Denver, Colo. : Center for Research in Ambulatory Health Care Administration, 1987 1 videocassette (50 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9301669A
[Boston, Mass.] : WGBH Educational Foundation, c1992 1 videocassette (57 min.) : sd., col. ; 1/2 in (The AIDS report) Unique Identifier : AIDSLINE AV/9414876
Mudd R
(Producer) Takes an in-depth look at the 1992 presidential candidates proposals for health reform and discusses what each plan will mean for both consumers and health care providers. The AIDS report looks at what San Francisco has learned over the last decade and what this city can share with the rest of the countr
(Producer) The purpose of these simulations is to provide the nurse an opportunity to plan nursing care for critically ill patients with Acquired Immunodeficiency Syndrome.
[Boston, Mass.] : WGBH Educational Foundation, c1993 1 videocassette (57 min.) : sd., col. ; 1/2 in (The AIDS report) Unique Identifier : AIDSLINE AV/9414877
Mudd R
(Producer) This program investigates the changing role of the physician from healer to businessman. It asks: do doctors who own their own high-tech equipment provide their patients with better continuity of care, or do they cross ethical boundaries in self interest? The AIDS report explores the link between sexual
Vienna : European Centre for Social Welfare Policy and Research, c1991 75 p. : ill (Eurosocial report ; 42 (1991)) Unique Identifier : AIDSLINE CAT/9319129
Washington, DC : AIDS Policy Center, Intergovernmental Health Policy Project, George Washington University, c1992 iii, 64 p. : ill Unique Identifier : AIDSLINE CAT/9413001
Rockville, MD : U.S. Dept. of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, [1993- v Unique Identifier : AIDSLINE CAT/9415457
Proc Annu Meet Am Assoc Cancer Res; 34:A2628 1993. Unique Identifier : AIDSLINE ICDB/94693569
Yang J; Offermann MK; Emory Univ., Atlanta, GA 30322
Interleukin-6 (IL-6) is a multifunctional cytokine that functions as an autocrine growth factor for AIDS-derived Kaposi s sarcoma (KS) cells. Although some KS cells in culture have been reported to express constitutively high levels of IL-6, we find variability in the levels of IL-6 expressed by KS cells isolated from
Proc Annu Meet Am Assoc Cancer Res; 34:A2637 1993. Unique Identifier : AIDSLINE ICDB/94693579
Srivastava MD; Srivastava R; Srivastava BI; Dept. of Lab. Medicine, Roswell Park Cancer Inst., Buffalo, NY; 14263
The culture supernatants from 36 human cell lines and from 4-5 day culture in RPMI 1640-5% fetal calf serum of purified leukemic cells from 16 patients (7 CLL, 2 PLL, 4 AML, 1 AMMOL, 2 dendritic cell leukemia) were examined for IL-8 using R and D ELISA Kits. IL-8 production was found for 14/15 B-cell lines (5 normal,
Proc Annu Meet Am Soc Clin Oncol; 12:A271 1993. Unique Identifier : AIDSLINE ICDB/94694671
Blay JY; Burdin N; Rousset F; Lenoir G; Biron P; Philip T; Banchereau J; Favrot M; Centre Leon Berard, 69008 Lyon, France
Serum levels of interleukin 10 (IL-10) were measured retrospectively in the serum of 60 normal subjects and 154 patients (pts) with non-Hodgkin s lymphoma (NHL), including 102 with evolutive NHL (87 at diagnosis, 15 in relapse) and 52 in first remission. We used an ELISA measuring
Proc Annu Meet Am Soc Clin Oncol; 12:A524 1993. Unique Identifier : AIDSLINE ICDB/94694923
Boaziz C; Raymond E; Morere JF; Breau JL; Israel L; Clinique Universitaire de Cancerologie, Hopital Avicenne, 93000; Bobigny, France
20 patients (pts), with metastatic renal cell carcinoma (MRCC), received two induction courses, every 4 wk with interferon alpha 2b (IFN-A) 10 x 106 units/day im day 1-5 followed by continuous iv infusion of interleukin-2 ( IL-2 ) 18 x 10(6) units/day days 8-12. Maintena
Parallel case-control studies of NHL have been conducted in Jamaica during 1984-1987 and in Trinidad during 1985-1992, in an attempt to quantify the role of HTLV-I as an etiological factor. A to
Proc Annu Meet AM Soc Clin Oncol; 12:A993 1993. Unique Identifier : AIDSLINE ICDB/94695392
Taguchi J; Niland J; Blume K; Forman S; City of Hope Natl. Medical Center, Duarte, CA 91010
Allogeneic BMT is a therapy aimed at achieving cure for patients suffering from a variety of fatal hematologic malignancies. Although the most common cause of malignancy after BMT is relapse, some reports indicate that long-term BMT survivors are at risk for developing secondary tumors. Between 1976 and 1990, 513 pati
Proc Annu Meet AM Soc Clin Oncol; 12:A1010 1993. Unique Identifier : AIDSLINE ICDB/94695409
Kaime EM; Ikehara O; Thomas R; Brodine S; Naval Hosp., San Diego, CA 92134
Between July 1982 and November 1992, 12 Okinawan healthy carriers (HCs) of HTLV-I admitted to Okinawa Chuba Hospital were identified as having OIs. HC is defined by Shimoyama et al (Br J Haem 79:428-37, 1991) as one seropositive for HTLV-I with less than 4000 absolute lymphs and less than 5% abnormal lymphs in periphe
Proc Annu Meet Am Soc Clin Oncol; 12:A1227 1993. Unique Identifier : AIDSLINE ICDB/94695626
Gisselbrecht C; Lepage E; Tirelli U; Oksenhendler E; Gabarre J; Farcet JP; Gastaldi R; Coiffier B; Thyss A; Rapahel M; et al; Hematology Inst., Saint Louis Hosp., Paris, France
An increased risk of high-grade non-Hodgkin s lymphoma is observed in patients (pts) who are seropositive for human immunodeficiency virus (HIV). Treatment of such patients is complicated by their underlying acquired immunodeficiency syndrome (AIDS). Pts without severe AIDS may der
Proc Annu Meet Am Soc Clin Oncol; 12:A1293 1993. Unique Identifier : AIDSLINE ICDB/94695692
McIntyre K; Maale G; Strauss J; Dickson B; Dallas/Fort Worth Sarcoma Group, Presbyterian Hosp. of Dallas,; Dallas, TX 75231
From December 1986 through 1992, 22 patients (pts) were diagnosed with primary non-Hodgkin s lymphoma of bone. Histopathologic material was classified according to the Working Formulation of non-Hodgkin s lymphoma and distribution was as follows: 18 diffuse large cell, 2 diffuse mi
Proc Annu Meet Am Soc Clin Oncol; 12:A1314 1993. Unique Identifier : AIDSLINE ICDB/94695713
Imashuku S; Hibi S; Kataoka Y; Ikushima S; Fujiwara F; Todo S; Fujita N; Kyoto Prefectural Univ. of Medicine, Kyoto, Japan
HPS includes heterogeneous disorders: a virus- or infection-associated HPS(VAHS/IAHS), which must be supportively treated; a familial type HPS(FEL); and a tumor-associated HPS often seen with malignant lymphomas or true histiocytic malignancy, which needs intensive chemotherapy. Since the clinical signs and symptoms c
Proc Annu Meet Am Soc Clin Oncol; 12:A1318 1993. Unique Identifier : AIDSLINE ICDB/94695717
Priest J; Moertel C; Toogood I; Nieder M; Morse M; Frierdich S; Children's Hosp. of St. Paul, MN 55102
CNS BL at diagnosis (dx) or relapse is a frequent cause of treatment (rx) failure in BL, necessitating aggressive prophylactic/therapeutic CNS rx. 8 children pts are reported with severe CNS and spinal cord toxicity following BL rx: 2 deaths with brain and spinal cord necrosis, 2 permanent paraplegia, 4 ambulatory spa
Proc Annu Meet Am Soc Clin Oncol; 12:A1346 1993. Unique Identifier : AIDSLINE ICDB/94695745
Goodman G; Hellstrom I; Hu SL; Hanson M; Klemola-Phillips R; Nicaise C; Hellstrom KE; Bristol-Myers Squibb Pharmaceutical Research Inst., Seattle, WA
A melanoma tumor immunogen (v-p97NY), consisting of a recombinant vaccinia virus was tested in a dose-escalating Phase I trial. 24 patients (pts) with melanoma, or at high risk for recurrence, were given a single intradermal injection. Doses started at 2 x 10(4) pfu and were escalated 10-fold/dose to a max of 2 x 10(7
Proc Annu Meet Am Soc Clin Oncol; 12:A1587 1993. Unique Identifier : AIDSLINE ICDB/94695986
Weinthal J; Briones G; Gillan E; Hodder F; Cairo MS; Children's Hosp. of Orange County, Orange, CA
Pneumocystic carinii pneumonia (PCP) was the most common cause of death in leukemia patients (pts) in remission treated with intensive multiagent chemotherapy until the advent of chemoprophylaxis with trimethoprim-sulfamethoxazole (TMP/SMX; Hughes, NEJM 316:1627, 1987) Previous attack rates in pts not given PCP prophy
Proc Annu Meet Am Soc Clin Oncol; 12:A1272 1993. Unique Identifier : AIDSLINE ICDB/94695671
Gil-Delgado M; Farabos C; Reynes M; Jasmin C; Musset M; Misset JL; ICIG, Hopital Paul-Brousse, 14 Av. Paul-Vaillant-Couturier, 94804; Villejuif, France
PTCL, described both in Japan and in Western countries, have been associated with poor outcome. As morphologically they can be classified both with intermediate- or low-grade lymphomas, lack of phenotype determination may result in suboptimal treatment. We have retrospectively revie
Proc Annu Meet Am Soc Clin Oncol; 12:A1550 1993. Unique Identifier : AIDSLINE ICDB/94695948
Malamud S; Perentesis V; Div. of Hematology-Oncology, Dept. of Medicine, Beth Israel; Medical Center, New York, NY 10003
G-CSF and GM-CSF are widely used biological agents in the treatment of neutropenia (NP) due to cancer chemotherapy (CT) and the acquired immunodeficiency syndrome (AIDS). Although recommended as prophylaxis for neutropenia, most hospitalized patients (pts) are treated during the neutropenic episode. This randomized tr
Childs Nerv Syst. 1990 Nov;6(7):406-8. Unique Identifier : AIDSLINE MED/94036895
Laverda AM; Cogo P; Condini A; Cattelan C; Giaquinto C; Cozzani S; Ruga E; Viero F; De Rossi A; Del Mistro A; et al; Department of Pediatrics, University of Padua, Italy.
To study the natural history of the neurological involvement in pediatric human immunodeficiency virus (HIV) infection, 77 children born to seropositive mothers have been followed up since birth. The median follow-up time has been 17.5 months. Fourteen children were classified as infected, 34 as not infected, and 21 a
Sofia M; II Facolta di Medicina e Chirurgia, Clinica delle Malattie; Respiratorie, Universita degli degli Studi di Napoli.
The HIV infection has resulted in a marked increase in the incidence of disease caused by non-tuberculous and tuberculous mycobacteria. Although tuberculosis, in spite of other mycobacterioses, should not be even regarded as a marker of AIDS, recent epidemiological data collected in many countries and in
Perna F; Sanduzzi A; Ponticiello A; Cattedra delle Malattie dell'Apparato Respiratorio, II Facolta; di Medicina e Chirurgia, Universita degli Studi di Napoli.
The severe immunologic alterations caused by HIV infection is at the base of respiratory tract infections, neoplasms and inflammatory complications which represent the most frequent cause of death in AIDS patients. The etiological diagnosis is difficult and often needs invasive procedures. Among those, BAL is surely t
Ponticiello A; Sanduzzi A; Pezzella V; Cattedra di Malattie dell'Apparato Respiratorio, II Facolta di; Medicina e Chirurgia, Universita degli Studi di Napoli.
Main etiologic agents of AIDS-related infections pneumonia and diagnostic tools useful to identify microorganism are discussed. Bronchoalveolar lavage (BAL) remains the most important performed technique to collect pulmonary secretions, but it needs to be completed by colorimetric, immunological (monoclonal antibodies
Ponticiello A; Pezzella V; Della Sala M; Cattedra di Malattie dell'Apparato Respiratorio, II Facolta di; Medicina e Chirurgia, Universita degli Studi di Napoli.
The acquired immunodeficiency syndrome (AIDS) is characterized by severe abnormalities of cellular immunity with a marked reduction of helper/inducer T lymphocyte from peripheral blood and, clinically, by a high incidence of infection caused by opportunistic or more common pathogen organisms and by development of Kapo
Ponticiello A; Pezzella V; Della Sala M; Cattedra di Malattie dell'Apparato Respiratorio, II Facolta di; Medicina.
The authors describe the clinical-radiological aspects of the most frequent lung infections during AIDS and point out the methods actually applied to define the correct etiological diagnosis of these complications. Therapy problems are widely reported at the ending part of the review together with useful parameters fo
Zamboni M; Igreja RP; Bonecker C; Torres Filho HM; Hospital da Casa do Hemofilico, Rio de Janeiro, RJ.
Mycobacterium szulgai is a scotochromogenic species recently recognized as a human pathogen. Twenty-nine cases of disease caused by M. szulgai in humans have been reported. Pulmonary disease indistinguishable from that caused by M. tuberculosis was the commonest type of infection caused by M. szulgai. Olecranon bursit
Glas Srp Akad Nauka [Med]. 1992;(42):83-91. Unique Identifier : AIDSLINE MED/94040967
Bugarski D; Sofronic-Milosavljevic Lj; Movsesijan M; Cuperlovic K; Institute of the Application of Nuclear Energy, Zemum.
The aim of this study was to assess a possible association between parameters of immune response and susceptibility/resistance to T. spiralis infection. The immune response to T. spiralis was monitored in two inbred strains of mice (BALB/c and C57Bl/6), as well as in the most important natural host--swine, by analysin
Tracey KJ; Cerami A; Division of Neurosurgery, North Shore University Hospital-Cornell; University Medical College, Manhasset, NY 11030.
Tumor necrosis factor is a cytokine that participates in the mediation of numerous diseases associated with inflammation, cachexia, shock, and tissue injury. Early studies of the biology of TNF delineated its hormonal actions as well as its systemic toxicity. More recent investigations have drawn attention to its para
Rev Soc Bras Med Trop. 1992 Oct-Dec;25(4):241-6. Unique Identifier : AIDSLINE MED/94052879
de Campos EP; Carvalho VO; Marinho SF; Kushnaroff TM; Galvao PA; Padovani CR; Hospital Emilio Ribas, Sao Paulo, Brasil.
A total of 112 AIDS and no AIDS cryptococcosis patients admitted at Emilio Ribas Hospital--Sao Paulo, Brazil , were treated with amphotericin B (AMB) or amphotericin B and 5 fluorocytosine (5FC). Age, race, predisposing and epidemiological factors, respiratory symptoms were evaluate
Rev Med Chil. 1992 Feb;120(2):174-9. Unique Identifier : AIDSLINE MED/94053153
Labarca J; Acuna G; Saavedra H; Oddo D; Sepulveda C; Ballesteros J; Alvarez M; Departamento de Medicina Interna, Hospitales Clinicos,; Universidad Catolica, Santiago de Chile.
We report 2 patients with AIDS who developed Chagas infection, one with encephalitis, the other with acute myocarditis. The implications of immune depression for the manifestations and course of Chagas disease are discussed. Chagas disease should be considered in patients with AIDS who live in endemic zones and who de
Rev Hosp Clin Fac Med Sao Paulo. 1992 May-Jun;47(3):146-9. Unique Identifier : AIDSLINE MED/94053294
Pasternak J; Teixeira ET; Hospital das Clinicas, Faculdade de Medicina, Universidade de; Sao Paulo.
In 1990, 12,319 patients, 235 of whom had AIDS (HIV IV), were admitted in the Emergency Division of the Hospital das Clinicas. The number of patients with AIDS represented 1.9% of all admissions and 4.2% of all clinical cases admitted. These 235 patients had 329 admissions; 163 were readmitted only once and 72 more th
Rev Hosp Clin Fac Med Sao Paulo. 1992 May-Jun;47(3):150-2. Unique Identifier : AIDSLINE MED/94053295
Guizelini E; Amato Neto V; Laboratorio de Investigacao Medica, Hospital das Clinicas,; Faculdade de Medicina, Universidade de Sao Paulo.
On the aim of knowing better the prevalence of cryptosporidiosis in Brazil , we performed a survey, in Sao Paulo, in loose stools of patients with AIDS and immunocompetent children and adults. Using strict methods oocysts of Cryptosporidium sp. were found in 10.4% of the samples; hi
Rev Hosp Clin Fac Med Sao Paulo. 1992 Sep-Oct;47(5):231-3. Unique Identifier : AIDSLINE MED/94053311
Amato Neto V; Braz LM; Campos R; Ogassawara S; Motta HM; Morandi NF; Marques HH; Laboratorio de Investigacao Medica-Parasitologia, Hospital; das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo.
Frequently it is necessary to search for oocysts of Cryptosporidium sp. in the stools potentially contaminated with human immunodeficiency virus (HIV). For the protection of the laboratory personal handling fecal material formalin has been considered useful. However, this disinfectant has not been evaluated when the s
Nagylucskay S; Vedres I; Lelkes M; Madi-Szabo L; Palfi I; Institute of Hygiene and Epidemiology, Semmelweis, University of; Medicine, Budapest, Hungary.
In view of epidemiologic aspects of AIDS we studied the immunological side-effects of oral hormonal contraceptives and the barbiturates--which are used by many people in Hungary . We studied healthy persons using more than six months
Horvath A; Department of Dermatology and Venereology, Semmelweis University; of Medical Sciences.
In the course of HIV infection atopic symptoms can often be experienced (atopic dermatitis, asthmatic like symptoms in upper respiratory tract, sensitivity to drugs). Total IgE increase has been detected which is in inverse correlation with CD4 positive lymphocytes. Using semi quantitative and quantitative methods tot
Boldorini R; Vago L; Lechi A; Tedeschi F; Trabattoni GR; V Cattedra di Anatomia patologica dell'Universita di Milano.
BACKGROUND. Wernicke encephalopathy (WE), acute (microhaemorrhages) and chronic (proliferation of capillaries) is actually considered as a not uncommon, and curable, condition in several diseases, and not only in alcoholic patients. Why serotoninergic nuclei, and whether blood brain barrier (BB) are involved were our
Trinchieri G; Wysocka M; D'Andrea A; Rengaraju M; Aste-Amezaga M; Kubin M; Valiante NM; Chehimi J; Wistar Institute, Philadelphia, PA 19104.
Natural Killer cell Stimulatory Factor (NKSF) or interleukin-12 (IL-12) is a heterodimeric cytokine of 70 kDa formed by a heavy chain of 40 kDa (p40) and a light chain of 35 kDa (p35). Although it was originally identified and purified from the supernatant of Epstein-Barr virus-transformed B cell lines, it has been sh
Voluntary HIV testing was used to study the extent of HIV-1 infection in patients attending sexually transmitted disease (STD) clinics in England and Wales between 1985 and 1990. Homosexual and bisexual men and 10-20% of heterosexual men and women were invited to complete a study record and have an HIV-1 antibody test
By the end of 1991, there had been 417 reports of AIDS and 1620 reports of HIV-1 infection in persons in England, Wales and Northern Ireland who probably acquired their infection through sexual intercourse between men and women. Bet
Gilbart VL; Evans BG; Noone A; Mortimer JY; Gill ON
Reports of 217 HIV-1 infected persons have been investigated. Initially, 122 were described as having no identified risk of HIV infection and 95 were described as probably infected through heterosexual intercourse. The sexual partners of 34 of these 95 cases were reported as having acquired their infection heterosexua
Pozniak A; Watson JM; Department of Genitourinary Medicine, King's College Hospital.
Outbreaks of tuberculosis in centres for the care of patients with AIDS, including outbreaks involving drug-resistant strains of Mycobacterium tuberculosis, have been reported from a number of countries and present special problems. Transmission of infection may be facilitated by procedures commonly used with AIDS pat
Bravo P; Resnati G; Viani F; De Montis A; Corrias S; La Colla P; Dipartimento di Chimica, Politecnico, Milano, Italy.
2 ,3 -Seco nucleosides 5 carrying fluorine and sulfur substituents at C-3 and C-5 , respectively, of acyclic sugar moiety were synthesized in enantiomerically and diastereoisomerically pure form. These products and some structurally similar 1 ,2 -seco-2 -nor-and 1 ,2 -seco-nucleosides 3 and 4 were tested in vitro for
Fiscus SA; Folds JD; van der Horst CM; Department of Microbiology, University of North Carolina, Chapel; Hill.
Using polyethylene glycol (PEG) precipitation we have found that most HIV-1 seropositive patients have IgG containing-circulating immune complexes (CIC). In addition these CIC sometimes contain IgA, IgM, C3, and/or HIV p24 antigen. Previous work has demonstrated that patients who have plasma viremia, CD4 cell counts l
Human complement, although not lytic for HIV-1, interacts with the virus and is closely involved in the infectious process. It enhances infection in the absence of antibody, and turns neutralizing antibodies into agents which increase viral infectivity. In this review M.P. Dierich et al. summarize available informatio
Volpe DA; Du DL; Verhoef V; Murphy MJ Jr; Hipple Cancer Research Center, Dayton, OH 45439-2092.
Mycobacterial infection is a common complication of acquired immunodeficiency syndrome (AIDS) frequently requiring antimycobacterial medication. It was of interest to determine if one such agent, rifabutin, could be tolerated by AIDS patients in conjunction with 3 -azido-3 -deoxythymidine (
Ushijima H; Kunisada T; Ami Y; Tsuchie H; Takahashi I; Schacke H; Muller WE; Division of AIDS Virus, National Institute of Health, Tokyo,; Japan.
The myeloid-monocytic cells ML-1, HL-60, THP-1 and U-937 were chronically infected (for more than 2 years) with the lymphotropic HIV-1 strain HTLV-IIIB. Reinfection experiments revealed that viruses obtained from chronically infected ML-1/HIV-1 and HL-60/HIV-1 cells show a low infectivity if tested with uninfected ML-
Gallicchio VS; Cibull ML; Hughes NK; Tse KF; Department of Medicine, University of Kentucky Medical Center,; Lexington.
Murine AIDS (MAIDS) is a disease that shows many similarities to human HIV infection. The etiological agent of MAIDS is a defective murine leukemia virus that seems to be able to induce disease in the absence of viral replication. This animal model has been useful in stimulating the search of answers to questions and
DNA Cell Biol. 1993 Nov;12(9):799-805. Unique Identifier : AIDSLINE MED/94030615
Wang B; Boyer J; Srikantan V; Coney L; Carrano R; Phan C; Merva M; Dang K; Agadjanan M; Gilbert L; et al; Department of Medicine, University of Pennsylvania School of; Medicine, Philadelphia 19104.
DNA, or genetic, inoculation mimics aspects of attenuated vaccines in that synthesis of specific foreign proteins is accomplished in the host. These proteins can be processed and presented on the relevant major histocompatibility complex (MHC) antigens and ultimately become the subject of immune surveillance. Very rec
DNA Cell Biol. 1993 Nov;12(9):831-7. Unique Identifier : AIDSLINE MED/94030618
Ranganathan PN; Ranganathan S; Srinivasan A; Department of Biochemistry, Thomas Jefferson University,; Philadelphia, PA 19107.
Earlier studies have revealed a distinct class of regulatory proteins known as trans-activator proteins in diverse biological systems. These proteins have been shown to act on both homologous and heterologous promoter targets. Activation of heterologous targets is speculated to be an integral part of virus-induced pat
Riddell SR; Gilbert MJ; Greenberg PD; Fred Hutchinson Cancer Research Center, Seattle.
The development of CD8+ cytotoxic T cell responses to viral pathogens is crucial for the prompt resolution of acute infections and for the control of viruses which persist in the host. Thus, cytomegalovirus often causes life threatening disease in immunosuppressed humans who fail t
Subauste CS; Remington JS; Department of Immunology and Infectious Diseases, Palo Alto; Medical Foundation, California 94301.
Recent advances in our understanding of the immunological mechanisms involved during infection with Toxoplasma gondii include evidence for the role of different subsets of lymphocytes and cytokines in acute infection as well as in reactivation of chronic infection. The mechanisms of presentation of T. gondii antigen h
Joag SV; Narayan O; Laboratory of Viral Pathogenesis, Marion Merrell Dow Foundation,; Kansas University Medical Center, Kansas City 66160-7424.
