concentration (MFC), were applied to study the effects of fluconazole, it
Acquired immunodeficiency syndrome (AIDS) has become a universal health care dilemma for both patient and provider [editorial; comment]: Nurs Adm Q. 1994 Winter;18(2):v-vi. Unique Identifier : AIDSLINE MED/94211390; Brown BJ
Each of us has been touched by the worldwide pandemic of human immunodeficiency virus (HIV) infection [editorial] [see comments]: Nurs Adm Q. 1994 Winter;18(2):vii-viii. Unique Identifier : AIDSLINE MED/94211391; Holzemer WL
Nursing dependency needs of HIV-infected patients, Part 1: Methods and clinical findings.: Nurs Adm Q. 1994 Winter;18(2):1-10. Unique Identifier : AIDSLINE MED/94211393; Corless IB; Halloran EJ; Belyea MJ; The adequacy with which nurses address the needs of patients infected with the human immunodeficiency virus (HIV) depends upon their ability to recognize such needs. A 61-item Nurse/Patient Summary was completed on all patients by day shift nurses at a tertiary care center. The Nurse/Patient Summary encompasses the ph
Nursing dependency needs of HIV-infected patients, Part 2: Implications for management.: Nurs Adm Q. 1994 Winter;18(2):11-5. Unique Identifier : AIDSLINE MED/94211394; Halloran EJ; Corless IB; Belyea MJ; Nurses on undifferentiated patient care units observed significant differences in the nursing needs of persons with human immunodeficiency virus (HIV) disease compared with other hospitalized patients. These needs were reflected in the provision of greater nursing hours per case and greater lengths of hospital stay. L
Development of a measure of willingness to provide nursing care to AIDS patients.: Nurs Adm Q. 1994 Winter;18(2):16-21. Unique Identifier : AIDSLINE MED/94211395; Dubbert PM; Kemppainen JK; White-Taylor D; The Nursing Willingness Questionnaire (NWQ) was developed to measure nurses willingness to perform specific direct care activities for an adult male patient with acquired immunodeficiency syndrome (AIDS). Measures of internal consistency and one-week test-retest stability indicated excellent reliability. NWQ scale sc
The AIDS epidemic: caring for caregivers.: Nurs Adm Q. 1994 Winter;18(2):22-9. Unique Identifier : AIDSLINE MED/94211396; Brewington JG; AIDS has become a global health problem for individuals, families and health care providers. This disease has a tremendous impact on the physical and psychological well-being of these groups. Nurses are on the front line providing physical care and support for these patients and their families; but nurses also need su
The impact of AIDS on recruitment and retention in hospitals.: Nurs Adm Q. 1994 Winter;18(2):30-5. Unique Identifier : AIDSLINE MED/94211397; Nagelkerk J; Little is reported about the impact of AIDS on the recruitment and retention of nurses in hospitals. The author reports a statewide survey of problems and strategies in recruiting and retaining nurses to care for AIDS patients. The major problems identified were fear of contagion, the need for strong educational train
Authentic caring: the sensible answer for clients and staff dealing with HIV/AIDS.: Nurs Adm Q. 1994 Winter;18(2):36-40. Unique Identifier : AIDSLINE MED/94211398; Neil RM; The Denver Nursing Project in Human Caring is a nurse-managed outpatient center providing integrated care and services for persons living with HIV/AIDS, their family members, and friends. The center is collaboratively sponsored by three Denver hospitals and the University of Colorado School of Nursing. Programs and se
A multidisciplinary, multifaceted HIV program: linking the resources.: Nurs Adm Q. 1994 Winter;18(2):41-5. Unique Identifier : AIDSLINE MED/94211399; Turjanica MA; Ardabell TR; Schiffer NA; Poirier M; Brodeur S; The current and potential impact of the human immunodeficiency virus (HIV) disease on the financial and human resources of institutions requires strategic planning by health care administrators and providers. The HIV disease devastates the lives of many individuals, and it continues to impact the health care industry
The structure and functions of an ambulatory care center for HIV/AIDS.: Nurs Adm Q. 1994 Winter;18(2):46-52. Unique Identifier : AIDSLINE MED/94211400; Cicatiello JS; Perdue ME; For the past decade, the spread of HIV infection in the United States has been marked by dramatic growth, increasing diversity in the population affected, a widening geographic focus and a broadened clinical spectrum. In response to this, the Ambulatory Care Center (ACC) of Jackson Mem
An integrated case management model: developing standards, evaluation, and outcome criteria.: Nurs Adm Q. 1994 Winter;18(2):53-64. Unique Identifier : AIDSLINE MED/94211401; Sowell RL; Meadows TM; Case management has become an important strategy in responding to the complex physical and social needs of persons with human immunodeficiency virus (HIV) disease. Yet, inconsistent implementation and professional turf guarding, based on disciplinary differences, have rendered traditional models ineffective. AID Atlan
A computer-based approach to quality improvement for telephone triage in a community AIDS clinic.: Nurs Adm Q. 1994 Winter;18(2):65-73. Unique Identifier : AIDSLINE MED/94211402; Henry SB; Borchelt D; Schreiner JG; Musen MA; Observation of the current procedure for telephone triage in a community-based acquired immunodeficiency syndrome (AIDS) clinic and a retrospective chart audit identified opportunities for improvement in the process for the management of telephone triage encounters. Specifically, it pointed out that the nurses faced d
HIV/AIDS training for health care providers working with women at risk.: Nurs Adm Q. 1994 Winter;18(2):74-80. Unique Identifier : AIDSLINE MED/94211403; Miramontes H; Tom K; Gillen M; Diagnosis of HIV/AIDS in women is frequently inadequate. Often women are not assessed for risk behaviors that put them at risk for HIV infection. Viral transmission is preventable through behavioral changes. Past experience has demonstrated that one effective method to educate women at risk is to train direct care pro
Educating advanced practice nurses to respond to the HIV pandemic.: Nurs Adm Q. 1994 Winter;18(2):81-7. Unique Identifier : AIDSLINE MED/94211404; Nokes KM; The subspecialization in the master s degree nursing program at Hunter College is preparing a cadre of nursing leaders and expert clinicians through formal didactic courses and clinical placements with master s prepared nurses who work in HIV/AIDS. The HIV/AIDS subspecialty option is offered to graduate nursing studen
Mandatory HIV testing: a position paper.: Nurs Adm Q. 1994 Winter;18(2):88-91. Unique Identifier : AIDSLINE MED/94211405; Davis AJ; This article takes the position that mandatory testing of health workers for HIV is unethical because it is a misuse of resources. This is an ethical dilemma in distributive justice. Six facts are detailed to support this position.
Computer networks show great promise in supporting AIDS patients.: Nurs Adm Q. 1994 Winter;18(2):92-5. Unique Identifier : AIDSLINE MED/94211406; Simpson RL
Respiratory failure in pregnancy due to Pneumocystis carinii: report of a successful outcome.: Obstet Gynecol. 1994 May;83(5 Pt 2):823-4. Unique Identifier : AIDSLINE MED/94211432; Albino JA; Shapiro JM; Pulmonary/Critical Care Division, St. Luke's Hospital, New York,; New York.; BACKGROUND: The incidence of infection with the human immunodeficiency virus (HIV) is rising rapidly among women of reproductive age. Pneumocystis carinii pneumonia during pregnancy may be the first manifestation of HIV infection. If respiratory failure ensures, the outcome has been reported as almost invariably fatal
Pregnancy complicated by thrombocytopenia secondary to human immunodeficiency virus infection.: Obstet Gynecol. 1994 May;83(5 Pt 2):825-7. Unique Identifier : AIDSLINE MED/94211433; Glantz JC; Roberts DJ; Department of Obstetrics and Gynecology, University of Rochester; School of Medicine and Dentistry, New York.; BACKGROUND: Human immunodeficiency virus (HIV)-positive pregnant women may manifest thrombocytopenia similar to that of immune thrombocytopenic purpura (ITP), putting the fetus at risk of thrombocytopenia and hemorrhage. Whereas the fetal platelet count can be assessed in cases of ITP, there is no safe way to evaluate
[The problem of obtaining virus-free blood products (letter)]: Orv Hetil. 1994 Mar 13;135(11):601. Unique Identifier : AIDSLINE MED/94211486; Peter S; Schnitzer F
Caring for pediatric patients with HIV: personal concerns and ethical dilemmas.: Pediatr Nurs. 1994 Mar-Apr;20(2):171-6; discussion 177-80. Unique Identifier : AIDSLINE MED/94211581; Murphy JM; Famolare NE; An informal survey was conducted to determine nurses professional and personal concerns related to caring for pediatric patients with HIV. Thirty registered nurses participated by responding to written open-ended questions. Risk of exposure in the workplace and fear of transmission to self or family are examples of t
Dual purpose [news]: Nurs Times. 1994 Mar 16-22;90(11):18. Unique Identifier : AIDSLINE MED/94211622; Faugier J
A confidence betrayed [news]: Nurs Times. 1994 Mar 23-29;90(12):16-7. Unique Identifier : AIDSLINE MED/94211634; Cassidy J
Inhibition of Rev-mediated HIV-1 expression [retraction of Constantoulakis P, Campbell M, Felber BK, Nasioulas G, Afonina E, Pavlakis GN. In: Science 1993 Feb 26;259(5099):1314-8]: Science. 1994 Apr 22;264(5158):492. Unique Identifier : AIDSLINE MED/94212159; Campbell M; Felber BK; Nasioulas G; Afonina E; Pavlakis GN
Human immunodeficiency virus infection in pregnancy.: Semin Perinatol. 1993 Dec;17(6):379-83. Unique Identifier : AIDSLINE MED/94212179; Duff P; Division of Maternal-Fetal Medicine, University of Florida; College of Medicine, Gainesville 32610-0294.
Viral hepatitis in pregnancy.: Semin Perinatol. 1993 Dec;17(6):384-93. Unique Identifier : AIDSLINE MED/94212180; Simms J; Duff P; Division of Maternal-Fetal Medicine, University of Florida; College of Medicine, Gainesville 32610-0294.; Hepatitis A is usually a benign, self-limited infection. A chronic carrier state does not exist, and perinatal transmission does not occur. Hepatitis B may cause chronic infection, and infants delivered to infected mothers are at considerable risk of developing neonatal hepatitis. Passive and active immunization with
Status of tuberculosis control in Thailand.: Southeast Asian J Trop Med Public Health. 1993 Sep;24(3):410-9. Unique Identifier : AIDSLINE MED/94212205; Sriyabhaya N; Payanandana V; Bamrungtrakul T; Konjanart S; Department of Communicable Disease Control, Ministry of Public; Health, Bangkok, Thailand.; The national tuberculosis control program (NTP) was implemented in Thailand as integrated with the provincial general health services since 1967, with BCG vaccination successfully introduced from the beginning, but progress in expansion of case-finding and chemotherapy had only b
Orbital lymphoma associated with acquired immune deficiency syndrome (AIDS).: Surv Ophthalmol. 1994 Jan-Feb;38(4):371-80. Unique Identifier : AIDSLINE MED/94212273; Reifler DM; Warzynski MJ; Blount WR; Graham DM; Mills KA; Department of Surgery (Ophthalmology), Michigan State University; College of Human Medicine, Butterworth Hospital.; A new case of AIDS-associated, small noncleaved cell (Burkitt s) lymphoma that presented as an orbital mass is described. Extraocular muscle involvement was documented by computed tomography and confirmed by orbital biopsy. Extensive abdominal involvement was subsequently diagnosed and this caused the patient s death
Functions of HIV envelope glycans.: Trends Biochem Sci. 1994 Feb;19(2):65-70. Unique Identifier : AIDSLINE MED/94212445; Fenouillet E; Gluckman JC; Jones IM; CNRS URA 1463, Paris, France.; The unusually highly glycosylated state of the major envelope glycoprotein (gp160) of the human immunodeficiency virus has offered a challenge to both glycobiologists and virologists. What is the functional significance of such a mass of glycans and how might they be manipulated to disadvantage virus pathogenesis? Som
Monoclonal cytoplasmic immunoglobulin and pathomorphological reactions in lymph nodes in spontaneous bovine leukemia virus infection.: Vet Immunol Immunopathol. 1994 Feb;40(2):163-70. Unique Identifier : AIDSLINE MED/94212551; Levkut M; Plank L; Levkutova M; Konrad V; Department of Pathological Anatomy, University of Veterinary; Medicine, Kosice, Slovakia.; Prescapular lymph nodes from 109 cows seropositive to bovine leukemia virus (BLV) were examined for the presence of light chains of bovine immunoglobulin (Ig) kappa or lambda. A variety of reactions were present in prescapular lymph nodes, including B-zonal hyperplasia (23 cases, 21.1%), T-zonal hyperplasia (52 cases,
[The main results of the research performed on AIDS under the Russian Government Scientific and Technical Program on National Priorities in Medicine and Public Health for 1992. The Expert Commission on AIDS of the Russian Government Scientific and Technical Program on National Priorities in Medicine and Public Health]: Vopr Virusol. 1994 Jan-Feb;39(1):38-41. Unique Identifier : AIDSLINE MED/94212648; Pokrovskii VI; Kraevskii AA; Pokrovskii VV; Matsevich GR; Iurin OG; Uryvaev LV; Reshetnikova LN
[The register of scientific topics approved by the Expert Commission on AIDS of the Russian Government Scientific and Technical Program on National Priorities in Medicine and Public Health in 1993]: Vopr Virusol. 1994 Jan-Feb;39(1):43-5. Unique Identifier : AIDSLINE MED/94212650
[The antiviral action of recombinant receptorotoxins based on the diphtheria toxin and the human T-lymphocyte CD4-receptor]: Vopr Virusol. 1994 Jan-Feb;39(1):6-10. Unique Identifier : AIDSLINE MED/94212651; Sidorov AV; Zverev VV; Zdanovskii AG; Pugach AV; Maliushova VV; Andzhaparidze OG; A number of vectors expressing in E. coli hybrid proteins (receptorotoxins) composed of diphtheria toxin lacking the C-terminal region and CD4-receptor fragment including N-terminal region of the natural protein have been constructed. The receptorotoxins consisting of the CD4 fragment in their N-terminal region were m
Facts concerning the human immunodeficiency virus (HIV) infection and also the acquired immune deficiency syndrome (AIDS) [editorial]: West Indian Med J. 1993 Dec;42(4):137. Unique Identifier : AIDSLINE MED/94212652; Persaud V
Jamaican neuropathy revisited.: West Indian Med J. 1993 Dec;42(4):138-41. Unique Identifier : AIDSLINE MED/94212653; Morgan OS; Barton EN; Department of Medicine, U.W.I., Jamaica.
