A clinical and pathological comparison of the WHO and CDC case definitions for AIDS in Kinshasa, Zaire: is passive surveillance valid? [see comments] NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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A clinical and pathological comparison of the WHO and CDC case definitions for AIDS in Kinshasa, Zaire: is passive surveillance valid? [see comments]

AIDS. 1993 Sep;7(9):1241-5. Unique Identifier : AIDSLINE MED/94030756
Nelson AM; Perriens JH; Kapita B; Okonda L; Lusamuno N; Kalengayi MR; Angritt P; Quinn TC; Mullick FG; Projet SIDA, Kinshasa, Zaire.

Abstract: OBJECTIVES: To compare the specificity of the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) case definitions for AIDS in autopsy cases from Zaire. SETTING: Mama Yemo Hospital and University Hospital morgues in Kinshasa, and Karawa Hospital in Equateur Region, Zaire. METHODS: Autopsy cases with a clinical diagnosis of AIDS on the death certificate or chart were studied. Evaluation included post-mortem HIV-1 serology, chart review for specific AIDS-related symptoms and signs, and application of WHO and CDC case criteria to the clinical and autopsy diagnoses. RESULTS: Of the 68 diagnosed AIDS cases, 98% fulfilled WHO criteria for AIDS and 93% fulfilled both WHO and CDC criteria. All cases fulfilling both criteria were HIV-1-seropositive. Opportunistic infections accounted for 84% of CDC AIDS-defining conditions. Disseminated tuberculosis was the most frequent (41%) specific diagnosis; Pneumocystis carinii pneumonia was rare (< 2%). CONCLUSIONS: There was good concordance between WHO and CDC case definitions. A diagnosis of AIDS on the chart or death certificate is adequate for surveillance purposes in this population.
Keywords: Acquired Immunodeficiency Syndrome/*DIAGNOSIS/EPIDEMIOLOGY/ PATHOLOGY Adolescence Adult Autopsy Centers for Disease Control and Prevention (U.S.) Comparative Study Death Certificates Female Human Male Medical Records Middle Age United States World Health Organization Zaire/EPIDEMIOLOGY JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDdiagnosis/epidemiology/pathologyadolescenceadultautopsycentersfordiseasecontrolandprevention(uKWDsKWD)comparativestudydeathcertificatesfemalehumanmalemedicalrecordsmiddleageunitedstatesworldhealthorganizationzaire/epidemiologyjournalarticle
Comment in: AIDS 1994 May;8(5):714
940228
M9420765

Copyright © 1994 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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