Infectious immune complexes in HIV-1-infected patients. NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Infectious immune complexes in HIV-1-infected patients.

Viral Immunol. 1993 Summer;6(2):135-41. Unique Identifier : AIDSLINE MED/94030457
Fiscus SA; Folds JD; van der Horst CM; Department of Microbiology, University of North Carolina, Chapel; Hill.

Abstract: Using polyethylene glycol (PEG) precipitation we have found that most HIV-1 seropositive patients have IgG containing-circulating immune complexes (CIC). In addition these CIC sometimes contain IgA, IgM, C3, and/or HIV p24 antigen. Previous work has demonstrated that patients who have plasma viremia, CD4 cell counts less than 170/mm3, or who are symptomatic are more apt to have HIV that is precipitable with PEG. In this study we report that the infectious HIV found in the plasma of patients with plasma viremia could only be found in the 2% PEG precipitates, i.e., PEG supernatants never contained infectious HIV, although they often contained noninfectious p24 antigen. These results suggested that at least some of the infectious HIV circulating in the plasma of infected patients is in the form of immune complexes. To support this idea we also demonstrated that infectious HIV could be precipitated with antiserum raised to either immunogloblins or complement components.
Keywords: Antigen-Antibody Complex/*IMMUNOLOGY Complement 3/ANALYSIS Enzyme-Linked Immunosorbent Assay Human HIV Antibodies/ANALYSIS HIV Core Protein p24/ANALYSIS HIV Infections/*IMMUNOLOGY HIV Seropositivity/IMMUNOLOGY HIV-1/*IMMUNOLOGY/ISOLATION & PURIF Immunoglobulins/ANALYSIS Microbiological Techniques Polyethylene Glycols Precipitin Tests Support, U.S. Gov't, P.H.S. Viremia/IMMUNOLOGY JOURNAL ARTICLEKWDantigen-antibodycomplex/KWDimmunologycomplement3/analysisenzyme-linkedimmunosorbentassayhumanhivantibodies/analysishivcoreproteinp24/analysishivinfections/KWDimmunologyhivseropositivity/immunologyhiv-1/KWDimmunology/isolation&purifimmunoglobulins/analysismicrobiologicaltechniquespolyethyleneglycolsprecipitintestssupport,uKWDsKWDgov't,pKWDhKWDsKWDviremia/immunologyjournalarticle
940228
M9420787

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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