California AIDS Drug Assistance Program expansion [letter]: West J Med. 1994 Feb;160(2):185. Unique Identifier : AIDSLINE MED/94212681; Sauseda WE
[AIDS phobia (its clinical picture and typology)]: Zh Nevropatol Psikhiatr Im S S Korsakova. 1993;93(6):73-6. Unique Identifier : AIDSLINE MED/94212717; Medvedeva SB; Clinical, psychological and neurological examinations were performed of 478 subjects (208 males and 270 females) seeking confidential testing for HIV infection in one-on-one counseling facilities. The findings were correlated with serological evidence on HIV-antibodies and somatic status. The psychological response to
The making of female fertility. Anthropological perspectives on a bodily issue [see comments]: Acta Obstet Gynecol Scand. 1994 Apr;73(4):280-3. Unique Identifier : AIDSLINE MED/94212737; Talle A
Three primitive reflexes in HIV-1-infected individuals: a possible clinical marker of early central nervous system involvement.: Acta Neurol (Napoli). 1993 Dec;15(6):409-15. Unique Identifier : AIDSLINE MED/94212758; Orefice G; Carrieri PB; Troisi E; Chirianni A; Maiorino A; Nolfe G; Rubino S; Coppola M; Campanella G; Department of Neurology, Medical School, Federico II, University; of Naples.; We studied one hundred and six neurologically asymptomatic HIV-1-seropositive patients, mostly drug abusers, in various stages of HIV-1 infection to evaluate the frequency of three primitive reflexes: snout, palmomental, and glabellar. We also examined one hundred HIV-1-seronegative drug abusers and one hundred health
Howell-Jolly body-like inclusions in the neutrophils of patients with acquired immunodeficiency syndrome [see comments]: Am J Clin Pathol. 1994 Apr;101(4):429-31. Unique Identifier : AIDSLINE MED/94212845; Slagel DD; Lager DJ; Dick FR; Department of Pathology, University of Iowa Hospitals and; Clinics, Iowa City.; The authors have observed discrete, densely basophilic inclusions in the peripheral blood neutrophils of 10 patients with acquired immunodeficiency syndrome (AIDS) and two additional patients without documented evidence of human immunodeficiency virus seropositivity. These inclusions were seen in 3 of 25 (12%) patient
Concurrent invasive thymoma and T-cell lymphoblastic leukemia and lymphoma. A case report with necropsy findings and literature review of thymoma and associated hematologic neoplasm.: Am J Clin Pathol. 1994 Apr;101(4):432-7. Unique Identifier : AIDSLINE MED/94212846; Friedman HD; Inman DA; Hutchison RE; Poiesz BJ; Department of Pathology and Laboratory Medicine, Department of; Veterans Affairs Medical Center, Syracuse, New York 13210.; Thymoma is associated with benign and neoplastic diseases. The authors report the concurrence of invasive thymoma and T-lymphoblastic leukemia/lymphoma in a 95-year-old man. The hematologic malignancy was suspected terminally, whereas the thymoma was discovered at necropsy. The lymphoblastic leukemia/lymphoma had a cl
Mycobacterial spindle-cell pseudotumor of the spleen.: Am J Clin Pathol. 1994 Apr;101(4):539-42. Unique Identifier : AIDSLINE MED/94212867; Suster S; Moran CA; Blanco M; Arkadi M. Rywlin Department of Pathology and Laboratory Medicine,; Mount Sinai Medical Center, Miami Beach, FL 33140.; A case of spindle-cell pseudotumor of the spleen due to nontuberculous mycobacteria in a patient with acquired immunodeficiency syndrome (AIDS) is described. The patient was a 55-year-old, human immunodeficiency virus-positive Haitian man who died of acute neurologic complications while on treatment for central nervou
Human immunodeficiency virus-associated nephropathy: current concepts.: Am J Med Sci. 1994 Mar;307(3):212-7. Unique Identifier : AIDSLINE MED/94212942; Stone HD; Appel RG; Department of Medicine, Bowman Gray School of Medicine,; Winston-Salem, North Carolina 27157.; A distinct form of renal disease has been described in patients at various stages of HIV infection that is becoming increasingly important as a cause of morbidity and mortality. Black race and intravenous drug abuse appear to predispose one to its development. The HIV-associated nephropathy is characterized by nephrot
In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system.: Am J Pathol. 1994 Apr;144(4):659-66. Unique Identifier : AIDSLINE MED/94213005; Nuovo GJ; Gallery F; MacConnell P; Braun A; Department of Pathology, SUNY at Stony Brook 11794-8691.; This study determined the distribution of in situ polymerase chain reaction (PCR)-amplified HIV-1 nucleic acids in the central nervous system (CNS). Amplified viral DNA was detected in each of the seven HIV-1-positive cases and in none of the seven negative controls. HIV-1 DNA was rarely detected with standard in situ
Three-dimensional laser-scanning confocal microscopy of in situ hybridization in the skin.: Am J Dermatopathol. 1994 Feb;16(1):44-51. Unique Identifier : AIDSLINE MED/94213185; Mahoney SE; Paddock SW; Smith LC; Lewis DE; Duvic M; Department of Dermatology, University of Texas Medical School,; Houston 77030.; In situ hybridization is an important tool in molecular and developmental biology to detect specific nucleic acid sequences (either mRNA or DNA) within cells. This technique is especially applicable to tissue sections since it provides information about the spatial distribution of DNA or mRNA sequences. However, previ
Hurricane-related emergency department visits in an inland area: an analysis of the public health impact of Hurricane Hugo in North Carolina.: Ann Emerg Med. 1994 Apr;23(4):731-6. Unique Identifier : AIDSLINE MED/94213319; Brewer RD; Morris PD; Cole TB; Epidemic Intelligence Service, Centers for Disease Control and; Prevention, Atlanta, Georgia.; STUDY OBJECTIVE: To evaluate the public health impact of a hurricane on an inland area. DESIGN: Descriptive study. SETTING: Seven hospital emergency departments. PARTICIPANTS: Patients who were treated from September 22 to October 6, 1989, for an injury or illness related to Hurricane Hugo. INTERVENTION: None. MEASURE
[Current aspects of tuberculosis (editorial)]: Ann Dermatol Venereol. 1993;120(10):667-8. Unique Identifier : AIDSLINE MED/94213374; Martin P; Bonnetblanc JM; Denis F
[Septicemic cutaneous localization of cryptococcosis following renal transplantation in a female]: Ann Dermatol Venereol. 1993;120(9):612-5. Unique Identifier : AIDSLINE MED/94213395; Dupond AS; Humbert P; Faivre B; Hory B; Barale T; Laurent R; Agache P; Service de Dermatologie, CHU Saint-Jacques.; Cryptococcosis is a systemic disease caused by the yeast-like fungus Cryptococcus neoformans. Cutaneous manifestations, although rare, may precede other organ involvements. A case of cutaneous cryptococcosis is described herein. The skin lesions in our patient (a 47-year old female with renal transplant) consisted of
Immunohistochemical characterization of leucocyte subpopulations in endometriotic lesions.: Arch Gynecol Obstet. 1993;253(4):197-206. Unique Identifier : AIDSLINE MED/94213538; Oosterlynck DJ; Cornillie FJ; Waer M; Koninckx PR; Rega Institute for Medical Research, University of Leuven,; Belgium.; Leucocyte subpopulations localized in endometriotic lesions were analysed using the avidin-biotin immunoperoxidase technique on 15 biopsies obtained by CO2 laser excision. Qualitative assessment of the leucocyte subpopulations was performed with a panel of antihuman monoclonal antibodies for leucocytes (anti-Hle-1), T
[The fundamentals for a new program on AIDS (editorial)]: Bol Oficina Sanit Panam. 1994 Feb;116(2):i. Unique Identifier : AIDSLINE MED/94213695; Guerra de Macedo C
Monitoring the activity of antiviral therapy for HIV infection using a polymerase chain reaction method coupled with reverse transcription.: AIDS. 1993 Nov;7 Suppl 2:S101-5. Unique Identifier : AIDSLINE MED/94213716; Kojima E; Shirasaka T; Anderson B; Chokekijchai S; Sei S; Yarchoan R; Mitsuya H; Experimental Retrovirology Section, National Cancer Institute,; Bethesda, Maryland 20892.; AIM: To monitor the anti-HIV-1 activity of antiretroviral agents in patients with HIV-1 infection. METHOD: Quantification of viral RNA copy in plasma or serum using a polymerase chain reaction method coupled with reverse transcription. CONCLUSIONS: The HIV-1 RNA copy number represents the HIV-1 viremia status in patie
Qualitative and quantitative detection of HIV-1 RNA by nucleic acid sequence-based amplification.: AIDS. 1993 Nov;7 Suppl 2:S107-10. Unique Identifier : AIDSLINE MED/94213717; van Gemen B; Kievits T; Nara P; Huisman HG; Jurriaans S; Goudsmit J; Lens P; Organon Teknika, Boxtel, The Netherlands.; AIM: To develop a method to detect HIV-1 viral RNA by amplifying a specific nucleic acid sequence. METHOD: The nucleic acid sequence-based amplification (NASBA) method uses the simultaneous activity of avian myeloblastosis virus reverse transcriptase, T7 RNA polymerase and RNase H to amplify a specific nucleic acid ta
Direct and quantitative detection of HIV-1 RNA in human plasma with a branched DNA signal amplification assay.: AIDS. 1993 Nov;7 Suppl 2:S11-4. Unique Identifier : AIDSLINE MED/94213718; Urdea MS; Wilber JC; Yeghiazarian T; Todd JA; Kern DG; Fong SJ; Besemer D; Hoo B; Sheridan PJ; Kokka R; et al; Nucleic Acid Systems, Chiron Corporation, Emeryville, California; 94608.; AIM: To determine the relative effect of sample matrix on the quantitation of HIV RNA in plasma. METHOD: Two HIV-positive specimens were diluted into five and 10 different HIV-negative plasma samples, respectively. Branched DNA signal amplification technology and reverse-transcriptase polymerase chain reaction were us
Use of competitive polymerase chain reaction to determine HIV-1 levels in response to antiviral treatments.: AIDS. 1993 Nov;7 Suppl 2:S15-20. Unique Identifier : AIDSLINE MED/94213719; Bruisten SM; Koppelman MH; Roos MT; Loeliger AE; Reiss P; Boucher CA; Huisman HG; Central Laboratory, The Netherlands Red Cross Blood Transfusion; Service, Amsterdam.; OBJECTIVE: To develop a competitive polymerase chain reaction technique with which to evaluate the usefulness of HIV-1 level as a marker of response to antiviral treatment. DESIGN: HIV-1 sequences were assessed by competitive polymerase chain reaction in four subjects participating in a double-blind study of monothera
Development and validation of a polymerase chain reaction method for the precise quantitation of HIV-1 DNA in blood cells from subjects undergoing a 1-year immunotherapeutic treatment.: AIDS. 1993 Nov;7 Suppl 2:S21-7. Unique Identifier : AIDSLINE MED/94213720; Ferre F; Marchese AL; Griffin SL; Daigle AE; Richieri SP; Jensen FC; Carlo DJ; Immune Response Corporation, Carlsbad, California 92008.; OBJECTIVE: To validate a quantitative polymerase chain reaction method developed to measure HIV-1 DNA in peripheral blood mononuclear cells. DESIGN: The assay was used to measure HIV-1 DNA in 15 consecutive blood samples taken from subjects enrolled in a multicenter, randomly allocated, double-blind, placebo-controlle
The application of quantitative polymerase chain reaction to therapeutic monitoring.: AIDS. 1993 Nov;7 Suppl 2:S29-34. Unique Identifier : AIDSLINE MED/94213721; Sninsky JJ; Kwok S; Department of Infectious Diseases, Roche Molecular Systems, Inc.,; Alameda, California 94501.; Use of polymerase chain reaction in HIV monitoring: The polymerase chain reaction can be used not only to detect the presence of viral sequences but also to provide a semiquantitative or a precise evaluation of the number of copies of genome present. Integral to the development of accurate and reproducible assays have
HIV transmission by organ and tissue transplantation.: AIDS. 1993 Nov;7 Suppl 2:S35-8. Unique Identifier : AIDSLINE MED/94213723; Simonds RJ; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333.; PURPOSE: Published reports in English of HIV infection in organ and tissue recipients were reviewed to examine (1) the effect of donor screening, allograft type, and allograft processing on risk of HIV transmission by transplantation; (2) the antibody response to HIV infection in organ recipients taking antirejection
Neutralizing antibodies and viral characteristics in mother-to-child transmission of HIV-1.: AIDS. 1993 Nov;7 Suppl 2:S45-8. Unique Identifier : AIDSLINE MED/94213725; Scarlatti G; Leitner T; Hodara V; Halapi E; Rossi P; Albert J; Fenyo EM; Department of Virology, Karolinska Institute, Stockholm, Sweden.; OBJECTIVE: To determine viral characteristics and the protective effect of virus neutralizing antibodies in mother-to-child transmission of HIV-1. MOLECULAR STUDIES: Ten HIV-1-infected mother-child pairs were sampled within 4 months of delivery. Variable region 3 of the viral envelope was amplified by nested polymeras
Timing of mother-to-child HIV-1 transmission depends on maternal status. The HIV Infection in Newborns French Collaborative Study Group.: AIDS. 1993 Nov;7 Suppl 2:S49-52. Unique Identifier : AIDSLINE MED/94213726; Rouzioux C; Costagliola D; Burgard M; Blanche S; Mayaux MJ; Griscelli C; Valleron AJ; Virology Laboratory, Necker Hospital for Sick Children, Paris,; France.; OBJECTIVES: To estimate when mother-to-child transmission occurs and investigate the possible role of maternal factors. DESIGN: We studied virological data obtained in the first 3 months of life of 95 infected newborns born to HIV-1-seropositive mothers included in the French Prospective Cohort Study who did not breas
HIV-1 infection in the lymphoid organs.: AIDS. 1993 Nov;7 Suppl 2:S53-8. Unique Identifier : AIDSLINE MED/94213727; Graziosi C; Pantaleo G; Demarest JF; Cohen OJ; Vaccarezza M; Butini L; Montroni M; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.; AIM: To develop a model of HIV disease progression. METHOD: Comparative analysis of viral burden and replication between peripheral blood and lymphoid organs and of the changes in viral distribution in the lymphoid tissue. RESULTS: In early-stage disease HIV-1-infected cells were sequestered in the lymphoid tissue, an
Legionnaires' disease in human immunodeficiency virus-infected patients: eight cases and review [see comments]: Clin Infect Dis. 1994 Feb;18(2):227-32. Unique Identifier : AIDSLINE MED/94213956; Blatt SP; Dolan MJ; Hendrix CW; Melcher GP; Department of Medicine, Wilford Hall Medical Center, Military; Medical Consortium for Applied Retroviral Research, Lackland Air; Force Base, Texas.; Despite being a well-known pathogen for immunocompromised patients, Legionella pneumophila has infrequently been described in persons with infection due to human immunodeficiency virus (HIV). Since 1986, we have identified eight cases of legionella pneumonia among seven HIV-infected persons enrolled in the HIV Natural
Resistance of Candida albicans to fluconazole during treatment of oropharyngeal candidiasis in a patient with AIDS: documentation by in vitro susceptibility testing and DNA subtype analysis.: Clin Infect Dis. 1994 Feb;18(2):240-2. Unique Identifier : AIDSLINE MED/94213958; Redding S; Smith J; Farinacci G; Rinaldi M; Fothergill A; Rhine-Chalberg J; Pfaller M; Department of General Practice, University of Texas Health; Science Center at San Antonio, Texas 78284.; We describe a patient with recurrent episodes of oropharyngeal candidiasis who required progressively higher doses of fluconazole to control and infection. The patient was treated for 14 infections over a 2-year period with doses of fluconazole that ranged from 100 to 800 mg per day. Clinical response, two methods of
Disseminated Penicillium marneffei infection diagnosed on examination of a peripheral blood smear of a patient with human immunodeficiency virus infection.: Clin Infect Dis. 1994 Feb;18(2):246-7. Unique Identifier : AIDSLINE MED/94213960; Supparatpinyo K; Sirisanthana T; Faculty of Medicine, Chiang Mai University, Thailand.; We describe a case of disseminated Penicillium marneffei infection in a patient infected with human immunodeficiency virus. The diagnosis was made by examination of a peripheral blood smear. The patient presented with fever, jaundice, generalized lymphadenopathy, hepatosplenomegaly, and an erythematous, papular rash.
