Cytokine network and acute primary HIV-1 infection.

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

Cytokine network and acute primary HIV-1 infection.

AIDS. 1993 Sep;7(9):1167-72. Unique Identifier : AIDSLINE MED/94030745
Sinicco A; Biglino A; Sciandra M; Forno B; Pollono AM; Raiteri R; Gioannini P; Institute of Infectious Disease, University of Turin, Italy.

Abstract: OBJECTIVE: To investigate the relationship between cytokine serum levels, peripheral blood lymphocyte subsets and clinical picture in acute primary HIV-1 infection. PATIENTS AND METHODS: Absolute number/microliters total lymphocytes, CD4+, CD8+ and natural killer (NK) cells, as well as serum levels of soluble CD8 receptor, interleukin (IL)-1 beta, IL-2, IL-4, IL-6, tumour necrosis factor (TNF)-alpha, interferon (IFN)-gamma, beta 2-microglobulin and 5'-neopterin were determined in 15 patients with acute primary HIV-1 infection, 16 asymptomatic HIV-1-seropositive individuals and 18 HIV-1-seronegative individuals at risk for HIV-1 infection. RESULTS: Acute primary HIV-1 infection was characterized by significant CD4+ lymphocytopenia with low IL-2 serum concentrations, and by high absolute number of circulating CD8+ and NK cells, with elevated serum levels of soluble CD8 receptor, IL-1 beta, IFN-gamma and 5'-neopterin. Follow-up of acute seroconverters showed a significant decrease in NK cell counts and IL-1 beta levels, with an increase of IL-6. CONCLUSIONS: In acute primary HIV-1 infection, significant alteration of cytokine release, possibly induced by viral antigens, could be responsible for both clinical picture and activation of cytotoxic cells through abnormal mechanisms.

Keywords: beta 2-Microglobulin/METABOLISM Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY Adult Biopterin/ANALOGS & DERIVATIVES/METABOLISM Cytokines/*BLOOD Female Follow-Up Studies Human HIV Seropositivity/IMMUNOLOGY Interferon Type II/BLOOD Interleukins/BLOOD Leukocyte Count Lymphocyte Subsets/IMMUNOLOGY Lymphocyte Transformation Male Middle Age Tumor Necrosis Factor/METABOLISM JOURNAL ARTICLE
940228
M9420775

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