Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.
Primary non-Hodgkin's lymphoma of bone (Meeting abstract).
Proc Annu Meet Am Soc Clin Oncol; 12:A1293 1993. Unique Identifier : AIDSLINE ICDB/94695692 McIntyre K; Maale G; Strauss J; Dickson B; Dallas/Fort Worth Sarcoma Group, Presbyterian Hosp. of Dallas,; Dallas, TX 75231
Abstract:
From December 1986 through 1992, 22 patients (pts) were diagnosed with primary non-Hodgkin's lymphoma of bone. Histopathologic material was classified according to the Working Formulation of non-Hodgkin's lymphoma and distribution was as follows: 18 diffuse large cell, 2 diffuse mixed large and small cells, 1 large cell immunoblastic and 1 high-grade lymphoblastic lymphoma. T-cell origins were demonstrated in 3 pts. Age at diagnosis ranged from 16 to 67 yr with a bimodal distribution. Follow-up period ranged from 2 mo to 49 mo. All pts presented with pain at the primary site, and 20 pts had destructive lesions on plain films. Pathologic fractures occurred in 2 pts. Staging included MRI scan of the primary skeletal site demonstrating bulky soft tissue disease (greater than 10 cm diameter) in 14 pts. 17 pts had monostotic and 5 had polyostotic involvement. Ann Arbor staging was difficult, with 18 Stage IE, 1 Stage IIE and 3 Stage IVE pts. All pts were treated with multiagent combination chemotherapy. Seven pts with bulky disease were given concurrent local radiation therapy. 19 pts achieved a complete clinical remission with 16 remaining disease-free to date and 2 relapses resulting in death. Three pts did not achieve a complete remission one of whom had an AIDS-related bone lymphoma, one with a T-cell large cell lymphoma, and one who died of paraneoplastic complications. Uniform staging to include percutaneous bone marrow aspirate and biopsy are necessary to evaluate extent of disease. Newer staging system may be required to accurately assess extranodal lymphomas. T-cell immunophenotypes and bulky disease may portend unfavorable prognostic groups. HIV testing should be included at diagnosis and is an emerging population. Solitary bone site and diffuse large-cell histology represents a favorable prognostic category with high remission rates.
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/DIAGNOSIS Adolescence Adult Aged Bone Neoplasms/COMPLICATIONS/DRUG THERAPY/*PATHOLOGY/RADIOTHERAPY/ *THERAPY Combined Modality Therapy Human HIV Seropositivity/DIAGNOSIS Lymphoma, Non-Hodgkin's/COMPLICATIONS/DRUG THERAPY/*PATHOLOGY/ RADIOTHERAPY/*THERAPY Magnetic Resonance Imaging Middle Age Neoplasm Staging ABSTRACT 940228
M9420823
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Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.
