Various responses of lymphocytes to Epstein-Barr virus in patients with common variable immunodeficiency. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Various responses of lymphocytes to Epstein-Barr virus in patients with common variable immunodeficiency.

J Clin Lab Immunol. 1992;37(4):183-9. Unique Identifier : AIDSLINE MED/94016478
Kondo N; Inoue R; Orii T; Department of Pediatrics, Gifu University School of Medicine,; Japan.

Abstract: The responses of lymphocytes to Epstein-Barr virus (EBV) were investigated in five patients with common variable immunodeficiency (CVID). In three patients with CVID in whom the percentages of CD20+ cells and CD21/EBV receptor+ cells were markedly reduced, PBMCs and/or B cells did not respond (or scarcely) to EBV. This may be due to reduction of B cell numbers or reduction of EBV receptor bearing cells. In one patient with CVID in whom the percentages of CD20+ cells and CD21/EBV receptor+ cells were mildly reduced, PBMCs and/or B cells responded well to EBV and secreted immunoglobulin (Ig). This result shows that the patient's B cells with EBV receptors are sufficient to transduct EBV-signals into the nucleus and to respond to EBV. In another patient in whom the percentages of CD20+ cells and CD21/EBV receptor+ cells were not reduced, PBMCs mildly responded to EBV and scarcely secreted Ig. This result shows that the patient's B cells with EBV receptors may not be sufficient to transduct EBV-signals into the nucleus and to respond to EBV.
Keywords: Antibody-Producing Cells/IMMUNOLOGY Antigens, CD/METABOLISM Antigens, Differentiation, B-Lymphocyte/METABOLISM B-Lymphocytes/*IMMUNOLOGY Child Child, Preschool Common Variable Immunodeficiency/*IMMUNOLOGY Female Herpesvirus 4, Human/*IMMUNOLOGY Human In Vitro Lymphocyte Transformation Male Receptors, Complement 3d/METABOLISM Receptors, Virus/IMMUNOLOGY JOURNAL ARTICLEKWDantibody-producingcells/immunologyantigens,cd/metabolismantigens,differentiation,b-lymphocyte/metabolismb-lymphocytes/KWDimmunologychildchild,preschoolcommonvariableimmunodeficiency/KWDimmunologyfemaleherpesvirus4,human/KWDimmunologyhumaninvitrolymphocytetransformationmalereceptors,complement3d/metabolismreceptors,virus/immunologyjournalarticle
940130
M9410808

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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