Intestinal antibody responses to oral vaccination in HIV-infected individuals.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Intestinal antibody responses to oral vaccination in HIV-infected individuals.

AIDS. 1993 Aug;7(8):1087-91. Unique Identifier : AIDSLINE MED/94000539
Eriksson K; Kilander A; Hagberg L; Norkrans G; Holmgren J; Czerkinsky C; Department of Medical Microbiology and Immunology, University of; Goteborg, Sweden.

Abstract: OBJECTIVE: To examine whether and at what stage mucosal immune responsiveness is impaired during HIV-1 infection. DESIGN: Intestinal and systemic antibody-secreting cell (ASC) responses were examined in eight HIV-1-infected volunteers and 10 seronegative control subjects after oral cholera and parenteral tetanus vaccinations. METHODS: ASC numbers were determined before and after booster vaccinations by the enzyme-linked immunospot (ELISPOT) technique. This technique was performed on cell suspensions obtained from enzymatically dispersed duodenal biopsies and from peripheral blood. RESULTS: Oral cholera vaccination evoked ASC responses in the intestinal mucosa of six out of eight HIV-1-infected volunteers, including patients with advanced disease and very low levels of circulating CD4+ T cells. The intestinal cholera ASC responses in HIV-infected volunteers were comparable to those in uninfected controls with regard to both magnitude and distribution of antibody classes. Most HIV-infected volunteers with only moderately reduced CD4+ T-cell counts also responded with vaccine-specific ASC in the blood, whereas none of the patients with < 200 x 10(6)/l CD4+ T cells per litre blood had detectable circulating ASC. CONCLUSION: These findings indicate that mucosal humoral immune responsiveness to a T-cell dependent antigen is maintained in HIV-infected individuals, despite concomitant systemic humoral hyporesponsiveness.

Keywords: Administration, Oral Adult Antibodies, Bacterial/BIOSYNTHESIS/IMMUNOLOGY *Antibody Formation Cholera Vaccine/ADMINISTRATION & DOSAGE/IMMUNOLOGY Human HIV Infections/*IMMUNOLOGY IgA/BIOSYNTHESIS/IMMUNOLOGY IgG/BIOSYNTHESIS/IMMUNOLOGY Intestinal Mucosa/*IMMUNOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Vaccination JOURNAL ARTICLE
940130
M9410788

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