Prognostic value of IL-10 in non-Hodgkin's lymphoma (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Prognostic value of IL-10 in non-Hodgkin's lymphoma (Meeting abstract).

Proc Annu Meet Am Soc Clin Oncol; 12:A271 1993. Unique Identifier : AIDSLINE ICDB/94694671
Blay JY; Burdin N; Rousset F; Lenoir G; Biron P; Philip T; Banchereau J; Favrot M; Centre Leon Berard, 69008 Lyon, France

Abstract: Serum levels of interleukin 10 (IL-10) were measured retrospectively in the serum of 60 normal subjects and 154 patients (pts) with non-Hodgkin's lymphoma (NHL), including 102 with evolutive NHL (87 at diagnosis, 15 in relapse) and 52 in first remission. We used an ELISA measuring both human IL-10 (hIL-10) and viral IL-10 (vIL-10, ie, the EBV BCRF1 molecule). IL-10 was detectable in 48 (47%) of 102 pts with evolutive NHL and on 3 of 52 (6%) pts in first remission (p less than 10(-4)). IL-10 was detectable with a similar frequency in all histological subtypes of NHL. Among the 70 pts with intermediate or high grade NHL, those with detectable serum IL-10 at diagnosis had a significantly shorter overall (p = 0.025) and progression free (p = 0.030) survival. Serum IL-10 was associated with a very poor prognosis in pts (p = 0.00004). Multivariate analysis with Cox model indicate that IL-10 is an independent prognosis factor for both overall and progression free survival in these pts. Using a second ELISA specific for vIL-10, IL-10 was identified as vIL-10 in 23 of the 48 pts with evolutive NHL and in none of the 11 EBV seronegative and in 30% of EBV seropositive pts. vIL-10 was detectable only in the serum of pts with B lymphoma (p = 0.03). These results strongly suggest that both hIL-10 and vIL-10 are involved in the physiopathology of non-HIV related NHL.
Keywords: Enzyme-Linked Immunosorbent Assay Human Interleukin-10/*BLOOD Lymphoma, Non-Hodgkin's/*BLOOD/CLASSIFICATION/DIAGNOSIS/PATHOLOGY Multivariate Analysis Prognosis Recurrence ABSTRACTKWDenzyme-linkedimmunosorbentassayhumaninterleukin-10/KWDbloodlymphoma,non-hodgkin's/KWDblood/classification/diagnosis/pathologymultivariateanalysisprognosisrecurrenceabstract
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M9420829

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