Challenges in the therapy of HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Challenges in the therapy of HIV infection.

Immunol Today. 1993 Jun;14(6):303-9. Unique Identifier : AIDSLINE MED/94000316
Yarchoan R; Mitsuya H; Broder S; Medicine branch, National Cancer Institute, National Institutes; of Health, Bethesda, MD 20892.

Abstract: Drugs that inhibit HIV replication have been shown to have clinical utility in patients with HIV infection. However, the immunological improvement induced by available anti-HIV therapies in patients with AIDS is incomplete and transient. Explanations for this may include immunological barriers to complete reconstitution, low therapeutic indices of the available drugs, and the development of viral resistance. An understanding of these processes may provide important leads for the development of improved therapy for AIDS.
Keywords: Acquired Immunodeficiency Syndrome/THERAPY Dideoxynucleosides/THERAPEUTIC USE Human HIV/DRUG EFFECTS HIV Infections/*THERAPY Immunosuppressive Agents/THERAPEUTIC USE Immunotherapy Virus Replication/DRUG EFFECTS JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDacquiredimmunodeficiencysyndrome/therapydideoxynucleosides/therapeuticusehumanhiv/drugeffectshivinfections/KWDtherapyimmunosuppressiveagents/therapeuticuseimmunotherapyvirusreplication/drugeffectsjournalarticlereviewreview,tutorial
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Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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