Immunological side effects of some long term taking medicaments. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Immunological side effects of some long term taking medicaments.

Acta Biomed Ateneo Parmense. 1992;63(1-2):125-31. Unique Identifier : AIDSLINE MED/94055517
Nagylucskay S; Vedres I; Lelkes M; Madi-Szabo L; Palfi I; Institute of Hygiene and Epidemiology, Semmelweis, University of; Medicine, Budapest, Hungary.

Abstract: In view of epidemiologic aspects of AIDS we studied the immunological side-effects of oral hormonal contraceptives and the barbiturates--which are used by many people in Hungary. We studied healthy persons using more than six months one of the above described drugs. We found significant decrease in the number of O cells and in the serum concentration of IgG in the O.C. test group. In B test group decreased significantly the number of T, B, T-active, T-helper lymphocytes and the serum concentration of IgM. The amount of IgA and IgD increased in both the test groups. We detected HBV-markers only in 0.83% of control-group but in 4.23% of O.C. group and in 2.28% of the B test group. The data suggests that all of studied medicaments cause increase in susceptibility against infections.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Adolescence Adult Barbiturates/*ADVERSE EFFECTS Contraceptives, Oral, Hormonal/*ADVERSE EFFECTS/IMMUNOLOGY Female Hepatitis B e Antigens/BLOOD/IMMUNOLOGY Human HIV Seropositivity/IMMUNOLOGY Immunity/*DRUG EFFECTS Immunoglobulins/BLOOD/IMMUNOLOGY Leukocyte Count Male Support, Non-U.S. Gov't T-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/immunologyadolescenceadultbarbiturates/KWDadverseeffectscontraceptives,oral,hormonal/KWDadverseeffects/immunologyfemalehepatitisbeantigens/blood/immunologyhumanhivseropositivity/immunologyimmunity/KWDdrugeffectsimmunoglobulins/blood/immunologyleukocytecountmalesupport,non-uKWDsKWDgov'tt-lymphocytes/drugeffects/immunologyjournalarticle
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M9420799

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