The plethora of disease syndromes (dystrophy of various organ systems, malignancies and opportunistic infections) caused by HIV are all potentiated by the profound virus-induced immunosuppression that accompanies this infection. The mechanism of this severe immunosuppression is poorly understood and the subject is cur
Birx DL; Redfield RR; Department of Retroviral Research, Walter Reed Army Institute of; Research, Washington D.C. 20307-5100.
The immune response against HIV does not result in complete viral clearance. Recent interventions have focused on novel strategies to modify human anti-HIV immunity. Active vaccination of patients with HIV infection (vaccine therapy) safely alters the immune repertoire against HIV. This unique approach will provide in
Sinicco A; Biglino A; Sciandra M; Forno B; Pollono AM; Raiteri R; Gioannini P; Institute of Infectious Disease, University of Turin, Italy.
OBJECTIVE: To investigate the relationship between cytokine serum levels, peripheral blood lymphocyte subsets and clinical picture in acute primary HIV-1 infection. PATIENTS AND METHODS: Absolute number/microliters total lymphocytes, CD4+, CD8+ and natural killer (NK) cells, as well as serum levels of soluble CD8 rece
Jordan EK; Heyes MP; Animal Health and Care Section, National Institute of; Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, Maryland 20892.
OBJECTIVE: In this 2.5-year study of simian immunodeficiency virus (SIVsm) infection in rhesus monkeys, quinolinic acid (QUIN) levels and virus isolation determinations were made in serial cerebrospinal fluid (CSF) and blood samples to evaluate the relationship between these parameters over the course of infection. ME
Leonard G; Chaput A; Courgnaud V; Sangare A; Denis F; Brechot C; Laboratoire de Virologie, CHU Dupuytren, Limoges, Paris, France.
OBJECTIVE: To evaluate the frequency of dual HIV-1 and HIV-2 DNA sequences in patients with dual serological profiles. DESIGN: We tested 40 samples from AIDS patients living in Abidjan, Cote d Ivoire . METHODS: Dual serological reactivity was determined by double Western blot a
Potts KE; Kalish ML; Lott T; Orloff G; Luo CC; Bernard MA; Alves CB; Badaro R; Suleiman J; Ferreira O; et al; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia.
OBJECTIVE: To examine the genetic heterogeneity of the V3 region of HIV-1 gp120 from 22 Brazilian HIV-1 specimens. DESIGN: Genetic heterogeneity was examined by DNA sequencing of the C2 V3 region of the HIV-1 envelope (env) gene from polymerase chain reaction (PCR)-amplified HIV-1 DNA. Deduced amino-acid sequences wer
Chaix ML; Chappey C; Couillin I; Rozenbaum W; Levy JP; Saragosti S; ICGM, INSERM U363, Hopital Cochin, Paris, France.
OBJECTIVE: To carry out, within France , a large-scale molecular epidemiological investigation on the principal neutralizing determinant of HIV-1, located in the third variable region (V3) of the envelope protein. Such investigations are of the utmost importance in the identificatio
Ennen J; Werner K; Kuhne FW; Kurth R; Paul-Ehrlich Institute, Langen, Germany.
OBJECTIVE: Since the chlorite-oxygen reaction product tetrachlorodecaoxygen (TCDO) anion complex promotes efficaciously tissue repair and has antibacterial activity, our aim was to determine the effects of TCDO on the replication of HIV and on the infectivity of free HIV particles. DESIGN: The effects of TCDO on cellu
Schwenk A; Buger B; Wessel D; Stutzer H; Ziegenhagen D; Diehl V; Schrappe M; Department of Internal Medicine I, University of Cologne,; Germany.
OBJECTIVE: To estimate the influence of fever, diarrhoea, stage of HIV disease, opportunistic infection and anorexia on malnutrition in HIV-infected patients we analysed data of patients undergoing a nutritional counselling programme from November 1989 to April 1992. PATIENTS AND METHODS: Our study group comprised 104
Bem C; Patil PS; Elliott AM; Namaambo KM; Bharucha H; Porter JD; Department of Surgery, School of Medicine, University of Zambia,; Lusaka.
OBJECTIVES: To evaluate wide-needle (19-gauge) aspiration in the diagnosis of tuberculous lymphadenitis. SETTING: Department of Surgery, University Teaching Hospital, Lusaka, Zambia . PATIENTS: Three hundred and four patients presenting to one surgeon for diagnostic surgical biopsy
Diaz T; Chu SY; Frederick M; Hermann P; Levy A; Mokotoff E; Whyte B; Conti L; Herr M; Checko PJ; et al; Surveillance Branch, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333.
OBJECTIVE: To describe the sociodemographic characteristics and sexual and drug use behaviors of men with AIDS who engage in bisexual activity. METHODS: We interviewed 2120 men aged > or = 18 years who were reported with AIDS in 11 states and cities. Men were considered bisexual if they reported having had sex with a
OBJECTIVES: To determine risk factors for HIV-1 infection in young men in northern Thailand . METHODS: At enrollment into a prospective study, data were collected from a self-administered questionnaire and serologic testing on a cohort of 1115 young men selected by lottery for con
OBJECTIVES: To compare the specificity of the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) case definitions for AIDS in autopsy cases from Zaire . SETTING: Mama Yemo Hospital and University Hospital morgues in
Seidlin M; Vogler M; Lee E; Lee YS; Dubin N; Department of Medicine, New York University Medical Center, New; York.
OBJECTIVE: Since heterosexual transmission of HIV in the United States is occurring at an increasing rate, especially among black and Hispanic couples and those in which one member has a history of intravenous drug use, we sought to study the heterosexual transmission of HIV in couples
Dowell SF; Davis HL; Holt EA; Ruff AJ; Kissinger PJ; Bijoux J; Boulos R; Boulos C; Halsey NA; Department of International Health, Johns Hopkins School of; Hygiene and Public Health, Baltimore, Maryland 21205.
OBJECTIVE: To determine whether deaths among Haitian infants born to HIV-1-seronegative women could be distinguished from deaths among children born to HIV-1-seropositive women using the verbal autopsy technique. METHODS: Mothers of 315 Haitian children who died were interviewed about events leading to the child s dea
Kane F; Alary M; Ndoye I; Coll AM; M'boup S; Gueye A; Kanki PJ; Joly JR; Groupe de Recherche en Epidemiologie, Universite Laval, Quec; City, Canada.
OBJECTIVES: To assess temporary expatriation as a risk factor for HIV infection in a rural area of Senegal and to examine the transmission of HIV from expatriates to their families. DESIGN: Cross-sectional study in identified expatriates and in a representative cluster sample of t
Jacobs RF; Eisenach KD; University of Arkansas for Medical Sciences, Arkansas Children's; Hospital, Little Rock.
The dramatic resurgence and increase in the total number of cases of tuberculous infection and disease in children is alarming in the United States . With poverty, poor access to health care, overcrowding (predominantly in inner-city areas), and an increase in immigration from areas wit
Dreier A; Martinez V; Jimenez ML; Orus C; Jurgens A; Amesti C; Hospital de San Pablo, Universidad Autonoma, Barcelona.
We present the clinical record of a positive HIV woman that presented with bilateral sudden hearing loss as a sign of neurosyphilis. We discuss the epidemiological, clinical, diagnostic, and therapeutic implications of positive HIV in syphilis.
Chung Hua Erh Pi Yen Hou Ko Tsa Chih. 1993;28(3):167-9, 188. Unique Identifier : AIDSLINE MED/94031214
Tan GL; Second Clinical College of Hunan Medical University, Changsha.
T lymphocyte subsets, IL-2 production and IL-2 receptor expression were detected in PBLs of 31 NPC patients and 28 normal subjects and of normal PBLs populations under the influence of serum of NPC patients. The results were as follows: CD4+ and IL-2 receptor expressio
AIDS Res Hum Retroviruses. 1993 Aug;9(8):709-13. Unique Identifier : AIDSLINE MED/94031262
Goubau P; Liu HF; De Lange GG; Vandamme AM; Desmyter J; Rega Institute and University Hospitals, Katholieke Universiteit; Leuven, Belgium.
HTLV-II-specific antibodies, with patterns similar to those in the Americas, were present in sera collected about 1970 from Bambuti pygmies in Zaire (14/102; 14%) and from pygmies in Cameroon (5/214; 2.3%), and were more prevalent than HTLV-I
AIDS Res Hum Retroviruses. 1993 Aug;9(8):715-9. Unique Identifier : AIDSLINE MED/94031263
Martin MP; Biggar RJ; Hamlin-Green G; Staal S; Mann D; Laboratory of Viral Carcinogenesis, National Cancer Institute,; Frederick Cancer Research and Development Center, Maryland; 21702-1201.
HTLV-II has been associated with a variety of lymphoproliferative disorders, including atypical hairy cell leukemia, chronic T cell leukemia, T prolymphocytic leukemia, and large granular lymphocytic leukemia. However, a direct or indirect role for HTLV-II in these disorders is not yet firmly established. We studied a
AIDS Res Hum Retroviruses. 1993 Aug;9(8):721-32. Unique Identifier : AIDSLINE GENBANK/L06860
Takahashi H; Zhu SW; Ijichi S; Vahlne A; Suzuki H; Hall WW; Division of Infectious Diseases, North Shore University Hospital,; Cornell University Medical College, Manhasset, New York 11030.
A study by Hall et al. (J Virol 1992;66:2456-2463; Ref. 11) has suggested the existence of two closely related molecular subtypes of HTLV-II, which were tentatively designated HTLV-IIa and HTLV-IIb. To confirm this nucleotide sequence analysis of 986 bp of the env gene region encoding the entire surface glycoprotein,
AIDS Res Hum Retroviruses. 1993 Aug;9(8):741-6. Unique Identifier : AIDSLINE MED/94031266
Masood R; Husain SR; Rahman A; Gill P; Department of Medicine, Norris Cancer Center, University of; Southern California, Los Angeles 90033.
Kaposi s sarcoma is an independent criterion for the diagnosis of AIDS and develops in nearly 15% of all cases. Current chemotherapy regimens are associated with substantial toxicity, particularly bone marrow suppression, which limit their long-term use. In an attempt to reduce treatment-related toxicity and enhance u
AIDS Res Hum Retroviruses. 1993 Aug;9(8):755-60. Unique Identifier : AIDSLINE MED/94031268
Sumida C; Vallette G; Thobie N; Nunez EA; INSERM U224 affiliated with CNRS, Faculte de Medecine Xavier; Bichat, Paris, France.
Liposoluble extracts of serum from healthy men and AIDS patients (stages IVC1 and IVD by CDC criteria) inhibited the incorporation of [3H]thymidine into isolated rat thymocytes, but AIDS extracts were less inhibitory, requiring 1.8 times more cortisol in the AIDS extracts than in the healthy extracts to inhibit [3H]th
AIDS Res Hum Retroviruses. 1993 Aug;9(8):781-5. Unique Identifier : AIDSLINE MED/94031271
Laal S; Burda S; Sharpe S; Zolla-Pazner S; Veterans Affirs Medical Center, New York, New York 10010.
A sensitive, rapid, and quantitative ELISA for p24 is described, which can be used as the read-out to test for HIV-1 neutralization in the syncytium-forming microassay and can replace the counting of syncytia under the microscope. This assay can be used reliably for divergent strains of HIV-1, including those that do
AIDS Res Hum Retroviruses. 1993 Aug;9(8):787-93. Unique Identifier : AIDSLINE MED/94031272
Toubert A; Schmitt D; Cordonnier A; Fenouillet E; Saragosti S; INSERM U.283, Universite Paris V-Rene Descartes, Hopital; Cochin, Paris, France.
The envelope (Env) protein from HIV-1 is the focus of several vaccine trials in humans. It could be considered for the optimization of Env vaccinal preparations to add within the molecule defined epitopes, for instance epitopes conserved among viral isolates from HIV-1, such as from Gag or Nef proteins. As a first ste
AIDS Res Hum Retroviruses. 1993 Aug;9(8):795-8. Unique Identifier : AIDSLINE MED/94031273
Ameglio F; Tilocca F; Arca MV; Alemanno L; Dolei A; Institute S. Gallicano, Rome, Italy.
Levels of serum ferritin are increased in AIDS patients in relation to the progression of the disease. To establish whether or not this in vivo increase could be due to a direct effect of the virus on the infected cells, three HIV-permissive cell lines, the CD4-positive HeLa-T4-6c and C8166 cells and the CD4-negative
AIDS Res Hum Retroviruses. 1993 Aug;9(8):799-801. Unique Identifier : AIDSLINE MED/94031274
Teng XC; Ashworth LA; Sharpe SA; Dennis MJ; Cranage MP; Division of Pathology, Centre for Applied Microbiology and; Research, Salisbury, Wilts, England.
AIDS Res Hum Retroviruses. 1993 Aug;9(8):803-6. Unique Identifier : AIDSLINE GENBANK/L20099
Hynes NA; Adger-Johnson D; Dapolito G; Hirsch VM; Immunodeficiency Viruses Section, National Institute of Allergy; and Infectious Diseases, National Institutes of Health,; Rockville, Maryland 20852.
Br Heart J. 1993 Oct;70(4):376-81. Unique Identifier : AIDSLINE MED/94031387
Hofman P; Drici MD; Gibelin P; Michiels JF; Thyss A; Department of Pathology, University of Nice, France.
OBJECTIVE--To evaluate the prevalence of cardiac toxoplasmosis in a series of 182 necropsies performed between 1987 and 1991 on patients infected with the human immunodeficiency virus (HIV), to correlate this prevalence with the ante mortem diagnosis of cardiac involvement, and to assess the role of such cardiac lesio
AIDS Educ Prev. 1993 Fall;5(3):185-95. Unique Identifier : AIDSLINE MED/94031411
Beltran ED; Ostrow DG; Joseph JG; University of Michigan, Ann Arbor.
It has been proposed that human immunodeficiency virus (HIV) antibody testing and counseling are effective means of altering sexual behavior among individuals at risk of HIV infection and transmission. However, the evidence supporting this hypothesis is inconclusive. This study examines the factors associated with sex
AIDS Educ Prev. 1993 Fall;5(3):196-211. Unique Identifier : AIDSLINE MED/94031412
Friedman SR; Young PA; Snyder FR; Shorty V; Jones A; Estrada AL; National Development and Research Institutes, Inc., New York, NY; 10013.
Questionnaire data from almost 12,000 street-recruited drug injectors in 19 cities were analyzed to determine racial differences that may affect transmission of the human immunodeficiency virus (HIV). Self-reported sexual behaviors of drug injectors differ by city-type. White male drug injectors reported less unprotec
AIDS Educ Prev. 1993 Fall;5(3):212-9. Unique Identifier : AIDSLINE MED/94031413
Pitts M; Jackson H; Division of Psychology, Staffordshire University, Stoke on Trent,; U.K.
One hundred and forty-two social work students in Harare, Zimbabwe , were questioned concerning their sources and memory of information concerning the human immunodeficiency virus (HIV) and AIDS. Newspapers were cited most frequently as the major source of information. Family and
AIDS Educ Prev. 1993 Fall;5(3):220-33. Unique Identifier : AIDSLINE MED/94031414
Keller ML; School of Nursing, University of Wisconsin, Madison 53792-2455.
Using theories of health behavior, this study aimed to advance the understanding of risk-taking regarding human immunodeficiency virus (HIV) infection among young adults by describing: (a) their representation (i.e., schema) about HIV infection, (b) their problems with use of condoms and comfort with safe-sex practice
AIDS Educ Prev. 1993 Fall;5(3):234-43. Unique Identifier : AIDSLINE MED/94031415
Kalichman SC; Hunter TL; Department of Psychiatry, Medical College of Wisconsin, Milwaukee; 53226.
The present study investigated patterns of human immunodeficiency virus (HIV) antibody testing in a diverse urban sample. Five hundred seventy-nine men and women (representing 88% cooperation and 67% response rates) were surveyed in Chicago s downtown at mass transit waiting areas. Participants completed measures of d
AIDS Educ Prev. 1993 Fall;5(3):244-53. Unique Identifier : AIDSLINE MED/94031416
Malow RM; Corrigan SA; Cunningham SC; West JA; Pena JM; Addiction Research and Treatment Center, University of Miami, FL; 33136.
Although strategies for decreasing injection drug use have met with moderate success, efforts to decrease high-risk sexual behaviors have been less successful. Because condom use reduces HIV transmission, it is critically important to identify the attitudinal, emotional, and behavioral factors associated with using co
AIDS Educ Prev. 1993 Fall;5(3):254-62. Unique Identifier : AIDSLINE MED/94031417
Linn JG; Lewis FM; Cain VA; Kimbrough GA; School of Nursing, Tennessee State University, Nashville 37203.
This study tests a set of hypotheses that predict self-esteem and anxiety in adults infected with human immunodeficiency virus (HIV). The analysis is motivated by the following question: Is the level of perceived coherence, i.e., the extent to which individuals derive meaning and purpose in their lives despite their H
AIDS Educ Prev. 1993 Fall;5(3):263-71. Unique Identifier : AIDSLINE MED/94031418
Lewis CE; Bursch B; Klau M; Konitsney D; Conrow S; Division of Preventive and Occupational Medicine, UCLA School of; Medicine 90024-1772.
The Management of the Southern California Kaiser-Permanente Medical Group mandated a day-long program of continuing medical education on AIDS for all staff physicians at one facility. Presentations dealt with cognitive (transmission/diagnosis), skills (risk factors, history taking), and affective (discomfort/attitudes
Ann Ital Med Int. 1993 Jul-Sep;8(3):166-70. Unique Identifier : AIDSLINE MED/94031420
Calzetti C; Magnani G; Elia G; Avanzi M; Pasetti G; Fiaccadori F; Cattedra di Malattie Infettive, Universita degli Studi di Parma.
We discuss here our experience with Mycobacterium avium complex (MAC) infection in 446 HIV-positive patients. MAC was found in 13 cases (2.9%): 10 males, 3 females, age range 21-47 years. Infection was disseminated in 10 cases and limited to the lung in 3. CD4+ cells were, on average, 48 per microliters. At clinical o
Ann Ital Med Int. 1993 Jul-Sep;8(3):171-4. Unique Identifier : AIDSLINE MED/94031421
Falco M; Sorrenti A; Priori R; Luan FL; Pittoni V; Agresti MG; Valesini G; Istituto di Clinica Medica I, Universita degli Studi La Sapienza; di Roma.
The aim of the present study was to evaluate the fine specificity of anticardiolipin (aCL) antibodies detectable in the sera of patients with HIV infection. aCL are generally associated with thrombotic events in autoimmune diseases. A solid phase ELISA which discriminates between aCL binding to phospholipids and aCL b
This article discusses a research study into the effect of religious beliefs on attitudes to HIV/AIDS. The author sought to clarify the issues involved and to discover which elements within a religious belief tend to dispose the adherent to negative attitudes towards a person with HIV/AIDS. Only 6 per cent of the va
Magnani M; Brandi G; Rossi L; Carnevali A; Fraternale A; Albano A; Istituto di Chimica Biologica G. Fornaini, Universita degli; Studi di Urbino, Italy.
In order to increase the understanding of blood cytopenias in HIV infection we have investigated the bone marrow in murine AIDS. C57BL/6 mice infected with the LP-BM5 retrovirus show a decrease in cellularity, numerous haemophagocytic histiocytes, a reduction of all erythroid precursor cells, an increase in eosinophil
AIDS Clin Rev. 1993-94;:213-38. Unique Identifier : AIDSLINE MED/94031908
Kahn JO; Birx DL; University of California-San Francisco.
Vaccine therapy studies in HIV-seropositive volunteers over the next year should provide additional insights into whether different vaccine viral strains (LAI, IIIB, MN, SF2), different protein sources (whole virus particles, recombinant protein, peptides), different expression systems (baculovirus, mammalian), or dif
AIDS Clin Rev. 1993-94;:43-60. Unique Identifier : AIDSLINE MED/94031911
Berger TG; Koehler JE; University of California-San Francisco.
The manifestations of bacillary angiomatosis include diverse cutaneous lesions, visceral parenchymal bacillary peliosis of the spleen and liver, and involvement of single or multiple organ systems. The organisms causing BA are R. henselae and R. quintana, and these organisms
AIDS Clin Rev. 1993-94;:61-72. Unique Identifier : AIDSLINE MED/94031912
Tramont EC; Medical Biotechnology Center, University of Maryland, Baltimore.
Since syphilis and HIV infection are associated with each other at a higher rate than expected by chance, all HIV-infected persons and persons with syphilis should be tested for syphilis and vice versa. Because the immunological dysfunction of HIV-infected patients can interfere in clearing of T. pallidum, concomitant
Biochemistry. 1993 Oct 19;32(41):11087-99. Unique Identifier : AIDSLINE MED/94032220
Yeh JC; Seals JR; Murphy CI; van Halbeek H; Cummings RD; Department of Biochemistry and Molecular Biology, University of; Oklahoma Health Sciences Center, Oklahoma City 73190.
We report the complete structures of the N-linked oligosaccharides and the site-specificity of the N-glycosylation of recombinant gp120 (rgp120) of the HIV-1 BH8 isolate produce by a baculovirus expression system. Glycopeptides derived from the tryptic digests of intact rgp120 or of cyanogen bromide-generated fragment
Biochemistry. 1993 Oct 26;32(42):11453-7. Unique Identifier : AIDSLINE MED/94032264
Awang G; Sen D; Department of Chemistry, Simon Fraser University, Burnaby, BC,; Canada.
Retroviral genomes consist of two identical RNA molecules joined noncovalently near their 5 ends, at domains called dimerization linked sequences (DLS). This physical linkage of the genomic RNAs is considered important for the control of several steps in the viral life cycle, such as recombination, translation, and e
Biochemistry. 1993 Nov 9;32(44):11769-75. Unique Identifier : AIDSLINE MED/94032302
Cole JL; Gehman JD; Shafer JA; Kuo LC; Department of Biological Chemistry, Merck Research Laboratories,; West Point, Pennsylvania 19486.
rev is an RNA-binding protein of human immunodeficiency virus-1 and is required for the expression of incompletely spliced viral transcripts. Oligomerization of rev is thought to be associated with RNA binding and rev function. Here, we have characterized the oligomerization of rev using equilibrium analytical centrif
Kokai M; Hirata I; Adachi M; Hatotani N; Hakomori S; Tachibana T; Department of Immunology, Tohoku University, Sendai, Japan.
Le(y) is a carbohydrate determinant of membrane glycoconjugates and is expressed in some tumor and embryonic cells. On T lymphocytes, it is known that human immunodeficiency virus (HIV)-infected human lymphocyte T-cell lines express elevated Le(y) antigen and AIDS patients show the highest Le(y) expression in T lympho
AIDS Care. 1993;5(3):261-71. Unique Identifier : AIDSLINE MED/94032535
Sittitrai W; Brown T; Sakondhavat C; Thai Red Cross Society, Bangkok.
Although many of the earliest cases of AIDS and HIV infection in Thailand were men who had sex with other men (MHSWM), transmission by heterosexual intercourse and needle sharing rapidly became dominant. This resulted in comparatively little attention being given to studies of ri
AIDS Care. 1993;5(3):273-81. Unique Identifier : AIDSLINE MED/94032536
Singh S; Crofts N; Hospital Besar, Kelantan, Malaysia.
Human immunodeficiency virus (HIV) has spread widely among injecting drug users (IDUs) in countries to the north and west of the Golden Triangle region of South-East Asia; it is likely to have spread southwards to Malaysia as well. In order to assess HIV seroprevalence among ID
AIDS Care. 1993;5(3):283-8. Unique Identifier : AIDSLINE MED/94032537
Tan ML; Department of Anthropology, College of Social Sciences and; Philosophy, University of the Philippines, Diliman, Quezon City.
This paper analyses the potential socio-economic impact of HIV disease in the Philippines , with focus on the situation of two vulnerable populations: overseas contract workers and sex workers. The potential impact of HIV disease is examined in the context of recent development
AIDS Care. 1993;5(3):289-303. Unique Identifier : AIDSLINE MED/94032538
Wirawan DN; Fajans P; Ford K; Faculty of Medicine, Udayana University, Bali, Indonesia.
This study investigated AIDS and STD knowledge, risk behaviour patterns and condom use among three distinct groups of female commercial sex workers (CSWs) in Bali, Indonesia . Individual in-depth interviews were conducted with 71 female CSWs. These CSW groups differ in the prices
AIDS Care. 1993;5(3):305-12. Unique Identifier : AIDSLINE MED/94032539
Li VC; Cole BL; Zhang SZ; Chen CZ; Department of Community Health Sciences, UCLA School of Public; Health 90024-1772.