Syphilitic osteitis in a patient with secondary syphilis and concurrent human immunodeficiency virus infection.: Clin Infect Dis. 1994 Feb;18(2):250-2. Unique Identifier : AIDSLINE MED/94213962; Kastner RJ; Malone JL; Decker CF; Department of Internal Medicine, National Naval Medical Center,; Bethesda, Maryland 20889-5000.; Destructive bone disease is a well-recognized complication of congenital and tertiary syphilis. Clinically significant osteitis and osteomyelitis are rare complications of primary or secondary syphilis in patients who are not infected with human immunodeficiency virus (HIV). We report a case of an HIV-infected man who
Streptococcus bovis bacteremia and meningitis associated with Strongyloides stercoralis colitis in a patient infected with human immunodeficiency virus.: Clin Infect Dis. 1994 Feb;18(2):253-4. Unique Identifier : AIDSLINE MED/94213963; Jain AK; Agarwal SK; el-Sadr W; Department of Medicine, Harlem Hospital Center, Columbia; University College of Physicians and Surgeons, New York, New York; 10037.; We present a case of human immunodeficiency virus (HIV) infection complicated by Streptococcus bovis meningitis and bacteremia and severe Strongyloides stercoralis colitis. The association between S. bovis infection and strongyloidiasis has not been described previously. This case highlights the importance of searchin
Disseminated Nocardia asteroides infection presenting as septic arthritis in a patient with AIDS [letter; comment]: Clin Infect Dis. 1994 Feb;18(2):256-7. Unique Identifier : AIDSLINE MED/94213965; Ray TD; Nimityongskul P; Ramsey KM
Aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia: what is the correct dose? [letter]: Clin Infect Dis. 1994 Feb;18(2):257-8. Unique Identifier : AIDSLINE MED/94213966; Weiss PJ; Wallace MR
Osteitis cystica tuberculosa multiplex in a patient infected with human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1994 Feb;18(2):260-1. Unique Identifier : AIDSLINE MED/94213969; Huth RG; Acebo R; Matthew EB
Disseminated Mycobacterium kansasii infection presenting as pneumonia and osteomyelitis of the skull in a patient with AIDS [letter]: Clin Infect Dis. 1994 Feb;18(2):261-2. Unique Identifier : AIDSLINE MED/94213970; Weinroth SE; Pincetl P; Tuazon CU
Concomitant systemic cryptococcosis and coccidioidomycosis in a patient with AIDS [letter]: Clin Infect Dis. 1994 Feb;18(2):262-3. Unique Identifier : AIDSLINE MED/94213971; Huth RG
Coadministration of rifampin and itraconazole leads to undetectable levels of serum itraconazole [letter]: Clin Infect Dis. 1994 Feb;18(2):266. Unique Identifier : AIDSLINE MED/94213974; Drayton J; Dickinson G; Rinaldi MG
Drug-resistant tuberculosis: laboratory issues. World Health Organization recommendations.: Tuber Lung Dis. 1994 Feb;75(1):1-7. Unique Identifier : AIDSLINE MED/94214095; Vareldzis BP; Grosset J; de Kantor I; Crofton J; Laszlo A; Felten M; Raviglione MC; Kochi A; Tuberculosis Programme, World Health Organization, Geneva,; Switzerland.; There is a suggestion that drug resistance rates decreased in developing countries over the period 1962-85, while recent data suggest that resistance may be increasing. The initial decrease in resistance appears to be associated with well-functioning National Tuberculosis Control Programmes (NTP), while the recently o
The effect of human immunodeficiency virus type-1 on the infectiousness of tuberculosis.: Tuber Lung Dis. 1994 Feb;75(1):25-32. Unique Identifier : AIDSLINE MED/94214096; Nunn P; Mungai M; Nyamwaya J; Gicheha C; Brindle RJ; Dunn DT; Githui W; Were JO; McAdam KP; Kenya Medical Research Institute/Wellcome Trust Collaborative; Research Programme.; SETTING: Developing country tertiary referral hospital plus catchment community. OBJECTIVE: To determine the infectiousness of culture-confirmed pulmonary tuberculosis in patients infected with Human Immunodeficiency Virus type-1 (HIV-1). DESIGN: Comparison of the incidence of tuberculosis and the prevalence of tuberc
Reduced sensitivity of tuberculosis serodiagnosis in patients with AIDS in Uganda.: Tuber Lung Dis. 1994 Feb;75(1):33-7. Unique Identifier : AIDSLINE MED/94214097; Daniel TM; Sippola AA; Okwera A; Kabengera S; Hatanga E; Aisu T; Nyole S; Byekwaso F; Vjecha M; Ferguson LE; et al; Case Western Reserve University School of Medicine, Cleveland,; Ohio 44106-4978.; SETTING: The diagnostic utility of serodiagnosis of tuberculosis in HIV-infected persons was studied in Kampala, Uganda . OBJECTIVE: This study was undertaken to evaluate the utility of a recently described serologic assay for the diagnosis of tuberculosis in HIV-infected patients.
Tuberculous meningitis in France in 1990: characteristics and impact of BCG vaccination [see comments]: Tuber Lung Dis. 1994 Feb;75(1):44-8. Unique Identifier : AIDSLINE MED/94214099; Schwoebel V; Hubert B; Grosset J; Centre National de Reference pour la Surveillance de la; Tuberculose et des Infections a Mycobacteries Atypiques,; Hopital de la Pitie-Salpetriere, Paris, France.; SETTING: France , 1990. OBJECTIVE: To measure the incidence and describe the characteristics of bacteriologically-confirmed tuberculous meningitis (TBM) and to estimate the protective efficacy of BCG vaccination in children aged less than 5 years. DESIGN: An active surveillance of T
Case-finding of pulmonary tuberculosis on admission to a penitentiary centre.: Tuber Lung Dis. 1994 Feb;75(1):49-53. Unique Identifier : AIDSLINE MED/94214100; Martin V; Gonzalez P; Cayla JA; Mirabent J; Canellas J; Pina JM; Miret P; Centre Penitenciari de Quatre Camins, Barcelona, Spain.; SETTING: The prison population is considered to be at high risk of tuberculosis infection and illness. Therefore, a tuberculosis prevention and control program was put into effect upon the opening of a penitentiary center in Barcelona whose inmates suffered a high prevalence of intravenous drug use (IVDU) (48.4%) and
HIV-associated tuberculosis in developing countries [letter; comment]: Tuber Lung Dis. 1994 Feb;75(1):80-2. Unique Identifier : AIDSLINE MED/94214108; Houston S
Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells.: Blood. 1994 Apr 15;83(8):2191-7. Unique Identifier : AIDSLINE MED/94214130; Rivas CI; Golde DW; Vera JC; Kolesnick RN; Program in Molecular Pharmacology and Therapeutics, Memorial; Sloan-Kettering Cancer Center, New York, NY 10021.; Tumor necrosis factor (TNF) is a potent inducer of human immunodeficiency virus (HIV) proviral transcription and subsequent mature virus production. Recent investigations have shown that TNF can use a signal transduction pathway in HL-60 cells involving sphingomyelin hydrolysis to ceramide with subsequent stimulation
Collaborative problem solving with a total quality model.: Am J Med Qual. 1993 Winter;8(4):181-6. Unique Identifier : AIDSLINE MED/94214294; Volden CM; Monnig R; University of North Dakota, Grand Forks.; A collaborative problem-solving system committed to the interests of those involved complies with the teachings of the total quality management movement in health care. Deming espoused that any quality system must become an integral part of routine activities. A process that is used consistently in dealing with proble
Idiopathic esophageal ulceration in the acquired immunodeficiency syndrome: radiologic reappraisal in 10 patients.: Abdom Imaging. 1994 Jan-Feb;19(1):2-5. Unique Identifier : AIDSLINE MED/94214301; Frager D; Kotler DP; Baer J; Department of Radiology, Columbia University College of; Physicians and Surgeons, St. Luke's/Roosevelt Hospital Center,; New York, NY 10025.; Idiopathic esophageal ulceration in patients with AIDS has previously been described. Establishing this diagnosis is important because of the excellent response of these ulcers to corticosteroid therapy. We studied 10 such patients with esophagography and endoscopy. HIV was isolated from the ulcer base in six of the 1
Unusual morphological features of adult T-cell leukemia cells with aberrant immunophenotype.: Leuk Lymphoma. 1993 Dec;12(1-2):123-30. Unique Identifier : AIDSLINE MED/94214337; Kamihira S; Sohda H; Atogami S; Fukushima T; Toriya K; Miyazaki Y; Ikeda S; Yamada Y; Tomonaga M; Blood Transfusion Service, Nagasaki University Hospital, Japan.; We describe 4 cases of adult T-cell leukemia (ATL) with unusual morphology and aberrant immunophenotype. All patients were Japanese and born in the Nagasaki district, an area endemic for HTLV-I. Peripheral blood and/or bone marrow films revealed bizarre giant cells with and without large nucleoli; the cells were 5 to
[Immunopathogenesis progress of HIV infection (editorial)]: Rev Assoc Med Bras. 1993 Oct-Dec;39(4):191. Unique Identifier : AIDSLINE MED/94214533; Castelo A
Characterization and quality control of autologous gene transfer therapeutics.: Cell Transplant. 1994;3 Suppl 1:S57-60. Unique Identifier : AIDSLINE MED/94214831; Jolly DJ; Viagene, Inc., San Diego, CA 92121-1204.
[Toxoplasmosis and cytomegalovirus serology in patients infected with HIV in Congo]: Sante. 1994 Jan-Feb;4(1):15-9. Unique Identifier : AIDSLINE MED/94214884; Makuwa M; Loemba H; Ngouonimba J; Beuzit Y; Louis JP; Livrozet JM; Service de virologie, laboratoire national de sante publique, BP; 120, Brazzaville, Congo.; Cerebral toxoplasmosis and cytomegalovirus ( CMV ) infection are very frequent in AIDS. Biological markers of toxoplasmosis and CMV were studied in blood and cerebrospinal fluid (CSF) of 121 HIV-positive and 35 HIV-negative pat
[Reactivity differences between serums of patients infected with HIV-2 and HIV-1 antigens according to the patients' geographic origin]: Sante. 1994 Jan-Feb;4(1):27-31. Unique Identifier : AIDSLINE MED/94214886; Simon F; Loussert-Ajaka I; Collin G; Gamba E; Powell-Smith A; Gadelle S; Brun-Vezinet F; Laboratoire de virologie, Hopital Bichat-Claude Bernard, Paris,; France.; We tested 98 sera from HIV-2-infected patients for cross-reactivity with HIV-1 antigens in a competitive EIA test and western blotting. The sera were obtained during epidemiological surveys in Cape Verde Islands (n = 47) and Mali (n = 51). Ther
[Blood transfusions in Africa during the AIDS epidemic. Condition of localities and perspectives in the Ivory Coast]: Sante. 1994 Jan-Feb;4(1):37-42. Unique Identifier : AIDSLINE MED/94214888; Kerouedan D; Bontez W; Bondurand A; Abisse S; Konate S; Mission de cooperation et d'action culturelle, Abidjan,; Cote-d'ivoire.; HIV is transmitted essentially by the heterosexual route in Africa. As part of an international mobilization against the Aids epidemic, information, education and communication strategies should continue to reduce the frequency of the infection. In this paper, we underline the high risk of HIV infection from blood tra
Human and simian immunodeficiency viruses: virus-receptor interactions.: Trends Microbiol. 1993 Dec;1(9):328-33. Unique Identifier : AIDSLINE MED/94214977; Signoret N; Poignard P; Blanc D; Sattentau QJ; Centre d'Immunologie de Marseille-Luminy, France.; The major cellular receptor for the primate immunodeficiency viruses is the CD4 molecule. As well as mediating virion attachment to the cell surface, CD4 is thought to activate the viral fusion pathway. CD4 is not, however, sufficient for viral entry; other molecules are probably involved, and in certain circumstances
HIV-1 variation: consequences for disease progression and vaccine strategies.: Trends Microbiol. 1993 Dec;1(9):353-5. Unique Identifier : AIDSLINE MED/94214982; Cheng-Mayer C; Cancer Research Institute, University of California, School of; Medicine, San Francisco 94143-0128.; HIV-1 displays a high degree of biological heterogeneity in vitro, differing in tropism, kinetics of replication, cytopathogenicity, resistance to antiviral drugs and susceptibility to serum neutralization. Some of these properties can be linked to pathogenesis in the host. HIV variation is a major challenge to the de
Designer antiviruses for HIV.: Trends Microbiol. 1993 Dec;1(9):355-7. Unique Identifier : AIDSLINE MED/94214983; Norris V; Madsen MS; Heaphy S; Dept of Microbiology, University of Leicester, School of; Medicine, UK.; Potentially, antiviruses that interfere with HIV propagation could be used as AIDS therapy. If problems associated with HIV recombination and the dynamics of the interactions between HIV and antivirus can be resolved by an appropriate design, an antivirus might defer or prevent the development of AIDS, and might benef
Tuberculosis in AIDS presenting as a testicular abscess.: Br J Urol. 1994 Mar;73(3):325-6. Unique Identifier : AIDSLINE MED/94215082; Desai G; Department of Surgery, School of Medicine, University of Zambia,; Lusaka.
Short-course therapy for tuberculosis in infants and children. Infectious Diseases and Immunization Committee, Canadian Paediatric Society [see comments]: Can Med Assoc J. 1994 Apr 15;150(8):1233-9. Unique Identifier : AIDSLINE MED/94215134; OBJECTIVE: To improve efficacy of and compliance with therapy for tuberculosis in children. OPTIONS: Short-course (6-month) multi-drug therapy, either non-supervised or directly supervised, versus long-course (more than 6-month) multi-drug therapy. OUTCOMES: Success (more than 90% of cases cured without relapse or ser
Second conference on spondylarthropathies and the gut.: Clin Exp Rheumatol. 1994 Jan-Feb;12(1):111-6. Unique Identifier : AIDSLINE MED/94215242; Mielants H; Veys EM; De Keyser F; Ghyselen G; Malfait AM; Department of Rheumatology, University Hospital, Gent, Belgium.
Clinical utility of the polymerase chain reaction in the diagnosis of infections due to Mycobacterium tuberculosis.: Chest. 1994 Apr;105(4):1116-21. Unique Identifier : AIDSLINE MED/94215352; Schluger NW; Kinney D; Harkin TJ; Rom WN; Division of Pulmonary and Critical Care Medicine, New York; University Medical Center, New York.; OBJECTIVE: To evaluate the clinical utility of the polymerase chain reaction (PCR) in the diagnosis of infections due to Mycobacterium tuberculosis. DESIGN: Clinical specimens were assayed by PCR for the presence of the insertion element IS6110, a DNA sequence unique to the M tuberculosis complex of organisms. The PCR
Diagnosis of localized Pneumocystis carinii and Aspergillus growth in two HIV-infected patients by ultrasonically guided percutaneous lung biopsy.: Chest. 1994 Apr;105(4):1285-6. Unique Identifier : AIDSLINE MED/94215393; Zachgo W; Mikloweit P; Ebermann F; Lungenklinik Hemer, Department of Pneumology, LVA-Krankenhaus; Grosshansdorf, Germany.; The diagnostic value of ultrasonic (US) examinations followed by US-guided needle biopsy in the differential diagnosis of peripheral pulmonary infiltrates is demonstrated examining two patients with AIDS-related pulmonary infiltrates. Ultraso-guided needle biopsy was performed after thoracic radiograph, computed tomog
[Diagnosis of adrenal cortex insufficiency]: Dtsch Med Wochenschr. 1994 Apr 15;119(15):555-9. Unique Identifier : AIDSLINE MED/94215473; Oelkers W; Diederich S; Bahr V; Abteilung Innere Medizin mit Schwerpunkt Endokrinologie,; Universitatsklinikum Steglitz, Berlin.
