Heterosexual transmission of HIV in a cohort of couples in New York City [published erratum appears in AIDS 1993 Nov;7(11):following 1541] NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Heterosexual transmission of HIV in a cohort of couples in New York City [published erratum appears in AIDS 1993 Nov;7(11):following 1541]

AIDS. 1993 Sep;7(9):1247-54. Unique Identifier : AIDSLINE MED/94030757
Seidlin M; Vogler M; Lee E; Lee YS; Dubin N; Department of Medicine, New York University Medical Center, New; York.

Abstract: OBJECTIVE: Since heterosexual transmission of HIV in the United States is occurring at an increasing rate, especially among black and Hispanic couples and those in which one member has a history of intravenous drug use, we sought to study the heterosexual transmission of HIV in couples. DESIGN: Multiple logistic regression analysis of risks for HIV infection in female partners. METHODS: We enrolled 158 non-intravenous drug user (IVDU) steady heterosexual partners of HIV-infected individuals (indexes) in this study. Of these, 93% were women, 54% were Hispanic whites, 23% were black and 65.6% were partners of IVDU. RESULTS: In a multiple logistic regression analysis of risks for HIV infection in female partners, the strongest predictors of transmission were AIDS or AIDS-related complex (ARC) in the index [adjusted odds ratios (OR), 16.81; P < 0.001 and 12.53; P = 0.003, respectively], a history of anal intercourse (adjusted OR, 10.81; P < 0.001) and bleeding as a result of intercourse (adjusted OR, 4.90; P < 0.05). Female-to-male transmission was detected in seven out of 11 couples at risk. Ethnicity, number of episodes of vaginal intercourse, number of other sexual partners and history of sexually transmitted infections were not significantly associated with transmission to women. CONCLUSION: Our study demonstrates that health of the index, anal intercourse and bleeding as a result of intercourse are the major determinants of sexual transmission of HIV to women in couples.
Keywords: Adolescence Adult Age Factors Aged Cohort Studies Contraceptive Devices, Male/UTILIZATION Female Human HIV Infections/ETHNOLOGY/EPIDEMIOLOGY/*TRANSMISSION Male Middle Age New York City/EPIDEMIOLOGY Racial Stocks Regression Analysis Sex Behavior *Sexual Partners Sexually Transmitted Diseases/EPIDEMIOLOGY Substance Abuse Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDadolescenceadultagefactorsagedcohortstudiescontraceptivedevices,male/utilizationfemalehumanhivinfections/ethnology/epidemiology/KWDtransmissionmalemiddleagenewyorkcity/epidemiologyracialstocksregressionanalysissexbehaviorKWDsexualpartnerssexuallytransmitteddiseases/epidemiologysubstanceabusesupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
940228
M9420764

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