A modified version of the WHO/KABP Questionnaire for Students was administered to 302 students at a medical university in China . The instrument included items to assess the students demographic background, knowledge of AIDS/HIV, attitudes about AIDS, as well as towards people inf
Injecting drug use is being reported from an increasing number of Asian and other Third World countries. HIV continues to spread globally among and from populations of injecting drug users (IDUs), although the rate of spread appears to have slowed down recently in some industrialized countries. Asia produces two-third
AIDS Care. 1993;5(3):321-35. Unique Identifier : AIDSLINE MED/94032541
Green ST; Goldberg DJ; Christie PR; Frischer M; Thomson A; Carr SV; Taylor A; Department of Infection & Tropical Medicine, Ruchill Hospital,; Glasgow.
The objective of this study is to describe the lifestyle of a group of female prostitutes. The collection of information was achieved by: (i) using a self administered questionnaire; and (ii) conducting conversational type interviews. Of 85 women attending a health care drop-in centre for female street prostitutes in
AIDS Care. 1993;5(3):337-46. Unique Identifier : AIDSLINE MED/94032542
Church J; Green J; Vearnals S; Keogh P; Department of Psychology, St Mary's Hospital, Paddington, London.
One-hundred-and-thirty-four individuals engaging in cottaging returned postal questionnaires. The sample was mainly urban and gay identified. Cottagers reported that cottaging was one way of meeting partners amongst a range of others they used. Most enjoyed it and felt in control of their cottaging. The majority of co
AIDS Care. 1993;5(3):347-57. Unique Identifier : AIDSLINE MED/94032543
Lwihula G; Dahlgren L; Killewo J; Sandstrom A; Department of Behavioural Sciences, Muhimbili Medical Centre, Dar; es Salaam, Tanzania.
This study is part of a collaborative study of HIV infection and AIDS which was launched in 1987 in the Kagera region, Tanzania . This region is characterized as one of the areas most affected by the AIDS epidemic. In order to describe and analyse the epidemiology of HIV infection
AIDS Care. 1993;5(3):359-67. Unique Identifier : AIDSLINE MED/94032544
Gordon JH; Ulrich C; Feeley M; Pollack S; Haemophilia Treatment Center, Long Island Jewish Medical Center,; Queens, New York.
To investigate the severity, sources, and means used to cope with the distress experienced by haemophilia nurses as a result of the widespread infection with Human Immunodeficiency Virus among haemophiliacs, we collected anonymous questionnaire data from all nurses in the Haemophilia Nursing Network Directory, compile
AIDS Care. 1993;5(3):369-78. Unique Identifier : AIDSLINE MED/94032545
McCormick WC; Hopkins SG; Wood RW; Wood CD; Deyo RA; Inui TS; Department of Medicine, University of Washington, Seattle 98195.
We surveyed 77 persons with AIDS, their physicians and their social workers during the autumn of 1987 to ascertain health status and to quantify use of health services in Seattle, Washington. Participants included the majority (59%) of persons living with AIDS in the area. Information was gathered regarding demography
Bernstein L; Hamilton AS; Department of Preventive Medicine, University of Southern; California School of Medicine, Los Angeles 90033.
Immunosuppression resulting from HIV infection does not explain the unique distribution of Kaposi s sarcoma across risk groups. A majority of cases occur among homosexual men, particularly those with oral-anal contact, those with sexual contacts in high-risk cities, and those frequently use nitrite inhalants, suggesti
Masood R; Cai J; Law R; Gill P; Norris Cancer Hospital and Research Institute, Los Angeles,; California.
Kaposi s sarcoma is the most common tumor associated with HIV-1 infection. Kaposi s sarcoma is seen most frequently among homosexual or bisexual men, the reasons for which are unknown. Culture of Kaposi s sarcoma spindle cells has been very useful to study various biologic features of the tumor and to develop novel dr
Mitsuyasu RT; UCLA Center for Clinical AIDS Research and Education, Department; of Medicine 90024-1793.
Kaposi s sarcoma was one of the first conditions defining the new disease AIDS in 1981. From the outset, it was quite apparent that the biology of Kaposi s sarcoma in the setting of AIDS was quite different from that of most other known neoplasms. This observation led many investigators to speculate that Kaposi s sarc
Knowles DM; Department of Pathology, Columbia University, College of; Physicians and Surgeons, New York, NY 10032.
Acquired immunodeficiency syndrome-associated non-Hodgkin s lymphomas represent a significant and formidable clinical problem. They also represent an important biologic model for investigating the development and progression of high-grade malignant lymphomas and for studying lymphomas that develop in the setting of im
Irwin D; Kaplan L; San Francisco General Hospital, California.
The number of cases HIV-associated non-Hodgkin s lymphoma continues to increase as the AIDS epidemic grows. Approximately 3% of AIDS-defining illnesses are non-Hodgkin s lymphoma. The number of non-Hodgkin s lymphoma cases may actually be higher because many cases go unreported. Th
Lipsey LR; Northfelt DW; Division of Hematology/Oncology, University of California at San; Francisco School of Medicine 94143-0324.
Individuals infected with HIV have been noted to have an increased rate of anogenital neoplasia. Recent studies have attempted to demonstrate the extent of anal and cervical cancer in the HIV-infected population as well as describe the role of human papillomavirus coinfection in the pathogenesis of these malignancies.
There is a need for new hypotheses to supplement existing explanations for the observed differences in HIV prevalence between countries and within countries. Due to high levels of viraemia during the initial phase of HIV infection, networks of concurrent regular partnerships in a community could be the determining fac
Intravenous drug-users comprise a major group of HIV-infected individuals in the developed world and, whilst progression of HIV disease in them appears little different from other risk groups, their medical presentations may be altered by continuing drug use. Drug-users are particularly susceptible to bacterial infect
Williams P; Department of Mathematical & Computing Sciences, University of; Surrey, Guildford, UK.
Since January 1985 James Pringle House, the genitourinary medicine (GUM) clinic at London s Middlesex Hospital, has built up an extensive computerized patient database. Yearly statistics relating to 1) individual patients, 2) diagnoses, 3) attendances, and 4) an activity estimator (combining features of attendances an
Handley J; Dinsmore W; Maw R; Corbett R; Burrows D; Bharucha H; Swann A; Bingham A; Department of Dermatology, Royal Victoria Hospital, Belfast, N.; Ireland, UK.
Forty-two prepubertal children presenting with anogenital (AG) warts (15 boys and 27 girls) were prospectively followed up (mean 15.9 months, SD 12.24). Most (73.8%) of these children had perianal condylomatous-type warts and 11 (26.2%) had concurrent non-genital (NG) warts. None had any other AG infections or sexuall
Bhatt P; Gurubacharya VL; Vadies G; National AIDS Prevention and Control Programme of Nepal, (Her; Majesty's Government), Ministry of Health.
In the Mid Western and Far Western regions of Nepal live a unique group of prostitutes which maintains strong bonds resulting from untouchable caste status and family tradition. Known as the Badis (pronounced bod ee ), it is esti
Ruden AK; Jonsson A; Lidbrink P; Allebeck P; Bygdeman SM; Department of Dermatovenereology, Sodersjukhuset, Stockholm,; Sweden.
The aim of the present study was to characterize endemic versus non-endemic gonorrhoea to identify risk groups for transmission and to evaluate the effects of intensified contact tracing performed by specially trained social workers at venereal clinics. A total of 671 gonorrhoea patients (283 women and 388 men) compri
Gompels M; McWilliams S; O'Hare M; Harris JR; Pinching AJ; Main J; Department of Immunology, St Mary's Hospital, London, UK.
This was an open, single centre study, to evaluate the safety and efficacy of ondansetron in the treatment of co-trimoxazole associated nausea and vomiting in AIDS patients. Sixteen patients presenting with their first episode of HIV-associated Pneumocystis carinii pneumonia (PCP) on high dose co-trimoxazole were give
Young SM; Malet RM; Department of GU Medicine, Leicester Royal Infirmary, UK.
A retrospective study compared one year s cervical smear results from 4920 women from the following 3 populations in Leicestershire; the Genitourinary Medicine (GUM) Departments; the city family planning clinic (FPC); and a general practice (GP) in a local University town. The results were standardized for age by logi
Giangaspero M; Vacirca G; Morgan D; Baboo KS; Luo NP; DuPont HL; Zumla A; University of Zambia, School of Medicine, Lusaka.
Bovine viral diarrhoea (BVD) virus is a cosmopolitan pestivirus of animals which is associated with diarrhoea, immunosuppression and synergy with other pathogens. This study was conducted to establish the prevalence of anti-BVD virus antibodies in healthy Zambian adults and those with asymptomatic and symptomatic HIV
Liu YC; Cheng DL; Liu WT; Liu CY; Yen MY; Wang RS; Lin HH; Chen YS; Department of Medicine, Veterans General Hospital-Kaohsiung,; Taiwan, Republic of China.
Kemper CA; Hostetler JS; Follansbee SE; Ruane P; Covington D; Leong SS; Deresinski SC; Stevens DA; Department of Medicine, Santa Clara Valley Medical Center, San; Jose, California 95128.
Tracheobronchitis is an uncommon manifestation of infection due to Aspergillus species, occurring in
del Arco A; Martinez MA; Pena JM; Gamallo C; Gonzalez JJ; Barbado FJ; Vazquez JJ; Department of Internal Medicine, Universidad Autonoma de Madrid,; Spain.
We report a case of thrombotic thrombocytopenic purpura (TTP) in a woman infected with human immunodeficiency virus (HIV) in whose endothelial cells we detected HIV p24 antigen. The patient had an excellent response to conventional therapy for TTP and remained in complete remission 12 months after diagnosis. We also p
Weber R; Kuster H; Visvesvara GS; Bryan RT; Schwartz DA; Luthy R; Department of Medicine, University Hospital, Zurich, Switzerland.
Four genera of microsporidia have been associated with disease in humans, which predominantly affects immunocompromised persons. Systemic infection with a newly characterized microsporidian species, Encephalitozoon hellem, was recently reported in a patient with AIDS. This article describes a second patient with AIDS
Weber R; Sauer B; Luthy R; Nadal D; Department of Medicine, University Hospital, Zurich, Switzerland.
The microsporidian Enterocytozoon bieneusi has been recognized as an important cause of chronic diarrhea in severely immunodeficient adults infected with human immunodeficiency virus (HIV). We report the first case of intestinal E. bieneusi infection in a child. The 9-year-old boy with connatal HIV infection presented
Huminer D; Dux S; Samra Z; Kaufman L; Lavy A; Block CS; Pitlik SD; Department of Internal Medicine C, Beilinson Medical Center,; Petach Tikvah, Israel.
Mycobacterium simiae is an environmental organism that has rarely been associated with human disease. In Israel M. simiae is frequently isolated from clinical specimens, and it usually colonizes damaged lungs. Until now, only two cases of AIDS patients with M. simiae infection have
An Med Interna. 1993 Aug;10(8):381-5. Unique Identifier : AIDSLINE MED/94032972
Fernandez Revuelta A; Arazo Garces P; Aguirre Errasti JM; Arribas Llorente JL; Unidad de Enfermedades Infecciosas, Hospital Miguel Servet,; Zaragoza.
423 cases of pulmonary tuberculosis (PT) are described, dividing them into two major groups depending on the presence (Group 1:54 cases) or the absence (Group 2:369 cases) of infection by the Acquired Immunodeficiency Virus, in order to compare their clinical-epidemiological characteristics. 70.37% patients of Group 1
An Med Interna. 1993 Aug;10(8):398-400. Unique Identifier : AIDSLINE MED/94032977
Suarez Ortega S; Artiles Vizcaino J; Balda Aguirre I; Melado Sanchez P; Arkuch Saade ME; Ayala Galan E; Betancor Leon P; Servicio de Medicina Interna, Complejo Hospitalario Las Palmas; Norte (Hospital El Pino y El Sabinal), Gran Canaria.
Over a 2-year period, 3 patients with deep venous thrombosis associated to advanced pulmonary tuberculosis have been observed. One of them died suddenly, probably due to thromboembolic complications. In the other two cases, a triggering factor of venous thrombosis, probably related to tuberculosis, was detected and th
An Med Interna. 1993 Sep;10(9):427-32. Unique Identifier : AIDSLINE MED/94032988
Salgueiro Rodriguez M; Zamarron Sanz C; Alvarez-Calderon Prat P; Tumbeiro Novoa M; Penela Penela P; Valle Vazquez JM; Alvarez Dobano JM; Perez del Molino ML; Valdes Cuadrado LG; Alvarez Garcia D; et al; Servicio de Neumologia, Hospital General Clinico Universitario; de Galicia, Facultad de Medicina, Santiago de Compostela.
In order to assess the incidence of tuberculous disease in our health area, we reviewed the clinical records of patients from the three hospitals of the area under study during the years 1989, 1990 and 1991, who had positive bacilloscopy, positive Lowenstein s culture in any specimen and/or compatible anatomopathologi
Zhang ZL; Georgiou HM; Mandel TE; Transplantation Unit, Walter and Eliza Hall Institute of Medical; Research, Parkville, Victoria, Australia.
The nonobese diabetic (NOD) mouse is a model for human Type 1 diabetes mellitus. Pancreatic beta-cell destruction in NOD mice is mediated by an autoimmune process which can be accelerated by cyclophosphamide (CP). We studied the phenotype of lymphocytes from central, peripheral and regional lymphoid tissues in prediab
Zagury JF; Bernard J; Achour A; Astgen A; Lachgar A; Fall L; Carelli C; Issing W; Mbika JP; Cantalloube H; et al; Universite Pierre et Marie Curie, Paris.
We have previously unravelled the striking SLWDQ pentapeptide identity between HIV-1 env gp120 and the CD4 molecule. We show here that this pentapeptide is required for the functioning of the co-stimulatory MHC-CD4 signal in T4-cell activation since it suppresses antigen-induced T-cell proliferation. Moreover, concern
Godfrey-Faussett P; Stoker NG; Scott JA; Pasvol G; Kelly P; Clancy L; Department of Clinical Sciences, London School of Hygiene and; Tropical Medicine, UK.
Drug-resistant tuberculosis has become a major public health problem. Resistance to rifampicin probably arises through mutations in the mycobacterial RNA polymerase. Patients may acquire rifampicin resistant tuberculosis by three mechanisms: (1) infection with a resistant organism, (2) selection of a sub-population of
By using routinely collected data and results from research studies at the Infectious Diseases Hospital (IDH), Nairobi, we have begun to determine the scale of the increase in resource utilisation and treatment costs for tuberculosis control services caused by the HIV epidemic. New cases of tuberculosis registered ann
Monno L; Angarano G; Carbonara S; Infante G; Coppola S; Costa D; Quarto M; Pastore G; Clinic of Infectious Diseases, University of Bari, Italy.
31 Italian HIV-infected patients with newly diagnosed tuberculosis (TB) were reviewed to verify the effectiveness of the most common antituberculosis drugs. The patients were mostly intravenous drug addicts (90%), and 14 (45%) had recently been in prison. 5 patients (16%) had pulmonary TB, 15 (48%) had both pulmonary
Blood. 1993 Nov 15;82(10):3075-80. Unique Identifier : AIDSLINE MED/94033518
Christie DJ; Sauro SC; Cavanaugh AL; Kaplan ME; University of Minnesota, Department of Laboratory Medicine and; Pathology, Minneapolis 55455.
Severe thrombocytopenia developed in a patient with acquired immunodeficiency syndrome during treatment with intravenous pentamidine for Pneumocystis carinii pneumonia. The patient s bone marrow contained adequate numbers of megakaryocytes, suggesting peripheral platelet destruction. Platelet counts ranged between les
Blood. 1993 Nov 1;82(9):2742-8. Unique Identifier : AIDSLINE MED/94033558
Kitano K; Rivas CI; Baldwin GC; Vera JC; Golde DW; Second Department of Internal Medicine, Shinshu University School; of Medicine, Nagano-Ken, Japan.
Tumor necrosis factor (TNF) may play a central role in proviral activation and release from latency in cells infected with the human immunodeficiency virus (HIV). We studied viral production and its relation to TNF in a HL-60 cell line (J22-HL-60) infected with a monocytotropic strain of HIV-1JR-FL. Viral production w
Itin PH; Department of Dermatology, University of Basel, Switzerland.
Oral hairy leukoplakia (OHL) was first observed in 1981 and reported in 1984. Initially, this entity was restricted to HIV-seropositive male homosexual patients, but the risk group has been expanded since 1986 to all patients infected with HIV. It has been recognized that OHL is caused by Epstein-Barr virus (EBV). In
Int J Med Microbiol Virol Parasitol Infect Dis. 1993 Jun;279(2):167-72. Unique Identifier : AIDSLINE MED/94033899
Rocha T; Cardoso EA; Terrinha AM; Nunes JF; Hovind-Hougen K; Cinco M; Laboratorio Nacional de Investigacao Veterinaria (Dept.; Bacteriologia), Lisboa, Portugal.
A leptospira-like spirochete was isolated from a lymphocyte culture from a HIV-I and HTLV-I/II-positive patient. On the basis of serological, biological and morphological characteristics of the cells of the isolated strain (strain Lisboa), we conclude that it is a member of the genus Leptonema.
Int J Med Microbiol Virol Parasitol Infect Dis. 1993 Jun;279(2):274-82. Unique Identifier : AIDSLINE MED/94033910
Momoi Y; Matsumoto Y; Watari T; Goitsuka R; Miyazawa T; Mikami T; Tsujimoto H; Hasegawa A; Department of Veterinary Internal Medicine, Faculty of; Agriculture, University of Tokyo, Japan.
The polymerase chain reaction (PCR) was applied to detect feline immunodeficiency virus (FIV) proviral DNAs in primary peripheral blood mononuclear cells (PBMC). Suitable conditions for PCR amplification were examined to obtain highly sensitive and specific results by simple staining in agarose gel. Specific amplifica
Amstad H; Muhlemann R; Schularztamt des Kantons Basel-Stadt.
In the spring of 1992, young actors, actresses and musicians presented in Basel for their schoolmates of the 8th and 9th school year a musical on the subject of AIDS. The information content of AIDS prevention was communicated by means of feelings, that means, in an emotional way (and no longer in a mainly cognitive w
Yamamoto H; Sekiguchi T; Yamamoto I; Laboratory of Pathology, Kohno Clinical Medicine Research; Institute, Tokyo, Japan.
Pathological examination of arthritic lesions in transgenic mice produced by the pX region of the human T-cell leukemia virus type-1 (HTLV-1) was carried out. Clinically, erythema, swelling and/or ataxia of the limb joints were observed in many transgenic mice about 1 month-old. Histopathologically, proliferation of s
Louis JP; Gardon J; Trebucq A; Hengy C; Louis FJ; Migliani R; Rey JL; Delaporte E; ORSTOM, Montpellier, France.
Subsaharian Africa is the most important reservoir of HTLV1 virus but its epidemiology is not well-known. The authors have studied from 1987 to 1990 the situation in 6 countries in Central Africa. The already described routes of transmission are present: through blood transfusions (but it s not such a common practice)
Giangaspero M; Vacirca G; Buettner M; Wolf G; Vanopdenbosch E; Muyldermans G; Institute of Special Pathology, Faculty of Veterinary Medicine,; University of Milan, Italy.
An epidemiological survey for pestivirus was undertaken in Zambia and Europe, in view of the recent serological findings obtained by previous studies in Europe with humans. Collected sera were tested for anti-bovine viral diarrhea virus (BVDV) specific antibodies by IIF and Western
Tex Heart Inst J. 1993;20(3):218-22. Unique Identifier : AIDSLINE MED/94034409
Richards PS; Nelson KA; Frazier OH; Radovancevic B; Van Buren C; Young JB; LifeGift Organ and Tissue Donation Center, Houston, Texas.
Heart donor demand far exceeds supply. We evaluated donor referrals to 1 organ procurement agency in an attempt to determine why many potential cardiac donors are not used. Of 430 referrals between September 1989 and August 1991, 169 hearts (39%) were harvested. In potential donors ultimately not yielding a heart, 38.
Can Fam Physician. 1993 Oct;39:2175-82. Unique Identifier : AIDSLINE MED/94034453
Bally G; AIDS Care and Treatment Unit, Health Canada, Ottawa.
Caring for and treating patients living with human immunodeficiency virus is challenging for busy family physicians. I present one strategy for managing patients with this complex infectious disease. Using averaged T4 blood cell counts as a marker of disease progression, I use antiretroviral treatment and preventive d
Wyatt SH; Fishman EK; Russell H. Morgan Department of Radiology and Radiological; Science, Johns Hopkins Medical Institutions, Baltimore, MD 21205.
We report a case of bacillary angiomatosis involving the liver in addition to multiple cutaneous sites in a patient with AIDS. Abdominal CT demonstrated multiple, small low-attenuation lesions throughout the hepatic parenchyma. Consideration of this entity in the proper clini
Soyer P; Van Beers B; Teillet-Thiebaud F; Grandin C; Kazerouni F; Barge J; Pringot J; Levesque M; Department of Radiology, Hopital Louis Mourier, Colombes,; France.
The sonographic studies of 72 patients with pathologically proven Hodgkin s or non-Hodgkin s hepatic lymphoma were retrospectively reviewed. Sixty-eight patients (94%) had secondary hepatic lymphoma (nine of them had AIDS-related lymphoma) and four patients (6%) had primary lymphoma of the liver. Forty-six of 72 patie
McLachlan C; Crofts N; Wodak A; Crowe S; Department of Psychology, School of Behavioural Sciences, Latrobe; University, Bundoora, Victoria, Australia.
Methadone maintenance therapy is advocated as a major preventive strategy for the spread of the human immunodeficiency virus (HIV) and other blood-borne infectious agents among injecting drug users (IDUs) because of its effects in decreasing the frequency of injecting and presumably sharing of equipment. As an opioid
Vandenberghe E; Van Hove J; Brock P; Schmidt P; Delabie J; Casteels-Van Daele M; Cassiman JJ; Vanderschueren-Lodeweyckx M; Van den Berghe H; Centre for Human Genetics, K. U. Leuven, Belgium.
Bloom s syndrome is an autosomal recessive disorder characterized by intrauterine growth retardation, typical physical signs, immunodeficiency and an increased risk of developing neoplasms at a young age, compared to the general population. Factors possibly involved in the pathogenesis of non-endemic Burkitt s lymphom
Di Raimondo F; Giustolisi R; Cacciola E; O'Brien S; Kantarjian H; Robertson LB; Keating MJ; Institute of Hematology, University of Catania, Italy.
Autoimmune hemolytic anemia (AHA) is a frequent complication of chronic lymphocytic leukemia (CLL). Although the pathogenesis of AHA is still unknown, an imbalance of normal residual T cells is believed to play a central role. Since fludarabine is reported to affect primarily T lymphocytes, we conducted a retrospectiv
Drouet M; Lees O; Laboratoire d'Immuno-Hematologie, CHRU Dupuytren, Limoges,; France.
Rapid developments in computer technology combined with new fluorescent dyes and monoclonal antibody production have led to the development of a powerful tool: flow cytometry. The techniques of flow cytometry can be applied in a wide clinical field, from routine tasks to research in immunology and hematology. The avai
Goguel AF; Crainic K; Ducailar A; Ouin M; Etalonorme, University Paris V, Hematology, Ambroise Pare; Hospital, Boulogne, France.
A 3-year interlaboratory proficiency testing for lymphocyte subset phenotyping was initiated as part of the Etalonorme national quality control program. Specimens consisted of fresh whole blood and of lyophilised mononuclear cells (Cytotrol Coulter). The number of participating laboratories was 62 in 1990, 99 in 1991
Modern medical technology has given us the ability to directly observe the fetus and its state of health. This ability has allowed the fetus to be newly individuated and has supported what often are called conflicts between the fetus and the pregnant woman. This article examines the nature of some of these conflicts a
Manfro RC; Stumpf AG; Horn CL; Wolffenbuttel I; Harzein RC; Prompt CA; Kronfeld M; Kopstein J; Servico de Nefrologia, Hospital de Clinicas de Porto Alegre,; Universidade Federal do Rio Grande do Sul.
BACKGROUND--A variety of metabolic and renal disturbances have been described in patients with Acquired Immunodeficiency Syndrome (AIDS) but their influence on the clinical outcome has not been reported. The present study was undertaken in order to evaluate the prevalence of fluid and electrolyte, acid-base, and renal
Bull Pan Am Health Organ. 1993;27(3):234-43. Unique Identifier : AIDSLINE MED/94035253
Adrien A; Cayemittes M; Bergevin Y; Center for AIDS Studies, Montreal General Hospital, Canada.