Bacterial pneumonia in HIV-infected patients: a prospective study of 68 episodes.: Eur Respir J. 1994 Feb;7(2):235-9. Unique Identifier : AIDSLINE MED/94215659; Falco V; Fernandez de Sevilla T; Alegre J; Barbe J; Ferrer A; Ocana I; Ribera E; Martinez-Vazquez JM; Dept of Internal Medicine, Hospital General Vall d'Hebron; Universidad Autonoma, Barcelona, Spain.; We collected clinical and microbiological observations, as well as follow-up on human immunodeficiency virus (HIV)-infected patients with bacterial pneumonia, and compared pneumococcal pneumonia in patients with and without HIV infection. Fifty five HIV-infected patients, who had had 68 episodes of bacterial pneumonia
Cell cycle-dependent association of Gag-Mil and hsp90.: FEBS Lett. 1994 Apr 18;343(1):15-21. Unique Identifier : AIDSLINE MED/94215698; Lovric J; Bischof O; Moelling K; Max-Planck-Institut fur Molekulare Genetik, Abt. Schuster,; Berlin (Dahlem), Germany.; Immunoprecipitated p100Gag-Mil protein kinase from MH2-transformed quail embryo fibroblasts is associated with an 89 kDa protein. The molar ratio between p89 and Gag-Mil in the immunocomplex is 0.72, indicating that the majority of Gag-Mil is complexed with p89. During mitosis part of Gag-Mil is shifted to a form with
[HIV test before ENT operations (editorial)]: HNO. 1994 Feb;42(2):81. Unique Identifier : AIDSLINE MED/94216166; Weidauer H; Universitats-HNO-Klinik, Heidelberg.
Distinguishable patterns of protein-DNA interactions involving complexes of basic helix-loop-helix proteins.: J Biol Chem. 1994 Apr 22;269(16):12099-105. Unique Identifier : AIDSLINE MED/94216323; Doyle K; Zhang Y; Baer R; Bina M; Department of Chemistry, Purdue University, West Lafayette,; Indiana 47907-1393.; Myogenic factors and TAL1 possess distinguishable DNA binding characteristics when they form a complex with basic helix-loop-helix (bHLH) proteins of class A. These characteristics were evident in electrophoretic mobility shift assays showing that complexes of myogenic factors and HTF4 displayed a relatively high affi
The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM).: J Biol Chem. 1994 Apr 22;269(16):12240-7. Unique Identifier : AIDSLINE MED/94216344; Decroly E; Vandenbranden M; Ruysschaert JM; Cogniaux J; Jacob GS; Howard SC; Marshall G; Kompelli A; Basak A; Jean F; et al; Laboratoire de Chimie Physique des Macromolecules aux; Interfaces, Universite libre de Bruxelles, Belgium.; Intracellular proteolytic processing of human immunodeficiency virus envelope glycoprotein precursor (gp160) is an essential step for virus infectivity. Northern blot analysis provided evidence that furin and PC1, but not PC2, are expressed in the CD4+ human lymphoblastoid H9 cell line, suggesting the possible partici
[Catheters with implantable chamber, technique of implantation. 168 consecutive patients in a single year]: J Chir (Paris). 1993 Dec;130(12):545-7. Unique Identifier : AIDSLINE MED/94216451; Keilani K; Duron JJ; Service de Chirurgie Generale et Digestive, La Pitie; Salpetriere, Paris.; Our experience with 168 consecutive implantable chamber catheters over a one year period led us to establish the criteria for this implantation technique. Implantation should be carried out under local anaesthesia and be well tolerated and comfortable for the patient who is often weak. It should be a first indication
Identification of a novel simian parvovirus in cynomolgus monkeys with severe anemia. A paradigm of human B19 parvovirus infection [see comments]: J Clin Invest. 1994 Apr;93(4):1571-6. Unique Identifier : AIDSLINE GENBANK/U26342; O'Sullivan MG; Anderson DC; Fikes JD; Bain FT; Carlson CS; Green SW; Young NS; Brown KE; Comparative Medicine Clinical Research Center, Bowman Gray School; of Medicine of Wake Forest University, Winston-Salem, North; Carolina 27157-1040.; Although human B19 parvovirus infection has been clearly associated with a number of distinct syndromes (including severe anemia, abortion, and arthritis), detailed knowledge of its pathogenesis has been hindered by the lack of a suitable animal model. We have identified a novel simian parvovirus in cynomolgus monkeys
Antibodies to opacity proteins (Opa) correlate with a reduced risk of gonococcal salpingitis.: J Clin Invest. 1994 Apr;93(4):1748-55. Unique Identifier : AIDSLINE MED/94216524; Plummer FA; Chubb H; Simonsen JN; Bosire M; Slaney L; Nagelkerke NJ; Maclean I; Ndinya-Achola JO; Waiyaki P; Brunham RC; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Canada.; Acute salpingitis complicating cervical gonococcal infection is a significant cause of infertility. Relatively little data are available concerning the pathophysiologic mechanisms of this disease. A cohort of 243 prostitutes residing in Nairobi were followed between March 1985 and April 1988. Gonococcal cultures were
The HIV-infected health care worker: legal, ethical, and scientific perspectives.: J Emerg Med. 1994 Jan-Feb;12(1):95-102. Unique Identifier : AIDSLINE MED/94216686; Head KC; Bradley-Springer L; Sklar D; University of New Mexico School of Medicine, Albuquerque.; Emergency medical health care workers may face restrictions on their practices as state responses to federal mandates concerning human immunodeficiency virus (HIV) and hepatitis B virus (HBV) evolve. This article presents an analysis of legal, ethical, and scientific considerations for making decisions about the pract
High morbidity and mortality of chronic viral liver disease in HIV-infected individuals in Spain [letter]: J Infect. 1994 Jan;28(1):100-2. Unique Identifier : AIDSLINE MED/94216696; Soriano V; Garcia-Samaniego J; Gutierrez M; Bravo R; Gonzalez-Lahoz J
Atovaquone as prophylaxis against Pneumocystis carinii pneumonia [letter]: J Infect. 1994 Jan;28(1):103-4. Unique Identifier : AIDSLINE MED/94216698; Fisher MJ; Gazzard BG; Hawkins DA; Nelson MR
Co-trimoxazole for the treatment of listeriosis and its successful use in a patients with AIDS [letter]: J Infect. 1994 Jan;28(1):110-3. Unique Identifier : AIDSLINE MED/94216705; Hale E; Habte-Gabr E; McQueen R; Gordon R
Relationship between the tumour-associated antigen 90K and cytokines in the circulation of persons infected with human immunodeficiency virus.: J Infect. 1994 Jan;28(1):31-9. Unique Identifier : AIDSLINE MED/94216707; Senaldi G; Peakman M; Natoli C; Hussain MJ; Gallati H; McManus T; Vergani D; Iacobelli S; WHO-Immunology Research and Training Centre, Department of; Pathology, University of Geneva, Basel, Switzerland.; A tumour-associated antigen known as 90K has been found in high concentrations in the serum of patients infected with human immunodeficiency virus (HIV) even in the absence of neoplastic complications. In order to investigate the relationship between the production of 90K and soluble inflammatory mediators, we studied
Cryptococcal meningitis in Lilongwe and Blantyre, Malawi.: J Infect. 1994 Jan;28(1):59-64. Unique Identifier : AIDSLINE MED/94216710; Maher D; Mwandumba H; Department of Medicine, Queen Elizabeth Central Hospital,; Blantyre, Malawi.; Infection with Human Immunodeficiency Virus is widespread in Malawi and cryptococcal meningitis is a common problem in those with AIDS. A review of microbiology laboratory records in Lilongwe and Blantyre between July 1991 and January 1993 identified 31 patients with cryptococcal m
Listeria ivanovii infection in a patient with AIDS.: J Infect. 1994 Jan;28(1):89-91. Unique Identifier : AIDSLINE MED/94216716; Cummins AJ; Fielding AK; McLauchlin J; Department of Microbiology, Whittington Hospital, Highgate Hill,; London, U.K.; We describe a case of bacteraemia due to Listeria ivanovii in a patient with AIDS. This organism is a rare human pathogen.
Antioxidants in infection.: J Nutr Sci Vitaminol (Tokyo). 1993;39 Suppl:S23-33. Unique Identifier : AIDSLINE MED/94216964; Keusch GT; Department of Medicine, New England Medical Center, Boston, MA.; Endogenous oxidation reactions are essential for the normal biochemistry of life and are especially critical for leukocyte microbial killing mechanisms in host defense to infectious diseases. However, reactive oxidative intermediates can damage normal tissues unless kept under antioxidant control. Three selected examp
The diagnosis of periodontal conditions associated with HIV infection.: J Periodontol. 1994 Mar;65(3):236-43. Unique Identifier : AIDSLINE MED/94217024; Robinson PG; Winkler JR; Palmer G; Westenhouse J; Hilton JF; Greenspan JS; University College Dental Hospital, London, UK.; Objective, reliable, and valid diagnostic criteria are required for studies of HIV-associated periodontal conditions. A set of diagnostic criteria were devised based on a literature review and the clinical experience of the authors. Validity was assessed by comparison with clinical photographs and the criteria were ev
Rheumatologic manifestations of pediatric human immunodeficiency virus infection.: J Rheumatol. 1993 Sep;20(9):1578-82. Unique Identifier : AIDSLINE MED/94217132; Schuval SJ; Bonagura VR; Ilowite NT; Department of Pediatrics, Schneider Children's Hospital, Long; Island Jewish Medical Center, New Hyde Park, NY 11042.; OBJECTIVE. Multiple rheumatologic signs and symptoms have been described in adult human immunodeficiency virus (HIV) infection. Our goals were to determine the incidence and characteristics of rheumatologic manifestations in HIV infected children, and to examine their relationship to laboratory evidence of autoimmunit
Application of the three-dimensional structures of protein target molecules in structure-based drug design.: J Med Chem. 1994 Apr 15;37(8):1035-54. Unique Identifier : AIDSLINE MED/94217167; Greer J; Erickson JW; Baldwin JJ; Varney MD; Department of Structural Biology, Abbott Laboratories, Abbott; Park, Illinois 60064.
Three-dimensional structure-activity analysis of a series of porphyrin derivatives with anti-HIV-1 activity targeted to the V3 loop of the gp120 envelope glycoprotein of the human immunodeficiency virus type 1 [published erratum appears in J Med Chem 1994 Jun 10;37(12):1898]: J Med Chem. 1994 Apr 15;37(8):1099-108. Unique Identifier : AIDSLINE MED/94217173; Debnath AK; Jiang S; Strick N; Lin K; Haberfield P; Neurath AR; Lindsley F. Kimball Research Institute of the New York Blood; Center, New York 10021.; Using comparative molecular field analysis (CoMFA), a 3D-QSAR model was developed for 21 porphyrin derivatives which have anti-HIV-1 activity and bind to the V3 loop of the envelope glycoprotein gp120 of the human immunodeficiency virus type 1. A significant PLS cross-validated r2cv (0.590) was obtained, indicating th
Calculation of relative differences in the binding free energies of HIV1 protease inhibitors: a thermodynamic cycle perturbation approach.: J Med Chem. 1994 Apr 15;37(8):1145-52. Unique Identifier : AIDSLINE MED/94217178; Reddy MR; Varney MD; Kalish V; Viswanadhan VN; Appelt K; Agouron Pharmaceuticals, Inc., San Diego, California 92121.; An iterative computer-assisted drug design (CADD) method that combines molecular mechanics, dynamics, thermodynamic cycle perturbation (TCP) calculations, molecular design, synthesis, and biochemical testing of peptidomimetic inhibitors and crystallographic structure determination of the protein-inhibitor complexes ha
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.: J Med Chem. 1994 Apr 15;37(8):1169-76. Unique Identifier : AIDSLINE MED/94217181; Gangjee A; Devraj R; McGuire JJ; Kisliuk RL; Queener SF; Barrows LR; Division of Medicinal Chemistry, Graduate School of; Pharmaceutical Sciences, Duquesne University, Pittsburgh,; Pennsylvania 15282.; Classical antifolate analogues containing a novel furo[2,3-d]pyrimidine ring system which include N-[4-[N-[(2,4-diaminofuro[2,3-d]pyrimidin-5- yl)methyl]amino]benzoyl]-L-glutamic acid (1) and its N-9 methyl analogue 2 were synthesized as potential dual inhibitors of thymidylate synthase (TS) and dihydrofolate reductas
The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.: J Med Chem. 1994 Apr 15;37(8):1177-88. Unique Identifier : AIDSLINE MED/94217182; Ghosh AK; Lee HY; Thompson WJ; Culberson C; Holloway MK; McKee SP; Munson PM; Duong TT; Smith AM; Darke PL; et al; Department of Medicinal Chemistry, Merck Research Laboratories,; West Point, Pennsylvania 19486.; Design and synthesis of a novel series of protease inhibitors incorporating conformationally constrained cyclic ligands for the S2-substrate binding site of HIV-1 protease is described. We recently reported urethanes of 3-tetrahydrofuranyl as P2 ligands for HIV-1 pr
Exercise and psychoneuroimmunology.: Med Sci Sports Exerc. 1994 Feb;26(2):182-90. Unique Identifier : AIDSLINE MED/94217487; LaPerriere A; Ironson G; Antoni MH; Schneiderman N; Klimas N; Fletcher MA; Department of Psychiatry, University of Miami School of Medicine,; FL 33136.; Psychoneuroimmunology is the study of the interrelationships among psychological, neuroendocrine, and immunological parameters and is concerned with how these relationships may affect an individual s health. Substantial evidence indicates that exercise is associated with improvements in mental health, neuroendocrine,
[Confronting AIDS. Prevention programs and therapeutic strategies]: Minerva Stomatol. 1993 Nov-Dec;42(11-12):501-11. Unique Identifier : AIDSLINE MED/94217586; Salvato A; Spadari F; Lauritano D; Istituto Scientifico San Raffaele, Universita degli Studi di; Milano.; HIV pathology and AIDS patterns represent a topical and serious reality. Now AIDS syndrome affects many types of population all ever the world. These types have different epidemiologic ratings according to the localization of the countries (3rd world or developed areas). Global Programme on AIDS (GPA) had a rapid deve
Heterosexually acquired AIDS--United States, 1993.: MMWR Morb Mortal Wkly Rep. 1994 Mar 11;43(9):155-60. Unique Identifier : AIDSLINE MED/94217600; From 1991 through 1992, persons with acquired immunodeficiency syndrome (AIDS) who were infected with human immunodeficiency virus (HIV) through heterosexual transmission accounted for the largest proportionate increase in reported AIDS cases in the United States (1). During 1993, a to
Update: impact of the expanded AIDS surveillance case definition for adolescents and adults on case reporting--United States, 1993.: MMWR Morb Mortal Wkly Rep. 1994 Mar 11;43(9):160-1, 167-70. Unique Identifier : AIDSLINE MED/94217601; During 1993, local, state, and territorial health departments reported 103,500 acquired immunodeficiency syndrome (AIDS) cases among persons aged > or = 13 years in the United States , an increase of 111% over the 49,016 reported in 1992 (Figure 1). This increase resulted from the expan
Surveillance for geographic and secular trends in congenital syphilis--United States, 1983-1991.: MMWR CDC Surveill Summ. 1993 Dec;42(SS-6):59-71. Unique Identifier : AIDSLINE MED/94217605; Dunn RA; Webster LA; Nakashima AK; Sylvester GC; PROBLEM/CONDITION: CDC monitors trends in the occurrence of congenital syphilis (CS) in the United States by using surveillance data sent from state and local health departments. Comparisons of data from this surveillance system with data from the Division of Sexually Transmitted Disea
Support for dental HIV transmission [letter; comment]: Nature. 1994 May 5;369(6475):24-5. Unique Identifier : AIDSLINE +; Hillis DM; Huelsenbeck JP
German institute under fire over HIV-blood reports [news]: Nature. 1994 May 5;369(6475):7. Unique Identifier : AIDSLINE MED/94217812; Abbott A
Bacillary angiomatosis of the spleen [see comments]: Pathology. 1993 Oct;25(4):398-401. Unique Identifier : AIDSLINE MED/94218105; Mulvany NJ; Billson VR; Department of Anatomical Pathology, Royal Women's Hospital,; Carlton, Victoria.; Bacillary angiomatosis is a recently described vasoproliferative lesion associated with infection by a newly characterized rickettsial organism, Rochalimaea henselae. Most previous reports have described skin lesions in immunocompromised patients infected with human immunodeficiency virus. This is the first case repor
Difficulties in assigning human immunodeficiency virus-1 infection and seroreversion status in a cohort of HIV-exposed in children using serologic criteria established by the Centers for Disease Control and Prevention.: Pediatrics. 1994 May;93(5):840-2. Unique Identifier : AIDSLINE MED/94218198; Simpson BJ; Andiman WA; Department of Pediatrics, Yale University School of Medicine, New; Haven, CT.
