HTLV-I and non-Hodgkin's lymphoma (NHL) in Jamaica and Trinidad (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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HTLV-I and non-Hodgkin's lymphoma (NHL) in Jamaica and Trinidad (Meeting abstract).

Proc Annu Meet Am Soc Clin Oncol; 12:A533 1993. Unique Identifier : AIDSLINE ICDB/94694932
Cleghorn F; Manns A; Hanchard B; Bartholomew C; Falk R; Murphy J; Blattner W; NCI, Bethesda, MD

Abstract: Parallel case-control studies of NHL have been conducted in Jamaica during 1984-1987 and in Trinidad during 1985-1992, in an attempt to quantify the role of HTLV-I as an etiological factor. A total of 135 cases were enrolled in Jamaica and 141 in Trinidad. All cases of African descent from both sites were combined for this analysis (n=195), since HTLV-I prevalence in other racial groups is low or absent. Odds ratios (OR) and 95% confidence intervals were calculated as a measure of the relative risk for the presence of HTLV-I in cases compared with hospital controls. There were 111 male and 84 female cases with a median age at diagnosis of 48 yr. 98/195 (50.3%) of cases had a T-cell phenotype. The prevalence of HTLV-I in controls (N=524) was 8.2%. The overall unadjusted OR for HTLV-I was 10.85 (6.99-16.88); for T-cell cases 25.36 (14.44-44.76). Risk was significantly higher among younger cases than older cases (chi2 test for trend = 14.86, p=0.00012). Results are presented in a table. There was no difference in risk for HTLV-I between males and females. Since it is well established that HTLV-I prevalence in the adult population increases with age, peaking in the seventh decade and rising more rapidly in females than males due to adult sexual exposure, the trend demonstrated by these data of declining HTLV-I risk with age supports the idea that HTLV-I infection early in life is important for HTLV-I-related lymphomagenesis.
Keywords: Female Human HTLV-I Infections/COMPLICATIONS/ETHNOLOGY/*EPIDEMIOLOGY Jamaica/EPIDEMIOLOGY Lymphoma, AIDS-Related/ETHNOLOGY/*EPIDEMIOLOGY Lymphoma, Non-Hodgkin's/ETHNOLOGY/*EPIDEMIOLOGY Male Middle Age Negroid Race T-Lymphocytes Trinidad and Tobago/EPIDEMIOLOGY ABSTRACTKWDfemalehumanhtlv-iinfections/complications/ethnology/KWDepidemiologyjamaica/epidemiologylymphoma,aids-related/ethnology/KWDepidemiologylymphoma,non-hodgkin's/ethnology/KWDepidemiologymalemiddleagenegroidracet-lymphocytestrinidadandtobago/epidemiologyabstract
940228
M9420827

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