AIDS constitutes an important public health problem in Haiti , where it appears to be spread mainly through heterosexual encounters. The study reported here employed in-depth interviews, focus group discussions, and a national cross-sectional survey of 1,300 men and 1,300 women 15 to
Kashima Y; Gallois C; McCamish M; Department of Psychology, La Trobe University, Bundoora,; Victoria, Australia.
The applicability of the Theories of Reasoned Action and Planned Behaviour to the cooperative behaviour of condom use were examined. Seventy-one male and 78 female students, all sexually active unmarried heterosexuals aged 17 to 21 years, gave information about their intentions for the next sexual encounter, as well a
Frottier J; Service des Maladies infectieuses Hopital Saint-Antoine, Paris.
Nosocomial infections develop within a hospital or are produced by microorganisms acquired during hospitalization. They may involve not only patients (2 to 10 percent) but also hospital personnel. They arise from complex interactions of multiple causal factors. Patients risk factors are these that reduce the patient s
The continuing presence of tuberculosis in the world and its reappearance in industrialized countries again emphasizes the need to maintain and reinforce tuberculosis control. Despite the existence of effective drugs, there are still, deplorably, nearly 20 million cases of active tuberculosis throughout the world, wit
Can J Public Health. 1993 Jul-Aug;84(4):265-8. Unique Identifier : AIDSLINE MED/94036593
Stewart SA; Beazley RP; Health Education Division, Dalhousie University.
Meeting a person with AIDS in the classroom was evaluated to determine if it had an impact on students perceived susceptibility to HIV infection and attitudes toward persons with AIDS. The meeting was incorporated into the Grade 9 AIDS education program of a school district in Nova Scotia. Four schools participated i
The vital issues at stake in the credibility and effectiveness of AIDS prevention programs for young people have led to the emergence of a trend in research focused on the study of adolescents understanding of AIDS, their attitudes and behaviour towards it, and their beliefs about it. This research can be classified
Can J Public Health. 1993 Jul-Aug;84(4):275-8. Unique Identifier : AIDSLINE MED/94036595
Ramsum DL; Marion SA; Mathias RG; Department of Health Care & Epidemiology, University of British; Columbia.
We evaluated changes in AIDS-related knowledge, attitudes and behaviours among students in residence at the University of British Columbia based on identical surveys conducted in 1988 and 1992. 493 randomly selected students in each year were sent a self-administered questionnaire on AIDS-related knowledge, fear of AI
Cancer. 1993 Nov 15;72(10):3078-90. Unique Identifier : AIDSLINE MED/94036709
Chadburn A; Cesarman E; Jagirdar J; Subar M; Mir RN; Knowles DM; Department of Pathology, Columbia University College of; Physicians and Surgeons, New York, NY 10032.
BACKGROUND. CD30 (Ki-1) positive anaplastic large cell lymphoma (ALCL) has been only rarely described in HIV-positive patients. METHODS. The clinicopathologic features of eight ALCLs occurring in four AIDS and four HIV-positive patients were investigated. The phenotype of each neoplasm was determined by immunohistoche
Cancer Lett. 1993 Sep 30;73(2-3):113-9. Unique Identifier : AIDSLINE MED/94036758
Benzair AB; Hirsch I; Chermann JC; INSERM, Unite 322, Retrovirus et Maladies Associees, Campus de; Luminy, Marseille, France.
Membrane proteins (MP) obtained from the human mesenchymal rhabdomyosarcoma cell line RD were coated on 96-well polystyrene microplates and tested for their ability to bind human immunodeficiency virus type 1 (HIV-1). The virus bound to MP was detected by solid phase assay. Anti-human CD4 monoclonal antibodies directe
Cancer Res. 1993 Nov 15;53(22):5569-75. Unique Identifier : AIDSLINE MED/94036860
Corallini A; Altavilla G; Pozzi L; Bignozzi F; Negrini M; Rimessi P; Gualandi F; Barbanti-Brodano G; Institute of Microbiology, University of Ferrara, Italy.
The human immunodeficiency virus tat protein, a transactivator of viral and cellular genes, is suspected to be involved in the pathogenesis of acquired immunodeficiency syndrome-associated tumors. We report that transgenic mice carrying a recombinant DNA containing BK virus early region and the human immunodeficiency
Cancer Treat Rev. 1993 Oct;19(4):387-413. Unique Identifier : AIDSLINE MED/94036876
Varthalitis I; Meunier F; Metaxa's Memorial Cancer Hospital, Piraeus, Greece.
Concern has been arisen about the recently reported increasing incidence of PCP in patients with cancer and the potential transmissibility of this infection. Whether or not there is an increase in the incidence of P. carinii infections, PCP should be considered in the differential diagnosis of pulmonary infiltrates in
Wang Z; National HIV Reference Laboratory, Chinese Academy of Preventive; Medicine, Beijing.
For helping HIV testing laboratories to improve their testing quality, a national external quality assessment (QA) Program was established and 2 QA survey were carried out in 1991 and 1992. It suggested that the established QA program, especially the scoring system, was suitable for use in our country and could be use
Carter PS; Imperial Cancer Research Fund, Colorectal Cancer Unit, St. Mark's; Hospital, London, UK.
Anal cancer is uncommon accounting for only 2% of anorectal cancers. The recognition of many similarities between cervical and anal cancer has stimulated research into the identification of a common aetiological agent. DNA from human papillomaviruses has consistently been found in both of these cancers and is thought
Vaira D; Cairns SR; Miglioli M; Mule P; Menegatti M; Barbara L; 1st Medical Clinic, University of Bologna, Italy.
Since the introduction of endoscopic retrograde cholangiopancreatography in the 1970s and of endoscopic sphincterotomy (EST) in 1974, endoscopic techniques for the diagnosis and therapy of biliary and pancreatic disorders have proliferated. Although some procedures have become part of routine practice, for example EST
Artymowicz RJ; James VE; Memorial Hospital at Easton Maryland.
The mechanism of action, pharmacokinetics and pharmacodynamics, clinical efficacy, adverse effects, and dosage of atovaquone in the management of mild to moderate Pneumocystis carinii pneumonia (PCP) are reviewed. Atovaquone has a novel mechanism of action that has been hypothesized to result in microbicidal rather th
Bertucci R; Leggieri A; Preziosi C; Milano R; Arduino C; Veglio V; Divisione C Malattie Infettive, USSL TO IV, Ospedale Amedeo di; Savoia, Torino.
The above study was intended to evaluate certain pharmacokinetic properties as well as the pharmacological activity of fluconazole in patients with cryptococcal meningitis. The results obtained show satisfactory bioavailability of the drug in the cerebrospinal fluid and marked reduction of the number of fungi found in
Robinson PG; Croucher R; University College Dental Hospital, London, UK.
A piloted self-complete questionnaire enquiring about dental experiences was administered to a consecutive sample of men with asymptomatic HIV infection attending a dedicated clinic in London. Forty-seven men completed questionnaires. Despite a high level of dental attendance before diagnosis of HIV infection, 60% of
The effectiveness and tolerability of Sulfamethoxazole with Trimethoprim (SMX-TMP), a dose of 400mg/80mg given twice a day as secondary prophylaxis (SP) against Pneumocystis carinii pneumonia (PCP) was assessed retrospectively in 166 AIDS patients. The mean observation period was 9.7 months (range 1.0-1.4). Relapse of
Wang QH; Ruijin Hospital, Shanghai Second Medical University.
Using CD series monoclonal antibody indirect immune fluorescent assay and LDH enzyme-release assay, we investigated lymphocyte subsets and natural killer cells (NKC) activity in the peripheral blood of 30 patients with obstructive jaundice. The results showed that the percentage of CD3+, CD4+, B cells and that of CD8+
Chung Hua Yen Ko Tsa Chih. 1993 May;29(3):138-40. Unique Identifier : AIDSLINE MED/94038402
Liu T; Sun SM; Department of Ophthalmology, First Teaching Hospital, Beijing; Medical University.
The peripheral lymphocyte subsets were analyzed in 37 patients with VKH and 32 normal controls by indirect fluorescein assay, using monoclonal antibodies. The percentages of OKT3+, OKT4+, and OKT8+ T-cells in active patients were found to differ insignificantly from those in quiescent patients, as were those in patien
A 55-year-old homosexual Indonesian (last stay in Indonesia 2 years previously), known to be HIV positive since 1986, developed desquamating, in part ulcerating, skin eruption over the face and shoulder region. On admission his temperature was 38.2 degrees C, erythrocyte sedimentation rate 72/95 mm, white cell count 3
Dtsch Med Wochenschr. 1993 Nov 12;118(45):1636-40. Unique Identifier : AIDSLINE MED/94038629
Huber W; Bautz W; Holzmann B; Classen M; Schepp W; II. Medizinische Klinik, Institut fur Rontgendiagnostik,; Klinikum rechts der Isar der Technischen Universitat Munchen.
A 38-year-old man, HIV-positive for 6 years, developed fever and cough with deterioration in his general state. Chest radiography demonstrated an infiltration in the left upper lobe and computed tomography showed a septated cavity. Three bronchioalveolar lavages over 4 weeks recovered Klebsiella, Candida, Pseudomonas
Health Psychol. 1993 Sep;12(5):346-53. Unique Identifier : AIDSLINE MED/94038815
Wulfert E; Wan CK; Department of Psychology, University at Albany, State University; of New York 12222.
A survey of heterosexually active college students gathered information about condom use, self-efficacy (SE), outcome expectancies, sexual attitudes, peer group influences, acquired immunodeficiency syndrome (AIDS) knowledge, and perceived vulnerability to AIDS. On the basis of A. Bandura s (1986) social-cognitive the
Lauritzen E; Masson M; Rubin I; Bjerrum OJ; Holm A; Department of Virology, Statens Seruminstitute, Copenhagen,; Denmark.
Nitrocellulose membrane was preactivated with divinyl sulfone, and a spacer of 1,6-diaminohexane was coupled to the membrane which was functionalized by glutaraldehyde, leaving a reactive carbonyl group. The peptides were coupled to the carbonyl by the side chain and terminal amino groups. The octapeptide angiotensin
EMBO J. 1993 Nov;12(11):4261-7. Unique Identifier : AIDSLINE MED/94038908
Rattner A; Korner M; Walker MD; Citri Y; Department of Hormone Research, Weizmann Institute of Science,; Rehovot, Israel.
Human immunodeficiency virus (HIV) infection of the brain leads to massive neuronal damage, resulting in the AIDS (acquired immunodeficiency syndrome) dementia complex (ADC). A recent study using transgenic mice indicates that neurons possess transcription factors capable of activa
EMBO J. 1993 Nov;12(11):4269-78. Unique Identifier : AIDSLINE MED/94038909
Caron C; Rousset R; Beraud C; Moncollin V; Egly JM; Jalinot P; Laboratoire de Biologie Moleculaire et Cellulaire, Ecole Normale; Superieure de Lyon, UMR 49, CNRS, France.
The human T-cell leukemia virus type I (HTLV-I) codes for the potent transcriptional activator, Tax1, which induces the enhancer activity of various enhancer elements. In the case of the 21 bp enhancer of the HTLV-I provirus, this induction is correlated with the association of Tax1 with this DNA element via a specifi
EMBO J. 1993 Dec;12(12):4885-95. Unique Identifier : AIDSLINE MED/94038973
Levin HL; Weaver DC; Boeke JD; Department of Molecular Biology and Genetics, Johns Hopkins; School of Medicine, Baltimore, MD 21205.
In sharp contrast to the single ORF of the Schizosaccharomyces pombe retrotransposon Tf1, retroviruses and most retrotransposons employ two different ORFs to separately encode the Gag and Pol proteins. The different ORFs are thought to allow for overexpression of the Gag protein relative to Pol protein presumed necess
Gross U; Bohne W; Schroder J; Roos T; Heesemann J; Institute of Hygiene and Microbiology, University of Wurzburg,; Germany.
A commercial enzyme immunoassay (Platelia-Toxo IgA) and an immunoblot technique were compared with regard to their ability to detect IgA antibodies to the major surface protein P30(SAG1) of Toxoplasma gondii in 105 serum samples from patients with suspected or proven acquired toxoplasmosis. Comparison of the IgA-EIA w
Gabrilovich DI; Roberts MS; Harvey JJ; Botcherby M; Bedford PA; Knight SC; Antigen Presentation Group, Clinical Research Centre, Harrow, GB.
In asymptomatic human immunodeficiency virus-1 infection T cells respond normally to allogeneic dendritic cells (DC), but DC show reduced stimulatory capacity. By contrast in HTLV-1 infection no significant changes in allogeneic stimulation were seen but DC-stimulated activity of autologous T cells. In seeking animal
Nosaka T; Takamatsu T; Miyazaki Y; Sano K; Sato A; Kubota S; Sakurai M; Ariumi Y; Nakai M; Fujita S; et al; Institute for Virus Research, Kyoto University, Japan.
The rev protein (Rev) of the human immunodeficiency virus type 1 (HIV-1) is known as a post-transcriptional regulator of viral gene expression. It is located in the cell nucleolus. Transiently expressed Rev caused nucleolar ballooning and deformity with aberrant accumulation of rRNAs, and de novo synthesis of rRNAs de
FEBS Lett. 1993 Oct 25;333(1-2):21-4. Unique Identifier : AIDSLINE MED/94039743
Wondrak EM; Louis JM; de Rocquigny H; Chermann JC; Roques BP; Unite de Recherches sur les Retrovirus et Maladies Associees,; INSERM U 322, Marseille, France.
The predicted protease cleavage site (p7/p1; [J. Virol. 66 (1992) 1856-1865]) within the nucleocapsid precursor protein (p15) of human immunodeficiency virus, type 1, was confirmed using an in vitro assay employing recombinant HIV-1 protease and a chemically synthesized 72 amino acid polypeptide containing the p7 and
FEBS Lett. 1993 Nov 1;333(3):211-3. Unique Identifier : AIDSLINE MED/94039761
Hobohm U; Sander C; European Molecular Biology Laboratory, Heidelberg, Germany.
The sequence of the HIV Nef protein has no significant homology to other proteins in the SwissProt database, and experimental data concerning its function are sparse and contradictory. Using a novel protein sequence comparison method, we find similarities between different Nef sequences and the alpha chain of human MH
FEBS Lett. 1993 Nov 1;333(3):217-22. Unique Identifier : AIDSLINE MED/94039763
Ramsdale TE; Andrews PR; Nice EC; Centre for Drug Design and Development, University of Queensland,; St. Lucia, Australia.
Peptide T is currently in phase II clinical trials for the treatment of AIDS-associated dementia . Its putative mode of action is inhibition of binding of the HIV envelope protein (gp120) to its cellular receptor (CD4), thus preventing viral infectivity and gp120-induced neuronal to
FEBS Lett. 1993 Nov 1;333(3):325-30. Unique Identifier : AIDSLINE MED/94039786
Martin I; Dubois MC; Saermark T; Epand RM; Ruysschaert JM; Laboratoire de Chimie-Physique des Macromolecules aux; Interfaces, Universite Libre de Bruxelles, Belgium.
We report here on the interaction of a synthetic 12 residue peptide corresponding to the N-terminal sequence of gp32 from SIV with phospholipid bilayers. This peptide has been shown to induce lipid mixing of PC/PE/SM/Chol LUV (large unilamellar vesicles) at pH 7.4 and 37 degrees C [(1992) in: Advances in Membrane Flui
Garweg J; Fenner T; Bohnke M; Schmitz H; Department of Ophthalmology, University of Bern, Inselspital,; Switzerland.
We applied the technique of DNA amplification with the polymerase chain reaction to nine aqueous humor and five vitreous samples from HIV-1-infected patients with clinically diagnosed cytomegalovirus retinitis. For the amplification, recently published primers specific for herpes s
Ikuta K; Section of Serology, Hokkaido University.
There has been significant progress on several candidate vaccines against HIV infection over the past few years, i.e., live recombinant virus vaccines, inactivated virus vaccines, and purified antigens (subunit vaccines). There have been many phase I studies in healthy volunteers uninfected with HIV, as well as phase
Sugiura M; Matsuura A; Imai S; Sakurada K; Miyazaki T; Osato T; Section of Virology of Cancer Institute, Hokkaido University; School of Medicine, Sapporo, Japan.
The opportunistic herpesvirus infections in AIDS are often life-threatening and the patients have lowered Epstein-Barr virus (EBV)-specific T cell cytotoxicity. On the other hand, the asymptomatic human immunodeficiency virus (HIV) carriers have potentially lowered EBV-specific cytotoxic T cell function, which is show
Sakurada K; Third Department of Internal Medicine, Hokkaido University School; of Medicine, Sapporo, Japan.
Although Kaposi s sarcoma (KS) has been considered a rare disease, the disease is well known at present since the onset of AIDS in 1981. The characteristics of AIDS-associated KS are a multifocal, widespread distribution that may involve lymph node, gastrointestinal tract, and visceral organs. KS may be the first sign
Imai K; Tanaka K; Shibata K; Hinoda Y; Chiba S; Sato N; Mori M; Kikuchi K; Sakano S; Imaizumi H; et al; Department of Internal Medicine (Section 1), Sapporo Medical; University School of Medicine.
We report two cases of AIDS whom we have recently experienced. One patient was a 54-year-old man who admitted our hospital due to third degree burn. In this case, we did not know whether or not he was suffered from AIDS, when he was delivered by the ambulance. In autopsy, pneumocystis carinii pneumonia and renal tuber
Maekawa I; Dept. of Internal Medicine, Asahikawa City Hospital, Japan.
We analysed problems on the front line of the AIDS medicine through our experience of a with hemophilia A, who had HIV infection developed to ARC and the AIDS and in addition, had non-Hodgkin s lymphoma in his rectum and died of pneumonitis caused by pneumocystis carinii. We have l
Imamura M; Third Department of Internal Medicine, Hokkaido University School; of Medicine, Sapporo, Japan.
It is reported that approximately 900 persons with human immunodeficiency virus (HIV) are present in Japan . Among them, almost 300 persons developed acquired immunodeficiency syndrome (AIDS). However, we have to assure that more persons infected with HIV or patients with AIDS, which
Fukuda H; First Department of Oral Surgery, Hokkaido University School of; Dentistry, Sapporo, Japan.
Oral manifestations of HIV infection include hairy leukoplakia, Sjogren s syndrome-like conditions, necrotizing stomatitis, Kaposi s sarcoma, and a variety of opportunistic viral or mycotic infections. The well awareness of HIV-associated oral lesions can contribute to the early detection and diagnosis of HIV infectio
Aiken LH; Lake ET; Semaan S; Lehman HP; O'Hare PA; Cole CS; Dunbar D; Frank I; Center for Health Services and Policy Research, University of; Pennsylvania 19104-6096.
This exploratory study examined whether outcomes of care for HIV-infected patients are related to whether the patient s primary provider is a physician (MD) or a nurse practitioner (NP). Functional status, symptom occurrence, self management, health service use and patients assessment of their care were evaluated for
Andrews S; Williams AB; Neil K; Yale School of Nursing, New Haven, CT 06536-0740.
Qualitative data (N = 80) from a larger study of HIV-1 positive mothers have revealed mother-child relationships, that is, a strong attachment along with a bond of secrecy. The relationship is described as a strong attachment along with a bond of secrecy. Children are perceived by the mothers as sources of support as
Based on our findings that HIV-1 gp41 independently of CD4 can bind to the helper T cell line H9 and B cell line Raji, we characterized the putative binding of HIV-1 gp41 to the monocyte cell lines U937 and HL60. Using flow cytometry (FACS) we examined the binding of soluble gp41 (sgp41; env amino acids 539-684) to th
Miesel R; Zuber M; Deutsches Rheumaforschungszentrum, Berlin, Germany.
Sera of patients with various inflammatory and autoimmune rheumatic diseases were screened for the presence of xanthine oxidase (XOD) and compared to sera from healthy donors and patients with nonrheumatic diseases including AIDS, internal diseases, and different carcinomas. Up to 50-fold higher levels of XOD were det
Blaser J; Joos B; Opravil M; Luthy R; Departement fur Innere Medizin, Universitatsspital Zurich,; Switzerland.
Serum kinetics of trimethoprim and sulfamethoxazole were studied in 23 patients during oral and i.v. treatment of Pneumocystis carinii pneumonia. Daily doses of 15-22 mg/kg trimethoprim and 75-110 mg/kg sulfamethoxazole were given every 6 h. Despite administration of a loading dose of twice the regular dose, serum tro
von Baeyer H; Neitzel H; Nundel M; Riedel E; Schultis HK; Freie Universitat Berlin, Institut fur Biochemie, Klinikum; Rudolf Virchow, Germany.
Covalent coupling of thymidine and azidothymidine (ZIDOVUDINE) to epsilon-amino groups of lysine side chains of LDL-Apo B is described. This procedure generates LDL-nucleoside particles that exhibits affinity solely for the scavenger receptor pathway on macrophages which is demonstrated by cell culture experiments. Au
Int J Epidemiol. 1993 Aug;22(4):716-9. Unique Identifier : AIDSLINE MED/94041813
Soriano V; Calderon E; Esparza B; Cilla G; Aguilera A; Gutierrez M; Tor J; Pujol E; Merino F; Perez-Trallero E; et al; Service for Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain.
Antibodies to HTLV-I/II were investigated in sera from 7521 individuals living in Spain . They were classified in four major groups: a) subjects at high risk of retroviral infections e.g. parenteral drug addicts, homosexuals, prostitutes, and multiple-transfused individuals; b) patie
Ir Med J. 1993 Sep-Oct;86(5):152-3. Unique Identifier : AIDSLINE MED/94042000
Bradley F; Bury G; O'Kelly FD; Shannon W; HIV Primary Care Research Unit, Dublin.
Over a quarter (499) of general practitioners in the Republic of Ireland were sent a questionnaire on the human immunodeficiency virus (HIV) infection. Two hundred and fifty eight (51.7%) general practitioners returned completed que
Ir Med J. 1993 Sep-Oct;86(5):167-9. Unique Identifier : AIDSLINE MED/94042006
MacLeod D; Kane B; Kidney D; Murphy J; O'Briain DS; Jackson F; Mulvihill B; Mulcahy F; Clancy L; Prichard JS; Department of Respiratory Medicine, St. James' Hospital, Dublin.
We investigated lung pathology in 61 HIV-positive patients who underwent 79 bronchoscopies. There were 27 cases of pneumocystis carinii pneumonia (PCP), 22 cases of pyogenic pulmonary infection and six cases of mycobacterial infection. Eleven cases of non-specific interstitial pneumonitis were found and 10 intravenous
Maayan S; Soskolne V; Engelhard D; Moses A; Rahav G; Raveh D; Newman D; Weinberger M; Department of Clinical Microbiology & Infectious Diseases,; Hadassah University Hospital, Jerusalem, Israel.
We investigated whether the sexual practices of homosexual and bisexual men attending the Jerusalem AIDS Clinic had changed between 1986/7 and 1990. The responses of a group of 79 homosexual and bisexual men to a questionnaire in 1986/7 were compared to the responses of a group of 37 homosexuals/bisexuals in 1990. Con
Health Bull (Edinb). 1993 Sep;51(5):310-9. Unique Identifier : AIDSLINE MED/94042044
Robertson BJ; McQueen DV; Research Unit in Health and Behavioural Change, University of; Edinburgh.
Knowledge levels among the Scottish general public about so called casual transmission of the AIDS virus were analysed using data collected by our Unit s survey using computer-assisted telephone interviewing methods. Five cross-sections of data from the period March to May of each year were analysed and compared to
Herpes simplex virus (HSV) infections causing severe disease are reported frequently in patients suffering from human immunodeficiency virus (HIV) infection. This disease pattern may also be seen in an immunocompromised disease state with other causes, however, as in the case presented in this paper. An 84-year-old wo
Naef M; Frei E; Soucek M; Berthold M; Schweizer W; Czerniak A; Universitatsklinik fur Viszerale und Transplantationschirurgie,; Inselspital Bern.
Pyogenic liver abscess is a relatively rare disease, often concerning elderly patients in bad general condition and with underlying diseases. Out of a retrospective study (1984-1991) of 44 patients (f 43%, m 57%) with pyogenic liver abscesses and 12 patients (f 17%, m 83%) with amebic liver abscesses we present 5 pati
Wermelinger S; Frick T; Opravil M; Speich R; Largiader F; Departement Chirurgie, Universitatsspital Zurich.
Pneumothoraces in patients with AIDS are a rare, acute and severe complication. Between January 1989 and December 1991 3 patients with spontaneous pneumothorax were operated after a 2-week treatment with chest tube drainage only had failed. The average follow-up time after the operation was 7 months. There was no recu
Walsh TJ; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland.