[Vaccination of immunocompromised children (editorial)]: Pediatrie. 1993;48(7-8):511-4. Unique Identifier : AIDSLINE MED/94218216; Veber F
Intestinal absorption of (-)-carbovir in the rat.: Pharm Res. 1994 Feb;11(2):267-71. Unique Identifier : AIDSLINE MED/94218309; Soria I; Zimmerman CL; Department of Pharmaceutics, University of Minnesota, Minneapolis; 55455.; (-)-Carbovir (CBV) is a carbocyclic nucleoside analogue with in vitro activity against the human immunodeficiency virus. The sites and mechanism of absorption of (-)-CBV from the rat small intestine were studied in the anesthetized male Sprague-Dawley rat. (-)-CBV was perfused through either duodenal, jejunal, or ilea
[Information theory as an instrument for research on verbal integration between the AIDS carrier and the nursing team]: Rev Esc Enferm USP. 1993 Apr;27(1):107-16. Unique Identifier : AIDSLINE MED/94218493; Gir E; Moriya TM; Dela Coleta JA; Stephaneck P; Pela NT; The objective of this paper was to verify the use of variables included in the information Theory in study that deals with verbal interaction between AIDS patients and Nursing team. The results showed that the use of the variability calculation in data retained in SAVI matrix improves the statistical data and permit t
[Cytomegalovirus colitis in patients with acquired immunodeficiency syndrome. Histopathologic, endoscopic, and clinical correlation]: Rev Gastroenterol Mex. 1993 Jul-Sep;58(3):214-9. Unique Identifier : AIDSLINE MED/94218633; Reyes E; Gamboa-Dominguez A; Departamento de Patologia, Instituto Nacional de la Nutricion; Salvador Zubiran, Mexico, DF.; We describe the frequency of cytomegalovirus ( CMV ) infection in colon and rectum biopsies obtained endoscopically in patients with AIDS. In 44 of 199 biopsies, CMV was the only opportunistic infection. Cytomegaly, intracytopl
Latest CDC stats hint at nurses' vulnerability to HIV [news]: RN. 1994 Apr;57(4):17. Unique Identifier : AIDSLINE MED/94218652
Primary cerebral lymphoma. A retrospective study of 27 cases.: Strahlenther Onkol. 1994 Apr;170(4):206-12. Unique Identifier : AIDSLINE MED/94218767; Grangier C; Coucke P; Croisille P; Guillemin C; Mirimanoff RO; Department of Radiotherapy, CHUV, Lausanne, Schwitzerland.; PURPOSE: Primary cerebral lymphoma is a rare disease. The aim of this study is to compare the survival of the patients treated with radiotherapy alone vs. patients treated with a combined schedule of radio-chemotherapy. Our results will be compared with currently published data and main prognostic factors will be brie
A physician's perspective on the advantages of home medical care: the other side of case management.: Tex Med. 1994 Feb;90(2):50-4. Unique Identifier : AIDSLINE MED/94218842; Hart JS; Redding KL; Ledbetter Clinic Association, Houston, TX 77027.; As medical costs increase, alternatives to hospitalization for medical care must be sought. Patient care provided through outpatient clinics and home settings offers such alternatives. Intravenous antibiotics, fluids, blood, total parenteral nutrition, chemotherapy, and pain management as well as dialysis may now be g
Immunoregulatory abnormalities in patients with Epstein-Barr virus-associated B cell lymphoproliferative disorders.: Transplantation. 1994 Apr 15;57(7):1042-5. Unique Identifier : AIDSLINE MED/94218968; Mathur A; Kamat DM; Filipovich AH; Steinbuch M; Shapiro RS; Department of Oral Science, University of Minnesota, Minneapolis; 55455.; EBVirus-associated B cell lymphoproliferative disorder (BLPD) is a recognized complication of primary immunodeficiency and organ as well as bone marrow transplantation. Although the nature of the immune defects that predispose to the development of BLPD are unknown, it is postulated that aberrant T cell responses are
Functional and molecular characterization of graft-infiltrating T lymphocytes propagated from different biopsies derived from one heart transplant patient.: Transplantation. 1994 Apr 15;57(7):1119-26. Unique Identifier : AIDSLINE MED/94218981; Datema G; Vaessen LM; Daane RC; Baan CC; Weimar W; Claas FH; van den Elsen PJ; Department of Immunohematology and Bloodbank, University Hospital; Leiden, The Netherlands.; Alloreactive T lymphocytes play an important role in graft rejection. In the present study, we have analyzed the cytolytic capacity against donor cells of graft infiltrating T lymphocyte cell lines, which were propagated from various endomyocardial biopsies taken at different time points after transplantation, includi
HIV infection among pregnant women. A worsening situation in Maiduguri, Nigeria.: Trop Geogr Med. 1994;46(1):46-7. Unique Identifier : AIDSLINE MED/94219015; Harry TO; Bukbuk DN; Idrisa A; Akoma MB; Department of Immunology, University of Maiduguri Teaching; Hospital, Nigeria.; A serosurvey of 1,233 pregnant women aged 15-41 years, and attending antenatal clinics in Maiduguri, Nigeria from July 1991 to February 1993 showed that 28 (2.3%) of the women were positive for HIV antibodies. Twenty-four (1.9%) were positive for HIV-1 only, 1 (0.08%) was positive
Studies of immune response in a patient with selective complete C1q deficiency.: Turk J Pediatr. 1993 Jul-Sep;35(3):221-6. Unique Identifier : AIDSLINE MED/94219045; Berkel AI; Department of Pediatrics, Hacettepe University Faculty of; Medicine, Ankara.; Immune response in a six-year-old girl with a rare complement defect, namely selective complete C1q deficiency, was studied. Her cell-mediated immune response (delayed hypersensitivity skin tests, E, EAC rosettes, in vitro lymphocyte transformation with phytohemagglutinin), isohemagglutinin titers, serum immunoglobuli
Management of prostatic abscess in patients with human immunodeficiency syndrome.: Urology. 1994 May;43(5):629-33. Unique Identifier : AIDSLINE MED/94219058; Trauzzi SJ; Kay CJ; Kaufman DG; Lowe FC; Department of Urology, St. Luke's-Roosevelt Hospital Center, New; York, New York.; OBJECTIVE. To review and assess the management and evaluation of prostatic abscess in patients with the acquired immunodeficiency syndrome (human immunodeficiency virus [HIV]). METHODS. Retrospectively reviewed 7 cases of prostatic abscess in HIV-positive patients treated at our institution. RESULTS. All 7 patients pr
AIDS programs to target youth [news]: W V Med J. 1994 Feb;90(2):72. Unique Identifier : AIDSLINE MED/94219112
Purification and characterization of simian immunodeficiency virus (SIVmac) envelope glycoprotein gp130 from virus-infected cells.: Vaccine. 1994;12(3):250-8. Unique Identifier : AIDSLINE MED/94219168; Jones DH; McBride BW; Roff MA; Maloney V; Farrar GH; Division of Pathology, Centre for Applied Microbiology &; Research, Salisbury, Wiltshire, UK.; A non-denaturing method has been developed for the purification of the envelope glycoprotein gp130 of the simian immunodeficiency virus (SIV) using infected cells as starting material. The procedure involves solubilization of cells infected with SIV (SIVmac251), enrichment of glycoproteins by lectin affinity chromatog
Impact of serum antibodies to p40tax gene product in the intrafamilial transmission of human T cell leukemia virus type I.: Acta Paediatr Jpn. 1994 Feb;36(1):62-4. Unique Identifier : AIDSLINE MED/94219224; Umemoto M; Take H; Sawada T; Department of Pediatrics, Kagoshima City Hospital, Japan.; We examined the sera of family members of human T cell leukemia virus type I (HTLV-I) seropositive pregnant women who had visited Kagoshima City Hospital since 1986, and studied the routes of transmission of HTLV-I. A new enzyme linked immunosorbent assay (ELISA) for detecting the antibody to an HTLV-I tax gene produc
Acute childhood leukemia in a patient with hemophilia: first report in Japan.: Acta Paediatr Jpn. 1994 Feb;36(1):91-4. Unique Identifier : AIDSLINE MED/94219231; Kawakami K; Takezaki T; Nakazono S; Kitahara T; Ikarimoto N; Tanaka Y; Miyata K; Yoshioka A; Department of Pediatrics, Faculty of Medicine, Kagoshima; University, Japan.; This study reports an unusual case of acute leukemia which was diagnosed as hemophilia A on initial admission for leukemia. A 3 year old boy was admitted to Kagoshima University Hospital with anemia. He was diagnosed as acute lymphoblastic leukemia. At the same time he was revealed to have severe hemophilia A- without
[Serologic diagnosis of several infectious diseases]: Acta Med Port. 1993 Dec;6(12):605-12. Unique Identifier : AIDSLINE MED/94219246; Valente C; Faria MJ; Trindade L; Barros MS; Vieira AA; Albuquerque I; Rodrigues R; Servico de Infecciologia, Patologia Clinica, Hematologia,; Centro Hospitalar de Coimbra.; Serological tests are, in some situations, the only method of diagnosis of some infectious diseases. The authors make a review of the literature about the most important tests used in the most common infectious diseases and also their interpretation. It is important to point out that serology should not be considered
[AIDS-related legal questions in trauma surgery]: Aktuelle Traumatol. 1994 Feb;24(1):35-7. Unique Identifier : AIDSLINE MED/94219274; Kaiser V; Holz-Berufsgenossenschaft, Stuttgart.; Over and above the medical problems, AIDS also presents manifold and likewise still mostly undecided or at least not yet uniformly rated aspects. This article is a roughly sketched attempt at reviewing a few essential complexes at the interface between accident surgery and statutory accident insurance. Special attenti
MR detection of white matter disease of the brain in patients with HIV infection: fast spin-echo vs conventional spin-echo pulse sequences.: AJR Am J Roentgenol. 1994 May;162(5):1199-204. Unique Identifier : AIDSLINE MED/94219327; Olson EM; Healy JF; Wong WH; Youmans DC; Hesselink JR; Department of Radiology, University of California, San Diego; Medical Center 92103-8756.; OBJECTIVE. Although fast spin-echo images and slower spin-echo images have similar contrast characteristics, the two techniques have not yet been shown to be equivalent in all aspects of brain imaging. To determine if the two sequences are equivalent, we compared detection of white matter lesions, image quality, and a
Pharmacotherapy of HIV. APhA Editorial Board on Pharmaceutical Care for Patients with HIV Infection.: Am Pharm. 1994 Feb;NS34(2):60-9; quiz 69-70. Unique Identifier : AIDSLINE MED/94219365
Acute pancreatitis in a prisoner with AIDS. Bugs or drugs?: Am J Forensic Med Pathol. 1994 Mar;15(1):28-31. Unique Identifier : AIDSLINE MED/94219432; Cina SJ; Conradi SE; Charleston County Medical Examiner's Office, Department of; Pathology and Laboratory Medicine, Medical University of South; Carolina, Charleston 29425.; Acute pancreatitis has been the cause of death in several patients with AIDS and AIDS-related complex (ARC). Documented etiologies include several microorganisms and adverse drug reactions. We present a case of an HIV-positive prison inmate who died of acute necrotizing pancreatitis. Although he was infected with Myco
Occupational exposure to human immunodeficiency virus (HIV)-infected blood in Denver, Colorado, police officers.: Am J Epidemiol. 1994 May 1;139(9):910-7. Unique Identifier : AIDSLINE MED/94219463; Hoffman RE; Henderson N; O'Keefe K; Wood RC; Division of Disease Control and Environmental Epidemiology,; Colorado Department of Health, Denver 80222-1530.; The authors undertook a study of Denver, Colorado, police department officers to measure their risk of exposure to blood and human immunodeficiency virus (HIV) by type of work assignment and to document how exposures occurred. From December 1989 through March 1991, 137 officers reported an exposure to either blood or
Voluntary testing for human immunodeficiency virus (HIV) in a prison population with a high prevalence of HIV.: Am J Epidemiol. 1994 May 1;139(9):918-26. Unique Identifier : AIDSLINE MED/94219464; Behrendt C; Kendig N; Dambita C; Horman J; Lawlor J; Vlahov D; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, MD 21205.; This study evaluated voluntary testing for human immunodeficiency virus (HIV) in a prison population with a high HIV seroprevalence. Data on demographic variables and participation in voluntary testing were linked to a blinded HIV serosurvey of consecutive Maryland prison entrants (April-July 1991). Among 2,842 entran
Zidovudine cuts rate of maternal transmission [news]: Am J Nurs. 1994 May;94(5):12. Unique Identifier : AIDSLINE MED/94219492
Type-specific immune response to human T cell lymphotropic virus (HTLV) type I and type II infections in Nigeria.: Am J Trop Med Hyg. 1994 Apr;50(4):479-86. Unique Identifier : AIDSLINE MED/94219707; Olaleye DO; Bernstein L; Sheng Z; Ekweozor CC; Li XY; Sullivan-Halley J; Rasheed S; Laboratory of Viral Oncology and AIDS Research, University of; Southern California School of Medicine, Los Angeles.; Type-specific antibody responses to human T cell lymphotropic virus type I (HTLV-I) and type II (HTLV-II) were studied in blood samples collected from 25 different locations in Nigeria between 1985 and 1991 and stored at the University College Hospital in Ibadan. A total of 4,153
[Immunophenotyping of lymphoid cells]: Ann Biol Clin (Paris). 1993;51(9):793-800. Unique Identifier : AIDSLINE MED/94219751; Bene MC; Faure GC; Laboratoire d'immunologie, faculte de medecine et CHU de Nancy,; Vandoeuvre-les-Nancy, France.; The increasing availability of reagents and technologies has resulted in the widespread use of immunophenotyping to define and assess the course of pathologic disorders involving lymphoid cells. The diversity of markers and of the disorders concerned has complicated the application of the technique. This paper reviews
The ligase chain reaction in DNA-based diagnosis.: Ann Biol Clin (Paris). 1993;51(9):821-6. Unique Identifier : AIDSLINE MED/94219756; Laffler TG; Carrino JJ; Marshall RL; Abbott Laboratories, Diagnostics Division, Abbott Park, IL 60064.; Clinical specimens containing a suspected pathogen often have too little of the pathogen s DNA to be detected directly. It is generally necessary to first amplify the DNA and then to detect the amplification products. An amplification technique called the ligase chain reaction (LCR) is described, which in conjunction
[Nephropathy associated with the human immunodeficiency virus in children]: An Esp Pediatr. 1993 Dec;39(6):471-4. Unique Identifier : AIDSLINE MED/94219758; Malaga Guerrero S; Santos Rodriguez F
[HIV-related nephropathy in children: the situation in Spain]: An Esp Pediatr. 1993 Dec;39(6):489-92. Unique Identifier : AIDSLINE MED/94219760; Analysis of pediatric AIDS surveillance revealed that 395 cases of pediatrics AIDS have been registered in Spain until the end of 1992. This accounts for about 3% of all cases of AIDS, a percentage higher than the cumulative pediatric percentage of 2% observed in USA and the rest of
Staphylococcus aureus carriage and HIV-1 disease: association with increased mucocutaneous infections as well as deep soft-tissue infections and sepsis [letter]: Arch Dermatol. 1994 Apr;130(4):521-2. Unique Identifier : AIDSLINE MED/94219872; Smith KJ; Wagner KF; Yeager J; Skelton HG; Ledsky R
