How frequent and how early does the neurological involvement in HIV-positive children occur? Preliminary results of a prospective study. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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How frequent and how early does the neurological involvement in HIV-positive children occur? Preliminary results of a prospective study.

Childs Nerv Syst. 1990 Nov;6(7):406-8. Unique Identifier : AIDSLINE MED/94036895
Laverda AM; Cogo P; Condini A; Cattelan C; Giaquinto C; Cozzani S; Ruga E; Viero F; De Rossi A; Del Mistro A; et al; Department of Pediatrics, University of Padua, Italy.

Abstract: To study the natural history of the neurological involvement in pediatric human immunodeficiency virus (HIV) infection, 77 children born to seropositive mothers have been followed up since birth. The median follow-up time has been 17.5 months. Fourteen children were classified as infected, 34 as not infected, and 21 as indeterminable. Only two children with full-blown acute immune deficiency syndrome had severe neurological manifestations. Soft neurological signs were found in six infected, and ten non-infected children (chi 2, P < 0.05). The mean development quotient and IQ scores in the infected and the non-infected children were 82.22, and 93.15, respectively (Mann-Whitney test, P > 0.05). These data suggest that neurological and developmental abnormalities do not occur early in the course of vertical HIV infection and that they are associated with severe immunodeficiency.
Keywords: Acquired Immunodeficiency Syndrome/CONGENITAL/DIAGNOSIS AIDS Dementia Complex/*DIAGNOSIS AIDS-Related Complex/CONGENITAL/DIAGNOSIS Female Follow-Up Studies Human HIV Seropositivity/*CONGENITAL/DIAGNOSIS Infant Infant, Newborn Intelligence Male Nervous System Diseases/*CONGENITAL/DIAGNOSIS *Neurologic Examination Pregnancy Support, Non-U.S. Gov't JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/congenital/diagnosisaidsdementiacomplex/KWDdiagnosisaids-relatedcomplex/congenital/diagnosisfemalefollow-upstudieshumanhivseropositivity/KWDcongenital/diagnosisinfantinfant,newbornintelligencemalenervoussystemdiseases/KWDcongenital/diagnosisKWDneurologicexaminationpregnancysupport,non-uKWDsKWDgov'tjournalarticle
940228
M9420816

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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