Invasive fungal infections have emerged as major causes of morbidity and mortality in immunocompromised patients, particularly granulocytopenic and HIV-infected hosts. Diagnosis and treatment of these infections is determined by the type of fungus and the sites of infection. While Candida spp. and Aspergillus spp. are
Perkins HA; Irwin Memorial Blood Centers, San Francisco, CA 94118-4496.
This is a review of events when the medical community realized that AIDS was an infectious disease which might be transmitted by blood transfusions and the response by the various organizations and agencies to curb the potential spread of HIV via blood products. It became possible through a number of approaches to mak
Aronson DL; George Washington University Medical Center, Washington, D. C.; 20037.
HIV was introduced into the blood supply at least 4 years before there was any clinical illness in hemophiliacs. While viral removal and inactivation techniques of plasma products have improved, contamination with a very stable virus is still a possibility.
Levine PH; Blood Research Laboratory, Medical Center of Central; Massachusetts, Worcester 01605-2982.
This report reviews the natural history of hemophilia and the development of concentrates as the preferred form of treatment and discusses the nature of immune defect in persons with hemophilia. It examines the risk of hepatitis and effect of HIV infection on treatment protocols, and it surveys the status of the safet
Mozen MM; Biochemical Research & Development, Miles/Cutter Biological,; Berkeley, CA 94701.
This is a review of therapeutic plasma products viz., coagulation factor concentrates, immunoglobulins, volume expanders, and protease inhibitors , and the progress made in rendering them free from transmitting infectious virus. Problems associated with the developme
Machtinger L; Telford SR 3d; Inducil C; Klapper E; Pepkowitz SH; Goldfinger D; Department of Pathology and Laboratory Medicine, Cedars-Sinai; Medical Center, Los Angeles, CA 90048.
Babesiosis is a malaria-like parasitic disease causing subclinical or mild illness in most cases. Splenectomized patients, however, may experience a more severe course. Although generally responsive to antibiotic therapy, several cases of severe babesiosis refractory to appropriate antibiotic therapy have been reporte
Srinivas SK; Srinivas RV; Anantharamaiah GM; Compans RW; Segrest JP; Department of Medicine, University of Alabama at Birmingham; 35294.
Calmodulin (CaM), the major intracellular receptor for calcium, is involved in regulation of diverse cellular functions. Positively charged amphipathic helical segments have been identified as an important structural motif in the recognition of CaM by different CaM-activated enzymes and peptides. The carboxyl-terminal
Joseph S; Burke JM; Department of Microbiology and Molecular Genetics, Markey Center; for Molecular Genetics, University of Vermont, Burlington 05405.
We have applied in vitro selection methods to achieve a large increase in the catalytic activity of a hairpin ribozyme targeted against a highly conserved 14-nucleotide sequence within HIV-1 pol RNA. The substrate specificity was changed by mutating 8 bases within the substrate-binding domain of the parental (-)sTRSV
Anderson ED; Thomas L; Hayflick JS; Thomas G; Vollum Institute, Oregon Health Sciences University, Portland; 97201.
Furin is a membrane-associated calcium-dependent serine endoprotease that cleaves proproteins on the carboxyl side of the consensus sequence -Arg-X-Lys/Arg-Arg-. Using site-directed mutagenesis, a variant alpha 1-antitrypsin (alpha 1-AT) was constructed which contains in its reactive site -Arg-X-X-Arg-, the minimal se
Jeang KT; Berkhout B; Dropulic B; Molecular Virology Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.
The activity of a promoter is influenced by chromosomal and cell cycle/replication context. We analyzed the influences of integration and replication on transcription of the human immunodeficiency virus (HIV)-1 long terminal repeat (LTR). We found that one requirement for Tat trans-activated expression differed for in
Selvam MP; Mayner RE; Buck SM; Epstein JS; Laboratory of Immunochemistry, Food and Drug Administration,; Bethesda, MD.
A radioimmunoprecipitation assay that provides an alternative to the Western blot assay was developed for characterizing antibodies against human immunodeficiency virus type-2 (HIV-2). The assay is based on radioiodination of antigen using Bolton-Hunter reagent. The antigen consists of a soluble preparation of the NIH
Zipeto D; Baldanti F; Zella D; Furione M; Cavicchini A; Milanesi G; Gerna G; Istituto di Genetica Biochimica ed Evoluzionistica, Consiglio; Nazionale delle Richerche, Pavia, Italy.
Human cytomegalovirus (HCMV) DNA amplification by the polymerase chain reaction (PCR) was utilized previously for successful monitoring of HCMV infections in immunocompromised patients. However, analysis of an extended series of clinical samples revealed the relatively frequent pre
King JA; Ball JK; Regional Virus Laboratory, East Birmingham Hospital, UK.
An extremely sensitive and convenient microtiter plate solution hybridisation assay for the detection of HIV-1 PCR products was developed. The PCR product is labelled by direct incorporation of digoxigenin-dUTP and after denaturation is captured by a microtitre plate coated with a streptavidin-linked biotinylated prob
Mori H; Tanaka R; Yoshida S; Ono K; Yamanaka R; Hara N; Takeda N; Department of Neurosurgery, Niigata University, Japan.
We have previously identified the suppression of lymphocyte blastogenesis and the acceleration of growth of subcutaneous tumors by bilateral anterior hypothalamic lesions in rats. The present study was performed to clarify the changes in lymphocyte subsets and natural killer (NK) activity after making the lesions. The
Portegies P; Godfried MH; Hintzen RQ; Stam J; van der Poll T; Bakker M; van Deventer SJ; van Lier RA; Goudsmit J; Department of Neurology, Academic Medical Centre, Amsterdam, The; Netherlands.
Concentrations of soluble receptors for tumor necrosis factor (sTNFR-p55 and sTNFR-p75) and soluble T cell antigens CD25 and CD27 (sCD25 and sCD27) were measured in paired serum/cerebrospinal fluid (CSF) samples of 15 patients with AIDS dementia complex (ADC) and 15 HIV-infected co
Blanshard C; Ellis DS; Dowell SP; Tovey G; Gazzard BG; HIV/Genitourinary Medicine Department, Chelsea and Westminster; Hospital, London.
AIM--To identify and describe electron microscopic changes occurring in Enterocytozoon bieneusi in patients treated with albendazole. METHODS--Eighteen HIV seropositive patients with E bieneusi infection of the small intestine were treated with albendazole 400 mg twice a day for one month. Duodenal biopsy specimens ob
Patil PS; Bem C; Department of Pathology, School of Medicine, University of; Zambia, Lusaka.
AIMS--To study the value of wide needle (19 gauge) aspiration cytology in the diagnosis of lymph node disease in Zambia in the absence of a trained cytologist. METHODS--Patients (n = 304) referred for surgical biopsy of an enlarged peripheral lymph node were studied prospectively.
Knupp CA; Brater DC; Relue J; Barbhaiya RH; Department of Metabolism and Pharmacokinetics, Bristol-Myers; Squibb Company, Syracuse, New York 13221-4755.
The steady-state pharmacokinetics of didanosine (DDI) and ketoconazole (KET) were evaluated when the agents were administered alone or concurrently to patients seropositive for the human immunodeficiency virus. Using a randomized, three-way crossover design, multiple oral doses of DDI (375 mg twice daily for 4 days),
Su IJ; Tsai TF; Cheng AL; Chen CC; Department of Pathology, National Taiwan University Hospital and; College of Medicine, Taipei.
BACKGROUND: In addition to human T-lymphotropic virus (HTLV-I), the Epstein-Barr virus (EBV) has recently been demonstrated to be associated with cutaneous T-cell lymphoma (CTCL). OBJECTIVE: Our purpose was to investigate characteristic clinicopathologic features of the cutaneous lesions of EBV-associated T-cell malig
Kaplan MH; Sadick NS; McNutt NS; Talmor M; Coronesi M; Hall WW; Department of Medicine, North Shore University Hospital/Cornell; University Medical College, Manhasset, NY 11030.
BACKGROUND: Papulosquamous eruptions are common in HIV-1-infected patients. Acquired ichthyosis may occur after profound T-cell depletion. Intravenous drug users infected with HIV-1 can be coinfected with human lymphotropic virus II (HTLV-II). OBJECTIVE: We examined the relation between acquired ichthyosis and concomi
Itin PH; Lautenschlager S; Fluckiger R; Rufli T; Department of Dermatology, University of Basel, Switzerland.
Oral lesions have been observed since the beginning of the AIDS epidemic. The number of HIV-infected patients is still increasing, especially in the heterosexual population. Oral diseases in HIV-infected patients are often more difficult to diagnose because the clinical presentations may differ from the same diseases
The need for continuing nursing education in the area of HIV/AIDS care and prevention has intensified. Planning community-wide HIV/AIDS programs is a challenge. This article describes a strategy that was successful in consolidating multi-agency expertise and in establishing a framework for subsequent continuing educat
Nichols CM; Flaitz CM; Hicks MJ; Dental Branch, University of Texas Health Sciences Center,; Houston.
Kaposi s sarcoma is the most frequent malignant neoplasm in AIDS, occurring in about 10 percent of all risk groups. This study evaluates the effect of intralesional vinblastine on intraoral Kaposi s sarcoma in 24 HIV-positive, homosexual males with 82 lesions. Complete resolution occurred in nearly 70 percent of the c
Skoner DP; Whiteside TL; Wilson JW; Doyle WJ; Herberman RB; Fireman P; Department of Pediatrics, University of Pittsburgh, PA.
Patients with allergic rhinitis (AR), compared with nonallergic persons, have been reported to respond differently to a variety of stimuli, some of which are immunologic in nature. This study compared the systemic cellular immune responses to experimental rhinovirus (RV) 39 challenge in RV-39-seronegative AR (n = 20)
Mounanga M; Revangue BS; Fondation Jeanne-Ebori, Libreville, Gabon.
The authors tried to find out the incidence of HIV positive women in 634 deliveries in the two large maternity units in Libreville. The prevalence was 1.26% which is a net rise compared with previous figures in the same city, but remains lower than figures for other large cities in Central Africa. Transmission is main
Desai SS; McCarthy CK; Kestin A; Metzmaker JN; Department of Orthopaedics and Physical Rehabilitation,; University of Massachusetts Medical Center, Worcester 01655.
Gonzalez MH; Garst J; Nourbash P; Pulvirenti J; Hall RF Jr; Department of Orthopaedics, University of Illinois, Chicago.
A 4-year retrospective review of 59 consecutive upper extremity abscesses associated with drug abuse by injection is reported. There were 57 patients, with the most common location being the forearm. All abscesses were treated with incision, drainage, and intravenous antibiotics. Seventeen patients required more than
Cappell MS; Hassan T; Department of Medicine, UMDNJ-Robert Wood Johnson Medical School,; New Brunswick 08903-0019.
Patients with the acquired immunodeficiency syndrome (AIDS) can develop pancreatic disease from causes unrelated to AIDS as well as AIDS-specific lesions. AIDS-specific causes include opportunistic infection, AIDS-associated neoplasia, and medications used to treat complications of AIDS. Reported pancreatic opportunis
Farr RW; Walton C; Department of Medicine, West Virginia University, Morgantown; 26506-9163.
OBJECTIVE: To study the ability of a medical waste disposal process using chlorine dioxide to inactivate human immunodeficiency virus type 1 (HIV-1). DESIGN: Stock HIV-1 (HTLV-IIIB strain) was treated with chlorine dioxide under the following settings: cell culture medium alone, culture medium with 25% blood, culture
Drusano GL; Division of Clinical Pharmacology, Albany Medical College, NY; 12208.
It has been demonstrated that systemic exposure to antiretroviral agents drives both the therapeutic and the toxic effects seen in clinical trials. Consequently, it is necessary to determine plasma concentrations of drugs and their metabolites (and possibly intracellular concentrations) during the course of Phase 1 an
J Immunol. 1993 Nov 15;151(10):5123-34. Unique Identifier : AIDSLINE MED/94044737
Anderson SJ; Coleclough C; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38101.
Phorbol esters are known to induce a loss of CD4 from the surface of mouse and human T cells, presumably through activation of protein kinase C. Here we describe additional, calcium-dependent processes that remove CD4 and CD8 from the surface of T cells and thymocytes, and that differ from the protein kinase C-mediate
Catimel B; Wilson KM; Kemp BE; St. Vincent's Institute of Medical Research, Fitzroy, Victoria,; Australia.
The kinetics of the autologous red cell agglutination test for detecting circulating antibodies to HIV-1 were studied. Two monoclonal anti-red blood cell antibodies (1C3/86 and 10F7MN) were used to construct Fab-peptide conjugates for the test. Both antibodies recognize glycophorin alpha on the surface of erythrocytes
Ando Y; Tanigawa T; Ekuni Y; Ichijo M; Tohyama T; Department of Obstetrics and Gynecology, Nara Medical University,; Japan.
When pregnant women were tested for antibody to human T-cell leukemia virus-I, some were found to be positive although they had been negative during the previous pregnancy. In these women, HTLV-I infection was found from pedigree studies to have been acquired from their mothers rather than from their husbands. Further
Knight FR; Mackenzie DW; Evans BG; Porter K; Barrett NJ; White GC; Central Public Health Laboratory, London, U.K.
The incidence of infection with Cryptococcus neoformans in the United Kingdom during the years between 1953 and 1981 is compared with that between 1982 and 1991. The patients were those from whom samples were submitted to the PHLS Mycological Reference Laboratory (MRL), or those in who
Schuitemaker H; Meyaard L; Kootstra NA; Dubbes R; Otto SA; Tersmette M; Heeney JL; Miedema F; Department of Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red Cross Blood Transfusion Service, Amsterdam.
In asymptomatic human immunodeficiency virus (HIV) infection in humans, disturbed T cell functions such as anergy and programmed cell death, thought to result from inappropriate signaling by antigen-presenting cells due to HIV infection, precede increase in virus load, decline in CD4+ T cell numbers, and subsequent di
Perno CF; Bergamini A; Pesce CD; Milanese G; Capozzi M; Aquaro S; Thaisrivongs S; Tarpley WG; Zon G; D'Agostini C; et al; Department of Experimental Medicine, University of Rome Tor; Vergata, Italy.
Because of the importance of monocytes/macrophages (M/M) as an in vivo reservoir of human immunodeficiency virus (HIV), a study was done to investigate whether viral replication in chronically infected macrophages (HIV M/M) could be inhibited by various drugs, including U-75875, an inhibitor of HIV protease. HIV repli
Bagasra O; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, PA 19107.
Previous studies have shown that cocaine consumption alters the normal immune functions of animals. Several epidemiologic studies have indicated an association between cocaine consumption and an increased risk for AIDS. In the present studies, unstimulated peripheral blood mononuclear cells (PBMC) isolated from 8 heal
Glesby MJ; Moore RD; Chaisson RE; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.
To determine the prevalence, incidence, and effects on disease progression and survival of herpes zoster in patients with advanced human immunodeficiency virus (HIV) disease, data from a multicenter observational cohort study of 1044 patients with AIDS or AIDS-related complex (ARC) and CD4 cell count
Calabro ML; Luparello M; Grottola A; Del Mistro A; Fiore JR; Angarano G; Chieco-Bianchi L; Institute of Oncology, University of Padua, Italy.
A preliminary screening of 511 persons at risk for AIDS living in southeastern Italy disclosed 20 cases of seroreactivity to human T lymphotropic viruses (HTLV). To verify and type the HTLV infection among these subjects, confirmatory serologic tests, polymerase chain reaction (PCR)
Hagberg L; Dotevall L; Norkrans G; Larsson M; Wachter H; Fuchs D; Dept. of Infectious Diseases, University of Goteborg, Sweden.
Cerebrospinal fluid (CSF) neopterin levels were determined by RIA in individuals with central nervous system (CNS) or human immunodeficiency virus (HIV) infections and in healthy controls. The mean CSF neopterin concentrations were 63.0 nmol/L in 15 patients with acute bacterial meningitis, 54.9 nmol/L in 15 patients
Boldt-Houle DM; Rinaldo CR Jr; Ehrlich GD; Department of Pathology, University of Pittsburgh School of; Medicine, Pennsylvania 15261.
A cross-sectional PCR analysis of the TCR V beta repertoires in HIV-1 seronegative controls and HIV-1 infected individuals with either clinically or immunologically defined AIDS [1] was performed to examine the proposed superantigen model for HIV-1 pathogenesis. In contrast to previous reports, we find neither uniform
Buranasin P; Kunakorn M; Petchclai B; Raksakait K; Wichukchinda N; Jirapinyo M; Thongcharoen P; Maharaj Hospital, Nakhon Ratchasima, Thailand.
There is increasing evidence of vertical transmission of HIV-1 to infants through breast feeding of milk from HIV-1 infected mothers. It has been postulated that transmission occurs mainly via ingestion of infected cells in breast milk and colostrum. In this study, detection of HIV-1 proviral DNA was used to prove tha
Tori CD; Amawattana T; California School of Professional Psychology, Berkeley/Alameda.
Knowledge about AIDS among: (a) 89 individuals involved in prostitution related occupations, (b) 465 university students, and (c) 220 Thais living in the United States was assessed to further evaluate the efficacy of Thailand s AIDS educational programs. While the average number of ite
An increased ratio of T helper type 2 (Th2)- vs Th1-like cells contributes to the immune dysregulation in allergic disease situations and in many chronic infections, including AIDS. Th2-type immune responses are characterized by Th cells that produce increased levels of interleukin-4 (IL-4) and decreased levels of int
Li L; Zhang X; Constantine NT; Smialek JE; Office of the Chief Medical Examiner, State of Maryland,; Baltimore.
HIV, HBV, HCV, and HTLV show similar modes of transmission and infection is frequently identified in certain population groups. The seroprevalence of these infectious agents and interrelation in forensic autopsy populations are described here. A total of 414 serum samples were collected sequentially from autopsy cases
J Med Virol. 1993 Aug;40(4):291-306. Unique Identifier : AIDSLINE GENBANK/M86771
Muller HM; Pfaff E; Goeser T; Theilmann L; Department of Internal Medicine, University of Heidelberg,; Federal Republic of Germany.
Heterogeneity of hepatitis C viral (HCV) genomes of several isolates from different countries has been reported, but there is little information on HCV isolates for the Federal Republic of Germany . Therefore, the nucleotide (nt) and deduced amino acid (aa) sequences of interesting
J Med Virol. 1993 Sep;41(1):79-84. Unique Identifier : AIDSLINE MED/94045592
Brown DR; Bryan JT; Wools K; Rodriguez M; Tyring S; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202.
Immunohistochemical assays for human papillomavirus (HPV) L1 protein, using antiserum directed against the L1 major capsid protein of bovine papillomavirus (anti-BPV serum), were performed on 101 condylomata acuminata biopsy samples from 47 men (40 of whom had intact cell mediated immunity [CMI], and 7 with conditions
Paris A; Strukelj B; Renko M; Turk V; Pukl M; Umek A; Korant BD; Department of Biochemistry, Jozef Stefan Institute, Ljubljana,; Slovenia.
In order to find new effective HIV protease inhibitors , two diterpenes (carnosic acid [1] and carnosol [5]) were isolated from rosemary (Rosmarinus officinalis L.), and rosmanol [2] and semisynthetic derivatives (7-O-methylrosmanol [3], 7-O-ethylrosmanol [4], and 11
Kataoka A; Imai H; Inayoshi S; Tsuda T; Third Department of Internal Medicine, Oita Medical University,; Japan.
The efficacy of intermittent high-dose vitamin C therapy was evaluated in seven patients with HTLV-I-associated myelopathy (HAM). All HAM patients responded well to this therapy without serious side effects. Grade of disability score improved at 9.7 (SD 5.8) months after the therapy from 7.1 (3.3) to 3.6 (2.0) (p
Confort-Gouny S; Vion-Dury J; Nicoli F; Dano P; Donnet A; Grazziani N; Gastaut JL; Grisoli F; Cozzone PJ; Centre de Resonance Magnetique Biologique et Medicale,; URA-CNRS 1186, Faculte de Medecine, Marseille, France.
We conducted an extended clinical evaluation of localized proton magnetic resonance spectroscopy (MRS) of the brain, performed on various brain diseases using short stimulated echo times. Pathologies studied were mainly multiple sclerosis, stroke, leukoaraiosis, AIDS-related leukoencephalopathies and glial tumors. Oth
Yoshida Y; Sakamoto Y; Yoshimine A; Maruyama Y; Ikegami N; Inose M; Imamura H; Nakahara K; Nakagawa M; Osame M; College of Allied Medical Sciences, Kagoshima University, Japan.
Among 201 patients diagnosed with HAM/TSP at Kagoshima University, 21 juvenile onset patients had manifested clinical signs and symptoms at less than 15 years of age. They appeared to have common characteristics such as short stature and slight mental retardation. These signs prompted us to investigate five of them en
Everall I; Luthert P; Lantos P; Department of Psychiatry, Institute of Psychiatry, London, United; Kingdom.
Over the past decade it has been realized that HIV affects the central nervous system, and various investigations have illuminated the spectrum of neuropathology in AIDS. One major advance has been the demonstration that there is substantial neuronal loss, which appears independent of the HIV-associated inflammatory l
Lawrence VA; Gafni A; Kroenke K; Department of Medicine, University of Texas Health Science Center; at San Antonio 78284-7879.
Universal precautions are officially recommended to prevent HIV transmission in health care settings but for elective surgery some advocate routine preoperative HIV testing. These strategies have not been tested in clinical trials but universal precautions are very expensive and not cost-effective. Thus, for elective
PURPOSE. Limited documentation is found on dental hygienists attitudes toward acquired immunodeficiency syndrome (AIDS) patients and their knowledge and practice of clinical infection control to prevent disease transmission to themselves and their patients. The purpose of this paper was to survey practicing Pennsylva
Duffy PR; University of Arizona, Department of Family & Community Medicine,; Tucson.
The HIV/AIDS epidemic has posed unprecedented challenges for nurse faculty. The purpose of this article is to describe a model for the integration of HIV/AIDS content into health professions curricula over time, specifically into baccalaureate nursing programs. The model was developed through nurse faculty experience
Ellis E 3d; Sinn DP; Department of Oral and Maxillofacial Surgery, University of Texas; Southwestern Medical Center, Dallas 75235-9109.
Homologous bone grafts were used in 135 maxillofacial surgical procedures, including acute midfacial fracture repair (n = 77), elective osteotomies of the facial bones (n = 35), secondary correction of traumatic deformities (n = 6), mandibular reconstruction (n = 10), facial bone augmentation (n = 5), and reconstructi
Marx RE; Carlson ER; Department of Surgery, University of Miami School of Medicine,; FL.
Oral and maxillofacial reconstructive surgeons using allogeneic tissues have expressed justifiable concern over the safety of these tissues as they relate to the transmission of infectious disease. This report reviews cases of infectious disease transmission from inadequately screened donors of allogeneic tissues, as
Rossi L; Brandi G; Fraternale A; Schiavano GF; Chiarantini L; Magnani M; Istituto di Chimica Biologica G. Fornaini, University of Urbino,; Italy.
The antiretroviral activity of many nucleoside analogues depends not only on their ability to inhibit the virus reverse transcriptase but also on the specific cellular pools of natural deoxynucleosides and on the level of the enzymes responsible for their phosphorylation. In an attempt to overcome these limitations, w
Saukkonen JJ; Kornfeld H; Berman JS; Pulmonary Center, Boston University School of Medicine,; Massachusetts.
CD8+ cytotoxic T lymphocytes (CTLs) in human immunodeficiency virus (HIV) patients have defects in cytolytic ability and proliferative potential. The surface receptor CD28 is important in regulating antigen-specific responses to T cells. We hypothesized that activated CD8+ CTLs in HIV patients would have altered expre
Arya SK; Sadaie MR; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.
Analysis of the phenotype of the molecular clones of cytopathic and fusogenic, noncytopathic and nonfusogenic, and chimeric proviruses of human immunodeficiency virus type 2 (HIV-2) suggests that the major determinant of the attenuated fusogenicity and cytopathicity of HIV-2 was located in the 3 -half of the genome, w
Richardson D; Liou SH; Kahn JO; Department of Biostatistics, Harvard School of Public Health,; Boston, Massachusetts.
An analysis is presented that promotes the use of uric acid levels as an indicator of patients didanosine (ddI) use. Logistic regression techniques were used on data from two test groups that best represent patients entered on ACTG protocols 116A and 116B/117. Two classification functions resulted that are based on se
Vagnucci AH; Winkelstein A; Department of Medicine, Montefiore University Hospital,; Pittsburg, Pennsylvania 15213.