Transfusion-transmitted viral infections other than hepatitis and human immunodeficiency virus infection. Cytomegalovirus, Epstein-Barr virus, human herpesvirus 6, and human parvovirus B19.: Arch Pathol Lab Med. 1994 Apr;118(4):346-9. Unique Identifier : AIDSLINE MED/94219970; Sayers MH; Transfusion Surveillance Department, Puget Sound Blood Center,; Seattle, WA 98104-1256.; During the last decade, there has been a sharp increase in the number of tests routinely used to screen all volunteer whole blood donations for evidence of transfusion-transmissible infection. These measures have had a dramatic effect on improvements in transfusion safety, especially as far as hepatitis viruses and th
Legal issues for blood banks.: Arch Pathol Lab Med. 1994 Apr;118(4):442-53. Unique Identifier : AIDSLINE MED/94219983; Bierig JR; Sidley & Austin, Chicago, IL 60603.; This article first examines the standard of care applied by courts in litigation brought against blood banks by persons who contracted the acquired immunodeficiency syndrome (AIDS) from a transfusion. It describes cases that have held as a matter of law that a blood bank was not negligent if it followed the screening
Introducing new tests before transfusion. Who shall decide?: Arch Pathol Lab Med. 1994 Apr;118(4):454-6. Unique Identifier : AIDSLINE MED/94219984; Schmidt PJ; Transfusion Medicine Academic Center, Southwest Florida Blood; Bank, Tampa 33601-2125.; The processes by which decisions are made to ensure the safety of the nation s blood supply are in disarray. Earlier decisions on the appropriate screening of donated blood, such as the test for the hepatitis B virus, were made on scientific grounds. Since 1983, because of the acquired immunodeficiency syndrome, decis
Preoperative autologous blood donation in total-hip arthroplasty. A cost-effectiveness analysis.: Arch Pathol Lab Med. 1994 Apr;118(4):465-70. Unique Identifier : AIDSLINE MED/94219986; Healy JC; Frankforter SA; Graves BK; Reddy RL; Beck JR; Department of Pathology, Creighton University School of Medicine,; Omaha, Neb.; Preoperative autologous blood donation is employed with increasing frequency, particularly in patients undergoing elective orthopedic procedures. While autologous transfusion decreases the incidence of postoperative infections and other complications, the cost-effectiveness of this therapy has not been fully investiga
Transmission of HIV-1 from one child to another. European Collaborative Study [letter; comment]: N Engl J Med. 1994 May 5;330(18):1313-4. Unique Identifier : AIDSLINE MED/94195357; Dunn D; Newell ML
Action on AIDS [letter; comment]: Am J Nurs. 1994 May;94(5):16. Unique Identifier : AIDSLINE MED/94219494; Stevens MT
AIDS and dentistry [letter; comment]: J Can Dent Assoc. 1994 Mar;60(3):177. Unique Identifier : AIDSLINE MED/94207876; Fisher SJ
Women's reproductive health. Family planning and AIDS prevention can be combined [letter; comment]: BMJ. 1994 Mar 19;308(6931):790. Unique Identifier : AIDSLINE MED/94191473; Elias CJ
Sarcoidosis and HIV infection [letter; comment]: Chest. 1994 Apr;105(4):1299-300. Unique Identifier : AIDSLINE MED/94215404; Whitlock WL; Lowery WS; Fine JM
Treatment of anorexia with megestrol acetate [letter; comment]: Nutr Clin Pract. 1994 Feb;9(1):39. Unique Identifier : AIDSLINE MED/94211178; Plasse TF
Summary report: workshop on the potential risks of antibody-dependent enhancement in human HIV vaccine trials.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1175-84. Unique Identifier : AIDSLINE MED/94190622; Mascola JR; Mathieson BJ; Zack PM; Walker MC; Halstead SB; Burke DS; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850.; Concern that ADE of HIV infection could occur in vivo, as a result of HIV immunization, has arisen for several reasons. Immune-mediated disease enhancement occurs in several human and animal viral diseases, including lentiviral diseases. Tropism for host M/M cells is a common characteristic in these diseases. Sera fro
Alterations in spliced and unspliced HIV-1-specific RNA detection in peripheral blood mononuclear cells of individuals with varying CD4-positive lymphocyte counts.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1257-63. Unique Identifier : AIDSLINE MED/94190631; Arens M; Joseph T; Nag S; Miller JP; Powderly WG; Ratner L; Department of Pediatrics, Washington University School of; Medicine, St. Louis, Missouri 63110.; Reverse transcriptase-polymerase chain amplification reactions (RT-PCR) were used to identify transcripts for HIV-1 structural and regulatory proteins in peripheral blood mononuclear cells of a cohort of 48 patients. At least one set of PCR primers was capable of detecting HIV-1 transcripts in 94% of patients. Unsplic
HIV-associated CMV retinitis occurring in the setting of a high CD4+ count: what about AIDS definitions? [letter]: Int J STD AIDS. 1994 Jan-Feb;5(1):71-2. Unique Identifier : AIDSLINE MED/94191079; Angus BJ; Green ST; McKinlay JJ; McMenamin J; Walker E
Immune status of human immunodeficiency virus seropositive and seronegative hemophiliacs infused for 3.5 years with recombinant factor VIII. The Kogenate Study Group.: Blood. 1994 Apr 1;83(7):1958-62. Unique Identifier : AIDSLINE MED/94191264; Mannucci PM; Brettler DB; Aledort LM; Lusher JM; Abildgaard CF; Schwartz RS; Hurst D; Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Maggiore; Hospital, Italy.; Recent studies suggest that treatment of hemophiliacs with highly purified factor VIII concentrates may preserve immune function. To test this hypothesis, we prospectively studied 51 hemophilic patients (21 human immunodeficiency virus [HIV] seropositive and 30 seronegative) who were on home therapy exclusively with r
[HIV-positive: recommendations for tropical travel. Preventive measures--vaccination]: Fortschr Med. 1994 Jan 20;112(1-2):20-1. Unique Identifier : AIDSLINE MED/94193095; Kreutzberg K
Treatment dilemmas in HIV infection.: Hosp Pract (Off Ed). 1994 Apr 15;29(4):49-54, 59-60. Unique Identifier : AIDSLINE MED/94193863; Volberding PA; University of California, School of Medicine, San Francisco.; Recent trials of early treatment with the nucleoside analogues have produced conflicting data, raising fundamental questions about this therapy. Nevertheless, these drugs do lengthen clinical latency and delay the onset of AIDS, and for that reason alone should not be abandoned. The new treatment guidelines of the Nat
Cotton wool spots in AIDS: a review.: J Am Optom Assoc. 1994 Feb;65(2):110-6. Unique Identifier : AIDSLINE MED/94193984; Wilson R; New England College of Optometry, Beacon St., Boston, MA 02115.; BACKGROUND: Cotton wool spots (CWS) result from infarctions of the retinal nerve fiber layer and are seen in a variety of clinical conditions. Most patients with human immunodeficiency virus (HIV) disease, the agent that causes the acquired immune deficiency syndrome (AIDS), demonstrate CWS at some point during their
Impaired interleukin 12 production in human immunodeficiency virus-infected patients.: J Exp Med. 1994 Apr 1;179(4):1361-6. Unique Identifier : AIDSLINE MED/94194293; Chehimi J; Starr SE; Frank I; D'Andrea A; Ma X; MacGregor RR; Sennelier J; Trinchieri G; Division of Allergy, Immunology and Infectious Diseases,; Children's Hospital of Philadelphia, Pennsylvania.; Peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus (HIV)-infected patients, asymptomatic or with acquired immunodeficiency virus, produced 10-fold less interleukin 12 (IL-12) free heavy chain and fivefold less biologically active IL-12 heterodimer than PBMC from uninfected healthy donors when
Concorde lands [comment]: Lancet. 1994 Apr 9;343(8902):866-7. Unique Identifier : AIDSLINE MED/94195011; Lipsky JJ; Department of Medicine, Mayo Clinic, Rochester, MN.
Concorde: MRC/ANRS randomised double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection. Concorde Coordinating Committee [see comments]: Lancet. 1994 Apr 9;343(8902):871-81. Unique Identifier : AIDSLINE MED/94195015; Concorde is a double-blind randomised comparison of two policies of zidovudine treatment in symptom-free individuals infected with human immunodeficiency virus (HIV): (a) immediate zidovudine from the time of randomisation (Imm); and (b) deferred zidovudine (Def) until the onset of AIDS-related complex (ARC) or AIDS (
HIV vaccine trials for Uganda? [news]: Lancet. 1994 Apr 9;343(8902):910. Unique Identifier : AIDSLINE MED/94195024; Epstein H
Injecting drugs and AIDS [news]: Lancet. 1994 Apr 9;343(8902):911. Unique Identifier : AIDSLINE MED/94195025; McCarthy M
HIV infection and people with learning disabilities [letter]: Lancet. 1994 Apr 9;343(8902):919. Unique Identifier : AIDSLINE MED/94195039; Dent JA; Vergnaud S; Piachaud J
Rifampicin-resistant staphylococcal bacteraemia in patient with AIDS receiving rifabutin [letter]: Lancet. 1994 Apr 9;343(8902):919-20. Unique Identifier : AIDSLINE MED/94195040; Wood CA
Antibodies in HIV Tat in Kawasaki disease [letter]: Lancet. 1994 Apr 9;343(8902):920-1. Unique Identifier : AIDSLINE MED/94195041; Rautonen N; White C; Martin NL; Wara DW; Salo E; Pelkonen P; Rautonen J
Clostridium difficile diarrhoea and rifabutin [letter]: Lancet. 1994 Apr 9;343(8902):922. Unique Identifier : AIDSLINE MED/94195044; Pollock RC; Shanson DC; Nelson M; Neild PJ; Gazzard BG
Does HIV disrupt a naturally occurring immune modulation system?: Med Hypotheses. 1993 Nov;41(5):445-9. Unique Identifier : AIDSLINE MED/94195125; Kennedy JR; An immune modulation complex is proposed which recognizes and is driven by an MHC presented epitope of the CD4 molecule present on the surface of up regulated CD4+ lymphocytes. Immune modulation is affected by both CD4 lymphocyte destruction and impairment of their potential for immune recognition. These two processes
1994 revised guidelines for the performance of CD4+ T-cell determinations in persons with human immunodeficiency virus (HIV) infections. Centers for Disease Control and Prevention.: MMWR Morb Mortal Wkly Rep. 1994 Mar 4;43(RR-3):1-21. Unique Identifier : AIDSLINE MED/94195213; This document contains revised guidelines developed by CDC for laboratories performing lymphocyte immunophenotyping assays in human immunodeficiency virus-infected persons. The recommendations in this document reflect current technology in a field that is rapidly changing. The recommendations address laboratory safety
A primate T-lymphotropic virus, PTLV-L, different from human T-lymphotropic viruses types I and II, in a wild-caught baboon (Papio hamadryas).: Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2848-52. Unique Identifier : AIDSLINE GENBANK/Z29673; Goubau P; Van Brussel M; Vandamme AM; Liu HF; Desmyter J; Department of Microbiology, Rega Institute and University; Hospitals, Katholieke Universiteit Leuven, Belgium.; Searching for clues to the evolution of the primate T-lymphotropic viruses (PTLVs), which include the human and the simian T-lymphotropic viruses (HTLV and STLV), we have identified another PTLV, which differs sufficiently from the known PTLV-I and PTLV-II types to be designated here PTLV-L. The virus was isolated fro
Kinetics and specificities of the T helper-cell response to gp120 in the asymptomatic stage of HIV-1 infection.: Scand J Immunol. 1994 Apr;39(4):355-62. Unique Identifier : AIDSLINE MED/94196295; Geretti AM; Van Baalen CA; Borleffs JC; Van Els CA; Osterhaus AD; Department of Virology, Erasmus University, Rotterdam, The; Netherlands.; Peripheral blood mononuclear cells from 36 asymptomatic HIV-1 seropositive individuals were tested longitudinally for in vitro T-cell proliferation and IL-2 production in response to synthetic peptides spanning the entire gp120 of HIV-1. At baseline, significant T-cell
Screening of blood donors for idiopathic CD4+ T-lymphocytopenia.: Transfusion. 1994 Mar;34(3):192-7. Unique Identifier : AIDSLINE MED/94196614; Busch MP; Valinsky JE; Paglieroni T; Prince HE; Crutcher GJ; Gjerset GF; Operskalski EA; Charlebois E; Bianco C; Holland PV; et al; Irwin Memorial Blood Centers, San Francisco, California.; BACKGROUND: The recent recognition of idiopathic CD4+ T-lymphocytopenia (ICL) had led to concern that an unknown immunodeficiency virus may be transmissible by transfusion. STUDY DESIGN AND METHODS: To evaluate the prevalence and significance of low CD4+ values among blood donors, CD4+ data on 2030 blood donors who we
Isotypes and IgG subclasses of anti-Fab antibodies in human immunodeficiency virus-infected hemophilia patients.: Vox Sang. 1994;66(1):37-45. Unique Identifier : AIDSLINE MED/94196732; Susal C; Oberg HH; Daniel V; Dorr C; Terness P; Huth-Kuhne A; Zimmermann R; Opelz G; Department of Transplantation Immunology, University of; Heidelberg, FRG.; We reported recently that anti-Fab autoantibodies of the IgG isotype are associated with the decrease of helper/inducer (CD4+) lymphocytes in human immunodeficiency virus-infected (HIV+) hemophilia patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC). In the present study we investigat
Detection of HIV-1 DNA in leukocytes using a commercially available assay.: Vox Sang. 1994;66(1):78-80. Unique Identifier : AIDSLINE MED/94196740; Zaaijer HL; Cuypers HT; Reesink HW; ten Veen JH; Schoon-Visser SC; Lelie PN; Central Laboratory of The Netherlands Red Cross Blood Transfusion; Service, Amsterdam.; Recently, an assay for detection of proviral HIV-1 DNA in leukocytes became commercially available. This assay (Amplicor HIV-1 test, Roche Diagnostic Systems) multiplies HIV-1DNA up to a detectable level, using the polymerase chain reaction. We studied performance of this assay on 74 samples from HIV-1-infected patien
Cellular subsets and epithelial ICAM-1 and HLA-DR expression in human papillomavirus infection of the vulva.: Acta Derm Venereol. 1994 Jan;74(1):45-50. Unique Identifier : AIDSLINE MED/94197006; Morelli AE; Belardi G; DiPaola G; Paredes A; Fainboim L; Department of Immunogenetics, Hospital de Clinicas, Jose de San; Martin, School of Medicine, University of Buenos Aires,; Argentina.; Cryostat sections of 20 clinical condylomata of the vulva induced by human papillomavirus and 5 normal control biopsies were examined using immunohistochemistry. The results indicated that in vulvar papillomavirus infection the intraepithelial Langerhans cells showed abnormal morphology and a significantly lower dens
Effect of imipramine on mood and enumerative measures of immune status in depressed patients with HIV illness.: Am J Psychiatry. 1994 Apr;151(4):516-23. Unique Identifier : AIDSLINE MED/94197253; Rabkin JG; Rabkin R; Harrison W; Wagner G; New York State Psychiatric Institute, NY 10032.; OBJECTIVE: The authors first objective was to ascertain whether imipramine is superior to placebo in treating axis I depressive disorders in the context of HIV illness. Supplementary questions were whether severity of immunodeficiency is associated with antidepressant response and whether patients with greater immuno
Prevalence of HIV-1 syncytium-inducing phenotype [letter; comment]: Ann Intern Med. 1994 May 1;120(9):811. Unique Identifier : AIDSLINE MED/94197378; Kozal MJ; Ramachandran RV; Shafer RW
Mechanism of inhibitory effect of dextran sulfate and heparin on human T-cell lymphotropic virus type I (HTLV-I)-induced syncytium formation in vitro: role of cell-to-cell contact.: Antiviral Res. 1994 Feb;23(2):143-59. Unique Identifier : AIDSLINE MED/94197407; Ida H; Kurata A; Eguchi K; Yamashita I; Nakashima M; Sakai M; Kawabe Y; Nakamura T; Nagataki S; First Department of Internal Medicine, Nagasaki University School; of Medicine, Japan.; Cell-to-cell contact is usually essential for syncytium formation by HTLV-I-infected cell lines. The present study was undertaken to determine the inhibitory effect of polyanionic compounds, dextran sulfate and heparin, on HTLV-I-induced syncytium formation, as demonstrated by the fusion of HTLV-I-infected cells with