Glucocorticoids (Gc) are known to modulate protein synthesis by immune cells through binding to a specific receptor (GcR). We outlined the circadian rhythm of plasma cortisol, ACTH, of the peripheral blood mononuclear cells (PBMC isolated by Ficoll-Hypaque technique), and of their subsets CD4, CD8 in 14 asymptomatic H
Garland FC; Garland CF; Gorham ED; Miller MR; Brodine SK; Fallon A; Balazs LL; Division of Epidemiology, Naval Health Research Center, San; Diego, California 92186-5122.
The Navy population is centered around 19 U.S. home ports and several inland duty stations. This is a study of variation in human immunodeficiency virus (HIV) seroconversions in Navy enlisted men by location in the United States , based on 949,570 enzyme-linked immunosorbent assays and
Harris NV; Thiede H; McGough JP; Gordon D; Seattle-King County Department of Public Health, Washington; 98104.
Among injection drug users (IDUs) entering drug treatment in King County, Washington between 1988 and 1991, we investigated HIV seroprevalence in relationship to demographic, sexual, and drug-use characteristics. Eighty-two of 3,039 (2.7%) IDUs tested HIV positive. Gay or bisexual men had the highest HIV prevalence (3
A consensus has been reached on the classification of the oral manifestations of HIV infection and their diagnostic criteria, based on presumptive and definitive criteria. The former relate to the initial clinical appearance of the lesion and the latter are often the result of special investigations. Candidiasis, hair
Regezi JA; MacPhail LA; Daniels TE; Greenspan JS; Greenspan D; Dodd CL; Lozada-Nur F; Heinic GS; Chinn H; Silverman S Jr; et al; Department of Stomatology, School of Dentistry, University of; California, San Francisco 94143-0424.
Microscopic diagnosis of early Kaposi s sarcoma continues to be a challenge to the pathologist, as does the identification of bacillary angiomatosis (BA) which may have a similar appearance. 120 oral Kaposi s sarcoma (KS) biopsies submitted to the UCSF oral pathology service
Porter SR; Scully C; University Department of Oral Medicine, Pathology and; Microbiology, Bristol Dental School and Hospital, England.
The orofacial manifestations of 10 non-HIV-infected children with primary defects of cell mediated immunity are reported. Oral candidiasis was observed in 80% of patients, with oral ulceration present in 50%. Other oral manifestations included enamel hypoplasia, angular stomatitis, oral purpura and recurrent herpetic
Pergami A; Gala C; Burgess A; Durbano F; Zanello D; Riccio M; Invernizzi G; Catalan J; Department of Psychological Medicine, Chelsea and Westminster; Hospital, Charing Cross & Westminster Medical School (University; of London), U.K.
The aim of the investigation was to study the prevalence of current and past psychiatric morbidity and psychosocial problems in HIV seropositive (HIV +ve) asymptomatic women. A cross-sectional controlled study including 57 HIV +ve women belonging to CDC group II and III (43 intravenous drug users and 14 non-IVDUs hete
Ordi J; Selva A; Monegal F; Porcel JM; Martinez-Costa X; Vilardell M; Department of Internal Medicine, Vall d'Hebron General Hospital,; Barcelona, Spain.
OBJECTIVE. To evaluate the dependence on the serum cofactor of anticardiolipin antibodies (aCL) in infectious and autoimmune diseases. We also studied their correlation with some clinical manifestations, specially thrombosis. METHODS. aCL were determined with a standard ELISA method, and a modified ELISA in which we s
Belmonte MA; Garcia-Portales R; Domenech I; Fernandez-Nebro A; Camps MT; De Ramon E; Department of Internal Medicine, Regional Hospital of S.A.S.,; Malaga, Spain.
We describe 3 cases of human immunodeficiency virus (HIV) infected patients with antiphospholipid antibodies (aPL) in serum who developed avascular necrosis (AVN), an association that to our knowledge, has rarely been described. Given that the 3 patients had stopped their intravenous drug addiction 2 years before the
Gommon N; Bor R; Psychology Division, City University, Northampton Square, London.
Undergraduate students at an inner London university were surveyed at the beginning of 1992 about their basic knowledge regarding HIV/AIDS, HIV transmission and views about the HIV antibody test. Although they demonstrated good knowledge about HIV/AIDS and routes of transmission, a proportion had had unprotected inter
J Med Chem. 1993 Oct 15;36(21):3103-12. Unique Identifier : AIDSLINE MED/94046940
Rosowsky A; Mota CE; Wright JE; Freisheim JH; Heusner JJ; McCormack JJ; Queener SF; Dana-Farber Cancer Institute, Harvard Medical School, Boston,; Massachusetts 02115.
A series of eight previously undescribed 2,4-diaminothieno[2,3-d]pyrimidine analogues of the potent dihydrofolate reductase (DHFR) inhibitors trimetrexate (TMQ) and piritrexim (PTX) were synthesized as potential drugs against Pneumocystis carinii and Toxoplasma gondii, which are major causes of severe opportunistic in
J Med Chem. 1993 Oct 15;36(21):3113-9. Unique Identifier : AIDSLINE MED/94046941
Wonacott A; Cooke R; Hayes FR; Hann MM; Jhoti H; McMeekin P; Mistry A; Murray-Rust P; Singh OM; Weir MP; Protein Structure Group, Glaxo Group Research Limited, Greenford,; Middlesex, United Kingdom.
The binding modes of a series of penicillin-derived C2 symmetric dimer inhibitors of HIV-1 proteinase were investigated by NMR, protein crystallography, and molecular modeling. The compounds were found to bind in a symmetrical fashion, tracing and S-shaped course through the active site, with good hydrophobic interact
J Med Chem. 1993 Oct 15;36(21):3120-8. Unique Identifier : AIDSLINE MED/94046942
Humber DC; Bamford MJ; Bethell RC; Cammack N; Cobley K; Evans DN; Gray NM; Hann MM; Orr DC; Saunders J; et al; Department of Medicinal Chemistry, Glaxo Group Research Ltd.,; Greenford, Middlesex, United Kingdom.
The C2-symmetric diester 1 was identified by random screening as a novel inhibitor of HIV-1 proteinase. This led to the preparation of a series of related more potent amides from readily accessible penicillins. Many of the compounds showed potent antiviral activity in HIV-1-infected MT-4 cells and an ability to inhibi
J Med Chem. 1993 Oct 15;36(21):3129-36. Unique Identifier : AIDSLINE MED/94046943
Holmes DS; Bethell RC; Cammack N; Clemens IR; Kitchin J; McMeekin P; Mo CL; Orr DC; Patel B; Paternoster IL; et al; Department of Medicinal Chemistry II, Glaxo Group Research; Limited, Greenford, Middlesex, United Kingdom.
A series of HIV-1 proteinase inhibitors was synthesized based upon a single penicillin derived thiazolidine moiety. Reaction of the C-4 carboxyl group with (R)-phenylalaninol gave amide 10 which was a moderately potent inhibitor of HIV-1 proteinase (IC50 = 0.15 microM). Further modifications based on molecular modelin
J Med Chem. 1993 Oct 29;36(22):3230-9. Unique Identifier : AIDSLINE MED/94046959
Velazquez S; San-Felix A; Perez-Perez MJ; Balzarini J; De Clercq E; Camarasa MJ; Instituto de Quimica Medica (C.S.I.C.), Madrid, Spain.
Several purine and purine-modified analogues of the new lead anti-HIV-1 agent [[2 ,5 -bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl] thymine]-3 -spiro-5 -(4 -amino-1 ,2 -oxathiole 2 ,2 -dioxide) (TSAO-T) have been prepared and evaluated as inhibitors of HIV-1-induced cytopathicity. Reaction of O-mesylcyan
J Med Ethics. 1993 Sep;19(3):175-82. Unique Identifier : AIDSLINE MED/94047000
Ostini R; Bammer G; Dance PR; Goodin RE; Australian National University, Canberra.
In response to widespread concern about illegal drug use and the associated risk of the spread of HIV/AIDS, a study was undertaken to examine whether it was, in principle, feasible to conduct a trial providing heroin to dependent users in a controlled manner. Such a trial involves real ethical issues which are examine
J Med Primatol. 1993 Jun;22(4):253-6. Unique Identifier : AIDSLINE MED/94047037
Hillyer CD; Klumpp SA; Hall JM; Lackey DA 3d; Ansari AA; McClure HM; Department of Pathology, Emory University School of Medicine,; Atlanta, Georgia 30338.
We attempted to define the etiology of anemia in SIV-infected rhesus macaques. Bone marrow culture showed significantly decreased (75% reduction) burst forming unit-erythroid (BFU-E) growth in end-stage SIV+ sick animals. Direct antiglobulin tests (DAT) were positive in nine of 35 SIV+ well and 14 of 14 SIV+ sick monk
In this study peripheral blood mononuclear cells were tested for T lymphocyte subpopulations, interleukin-2 receptor (IL-2R) and HLA-DR antigen by monoclonal antibodies in 14 LN patients. In comparison with normal controls, 14 LN patients showed a decrease of T4 lymphocyte (0.01
Huang LM; Jeang KT; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Expression of the human immunodeficiency virus type 1 (HIV-1) is strongly activated by Tat. The proper action of Tat requires three elements: TATAA, TAR, and upstream motifs in the HIV-1 long terminal repeat. We show here that the correct spatial arrangement among Tat, Sp1, and TATAA crucially influences HIV expressio
Murphy KM; Sweet MJ; Ross IL; Hume DA; Centre for Molecular Biology and Biotechnology, University of; Queensland, Australia.
The RAW264 murine macrophage cell line was used as a model to examine the role of the tat and nef gene products in the transcription regulation of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in macrophages. Contrary to claims that the activity of the HIV-1 LTR responds poorly in rodent c
Tsuchiya H; Fujii M; Niki T; Tokuhara M; Matsui M; Seiki M; Department of Molecular Virology and Oncology, Cancer Research; Institute, Japan.
We have shown that Tax1 of human T-cell leukemia virus type 1 stimulates the expression of several cellular immediate-early genes (M. Fujii, T. Niki, T. Mori, T. Matsuda, M. Matsui, N. Nomura, and M. Seiki, Oncogene 6:1023-1029, 1991). In this study, the 5 -flanking region of the human fra-1 gene, which is a Tax1-indu
Polacino PS; Liang HA; Firpo EJ; Clark EA; Regional Primate Research Center, University of Washington; Medical Center SJ-50, Seattle.
The relationship between T-cell activation and early events in the replication cycle of simian immunodeficiency virus (SIV) was analyzed in resting T lymphocytes from macaques. We used the polymerase chain reaction to detect an early product of reverse transcription (R/U5) and almost complete viral DNA (long terminal
Weiss CD; White JM; Department of Pharmacology, School of Medicine, University of; California, San Francisco 94143-0450.
We generated Chinese hamster ovary cell lines that stably express wild-type, secreted, and glycosylphosphatidylinositol (GPI)-anchored envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1). The cells expressing wild-type Env (WT cells) express both the precursor gp160 and the mature gp120/gp41 and readi
Donzella GA; Jonsson CB; Roth MJ; Department of Biochemistry, Robert Wood Johnson Medical School,; University of Medicine and Dentistry of New Jersey, Piscataway; 08854-5635.
The disintegration activity of Moloney murine leukemia virus (M-MuLV) integrase (IN) was investigated through structural and sequence modifications of a Y substrate that resembles an integration intermediate. The Y substrates, constructed from individual oligonucleotides, contain a single viral long terminal repeat (L
Berkowitz RD; Luban J; Goff SP; Department of Biochemistry and Molecular Biophysics, College of; Physicians and Surgeons, Columbia University, New York, New York; 10032.
Packaging of retroviral genomic RNA during virion assembly is thought to be mediated by specific interactions between the gag polyprotein and RNA sequences (often termed the psi or E region) near the 5 end of the genome. For many retroviruses, including human immunodeficiency virus type 1 (HIV-1), the portions of the
Paxton W; Connor RI; Landau NR; Aaron Diamond AIDS Research Center, New York, New York.
The product of the vpr open reading frame of human immunodeficiency virus type 1 (HIV-1) is a 15-kDa, arginine-rich protein that is present in virions in molar quantities equivalent to that of Gag. We report here the results of our investigations into the mechanism by which Vpr is incorporated into virions during asse
Lenburg ME; Landau NR; Aaron Diamond AIDS Research Center, New York, New York.
Two functions have been attributed to the product of the human immunodeficiency virus type 1 vpu open reading frame: it increases virion release from infected cells and induces rapid degradation of CD4 shortly after its synthesis. In the absence of Vpu, newly synthesized gp160 and CD4 associate in the endoplasmic reti
Fitzgibbon JE; Farnham AE; Sperber SJ; Kim H; Dubin DT; Department of Molecular Genetics and Microbiology, University of; Medicine and Denstistry of New Jersey-Robert Wood Johnson Medical; School, Piscataway 08854.
Multiple mutations were found in the human immunodeficiency virus pol gene following treatment of an AIDS patient with antiretroviral drugs. After approximately 2.5 years of monthly alternating therapy with 3 -azido-3 -deoxythymidine ( AZT ) and 2 ,3 -d
Gitlin SD; Dittmer J; Shin RC; Brady JN; Laboratory of Molecular Virology, National Cancer Institute,; Bethesda, Maryland 20892.
Transcription regulation of the oncogenic retrovirus human T-lymphotropic virus type I (HTLV-I) involves the composite activity of both viral and cellular transcription factors. The HTLV-I transforming protein, Tax1, modulates the activity of several cellular transcription factors, upregulating the level of viral gene
Fridell RA; Partin KM; Carpenter S; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.
Several members of the lentivirus family of complex retroviruses have been shown to encode proteins that are functionally equivalent to the Rev posttranscriptional regulatory protein of human immunodeficiency virus type 1 (HIV-1). Furthermore, the domain organization of HIV-1 Rev, featuring a highly basic N-terminal R
Saksela K; Muchmore E; Girard M; Fultz P; Baltimore D; Rockefeller University, New York, New York 10021-6399.
We have examined human immunodeficiency virus type 1 (HIV-1) infection in chimpanzees by analyzing HIV-1 DNA and RNA in lymph nodes and peripheral mononuclear cells (PBMCs). Like certain asymptomatic HIV-infected persons, these chimpanzees had no detectable viral replication in their PBMCs. However, viral replication
Demarchi F; D'Agaro P; Falaschi A; Giacca M; International Centre for Genetic Engineering and Biotechnology,; Trieste.
The regulation of the rate of transcription of human immunodeficiency virus type 1 is mainly exerted through the long terminal repeat (LTR) at the 5 end of the provirus. A large number of cis-acting regulatory elements have been identified in the LTR by in vitro binding studies; the biological role of these sites wit
The tax gene sequence of human T-cell lymphotropic virus type II isolate G12 (HTLV-IIG12) was found to encode an extended Tax protein when compared with that of HTLV-IIMoT. In vitro transcription-translation of the HTLV-IIG12 tax gene produced a 40-kDa Tax protein that specifically reacted with serum specimens from HT
Franchini G; Mulloy JC; Koralnik IJ; Lo Monico A; Sparkowski JJ; Andresson T; Goldstein DJ; Schlegel R; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892.
The human T-cell leukemia/lymphotropic virus type I (HTLV-I) induces T-cell leukemia and transforms human T cells in vitro. A recently identified protein with a molecular weight of 12,000 (12K) (p12I), encoded by single- and double-spliced mRNAs transcribed from the 3 end of the HTLV-I genome, has been shown to local
Trujillo JR; McLane MF; Lee TH; Essex M; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115.
Immunologically cross-reactive proteins in the human brain that resemble the V3 loop of human immunodeficiency virus type 1 (HIV-1) gp120 have been identified. When several homogenized tissues from normal brains were used, a monoclonal antibody raised against amino acids 308 to 320 of the V3 loop reacted with three pr
Suzuki K; Makino M; Okada Y; Kinoshita J; Yui R; Kanazawa H; Asakura H; Fujiwara M; Mizuochi T; Komuro K; Department of Blood Products, National Institute of Health,; Tokyo, Japan.
BACKGROUND: Sjogren s syndrome (SS) is characterized by lymphocytic infiltration into, and destruction of exocrine glands, resulting in dryness of the mouth and eyes. The disease is considered to have an autoimmune etiology, however, its etiopathogenesis remains largely unknown. Recently, retrovirus is suggested to pa
Wrone-Smith T; Cankovic M; VanBuren E; Lerman S; Wayne State University School of Medicine, Department of; Immunology and Microbiology, Detroit, MI 48201-1998.
Lymphomas (formerly reticulum cell sarcomas (RCS)) which develop spontaneously in SJL mice are a murine counterpart of human low grade B-cell non-Hodgkin s lymphoma . Tumor cells stimulate proliferation of syngeneic CD4+ T-lymphocytes which secrete cytokines required for tumor growt
A 60-year-old woman from the town of Mashhad in northeastern Iran developed cardiac failure due to aortic and mitral regurgitations which needed cardiac valve replacement. Histopathological study of the valves revealed a T-cell non-Hodgkin s lymphoma
Med Biol Eng Comput. 1993 Jul;31 Suppl:S12-6. Unique Identifier : AIDSLINE MED/94048311
Jordan MM; Li P; National Institute for Biological Standards & Control, Potters; Bar, Herts, UK.
An information system has been established at the National Institute for Biological Standards & Control for the exchange of knowledge in AIDS research, particularly in relation to vaccine design. This system, the AIDS information exchange link (Ariel), is designed to act as a central store of relevant information f
Med Clin (Barc). 1993 Oct 2;101(10):365-7. Unique Identifier : AIDSLINE MED/94048340
Pulido Ortega F; Rubio Garcia R; Salmeron Beliz OJ; Castilla Castellano V; Carnevali Ruiz D; Perez-Herrero JR; del Palacio Medel A; Unidad de Infeccion VIH, Hospital 12 de Octubre, Madrid.
BACKGROUND: The coexistence of syphilis and infection by the human immunodeficiency virus (HIV) appears to modify the natural history of both diseases. The aim of this study was to know the prevalence of syphilis in a population of patients with HIV infection, the possible association with certain risk practices and t
Med Clin (Barc). 1993 Oct 9;101(11):421-3. Unique Identifier : AIDSLINE MED/94048357
Fernandez B de Quiros J; Telenti M; Fernandez Castro A; Mateos V; Arnaez Moral E; Servicio de Medicina Interna, Hospital General de Asturias,; Oviedo.
Amphotericin is a powerful antifungal agent of high toxicity. Encapsulation in liposomes has led to new perspectives although clinical experience is still slight. Four patients, who were neither carriers of antibodies against the human immunodeficiency virus nor neutropenic, diagnosed of meningeal cryptococcosis, pleu
Med Clin (Barc). 1993 Oct 23;101(13):505-14. Unique Identifier : AIDSLINE MED/94048388
Valencia E; Soriano V; Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas, Centro Nacional de; Investigaciones Clinicas y Medicina Preventiva, Instituto de; Salud Carlos III, Madrid.
Med Clin (Barc). 1993 Oct 30;101(14):525-9. Unique Identifier : AIDSLINE MED/94048398
Chaves F; Dronda F; Gonzalez Lopez A; Fernandez Gonzalez F; Catalan S; Unidad de Enfermedades Infecciosas-Microbiologia, Hospital; General Penitenciario, Madrid.
BACKGROUND: Tuberculosis continues to be a disease of great importance in Spain with few data known on prison populations. In the present study an analysis of the incidence and characteristics of tuberculosis in the prison population people is done. METHODS: The General Penitentiary
Med Clin (Barc). 1993 Oct 30;101(14):534-7. Unique Identifier : AIDSLINE MED/94048400
Dronda F; Chaves F; Gonzalez Lopez A; Catalan S; Fernandez Gonzalez F; Unidad de Enfermedades Infecciosas-Microbiologia, Hospital; General Penitenciario, Madrid.
BACKGROUND: Since the appearance of AIDS, bacteremia by Mycobacterium tuberculosis is an event described with ever greater frequency. The isolation of M. tuberculosis in blood cultures in patients coinfected by the human immunodeficiency virus and M. tuberculosis may vary the initial clinical diagnosis and confirm the
Med Clin North Am. 1993 Nov;77(6):1253-62. Unique Identifier : AIDSLINE MED/94048413
Peloquin CA; Infectious Disease Pharmacokinetics Laboratory, National Jewish; Center for Immunology and Respiratory Medicine, Denver, Colorado.
The management of MDR-TB requires that the clinician become familiar with the second-line antimycobacterial agents. These drugs are generally less potent and frequently more toxic than isoniazid and rifampin. Because they are less active, innovative dosing schedules may allow us to take advantage of the few strengths
Med Clin North Am. 1993 Nov;77(6):1263-75. Unique Identifier : AIDSLINE MED/94048414
Miller B; Division of Tuberculosis Elimination, Centers for Disease Control; and Prevention, Atlanta, Georgia.
TB is the most prevalent infection in the world. The emergence of the HIV epidemic has dramatically increased the risk of developing clinical TB in infected persons, substantially increasing TB rates globally. Preventive therapy with INH for 6 to 12 months substantially reduces the risk of developing clinical TB in pe
Med Clin North Am. 1993 Nov;77(6):1335-51. Unique Identifier : AIDSLINE MED/94048419
Jacobs RF; Starke JR; Department of Pediatrics, University of Arkansas for Medical; Sciences.
The dramatic resurgence and increase in the total number of cases of tuberculous infection and disease in children is alarming in the United States . With poverty, poor access to health care, overcrowding (predominantly in inner-city areas), and an increase in immigration from areas wit
Med Clin North Am. 1993 Nov;77(6):1369-90. Unique Identifier : AIDSLINE MED/94048421
Barnes PF; Le HQ; Davidson PT; Department of Medicine, University of Southern California School; of Medicine, Los Angeles.
Tuberculosis is the most common opportunistic infection in patients with HIV infection worldwide and is the only one that is transmissible to others by the respiratory route. Tuberculosis is curable and preventable. Early detection of tuberculosis disease and infection in individuals with or at risk for HIV infection
Med Clin North Am. 1993 Nov;77(6):1391-409. Unique Identifier : AIDSLINE MED/94048422
Kent JH; Division of Tuberculosis Elimination, National Center for; Prevention Services, Centers for Disease Control and Prevention,; Atlanta, Georgia.
There has been a significant increase in the number of cases of MDR-TB in the United States . Although cases of MDR-TB have been reported from many areas of the country, the majority of the cases are concentrated in large urban areas. MDR-TB is difficult and expensive to treat. CDC has
Bwire R; Kawuma HJ; St Francis Leprosy Centre, Buluba, Jinja, Uganda.
In this study a 28-year-old female with both BL leprosy and HIV infections is discussed. Her clinical progress was followed until she completed MDT. During this period she developed recurrent reactional episodes, nerve damage and intercurrent illnesses--some of which might have been due to steroids.
Med Law. 1993;12(3-5):439-43. Unique Identifier : AIDSLINE MED/94049006
Solursh LP; Solursh DS; Meyer CA Jr; Department of Veterans Affairs Medical Center, Augusta, Georgia.
Despite the growing frequency of treatment-resistant STDs, North American literature and practice continue to stress repression and to evidence denial of prison sexuality. The authors outline their observations concerning prison sex, including officer-inmate sex. (Since this article was submitted, officer-inmate sex h
Med Hypotheses. 1993 Aug;41(2):115-7. Unique Identifier : AIDSLINE MED/94049327
Mitchell RB
Based upon a literature survey, this paper outlines the argument that Treponema pallidum may be the etiologic agent of AIDS. AIDS and syphilis have similar epidemiology, immunology and pathologies. In addition, the current methods of detecting and treating syphilis are inadequate. The similarities between syphilis and
Med J Aust. 1993 Nov 15;159(10):672-7. Unique Identifier : AIDSLINE MED/94049351
MacIntyre CR; Dwyer B; Streeton JA; Health and Community Services Victoria, Infectious Diseases Unit,; Melbourne.
AIMS: To describe the epidemiology of Mycobacterium tuberculosis (MTb) in Victoria, Australia . METHODS: We analysed data from the Victorian Mycobacterium Reference Laboratory database and MTb notifications to Health and Community Services Victoria, for the period 1948 to 1992. R
Stark K; Warnecke C; Brinkmann V; Gelderblom HR; Bienzle U; Pauli G; Landesinstitut fur Tropenmedizin, Berlin, Germany.
To assess the sensitivity and specificity of HIV antibody detection in saliva we tested matched serum and saliva samples from HIV-infected and uninfected individuals. Saliva specimens were collected by two different devices of the Salivette system and stored at different temperatures. Samples were tested for HIV antib
Med War. 1993 Jul-Sep;9(3):234-41. Unique Identifier : AIDSLINE MED/94049429
Wakhweya AM; IPPNW Uganda, Makerere Medical School, Kampala.
This article gives a personal view of the health situation in a typical country in the South. Uganda is a country which is well endowed with natural resources, as are many countries in the South, but is plagued by poverty, conflict, endemic infectious diseases and, more recently, d
Piluso S; Ficarra G; Orsi A; Gaglioti D; Pierotti P; Orlando S; Institute of Odontology and Stomatology, University of Florence,; Italy.
This study examines the clinical aspects of HIV-associated periodontal lesions and the prevalence of periodontal pathogens. Subgingival plaque samples were taken from 55 subjects in six study groups: 1) HIV-seropositive patients with gingivitis, 2) necrotizing gingivitis, 3) periodontitis or 4) with health periodontiu
The need to train nurses to care for people with acquired immune deficiency syndrome (AIDS) is an important one. The need, also, to help them to develop counselling skills in this field is also vital. This paper reports the responses of 21 workers in the AIDS field (including nurse educators and teachers) to the quest
During the 1980s, human immunodeficiency virus (HIV) infection emerged as a leading cause of death in the United States (1). In 1992, HIV infection became the number one cause of death among men aged 25-44 years. This report updates national trends in deaths caused by HIV infection for
Street outreach programs for human immunodeficiency virus (HIV) prevention are designed to deliver HIV prevention messages, materials, and referral services to high-risk persons outside of traditional health-care and drug-treatment clinics. The Acquired Immunodeficiency Syndrome (AIDS) Evaluation of Street Outreach Pr
Human immunodeficiency virus (HIV) counseling and testing are important components of the public health effort to contain the acquired immunodeficiency syndrome (AIDS) epidemic. Project RESPECT is a multicenter randomized trial being conducted by CDC at five sexually transmitted disease (STD) clinics to evaluate the e
Keilbaugh SA; Hobbs GA; Simpson MV; Department of Biochemistry and Cell Biology, State University of; New York, Stony Brook 11794-5215.
A strategy for preventing or delaying the peripheral neuropathy induced by 2 ,3 -dideoxycytidine ( ddC ) therapy in patients with acquired immunodeficiency syndrome was suggested by findings, in two lab
Moran MJ; Andris JS; Matsumato Y; Capra JD; Hersh EM; Hematology and Oncology Section, Arizona Cancer Center,; University of Arizona, Tucson.
The extent of the expressed human V gene repertoire for the most part has been derived from fetal cDNA libraries, autoantibodies, and myeloma proteins. In order to continue to explore the utilization of the VH and VL gene repertoire in response to exogenous viral antigens, the heavy and light chain cDNAs from four hum
Bottone EJ; Clinical Microbiology Laboratory, Mount Sinai Hospital, New York,; NY.
Free-living amebas of the genera Acanthamoeba and Naegleria are allied in basic cell biology, ecology, and human disease-producing potential. However, several enigmas surrounding these amebas need further intellectual and scientific scrutiny. For instance, a clearer differentiation is needed of factors delineating pat
Visvesvara GS; Centers for Disease Control, U.S. Department of Health and Human; Services, Atlanta, GA 30333.
Acanthamoeba, leptomyxid ameba, and microsporidia have recently been recognized as organisms that cause opportunistic infections in patients with HIV and AIDS. As the numbers of patients with HIV and AIDS increase, more cases of amebic encephalitis and microsporidiosis
Dottino PR; Sperling R; Kee R; Department of Obstetrics, Gynecology, and Reproductive Science,; Mount Sinai Medical Center, New York, NY 10029.
Among patients attending an inner-city colposcopy clinic, the prevalence of Chlamydia trachomatis was 22/375 (5.0%), Neisseria gonorrhoeae, 3/375 (0.8%), and seropositivity for syphilis, 10/375 (2.7%). In addition, 13/261 (5.0%) of asymptomatic women agreeing to voluntary human immunodeficiency virus (HIV-1) antibody
N Engl J Med. 1993 Dec 2;329(23):1696-702. Unique Identifier : AIDSLINE MED/94050030
Thea DM; St. Louis ME; Atido U; Kanjinga K; Kembo B; Matondo M; Tshiamala T; Kamenga C; Davachi F; Brown C; et al; Division of Geographic Medicine and Infectious Diseases, New; England Medical Center, Boston, MA 02111.
BACKGROUND. Persistent diarrhea is a prominent feature of the acquired immunodeficiency syndrome in adults, but its cause and its effect on children with human immunodeficiency virus (HIV) infection are largely unknown, particularly in Africa. METHODS. We studied a birth cohort of 429 infants born to HIV-positive or H
The National Commission on AIDS ended its 4 years of operation just as President Clinton named the Administration s first AIDS Policy Coordinator, Kristine Gebbie, MN, RN, FAAN. A strong, consistent voice of leadership was a key recommendation from the commission and Ms. Gebbie promises to be the stimulus for such lea
OBJECTIVE. To estimate the risk of HIV or hepatitis B infection after pricking accidents in the ambulant care and treatment of drug addicts. DESIGN. Risk estimation. SETTING. Aid station for drug addicts in Nijmegen. METHOD. Inventorization of the pricking accidents at the above-named aid station and calculation of th
in't Veen JC; Kauffmann RH; Department of Internal Medicine, Municipal Hospital Leyenburg,; The Hague, Netherlands.
This report describes an HIV-seropositive patient with symptoms suggestive of Pneumocystis carinii pneumonia. The final diagnosis of pulmonary embolism was delayed because initially only HIV-specific complications were considered. The relation between AIDS and pulmonary embolism is discussed briefly.
Weis S; Haug H; Budka H; Institute of Neuropathology, University of Munich, Germany.
Astroglial changes in the cerebral cortex of AIDS brains were analysed by means of morphometry. Astrocytes with and without immunoreactivity for glial acidic protein (GFAP) were counted and their size was measured. In the two investigated cortical areas (frontal and parietal), a similar reaction pattern of astroglia w
Dean AF; Montgomery M; Baskerville A; Cook RW; Cranage MP; Sharpe SA; Dennis MJ; Luthert PJ; Hou ST; Lantos PL; Department of Neuropathology, Institute of Psychiatry, London,; UK.
The brains of 21 rhesus monkeys inoculated with SIVMAC251 were examined after intervals ranging from 3 to 27 months and compared with five uninoculated controls. Eighteen animals became infected and individually exhibited several distinct patterns of disease. Nine (50%) had largely intramural leptomeningeal venous inf
Glass JD; Wesselingh SL; Selnes OA; McArthur JC; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD 21287-6965.
The structural abnormalities that correlate with the clinical manifestations of HIV-associated dementia (HIVD) are unclear. In a prospectively categorized group of patients with and without HIVD who were followed to autopsy, we correlated HIV-related neuropathologic changes with th
McArthur JC; Hoover DR; Bacellar H; Miller EN; Cohen BA; Becker JT; Graham NM; McArthur JH; Selnes OA; Jacobson LP; et al; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, MD.
We determined incidence and future projections of dementia after AIDS onset in 492 homosexual men with AIDS in the Baltimore/Los Angeles sites of the Multicenter AIDS Cohort Study, 64 of whom developed dementia. We studied various risk factors for dementia, including demographic an
Bashir R; Luka J; Cheloha K; Chamberlain M; Hochberg F; Department of Internal Medicine, University of Nebraska, Medical; Center, Omaha 68198-2045.
We examined the expression of the Epstein-Barr virus (EBV)-induced proteins (LMP [latent membrane protein], EBNA-2, and CD23) and a lytic protein, viral capsid antigen (VCA), in five acquired immune deficiency syndrome (AIDS)-related primary CNS lymphomas (PCNSLs). We compared that expression with the expression of th
Mil Med. 1993 Sep;158(9):633-5. Unique Identifier : AIDSLINE MED/94050687
Moran CA; Angritt P; Department of Infectious and Parasitic Disease Pathology, Armed; Forces Institute of Pathology, Washington, DC.
Seven cases of Pneumocystis carinii pneumonia with granulomatous reaction in patients infected with the human immunodeficiency virus are described. The patients were all adult men between the ages of 32 and 45 years, with different high-risk factors. Clinically, all the patients presented with a history of non-product
Nucl Med Commun. 1993 Oct;14(10):830-48. Unique Identifier : AIDSLINE MED/94050942
O'Doherty MJ; Nunan TO; Department of Nuclear Medicine, St Thomas Hospital, London, UK.
The human immunodeficiency virus (HIV) infection and its associated illnesses in a relatively young population of patients provides an expanding role for nuclear medicine. The disease enforces a review of each department s infection control procedures. It also necessitates a widening of the differential diagnosis in h
Roarty JD; Fisher EJ; Nussbaum JJ; Department of Ophthalmology, Children's Hospital of Michigan,; Detroit.
BACKGROUND: Patient survival with the acquired immune deficiency syndrome (AIDS) and cytomegalovirus ( CMV ) retinitis is increasing because of earlier diagnosis and improved medical therapy. Visual morbidity that occurs with p
Cohen DB; Glasgow BJ; Department of Ophthalmology, University of California, Los; Angeles School of Medicine.
PURPOSE: A neuroanatomic study was undertaken to search for the cause of sudden, simultaneously bilateral blindness in a patient with acquired immune deficiency syndrome who had cryptococcal meningitis. METHODS: Careful gross examination was performed, and microscopic sections were cut at 50- to 100-microns intervals
Ficarra G; Flaitz CM; Gaglioti D; Piluso S; Milo D; Adler-Storthz K; Eversole LR; Institute of Stomatology, University of Florence, Italy.
We report on eight patients who developed white lichenoid lesions of the buccal mucosa during the course of human immunodeficiency virus infection. In five patients the lesions appeared after the administration of zidovudine, in two after the intake of both zidovudine and ketoconazole, and in one after ketoconazole. I
Rosen A; Isaacson D; Brady M; Corey JP; Section of Otolaryngology, University of Chicago Hospitals, IL; 60637.
Concern about transmission of acquired immunodeficiency syndrome and hepatitis has greatly increased the use of latex gloves. Latex allergy is a newly emerging problem with potential life-threatening sequelae among health care personnel. Patients are also at risk. We report on five cases of latex allergy in health car
Biavati MJ; Khan A; Kessler C; Department of Otolaryngology-Head and Neck Surgery, University of; Virginia, Charlottesville.
In summary, several points should be emphasized: 1. Adenoidal hypertrophy in a person who previously underwent adenoidectomy should lead to the suspicion of HIV infection. 2. P. carinii should be included in the differential diagnosis of adenoidal enlargement in HIV infections. 3. Extrapulmonary calcification should l
Ximenes E; Zuccarelli M; Dusart G; Simeon De Buochberg M; Laboratoire de Bacteriologie, Faculte de Pharmacie,; Montpellier, France.
Bactericidal activity of ciprofloxacin (CIP), clarithromycin (CLA), rifampin (RIF) alone and in combinations was studied against five atypical mycobacteria (4 isolates from patients with Acquired Immunodeficiency Syndrome and 1 collection strain) by time killing curves method. Drugs were used at their attainable serum
The authors emphasize the interest of detecting HIV p24 antigen after immune complexes dissociation as well as changes in cellular viremia titers in the therapeutic follow-up of HIV infected patients. A significant decline of cell virus titers was found in 4-8 weeks among 13 of 20 zidovudine treated patients. A signif
Collignon A; Jeantils V; Cruaud P; Javoy F; Thomas M; Torlotin JC; Service de Bacteriologie, Hopital Jean Verdier, Bondy, France.
Patients with AIDS are immunodeficient, receive multiple antibiotic treatments, occasionally anti-cancer chemotherapy and are often hospitalised; thus they are susceptible to develop a Clostridium difficile infection. The aim of this study was to evaluate the role of C. difficile in diarrhoea in this patient populatio
Colavecchio A; Cannatelli G; Dubini F; Riviera L; Servizio di Anatomia e Istologia Patologica e Citodiagnostica,; Ospedale Maggiore di Crema.
Bone marrow cryptococcosis as initial sign of AIDS. The Authors describe a case of bone marrow cryptococcosis in a patient, female aged 27, in which a toluene-induced aplastic anemia was suspected. The mycosis was at first extracerebral and represented the initial manifestation of unexpected AIDS. The Authors discute
Ha C; Haller JO; Rollins NK; Department of Radiology, State University of New York, Health; Science Center at Brooklyn 11203.
Two cases of smooth muscle tumor developing in immunocompromised children are described. Both children presented after transplant surgery, one with a hepatic leiomyoma and the other with a hepatic leiomyosarcoma.
Barks JD; Nair MP; Schwartz SA; Silverstein FS; Department of Pediatrics, University of Michigan, Ann Arbor; 48109.
In this study, we tested the hypothesis that human immunodeficiency virus (HIV)-1-derived peptides augment the neurotoxicity of excitatory amino acid agonists in vivo in postnatal day (PND) 7 rats. Stereotaxic intracerebral injections of the excitatory amino acid agonist N-methyl-D-aspartate (NMDA), alone or coinjecte
Msellati P; Lepage P; Hitimana DG; Van Goethem C; Van de Perre P; Dabis F; INSERM U 330, University of Bordeaux II, France.
OBJECTIVE. The results of developmental testing of 218 children born to human immunodeficiency virus (HIV)-seropositive mothers and infected or uninfected themselves were compared with those of 218 children born to HIV-seronegative mothers in an ongoing cohort study in Kigali, Rwanda
Strair RK; Medina DJ; Nelson CJ; Graubert TA; Mellors JW; Division of Medical Oncology, Yale University School of Medicine,; New Haven, CT 06510.
Two recombinant retroviral systems are described that can be used to analyze antiretroviral drug activity and HIV breakthrough (replication in the presence of the drug). The first system utilizes a recombinant HIV encoding beta-galactosidase as a reporter gene (HIV-LacZ). The defective HIV-LacZ virus is produced in CO
Pol Arch Med Wewn. 1993 Jul;90(1):78-82. Unique Identifier : AIDSLINE MED/94051816
Radkowski M; Kopicz-Kaminska E; Laskus T; Mian M; Zaklad Immunopatologii, Instytut Chorob Zakaznych i; Pasozytniczych Akademii Medycznej, Warszawie.
A case is described of a 62 years old patient in the initial stage of clinically overt HIV infection. The infection occurred probably 11 years earlier by means of blood transfusion during open heart surgery. The possible reasons for the long-term asymptomatic carriage of the virus and factors influencing the developme
Pol Tyg Lek. 1993 Mar 15-29;48(11-13):261-2. Unique Identifier : AIDSLINE MED/94051851
Laskus T; Radkowski M; Lupa E; Cianciara J; Slusarczyk J; Zakladu Immunopatologii: kierownik, Kliniki Hepatologii Zakaznej; Instytutu Chorob Zakaznych i Pasozytniczych AM, Warszawie.
Prevalence of HAV infection markers was studied in 100 drug addicts whose sera were collected between 1988 and 1989. Anti-HAV antibodies were found in 65 (65%) of the tested drug addicts and in 55% of the individuals serving as the control group. No correlation between the presence of HAV infection markers, and sex, d
Pol Tyg Lek. 1993 Mar 1-8;48(9-10):207-9. Unique Identifier : AIDSLINE MED/94051863
Radkowski M; Laskus T; Zakladu Immunopatologii Instytutu Chorob Zakaznych i; Pasozytniczych AM, Warszawie.
The mechanisms of HIV infection of target cells are described. Particularly the role of three types of cell receptors, which participate in the process of virus-cell interactions: CD4 protein, receptor for Fc fragment of antibodies and complement receptors are discussed. The variability of the virus variants, which de
Pol Tyg Lek. 1993 Mar 1-8;48(9-10):210-2. Unique Identifier : AIDSLINE MED/94051864
Radkowski M; Laskus T; Szymanska B; Kopicz-Kaminska E; Mian M; Babiuch L; Slusarczyk J; Zakladu Immunopatologii, Instytutu Chorob Zakaznych i; Pasozytniczych AM, Warszawie.
Results of quantitative determinations of thrombocytes and selected, basal immune parameters in 263 HIV infected subjects are presented. A decrease in the platelet count was observed more frequently in symptomatic subjects, including AIDS patients, than in asymptomatic HIV carriers or patients with generalized lymphad
Popul Rep L. 1993 Jun;(9):1-31. Unique Identifier : AIDSLINE MED/94051900
While AIDS seizes the headlines, other sexually transmitted diseases (STDs) create devastation of their own. In women STDs can lead to pelvic inflammatory disease, causing lifelong pain, infertility, and ectopic pregnancy, which can kill. Children are born with blinding eye infections. Men are left infertile. People d
Strausbaugh LJ; Veterans Affairs Medical Center, Portland, OR 97207.
Nonmenstrual cases of toxic shock syndrome now occur at least as often as the classic menstrual cases. The syndrome has been reported in every conceivable clinical setting involving colonization or infection with Staphylococcus aureus and as a complication of surgical procedures, traumatic injuries, and local infectio
Public Health Nurs. 1993 Sep;10(3):151-8. Unique Identifier : AIDSLINE MED/94051975
Nyamathi AM; School of Nursing, University of California, Los Angeles; 90024-6918.
It is theorized that persons with strong sense of coherence are likely to define an event as less stressful and be able to manage a problem more successfully than those with weak sense of coherence. The study investigated the relationship among coherence and personal and environmental concerns, appraisal of threat, em
Public Health Nurs. 1993 Sep;10(3):159-65. Unique Identifier : AIDSLINE MED/94051976
DiIorio C; Parsons M; Lehr S; Adame D; Carlone J; Nell Hodgson Woodruff School of Nursing, Emory University,; Atlanta, GA 30322.
We assessed knowledge of the acquired immunodeficiency syndrome (AIDS) and of safer sex practices among college freshmen. A second purpose of the study was to assess this knowledge among black as well as white students. Students attending classes at three private colleges in a large southern city were asked to partici
Lopez-Anaya A; Unadkat JD; Calkins DF; Smith AL; Department of Pharmaceutics, School of Pharmacy, Xavier; University of Louisiana, New Orleans 70125.
The brain tissue is an important target for anti-HIV drug therapy. Since the permeability of the blood-brain and blood-cerebrospinal fluid (CSF) barriers may differ between neonates and adults, we have determined the effect of age on the distribution of zidovudine (ZDV or azidothymidine) into the CSF in the macaque (M
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10013-7. Unique Identifier : AIDSLINE MED/94052093
Giovannangeli C; Thuong NT; Helene C; Laboratoire de Biophysique, Institut National de la Sante et de; la Recherche Medicale Unite 201, Paris, France.
Triple helices can be formed on single-stranded oligopurine target sequences by composite oligonucleotides consisting of two oligonucleotides covalently linked by either a hexaethylene glycol linker or an oligonucleotide sequence. The first oligomer forms Watson-Crick base pairs with the target, while the second oligo
Bradley WG; Gibbs C; Kraus L; Good RA; Day NK; Laboratory of Retrovirology, All Children's Hospital, St.; Petersburg, Florida 33701.
With the discovery that the cat is susceptible to infection by a lentivirus quite similar to the virus that causes the human acquired immune deficiency syndrome, the cat has become an important animal model with which the interactions between host and immunodeficiency virus can be studied. To facilitate investigation
Egan VG; Chiswick A; Brettle RP; Goodwin GM; Regional Infectious Diseases Unit, City Hospital, Edinburgh.
One hundred and six HIV-positive drug users were tested with a two-tone auditory evoked potential (AEP) task and a small battery of neuropsychological tests, to examine the relationship between the latency of the P300 component (P3) of the AEP, intellectual function, mood and drug use. Principal components analysis re
Katz RC; Frazer N; Wilson L; Psychology Department, University of the Pacific, Stockton, CA; 95211.
This study compared scores from three samples of college students (N = 810) on the Sexual Aversion Scale, a measure of sexual anxiety based on DSM-III-R criteria for diagnosing sexual aversion disorder. Measurements were taken in 1988, 1991, and 1992. There was a significant increase in sexual anxiety during this peri
Greenlee SP; Ridley DR; Department of Psychology, Christopher Newport University, Newport; News, VA 23606-2988.
A survey of beliefs about, knowledge of, and attitudes about AIDS was administered to 345 college students. While knowledge was generally high, reported behavior was not always consistent with that knowledge.
Bielec D; Patorska-Mach E; Rzeszowska G; Katedra i Klinika Chorob Zakaznych Akademii Medycznej w; Lublinie.
The poll carried out among selected community groups in the Lublin Voivodship has shown that the problem of AIDS is looked upon multifariously depending on age. The paper is an attempt to compare opinions of the 18-25 age group (118 people) with those of the 40-60 age group (100 people). The poll, which consisted of 8
Hinman GW; Rosa EA; Kleinhesselink RR; Lowinger TC; Office of Applied Energy Studies, Washington State University,; Pullman.
As part of a study of nuclear power development in Japan and the United States , surveys of perceptions of risk toward 30 activities, substances, and technologies have been carried out in the Pacific Northwest and Tokyo, Japan. The results show that p
Cardenes Santana MA; Suarez Ortega S; Jimenez Santana P; Carretero Hernandez G; Artiles Vicaino J; Melado Sanchez P; Servicio de Medicina Interna, Las Palmas Norte de Gran Canaria.
A patient with AIDS was admitted to our hospital because of pruritic and disabling erythroderma, it was treated with Lindane without improvement. Skin biopsy of a crusty lesion showed Sarcoptes scabiei hominis, and the diagnosis of Norwegian scabies was made. After a long and intensive treatment with several drugs, cu
Ruiz A; Falguera M; Puig T; Gazquez I; Perez J; Rubio M; Servicio de Medicina Interna, Hospital Arnau de Vilanova,; Facultad de Medicina, Lleida.
We reviewed the features of patients with human immunodeficiency virus (HIV) infection, whose only way of acquisition was heterosexual contacts, analyzing differences with others risk groups. Epidemiological features (age, gender, family situation, socioeconomic status and sexual behavior), clinical manifestations imm
Rev Med Chil. 1993 Jan;121(1):65-9. Unique Identifier : AIDSLINE MED/94053190
Perez C; Perez J; Oddo D; Labarca J; Guzman S; Acuna G; Leon ED; Departamento de Medicina Interna, Hospital Clinico P Universidad; Catolica de Chile, Santiago.
A twenty nine year old male homosexual presented with malaise, weight loss, fever and profuse sweating. An ill defined abdominal mass was found during physical examination in the right lower quadrant and chest X rays disclosed a pleural effusion. HIV antibodies and hepatitis B surface antigen were positive and immunol
Kosmadakis CS; Bungener C; Jouvent R; Maffre F; Widlocher D; INSERM 302, Hopital de la Salpetriere, Paris.
Psychiatric and neurological symptoms have been the target of many studies, but the emotional and behavioral modifications in HIV infection remain quite unknown. Working on the emotional dimensions and the heterogeneity of depressive mood, we were interested in evaluating the emotional symptomatology in HIV infected p
Laraki R; Bletry O; Raguin G; Agbalika F; Bouche P; Leger JM; Perol Y; Godeau P; Service de Medecine Interne, Groupe Hospitalier; Pitie-Salpetriere, Paris.
Neuromyositis is a very rare type of polymyositis where, beside the usual muscular manifestations, there are signs of peripheral neuropathy which can be found at clinical, electromyographic and/or pathological examination. We have seen between 1983 and 1990 four cases
Rev Prat. 1993 Jun 1;43(11):1349-53. Unique Identifier : AIDSLINE MED/94053469
Najman A; Service des maladies du sang, hopital Saint-Antoine, Paris.
Inflammatory low iron is the second cause, after true iron deficiency, of acquired anaemia. It is mainly due to insufficient erythropoiesis resulting from inhibition of the erythroid progenitor and to disturbances in the synthesis and action of erythropoietin. These changes seem to be dependent on factors, such as TNF
Pittis MG; Sternik G; Sen L; Diez RA; Planes N; Pirola D; Estevez ME; Instituto de Investigaciones Hematologicas Mariano R. Castex,; Academia Nacional de Medicina, Buenos Aires, Argentina.
We evaluated phagolysosomal fusion in peripheral blood monocytes from 20 HIV-infected individuals and 40 normal controls, using a fluorescence assay with acridine orange as marker. The percentages of phagolysosomal fusion of monocytes from HIV-infected subjects, after 30 and 60 min of yeast ingestion, (mean +/- standa
Matsuda S; Oka S; Honda M; Takebe Y; Takemori T; AIDS Research Center, National Institute of Health, Tokyo, Japan.
IgA antibodies were analysed in sera and saliva from 40 HIV-1 seropositive individuals. The level of total IgA in serum was elevated according to the progress of the disease. IgA antibodies against p24 and gp160 were detected in the asymptomatic phase of infection. However, they declined in the symptomatic phases in c
Faxvaag A; Moen T; Dalen AB; Institute of Cancer Research, University of Trondheim, Norway.