Mycobacterium tuberculosis induces expression of P-glycoprotein in promonocytic U1 cells chronically infected with HIV type 1.: Biochem Biophys Res Commun. 1994 Mar 30;199(3):1181-7. Unique Identifier : AIDSLINE MED/94197702; Gollapudi S; Reddy M; Gangadharam P; Tsuruo T; Gupta S; Division of Basic and Clinical Immunology, University of; California, Irvine.; A productive infection with HIV-1 is associated with an increased expression of a 170 kd plasma membrane P-glycoprotein (P-gp), that functions as a metabolically active drug efflux pump, in human T and macrophage cell lines. In this investigation we show that phagocytosis of M. tuberculosis by U1 cells, that are chron
Efficacy of neuroleptics for hypoactive delirium [letter]: J Neuropsychiatry Clin Neurosci. 1994 Winter;6(1):66-7. Unique Identifier : AIDSLINE MED/94198590; Platt MM; Breitbart W; Smith M; Marotta R; Weisman H; Jacobsen PB
[Beneficial effect of sulfasalazine in spondylarthropathy in 2 patients with HIV infection]: Rev Rhum Ed Fr. 1993 Jul-Sep;60(7-8):527-9. Unique Identifier : AIDSLINE MED/94198868; Mijiyawa M; David M; Service de Rhumatologie, CHU Tokoin, Lome, Togo.; Two HIV-positive males aged 27 and 30 years, respectively, developed spondyloarthropathy with axial and appendicular joint involvement and recurrent diarrhea. Neither patient was able to discontinue nonsteroidal antiinflammatory drugs. Consequently, sulfasalazine was given in a daily dosage of 2 grams. Improvements in
[Comparative epidemiology of HTLV and HIV retroviruses]: Bull Acad Natl Med. 1993 Oct;177(7):1131-48; discussion 1149-52. Unique Identifier : AIDSLINE MED/94199433; Tuppin P; de The G; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur,; Paris.; There are interesting contrasts between the epidemiological characteristics of the two subfamilies of human retroviruses. The oncoretrovirus HTLV-I and II are endemic in Intertropical Africa, North and South Americas and in the South of Japan . The lentiretroviruses HIV 1 and 2 are e
Multiple sub-sets of CD4+ and CD8+ cytotoxic T-cell clones directed to autologous human melanoma identified by cytokine profiles.: Int J Cancer. 1994 Apr 1;57(1):56-62. Unique Identifier : AIDSLINE MED/94200891; Maccalli C; Mortarini R; Parmiani G; Anichini A; Division of Experimental Oncology D, Istituto Nazionale Tumori,; Milan, Italy.; CD4+ and CD8+ cytotoxic T-cell (CTL) clones, selected for T-cell-receptor (TcR)-dependent lysis of the autologous tumor and isolated from peripheral-blood lymphocytes (PBL) or tumor-infiltrating lymphocytes (TIL) of 3 melanoma patients, were characterized for the pattern of 13 different cytokines released by antibody-
[Acute primary stage of HIV infection with documented seroconversion]: Hautarzt. 1994 Jan;45(1):29-33. Unique Identifier : AIDSLINE MED/94200971; Schroder U; Waller V; Kaliebe T; Agathos M; Breit R; Dermatologische und Allergologische Abteilung,; Ludwig-Maximilians-Universitat Munchen.; We report a 34-year-old homosexual man who developed a maculopapular, non-itchy exanthema mainly on the trunk in addition to fever up to 39.8 degrees C, general malaise, arthralgias, generalized enlargement of the lymph nodes, watery diarrhoea and weight loss. The patient was in an acute phase of the HIV infection acc
MT-2 cell tropism as prognostic marker for disease progression in human immunodeficiency virus type 1 infection [see comments]: J Clin Microbiol. 1994 Feb;32(2):364-70. Unique Identifier : AIDSLINE MED/94201359; Karlsson A; Parsmyr K; Sandstrom E; Fenyo EM; Albert J; Department of Virology, Karolinska Institute, Stockholm, Sweden.; The ability of human immunodeficiency virus type 1 (HIV-1) isolates to replicate in MT-2 cells was investigated as a prognostic marker for disease progression and CD4+ lymphocyte depletion in 53 HIV-1-infected, asymptomatic individuals. MT-2-negative viruses were isolated from 49% of the patients both early and late d
Induction of a major histocompatibility complex class I-restricted cytotoxic T-lymphocyte response to a highly conserved region of human immunodeficiency virus type 1 (HIV-1) gp120 in seronegative humans immunized with a candidate HIV-1 vaccine.: J Virol. 1994 May;68(5):3145-53. Unique Identifier : AIDSLINE MED/94202302; Johnson RP; Hammond SA; Trocha A; Siliciano RF; Walker BD; Infectious Disease Unit, Massachusetts General Hospital,; Charlestown 02129.; Efforts to induce broadly reactive immunity against human immunodeficiency virus type 1 (HIV-1) have been impaired by the extent of sequence variation exhibited by this lentivirus. Cytotoxic T lymphocytes (CTL) specific for other viruses such as influenza virus have been shown to mediate immunity against divergent vir
Naturally occurring genotypes of the human immunodeficiency virus type 1 long terminal repeat display a wide range of basal and Tat-induced transcriptional activities.: J Virol. 1994 May;68(5):3163-74. Unique Identifier : AIDSLINE +; Michael NL; D'Arcy L; Ehrenberg PK; Redfield RR; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland.; The primary body of information on the structure of human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)/gag leader genotypes has been determined from the analysis of cocultivated isolates. Functional studies of this regulatory portion of the provirus have been derived from the study of in vitro-gene
Changes in AIDS survival time in two San Francisco cohorts of homosexual men, 1983 to 1993 [see comments]: JAMA. 1994 Apr 13;271(14):1083-7. Unique Identifier : AIDSLINE MED/94202381; Osmond D; Charlebois E; Lang W; Shiboski S; Moss A; Department of Epidemiology and Biostatistics, University of; California-San Francisco.; BACKGROUND--During the first decade since the recognition of the acquired immunodeficiency syndrome (AIDS), new therapies have been introduced and the frequency of clinical manifestations has changed. The impact of these changes on AIDS survival, however, has not been well characterized. DESIGN--A prospective cohort s
Differential survival of patients with AIDS according to the 1987 and 1993 CDC case definitions.: JAMA. 1994 Apr 20;271(15):1197-9. Unique Identifier : AIDSLINE MED/94202413; Vella S; Chiesi A; Volpi A; Giuliano M; Floridia M; Dally LG; Binkin N; Laboratory of Virology, Istituto Superiore de Sanita, Rome,; Italy.; OBJECTIVE--To evaluate the impact of the 1993 Centers for Disease Control and Prevention (CDC) revised classification system for human immunodeficiency virus and expanded surveillance case definition for acquired immunodeficiency syndrome (AIDS) on the number of cases and on survival of patients with AIDS. DESIGN--Ret
Sexual transmission of simian T-lymphotropic virus type I: a model of human T-lymphotropic virus type I infection.: Leukemia. 1994 Apr;8 Suppl 1:S222-6. Unique Identifier : AIDSLINE MED/94202959; Lazo A; Bailer RT; Lairmore MD; Yee JA; Andrews J; Stevens VC; Blakeslee JR; Department of Veterinary Anatomy and Cellular Biology, Ohio State; University, Columbus 43210.; Simian T-lymphotropic virus type-I (STLV-I) seronegative females placed together with seropositive males for breeding purposes were followed from 1984-1990 to determined seroconversion rates by enzyme immunoassay and western immunoblot analysis. Two of 26 females and 1 of 4 males previously negative for antibodies to
Genetic instability of human cells with DNA related to human retrovirus.: Leukemia. 1994 Apr;8 Suppl 1:S36-40. Unique Identifier : AIDSLINE MED/94202965; Maruyama K; Fukushima T; Mochizuki S; Kawamura K; Koshikawa N; Miyauchi M; Nakano M; Chiba Cancer Center Research Institute, Japan.; To elucidate the role of HTLV-I in human neoplasia, DNA was extracted from tumor tissues, cultured cells, and/or sera from 20 HTLV-I seropositive and from 10 seronegative cancer patients, subjected to PCR-PAGE, and analyzed by Southern hybridization. HTLV-I related sequences were detected in tumors of the seropositive
Treatment of refractory disseminated nontuberculous mycobacterial infection with interferon gamma. A preliminary report.: N Engl J Med. 1994 May 12;330(19):1348-55. Unique Identifier : AIDSLINE MED/94203241; Holland SM; Eisenstein EM; Kuhns DB; Turner ML; Fleisher TA; Strober W; Gallin JI; Laboratory of Host Defenses, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.; BACKGROUND. Studies conducted in vitro and in animals suggest that cytokine signals to monocytes or macrophages by interferon gamma are important in the containment and clearance of disseminated nontuberculous mycobacterial infections. METHODS. We studied seven patients with refractory, disseminated nontuberculous myc
Eosinophils: a putative marker of immunodepression in HIV-infected African patients with tuberculosis?: Trans R Soc Trop Med Hyg. 1994 Jan-Feb;88(1):117-8. Unique Identifier : AIDSLINE MED/94205045; Ledru E; Diagbouga S; Tranchot-Diallo J; Cauchoix B; Yameogo M; Chami D; Soula G; Chiron JP; Centre MURAZ-ISTORIA, Organisation de Coordination et de; Cooperation pour la lutte contre les Grandes Endemies (OCCGE),; Burkina Faso.
Diagnostic lumbar puncture in HIV-infected patients: analysis of 138 cases.: Am J Med. 1994 Mar;96(3):223-8. Unique Identifier : AIDSLINE MED/94205623; Hollander H; McGuire D; Burack JH; Department of Medicine, University of California, San Francisco; 94143.; PURPOSE: This study was designed to describe the cerebrospinal fluid (CSF) findings and neurologic diagnoses observed in human immunodeficiency virus (HIV)-infected adults undergoing diagnostic lumbar puncture (LP) and to correlate the results of LP with indications and CD4 counts. DESIGN: Retrospective cross-sectiona
Direct comparison of the relationship between clinical outcome and change in CD4+ lymphocytes in human immunodeficiency virus-positive homosexual men and injecting drug users.: Arch Intern Med. 1994 Apr 25;154(8):869-75. Unique Identifier : AIDSLINE MED/94206147; Margolick JB; Munoz A; Vlahov D; Astemborski J; Solomon L; He XY; Nelson KE; Saah AJ; Department of Environmental Health Sciences, Johns Hopkins School; of Hygiene and Public Health, Baltimore, Md.; BACKGROUND AND METHODS: To compare rates of decline of CD4+ lymphocytes among human immunodeficiency virus-positive homosexual men and injecting drug users, we followed up prevalent human immunodeficiency virus-positive homosexual men and current or former injecting drug users from February 1988 through August 1991. S
Potential pitfalls on the road to an effective HIV vaccine.: Immunol Today. 1994 Feb;15(2):54-7. Unique Identifier : AIDSLINE MED/94206433; Schwartz DH; Dept of Immunology and Infectious Diseases, Johns Hopkins; University School of Hygiene and PUblic Health, Baltimore, MD; 21205.; Experimental vaccines for AIDS prophylaxis are being tested in larger and higher-risk populations. Here, David Schwartz, an advocate of HIV-vaccine research and development, highlights some of the concerns that have been voiced about this strategy and presents a simple mathematical model that considers the drawbacks t
Current concepts: tuberculosis and HIV infection [published erratum appears in Indian J Pathol Microbiol 1994 Apr;37(2):238]: Indian J Pathol Microbiol. 1993 Oct;36(4):503-11. Unique Identifier : AIDSLINE MED/94208917; Talib VH; Khurana SK; Pandey J; Verma SK; Department of Laboratory Medicine, Safdarjang Hospital, New; Delhi.
CD4+ blood dendritic cells are potent producers of IFN-alpha in response to in vitro HIV-1 infection [published erratum appears in J Immunol 1994 Jul 15;153(2):910]: J Immunol. 1994 May 1;152(9):4649-62. Unique Identifier : AIDSLINE MED/94209688; Ferbas JJ; Toso JF; Logar AJ; Navratil JS; Rinaldo CR Jr; Department of Infectious Diseases and Microbiology, University of; Pittsburgh, PA 15261.; We determined the relative abilities of cell subpopulations from all major PBMC lineages of normal donors to produce IFN-alpha in response to in vitro stimulation with lymphocytotropic HIV-1 (IIIb and RF), monocytotropic HIV-1 (BaL), Sendai virus, and HSV-1. Active and inactive cell-free preparations of HIV-1 IIIb and
Natural history of HIV illness.: J Indian Med Assoc. 1993 Dec;91(12):319-20. Unique Identifier : AIDSLINE MED/94209728; Lal S; Sengupta D; National AIDS Control Organisation, Ministry of Health and Family; Welfare, New Delhi.
Clinical significance of human immunodeficiency virus type 1 phenotypes in infected children.: J Infect Dis. 1994 Mar;169(3):491-5. Unique Identifier : AIDSLINE MED/94209741; Spencer LT; Ogino MT; Dankner WM; Spector SA; Department of Pediatrics, University of California, San Diego.; Human immunodeficiency virus type 1 (HIV-1) isolates from perinatally infected infants and children were examined for syncytium-inducing (SI) capacity. All isolates from 14 infants
Detection by PCR of human polyomaviruses BK and JC in immunocompromised individuals and partial sequencing of control regions.: J Med Virol. 1994 Feb;42(2):138-45. Unique Identifier : AIDSLINE GENBANK/S72999; Schatzl HM; Sieger E; Jager G; Nitschko H; Bader L; Ruckdeschel G; Jager G; Max von Pettenkofer Institute, University of Munich, Germany.; Immunocompromised individuals were tested for the presence of the human polyomaviruses JC (JCV) and BK (BKV) by the polymerase chain reaction (PCR). The use of appropriate primers in a nested PCR allowed the detection of both viruses simultaneously. Viruses were differentiated by restriction fragment length analysis o
Evidence for a defect of antibody-dependent cellular cytotoxic (ADCC) effector function and anti-HIV gp120/41-specific ADCC-mediating antibody titres in HIV-infected individuals.: J Acquir Immune Defic Syndr. 1994 May;7(5):428-37. Unique Identifier : AIDSLINE MED/94210366; Ahmad A; Morisset R; Thomas R; Menezes J; Laboratory of Immunovirology, Ste-Justine Hospital, Montreal,; Quebec, Canada.; Antibody-dependent cellular cytotoxicity (ADCC) is an important antiviral effector mechanism. However, its role, as well as the functional integrity of the ADCC-effector cells in HIV infections, is not well understood. For studying gp120/41-specific ADCC, we recently developed a virus-free target cell system, using a
The use of pentoxifylline alone in HIV-infected patients [letter; comment]: J Acquir Immune Defic Syndr. 1994 May;7(5):519-21. Unique Identifier : AIDSLINE MED/94210380; Mole L; Margolis D; Ghotbi L; Holodniy M
Slower heterosexual spread of HIV-2 than HIV-1.: Lancet. 1994 Apr 16;343(8903):943-6. Unique Identifier : AIDSLINE MED/94210968; Kanki PJ; Travers KU; MBoup S; Hsieh CC; Marlink RG; Gueye-NDiaye A; Siby T; Thior I; Hernandez-Avila M; Sankale JL; et al; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115.; Because of the similar virological properties of HIV types 1 and 2, HIV-2 was assumed to be as infectious and capable of inducing AIDS as HIV-1. Seroepidemiological studies have shown significant rates of HIV-2 infection in West Africa, and surveys from other regions of the world indicate that the spread of HIV-2 infe
Personal screening for HIV in developing countries [see comments]: Lancet. 1994 Apr 16;343(8903):960-2. Unique Identifier : AIDSLINE MED/94210975; Frerichs RR; Department of Epidemiology, University of California Los Angeles; 90024.
Maternal antibody response at delivery and perinatal transmission of human immunodeficiency virus type 1 in African women.: Lancet. 1994 Apr 23;343(8904):1001-5. Unique Identifier : AIDSLINE MED/94211008; Lallemant M; Baillou A; Lallemant-Le Coeur S; Nzingoula S; Mampaka M; M'Pele P; Barin F; Essex M; Department of Cancer Biology, Harvard School of Public Health, MA; 02115.; Prospective cohort studies indicate that 13-45% of human immunodeficiency virus type 1 (HIV-1)-infected pregnant women transmit the virus to their infants. Although factors that influence perinatal transmission are not well understood, drug and immunotherapy trials to interrupt transmission are underway. The identific
Two-year HIV-1-associated mortality in a Ugandan rural population [see comments]: Lancet. 1994 Apr 23;343(8904):1021-3. Unique Identifier : AIDSLINE MED/94211014; Mulder DW; Nunn AJ; Kamali A; Nakiyingi J; Wagner HU; Kengeya-Kayondo JF; MRC (UK)/ODA/UVRI Programme on AIDS in Uganda, Entebbe.; The mortality in 15 villages in South-West Uganda was studied in relation to HIV infection. After a population census, serum samples were tested for antibodies to HIV-1. Deaths were ascertained over 2 years. Unequivocal HIV-1 serology results were available for 9389 individuals. Th
HIV and cancer [news]: Lancet. 1994 Apr 23;343(8904):1032. Unique Identifier : AIDSLINE MED/94211017; McCarthy M
HIV-1 antibody serum negativity with vaginal secretions positivity [letter]: Lancet. 1994 Apr 23;343(8904):1046-7. Unique Identifier : AIDSLINE MED/94211042; Belec L; Tevi-Benissan C; Gresenguet G; Meillet D; Pillot J
Excess deaths in Africa from HIV: confirmed and quantified.: Lancet. 1994 Apr 23;343(8904):989-90. Unique Identifier : AIDSLINE MED/94211048; Dondero TJ; Curran JW; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia.
A cytotoxic response against AIDS [news]: Lancet. 1994 Apr 30;343(8905):1093-4. Unique Identifier : AIDSLINE MED/94211070; Thompson C
HHV-6 in AIDS [letter] [see comments]: Lancet. 1994 Apr 30;343(8905):1104-5. Unique Identifier : AIDSLINE MED/94211091; Griffiths PD; Emery VC; Lee C; Johnson MA; McLaughlin J
Frequency of cells positive for HIV-1 p24 antigen assessed by flow cytometry.: AIDS. 1993 Nov;7 Suppl 2:S3-5. Unique Identifier : AIDSLINE MED/94213722; Holzer TJ; Heynen CA; Novak RM; Pitrak DL; Dawson GJ; Abbott Laboratories, Diagnostics Division, Abbott Park, IL; 60064-3500.; OBJECTIVE: Markers of HIV disease progression such as soluble p24 antigen detection and CD4 lymphocyte depletion are most useful in the later stages of HIV disease and are relatively insensitive as therapeutic monitors. Flow cytometric detection of HIV-1 replication in CD4 lymphocytes was evaluated for use as a marker
Correlation between HIV provirus burden and in utero transmission.: AIDS. 1993 Nov;7 Suppl 2:S39-43. Unique Identifier : AIDSLINE MED/94213724; Roques P; Marce D; Courpotin C; Mathieu FP; Herve F; Boussin FD; Narwa R; Meyohas MC; Dollfus C; Dormont D; Laboratory for Experimental Neuropathology and Neurovirology,; CEA/CRSSA, DSV/DPTE, Fontenay aux Roses, France.; OBJECTIVE: No predictive parameters of in utero or perinatal vertical transmission of HIV to newborns are known at present. Vertical transmission may be related to several biological parameters of maternal HIV infection: (1) immunological parameters (neutralizing antibodies); (2) the concentration of viral particles a
High levels of circulating RNA in patients with symptomatic HIV-1 infection.: AIDS. 1993 Nov;7 Suppl 2:S59-64. Unique Identifier : AIDSLINE MED/94213728; Baumberger C; Kinloch-de-Loes S; Yerly S; Hirschel B; Perrin L; Central Laboratory of Virology, Geneva University Hospital,; Switzerland.; OBJECTIVE: To evaluate the concentration of circulating RNA (viraemia) in patients with symptomatic primary HIV infection and relate it to sero-immunological parameters. METHODS: Semiquantitation of circulating HIV RNA and proviral HIV DNA was performed using the polymerase chain reaction. Circulating HIV RNA concentr
Determination of plasma viral load in HIV-1 infection by quantitative competitive polymerase chain reaction.: AIDS. 1993 Nov;7 Suppl 2:S65-71. Unique Identifier : AIDSLINE MED/94213729; Piatak M Jr; Saag MS; Yang LC; Clark SJ; Kappes JC; Luk KC; Hahn BH; Shaw GM; Lifson JD; Division of HIV and Exploratory Research, Genelabs Technologies,; Incorporated, Redwood City, California 94063.; OBJECTIVES: To better characterize viral load profiles through the course of HIV-1 disease and in response to treatment, and to further evaluate quantitative competitive polymerase chain reaction for measurement of viral load, we extended our comparative evaluation of this and other viral load measurements to a total
Frequency of cells positive for HIV-1 sequences assessed by in situ polymerase chain reaction.: AIDS. 1993 Nov;7 Suppl 2:S7-10. Unique Identifier : AIDSLINE MED/94213730; Bagasra O; Seshamma T; Oakes JW; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107.; OBJECTIVE: HIV-1 infection of humans causes immunosuppression. The determination of precise levels of HIV-1 infection of cells in vivo may assist in the understanding of the pathogenetic processes involved in clinical infection with this virus. Studies using polymerase chain reaction have demonstrated higher levels of
Cytotoxic T-cell response and AIDS-free survival in simian immunodeficiency virus-infected macaques.: AIDS. 1993 Nov;7 Suppl 2:S73-9. Unique Identifier : AIDSLINE MED/94213731; Bourgault I; Villefroy P; Beyer C; Aubertin AM; Levy JP; Venet A; Cochin Institute for Molecular Genetics (ICGM), INSERM U152,; Cochin Hospital, Paris, France.; OBJECTIVES: To determine whether cytotoxic T lymphocytes have a beneficial effect during infection with the simian immunodeficiency virus (SIV) in macaques. DESIGN AND METHODS: We followed up 12 rhesus macaques experimentally infected with SIV. Cytotoxic T lymphocytes were detected in nine macaques, who were subdivide
HIV-specific CD8+ T-cell immune responses and viral replication.: AIDS. 1993 Nov;7 Suppl 2:S81-5. Unique Identifier : AIDSLINE MED/94213732; Buseyne F; Riviere Y; Unit for Virology and Cellular Immunology, URA CNRS 1157, Pasteur; Institute, Paris, France.; AIM: To review current knowledge of CD8+ T cells in relation to their effect on the replication of HIV and on disease progression. PRESENT KNOWLEDGE: Both CD8+ cytotoxic T lymphocytes capable of killing cells expressing HIV antigens and CD8+ lymphocytes that suppress HIV replication in vitro are detectable in response
A 7-year analysis of anti-Gag (p17 and p24) antibodies in HIV-1-seropositive patients with haemophilia: immunoglobulin G titre and avidity are early predictors of clinical course.: AIDS. 1993 Nov;7 Suppl 2:S87-90. Unique Identifier : AIDSLINE MED/94213733; Chargelegue D; Colvin BT; O'Toole CM; Department of Medical Microbiology, London Hospital Medical; College, UK.; OBJECTIVE: To study the humoral immune response to HIV-1 p17 and p24 Gag proteins longitudinally and assess any prognostic value. DESIGN AND METHODS: Fifteen HIV-1 infected patients with haemophilia were asymptomatic at entry to the study in 1986. Each patient was monitored at 6- to 12-month intervals for up to 7 year
Lack of isolate-specific neutralizing activity is correlated with an increased viral burden in rapidly progressing HIV-1-infected patients.: AIDS. 1993 Nov;7 Suppl 2:S91-9. Unique Identifier : AIDSLINE MED/94213734; Lu W; Shih JW; Tourani JM; Eme D; Alter HJ; Andrieu JM; Laboratory for Tumour Immunology, Laennec Hospital, University; of Paris V, France.; OBJECTIVE: To delineate the interaction between in vivo HIV replication and host antiviral immunity during disease progression in order to elucidate the pathogenesis of AIDS. DESIGN: In a cohort of HIV-seropositive patients, the serum concentration of viral particles, the blood concentration of mononuclear cells harbo
Intercellular adhesion molecule-1 (ICAM-1) is upregulated on alveolar macrophages from AIDS patients.: Eur Respir J. 1994 Feb;7(2):229-34. Unique Identifier : AIDSLINE MED/94215658; Bohnet S; Braun J; Dalhoff K; Dept of Internal Medicine, Medical University of Lubeck,; Germany.; In acquired immune deficiency syndrome (AIDS) patients, alveolar macrophages (AMs) have an increased ability to serve as accessory cells during the generation of an immune response. In addition to soluble mediators, like cytokines, molecules of the major histocompatibility complex (MHC) class II and adhesion molecules
[The pitfalls of lymphocyte immunophenotyping during HIV infection]: Ann Biol Clin (Paris). 1993;51(7-8):689-96. Unique Identifier : AIDSLINE MED/94219743; Martini E; Noet G; Laboratoire de biologie medicale et de cytopathologie, Paris,; France.; Preferential infection of CD4+ lymphocytes by HIV, related to both direct and indirect mechanisms, leads to progressive decrease in this population. A CD4 lymphocyte count has become the preferential test for monitoring the infection. Thus, a flow cytometry laboratory handles a great number of phenotyping prescription
Zidovudine improves psoriasis in human immunodeficiency virus-positive males.: Arch Dermatol. 1994 Apr;130(4):447-51. Unique Identifier : AIDSLINE MED/94219855; Duvic M; Crane MM; Conant M; Mahoney SE; Reveille JD; Lehrman SN; Department of Dermatology, University of Texas Medical School,; Houston.; BACKGROUND AND DESIGN: Patients with human immunodeficiency virus (HIV) infection can develop severe psoriasis, which is difficult to treat using conventional therapy. Anecdotal case reports have suggested that administration of zidovudine can improve psoriasis in the HIV-infected patient. An open-label study was cond
Blood donor testing for HIV-I/II and HTLV-I/II.: Arch Pathol Lab Med. 1994 Apr;118(4):337-41. Unique Identifier : AIDSLINE MED/94219968; Ness PM; Nass CC; Department of Pathology, Johns Hopkins University School of; Medicine, Baltimore, MD.; In 1985, serologic testing became available to screen blood donors for the viruses associated with the acquired immunodeficiency syndrome; these viruses are now called human immunodeficiency viruses I and II. In 1989, blood donor screening for other retroviruses, human T-cell lymphotropic viruses I and II, was initiat
Quarterly Communicable Disease Review. April to June 1993. From the PHLS Communicable Disease Surveillance Centre [see comments]: J Public Health Med. 1993 Dec;15(4):358-66. Unique Identifier : AIDSLINE MED/94206609
Gianotti-Crosti syndrome and human immunodeficiency virus infection [see comments]: Arch Dermatol. 1994 Apr;130(4):481-3. Unique Identifier : AIDSLINE MED/94219861; Blauvelt A; Turner ML; Dermatology Branch, National Cancer Institute, Bethesda, Md.; BACKGROUND: Patients with Gianotti-Crosti syndrome (GCS) present with a distinctive self-limiting acral papular or papulovesicular eruption associated with an underlying viral illness. Gianotti-Crosti syndrome in patients infected with human immunodeficiency virus has not been previously reported. OBSERVATIONS: We rep
Fluconazole and enhanced effect of rifabutin prophylaxis [letter; comment]: N Engl J Med. 1994 May 5;330(18):1316-7. Unique Identifier : AIDSLINE MED/94195361; Narang PK; Trapnell CB; Schoenfelder JR; Lavelle JP; Bianchine JR
Picture codes as discussion starters in AIDS education.: World Health Forum. 1994;15(1):39-41. Unique Identifier : AIDSLINE MED/94190426; Laver SM; Department of Community Medicine, Medical School, University of; Zimbabwe, Harare.
Antigenic variation in gp120s from molecular clones of HIV-1 LAI.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1185-93. Unique Identifier : AIDSLINE MED/94190623; Moore JP; Yoshiyama H; Ho DD; Robinson JE; Sodroski J; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10018.; To address the relationship between primary sequence variation in HIV-1 gp120 and its antigenic structure in a simple system, we have measured the binding of human and murine monoclonal antibodies (MAbs) to gp120 from four molecular clones of HIV-1 LAI: HxB2, HxB3, Hx10, and NL4-3. Despite the close relationship betwe
High antigenic cross-reactivity of the V3 consensus sequences of HIV-1 gp120.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1209-15. Unique Identifier : AIDSLINE MED/94190625; Baillou A; Brand D; Denis F; M'Boup S; Chout R; Goudeau A; Barin F; Departement de Microbiologie Medicale et Moleculaire, URA CNRS; 1334, CHU Bretonneau, Tours, France.; The principal neutralization determinant (PND) of the human immunodeficiency virus type 1 (HIV-1) is located within the variable V3 region of the external envelope protein gp120. Although it is recognized that V3 sequences induce antibody response with restricted neutralization activity in vitro, we observed that the
Efficient antigen presentation to cytotoxic T lymphocytes by cells transduced with a retroviral vector expressing the HIV-1 Nef protein.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1217-23. Unique Identifier : AIDSLINE MED/94190626; Robertson MN; Buseyne F; Schwartz O; Riviere Y; Unite de Virologie et Immunologie Cellulaire, Institut Pasteur,; Paris.; In the classic model of antigen processing and presentation, viral antigens must be synthesized within the cytoplasm of infected cells to be processed and presented to CD8+, MHC class I-restricted cytotoxic T lymphocytes (CTLs). We have examined the utility of a retroviral vector (pNeoNef) expressing the human immunod
Fidelity of in vitro DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.: Biochemistry. 1994 Apr 5;33(13):3890-5. Unique Identifier : AIDSLINE MED/94190915; Peliska JA; Benkovic SJ; Department of Chemistry, Pennsylvania State University, Wartik; Laboratory, University Park 16802.; The fidelity of DNA strand transfer reactions catalyzed by human immunodeficiency virus type 1 reverse transcriptase has been studied in vitro. A model system involving two sequential DNA strand transfers was developed to simulate the process of forced copy-choice recombination. A propensity for nucleotide misincorpor
Effect of the 1993 European AIDS case definition in the United Kingdom.: Commun Dis Rep CDR Wkly. 1994 Jan 14;4(2):5. Unique Identifier : AIDSLINE MED/94191747
AIDS and HIV-1 infection in the Uni