Polyclonal activation of B-lymphocytes accompanies many retroviral infections. Friend derived murine immunosuppressive virus (Fd-MIV) is a non-defective murine retrovirus which was isolated from T-helper cells from mice infected with the acute transforming retrovirus Friend leukaemia complex (FLC). In contrast to FLC,
Tiberio L; Caruso A; Pozzi A; Rivoltini L; Morelli D; Monti E; Balsari A; Department of Biomedical Sciences and Biotechnology, University; of Brescia, Italy.
Antibodies to interleukin-2 ( IL-2 ) have been reported in the sera of patients under therapies involving this cytokine and in the sera of patients infected with human immunodeficiency virus (HIV). Our study proves that auto-antibodies to IL-2 are present also, at a lowe
Danieli MG; Paoletti P; Recchioni A; Gabrielli A; Danieli G; Istituto di Clinica Medica dell'Universita di Ancona, Ospedale; Generale Regionale, Italy.
Soluble interleukin 2 receptor (sIL2R) may be used as an index of immune perturbation. We report on the correlation between the serum levels of sIL2R, as assessed with a sandwich-ELISA, and disease activity in 61 patients with Systemic Lupus Erythematosus (SLE) and in 15 with systemic idiopathic vasculitis (SIV). The
Scott Med J. 1993 Aug;38(4):112-3. Unique Identifier : AIDSLINE MED/94053670
Jacob AJ; Sutherland GR; Boon NA; Ludlam CA; Department of Cardiology, Royal Infirmary, Edinburgh.
Infection with the human immunodeficiency virus (HIV) can result in several cardiac abnormalities including dilated cardiomyopathy. These phenomena have been described in people contracting the virus through sexual intercourse, injection drug use and by vertical transmission. We have identified recently two Scottish h
Science. 1993 Nov 12;262(5136):1011-8. Unique Identifier : AIDSLINE MED/94053740
Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.
The immunopathogenic mechanisms underlying human immunodeficiency virus (HIV) disease are extremely complex; the disease process is multifactorial with multiple overlapping phases. Viral burden is substantial and viral replication occurs throughout the entire course of HIV infection. Inappropriate immune activation an
Science. 1993 Nov 19;262(5137):1257-61. Unique Identifier : AIDSLINE MED/94053788
Delwart EL; Shpaer EG; Louwagie J; McCutchan FE; Grez M; Rubsamen-Waigmann H; Mullins JI; Department of Microbiology and Immunology, Stanford University; School of Medicine, CA 94305-5402.
The genetic diversity of human immunodeficiency virus (HIV) is a major concern thought to impact on immunologic escape and eventual vaccine efficacy. Here, simple and rapid methods are described for the detection and estimation of genetic divergence between HIV strains on the basis of the observation that DNA heterodu
Barthel HR; Wallace DJ; Division of Rheumatology, Cedars-Sinai Medical Center, Los; Angeles, CA 90048.
Testing for human immunodeficiency virus (HIV) infection in patients with systemic lupus erythematosus (SLE) leads to a higher than expected rate of positive ELISA results and indeterminate Western blot results. Because most of these patients lack any risk factors for HIV infection and the coexistence of SLE and HIV i
Brown JE; Ayowa OB; Brown RC; Institut Medical Chretien du Kasai, Kananga, Zaire.
Both men and women in central Zaire like a dry, tight vagina because it increases pleasure during sexual intercourse. In focus group interviews, they described wiping and washing procedures, as well as 30 different substances, mostly leaves and powders, that women can insert int
South Med J. 1993 Nov;86(11):1197-201. Unique Identifier : AIDSLINE MED/94053910
Rathore MH; Department of Pediatrics, University of Florida Health Science; Center, Jacksonville 32209-6561.
Human herpesvirus 6 (HHV-6) is a relatively recently discovered virus. Although systematic studies on the spread of this virus are lacking, considerable data have been collected regarding the prevalence of HHV-6 infection. A number of laboratory methods are available for the diagnosis of HHV-6 infection, but currently
South Med J. 1993 Nov;86(11):1215-8. Unique Identifier : AIDSLINE MED/94053914
Edelstein H; Chirurgi VA; Hybarger CP; Kaiser Permanente Medical Center, San Rafael, Calif. 94903.
Eight patients with osteomyelitis of the jaw were identified at two county hospitals over a 4-year period. Three patients (37.5%) were found to be HIV-seropositive, including two patients not previously known to be HIV-seropositive. Signs and symptoms of infection were similar in both groups of patients, and commonly
Salud Publica Mex. 1993 Sep-Oct;35(5):508-17. Unique Identifier : AIDSLINE MED/94054046
del Rio-Chiriboga C; Uribe-Zuniga P; Consejo Nacional para la Prevencion y Control del SIDA; (CONASIDA), Mexico.
This paper deals with the last literature and examines the most relevant studies of recent years related to condom effectiveness in preventing sexually transmitted diseases (STD), with experimental, epidemiological and seroconversion models. On the basis of these studies, it can be stated that the efficacy of condoms
Okuda Y; Takasugi K; Imai A; Oyama T; Oyama H; Center for Rheumatic Diseases, Dohgo Spa Hospital,; Matsuyama-city.
Some patients of dermatomyositis (DM) with interstitial pneumonia (IP) have common clinical features. Clinical features of these patients are acute onset, very poor prognosis and that patients have fever, arthritis, typical skin rash, mild myositis and show low ratio of CPK/LDH, low incidence of antinuclear antibody (
Okuda Y; Takasugi K; Kurata N; Takahara J; Center for Rheumatic Diseases, Dohgo Spa Hospital,; Matsuyama-city.
In order to clarify the pulmonary involvement in rheumatoid arthritis (RA), bronchoalveolar lavage (BAL) was performed in 52 RA patients, in conjunction with pulmonary function test (PFT) and high-resolution CT (HRCT) of the chest. The results were as follows: 1. Out of nine RA patients with no evidence of lung involv
Lipman JM; Reichert JA; Davidovich A; Anderson TD; Department of Toxicology and Pathology, Hoffmann-La Roche Inc.,; Nutley, New Jersey 07110-1199.
The nucleoside analogue, 2 ,3 -dideoxycytidine ( ddC ), a potent inhibitor of human immunodeficiency virus reverse transcriptase (in its anabolized triphosphorylated form), mediates virologic and immunologic improvements in AIDS patients. Clinical studi
Trans R Soc Trop Med Hyg. 1993 May-Jun;87(3):263-6. Unique Identifier : AIDSLINE MED/94054581
Thea DM; Glass R; Grohmann GS; Perriens J; Ngoy B; Kapita B; Atido U; Mabaluku M; Keusch GT; International Co-operation in AIDS Research (ICAR) Unit, Project; SIDA, Mama Yemo Hospital, Kinshasa, Zaire.
Diarrhoea is the most common manifestation of acquired immunodeficiency syndrome (AIDS) in Africa. Numerous parasitic or bacterial agents have been implicated, but a pathogen-specific aetiology has not been found. Enteric viruses (i.e., rotavirus, small round structured viruses, coronavirus, and adenovirus) were detec
Trans R Soc Trop Med Hyg. 1993 May-Jun;87(3):330-2. Unique Identifier : AIDSLINE MED/94054605
Kapel N; Meillet D; Buraud M; Favennec L; Magne D; Gobert JG; Parasitaire, Faculte de Pharmacie, Universite Rene Descartes,; Paris, France.
The role of the mucosal immune response against Cryptosporidium has been suggested by studies on the therapeutic effects of hyperimmune colostrum. In order to study the intestinal response to this infection, we have developed a sandwich-type time-resolved immunofluorometric assay for the determination of anti-Cryptosp
Mariani G; Di Paolantonio T; Baklaya R; Morfini M; Mannucci PM; Department of Human Biopathology, University of Rome La Sapienza,; Italy.
This prospective study was carried out with the aim of evaluating the efficacy of solvent/detergent inactivation of the hepatitis C virus (HCV) as applied to a chromatographic factor VIII concentrate. In parallel, the markers for other viruses, either lipid-enveloped (human immunodeficiency virus types 1 and 2 [HIV-1
Hart H; McOmish F; Hart WG; Simmonds P; Yap PL; Protein Fractionation Centre, Scottish National Blood Transfusion; Service, Edinburgh.
Three examples of human plasma-derived concentrates, intermediate-purity factors VIII and IX, and fibrinogen were spiked with tissue culture-grown human immunodeficiency virus type 1 (HIV-1) strain RF. All examples were freeze-dried and heated at 80 degrees C for 72 hours by using validated production process models.
L'Herminez RH; Department of Tropical Medicine and Infectious Diseases,; Liverpool School of Tropical Medicine.
In many developing countries with a high prevalence of both tuberculosis and HIV infection a dramatic increase of tuberculosis is seen. Our present ability to diagnose tuberculosis in developing countries has its limitations. This review article discusses old and new approaches to the diagnosis of tuberculosis and the
Tumori. 1993 Jun 30;79(3):224-6. Unique Identifier : AIDSLINE MED/94054740
Landonio G; Nosari A; Oreste P; Cantoni S; Cattaneo D; Ghislandi E; Department of Oncology, Ospedale Niguarda Ca' Granda, Milano,; Italy.
We report nasopharyngeal angiofibroma in a 13 year old boy treated with embolization, surgical excision and radiotherapy, which recurred 13 years later. No features of sarcomatous transformation were found, but the tumor had a locally aggressive course, possibly due to the HIV-positivity of the patient who then died o
Turk J Pediatr. 1993 Jan-Mar;35(1):69-73. Unique Identifier : AIDSLINE MED/94054754
Aji DY; Altinkaya N; Guler A; Ayhan YI; Erginel A; Cenani A; Department of Pediatrics, Istanbul University Faculty of Medicine; at Cerrahpasa.
Two children with varicella associated thrombocytopenia are presented. Case 1, evidencing no mucosal or parenchymal bleeding was administered prednisone 2 mg/kg/day therapy after having been put under observation for a period of one week without medical treatment. There was an increase in the platelet count during the
A technique for purifying intact bovine leukemia virus (BLV) and a procedure for preparing gag protein (p24) and envelope glycoprotein (gp 51) from intact BLV are described. The preparation method employs solubilization of BLV by n-octyl-beta-D-Glycopyranoside and sodium desoxycholate with following ultracentrifugatio
Hofman P; Quintens H; Michiels JF; Taillan B; Thyss A; Department of Pathology, Hopital Pasteur, France.
Ante-mortem diagnosis of vesical toxoplasmosis in a patient with acquired immunodeficiency syndrome (AIDS), was made by cystoscopic examination and biopsy of the bladder. Vesical biopsies can be helpful in determining appropriate therapy for AIDS patients with urinary tract involvement/disease.
Lopez AE; Latiff GA; Ciancio G; Antun R; Department of Urology, University of Miami, School of Medicine,; Florida.
Primary involvement of the urethra by lymphoma is rare. We report the first case of a primary urethral B-cell lymphoma as the initial manifestation of the acquired immune deficiency syndrome (AIDS). A fifty-seven-year-old black man was evaluated for obstructive voiding symptoms and bloody urethral discharge. Workup re
Vet Rec. 1993 Sep 4;133(10):245-7. Unique Identifier : AIDSLINE MED/94054889
Koutinas A; Koptopoulos G; Department of Small and Large Animal Medicine, Aristotelian; University, Faculty of Veterinary Medicine, Thessaloniki, Greece.
The gene amplification technique was used for detection and sequence analysis of STLV-1 Papio proviral DNA. The polymerase chain reaction was performed with a primer pair at tax region of HTLV-1, 7336-7354, sense strand, and 7516-7494, antisense strand. One microgram of DNAs isolated from LUG-4 cells and autopsies was
Wien Klin Wochenschr. 1993;105(18):516-9. Unique Identifier : AIDSLINE MED/94055287
Sailer M; Gasser M; Fischer H; Neugebauer H; Bereuter L; Simma B; Universitatsklinik fur Kinderheilkunde, Innsbruck.
We studied the psycho-social circumstances of HIV-positive women and their children, who were born between January 1, 1984 and June 30, 1991 and are being treated at the Department of Pediatrics. We interviewed 19 women out of 21 families using the problem-centered interview technique according to Witzel. 29 out of 30
Ogiwara H; Nakamura T; Baba S; Okamoto T; Virology Division, National Cancer Center Research Institute,; Tokyo, Japan.
From the sera of patients with advanced cancer, a novel factor called SDF (serum-derived factor) was partially purified. SDF was shown to stimulate transcription from the long terminal repeat (LTR) of human immunodeficiency virus type 1 (HIV-1) by transient CAT assay. It did not stimulate gene expression of various co
Nick S; Diniz CA; Born G; Sauter M; Pees HW; Muller-Lantzsch N; Jahn G; Institut fur Klinische und Molekulare Virologie, Universitat; Erlangen-Nurnberg, Germany.
In 1991 a new HIV-2 isolate (HIV-2HOM) was isolated first from a German individual most likely infected in West Africa in the beginning of the 1970s. The virus was isolated from both, the plasma and the peripheral blood lymphocytes of the patient by using OKT-3-stimulated cord blood lymphocytes. The recovered viruses
Mempel W; Medizinische Klinik III, Klinikum Grosshadern,; Ludwig-Maximilians-Universitat Munchen.
Blood transfusion became the subject of major interest because of a possible HIV-infection. It should not been forgotten, however, that HIV-infection is not the only of a wide variety of risks. The leading complication is still the hemolytic transfusion reaction, followed by transmission of hepatitis or other viral or
Bergmann M; Kuchelmeister K; Winkelmuller W; Braun W; Behrens E; von Wild K; Institut fur Neuropathologie, Universitat Munster.
Primary cerebral lymphomas (PCL) were diagnosed with increasing frequency also in our retrospective study of 44 patients. Clinically these tumors presented with signs of a rapidly growing brain neoplasm. The analysis of CCT data showed that the tumors were of varying density before and showed mostly (60%) homogeneous
Buonavoglia C; Marsilio F; Tempesta M; Buonavoglia D; Tiscar PG; Cavalli A; Compagnucci M; Universita Degli Studi di Bari Facolta di Medicina Veterinaria,; Italia.
Cats in the primary stage of Feline Immunodeficiency Virus (FIV) infection and FIV seronegative cats were vaccinated with a modified live Feline Panleukopenia virus vaccine (FPV-MLV). The FPV-MLV strain was not pathogenic for FIV seronegative cats, whereas in FIV infected cats it produced severe clinical signs, simila
Chung Kuo Yao Li Hsueh Pao. 1993 May;14(3):238-42. Unique Identifier : AIDSLINE MED/94055734
Pei RJ; Qi LH; Liu XJ; Department of Pharmacology, Oriental Hospital, Fuzhou, China.
Triptonide (Tri) extracted from Tripterygium wilfordii Hook inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 microgram.ml-1. It showed a suppressive effect on one way mixed lymphocyte culture (MLC) at 0.
Berger DK; Rivera M; Perez G; Fierman A; New York University Medical Center/Gouverneur Diagnostic and; Treatment Center, Department of Pediatrics, New York 10002.
Inner-city adolescents are believed to be at increased risk for HIV infection because of their high-risk behaviors, and black and Hispanic teenagers may be at greatest risk as a consequence of these behaviors and inadequate AIDS education. In the present paper, the HIV risk status of pregnant Hispanic adolescents pres
Steitz JA; Munn JA; Memphis State University, Tennessee 38152.
Ninth- and tenth-grade adolescents AIDS knowledge and attitude were assessed before and after a mandated AIDS education program. A control group of adolescents not exposed to the education program was included. As a result of the AIDS education, knowledge gains were indicated for the girls, but not for the boys. Both
Frank ML; Bateman L; Poindexter AN; Department of Obstetrics and Gynecology, Baylor College of; Medicine, Houston, Texas.
This research examines the use of condoms to protect from disease women who selected hormonal implants for contraception. After receiving contraceptive implants, subjects were surveyed regarding their past use of condoms and their plans for using them to inhibit the transmission of HIV and other sexually transmitted d
Adv Exp Med Biol. 1993;335:13-20. Unique Identifier : AIDSLINE MED/94055935
Adler MW; Geller EB; Rogers TJ; Henderson EE; Eisenstein TK; Department of Pharmacology, Temple University School of Medicine,; Philadelphia, PA 19140.
The results achieved by those seeking to determine whether opioids and other drugs of abuse can affect immunity are quite astonishing given the short period of time that research has focused on this area. Despite the fact that there is no longer any question that opioids produce a variety of effects on the immune syst
Adv Exp Med Biol. 1993;335:143-51. Unique Identifier : AIDSLINE MED/94055937
Darban H; Watson RR; Alak J; Thomas N; Department of Family and Community Medicine, NIAAA Specialized; Alcohol Research Center, Tucson, AZ 85724.
As cocaine may affect progression of the Human Immunodeficiency Virus (HIV) infection to Acquired Immune Deficiency Syndrome (AIDS), we used a murine model of AIDS (MAIDS) induced by LP-BM5 murine leukemia virus to examine cocaine s possible role as a cofactor for secondary parasitic infections. Dissimilarities betwee
Adv Exp Med Biol. 1993;335:175-9. Unique Identifier : AIDSLINE MED/94055942
Alak JI; Shahbazian M; Huang D; Wang Y; Darban H; Watson RR; Jenkins EM; Tuskegee University, AL.
Significant immunological changes occur following LP-BM5 murine leukemia retrovirus infection as well as chronic alcohol consumption. Retrovirus infection which has proceeded to murine AIDS permitted persistent Cryptosporidium infection, while non-retrovirus infected mice were resistant. Dietary alcohol provided until
Adv Exp Med Biol. 1993;335:189-202. Unique Identifier : AIDSLINE MED/94055944
Bendinelli M; Pistello M; Matteucci D; Lombardi S; Baldinotti F; Bandecchi P; Ghilarducci R; Ceccherini-Nelli L; Garzelli C; Poli A; et al; Dipartimento di Biomedicina, Universita di Pisa, Italy.
Adv Exp Med Biol. 1993;335:211-7. Unique Identifier : AIDSLINE MED/94055947
Lyman WD; Department of Pathology, Albert Einstein College of Medicine,; Bronx, NY 10461.
The number of children infected by the human immunodeficiency virus type-1 (HIV-1) who develop the acquired immunodeficiency syndrome (AIDS) continues to increase. While some children become infected after birth and others at the time of parturition, a significant percentage are infected during gestation and there is
Adv Exp Med Biol. 1993;335:255-63. Unique Identifier : AIDSLINE MED/94055953
Sinkovics JG; Szakacs JE; Gyorkey F; Cancer Inst., St. Joseph's Hospital, Tampa, FL.
While lipopolysaccharide endotoxin is the most prominent inducer of the kinecascade (TNF alpha, IL-1, 4, 6, 8) that leads to shock and multiple organ failure, bacterial exotoxins and products of certain gram positive bacteria can induce the same end results. We theorize that more than one pathogen can induce the seque
Adv Exp Med Biol. 1993;335:35-9. Unique Identifier : AIDSLINE MED/94055957
Carr DJ; France CP; Department of Microbiology, LSU Medical Center, New Orleans; 70112-1393.
Both immune and neuroendocrine abnormalities have been documented in heroin abusers. We investigated immunocompetence of peripheral blood mononuclear cells (PBMs) among separate groups of rhesus monkeys that were drug naive or received morphine either infrequently (twice/week) or daily (3.2 mg/kg). Both infrequent and
Am Ind Hyg Assoc J. 1993 Oct;54(10):628-32. Unique Identifier : AIDSLINE MED/94056165
Tucker SP; Belinky BR; Seitz TA; Foley GD; Department of Health and Human Services, Centers for Disease; Control and Prevention, National Institute for Occupational; Safety and Health, Cincinnati, Ohio 45226.
A concern currently exists regarding the potential for exposure of health care workers to pentamidine isethionate, a drug used for prevention and treatment of Pneumocystis carinii pneumonia in immunocompromised patients, including those with human immunodeficiency virus infection. In order to evaluate worker exposures
Macallan DC; Noble C; Baldwin C; Foskett M; McManus T; Griffin GE; Department of Medicine, St George's Hospital Medical School,; London, UK.
Weight loss is a major manifestation of infection with the human immunodeficiency virus (HIV). Prospective analysis of weight change was performed in 30 male subjects with stage IV HIV infection over a period of 9-49 mo and weight change events (> 4 kg) related to contemporaneous clinical events. Two distinct patterns
Am J Gastroenterol. 1993 Nov;88(11):1882-6. Unique Identifier : AIDSLINE MED/94056316
Cheung AN; Ng IO; Department of Pathology, Queen Mary Hospital, University of Hong; Kong.
Cytomegalovirus infection is usually reported in immunocompromised patients. In this study, 19 patients with cytomegalovirus ( CMV ) infection of the alimentary tract were reviewed, none of whom had acquired immunodeficiency sy
Am J Hematol. 1993 Dec;44(4):249-55. Unique Identifier : AIDSLINE MED/94056383
Chow FP; Ordonez JV; Sutton PA; Hamburger AW; University of Maryland Cancer Center, Baltimore 21201.
We have recently demonstrated that azidothymidine ( AZT ) elevates the levels of circulating platelets in mice made immune deficient by infection with LP-BM5 murine leukemia virus (MAIDS mice). In an attempt to elucidate the mechanisms of the AZT platel
Am J Med. 1993 Nov;95(5):466-72. Unique Identifier : AIDSLINE MED/94056451
Agostini C; Trentin L; Zambello R; Bulian P; Siviero F; Masciarelli M; Festi G; Cipriani A; Semenzato G; Padua University School of Medicine, Department of Clinical; Medicine, Italy.
PURPOSE: Although the accumulation of CD4 cells in the lung and other involved tissues is regarded as the distinctive immunologic feature of sarcoidosis, a few sarcoid patients can present with CD8 alveolitis. This study evaluates the incidence as well as the clinical and immunologic features of sarcoidosis presenting
Am J Med Sci. 1993 Nov;306(5):313-6. Unique Identifier : AIDSLINE MED/94056477
Ahmed B; Jaspan JB; Department of Medicine, Tulane University School of Medicine, New; Orleans, Louisiana 70112-2699.
Pneumocystis carinii infection is commonly seen in patients infected with HIV, and there is evidence of macrophage involvement in the disease process. Macrophage dysfunction can result in abnormal vitamin D metabolism as is often seen in a granulomatous disease such as sarcoidosis. This article describes a patient wit
Lindsay MK; Adefris W; Willis S; Klein L; Department of Gynecology and Obstetrics, Emory University School; of Medicine, Atlanta, GA 30335.
OBJECTIVE: We assessed the prevalence of and defined the relationship between other sexually transmitted diseases and human immunodeficiency virus infection. STUDY DESIGN: We performed a case-control study among 121 human immunodeficiency virus-infected and 222 randomly selected seronegative parturient women. These wo
Am J Pathol. 1993 Nov;143(5):1263-8. Unique Identifier : AIDSLINE MED/94056647
Tokunaga M; Imai S; Uemura Y; Tokudome T; Osato T; Sato E; Department of Pathology, Kagoshima City Hospital, Japan.
Adult T-cell leukemia/lymphoma (ATLL) is a well-known human T-cell lymphotropic virus type-1-related disease. We studied Epstein-Barr virus (EBV) in the tumor cells of ATLL, to investigate the etiological significance of double infection with these viruses. We used polymerase chain reaction and EBV-encoded small RNA-1
Am J Pathol. 1993 Nov;143(5):1275-9. Unique Identifier : AIDSLINE MED/94056649
Reux I; Fillet AM; Fournier JG; Agut H; Gentilini M; LeHoang P; Hauw JJ; Laboratoire de Neuropathologie Raymond Escourolle, Groupe; Hospitalier La Pitie Salpetriere, Paris, France.
In situ hybridization of human immunodeficiency virus-1 (HIV-1) has been performed on eight eyes from eight distinct acquired immune deficiency syndrome patients (three cases had a normal fundus examination and five presented with cytomegalovirus retinitis). The eyes were removed a
Am J Pathol. 1993 Nov;143(5):1486-97. Unique Identifier : AIDSLINE MED/94056671
Davidson MG; Rottman JB; English RV; Lappin MR; Tompkins MB; Department of Companion Animal and Special Species Medicine,; North Carolina State University, Raleigh.
This study was designed to examine the effects of a pre-existing, clinically asymptomatic feline immunodeficiency virus (FIV) infection on a primary challenge with Toxoplasma gondii. Parenteral challenge of FIV-infected cats with tachyzoites of the ME49 strain of T. gondii caused a precipitous drop in all lymphocytes
Am J Public Health. 1993 Nov;83(11):1609-15. Unique Identifier : AIDSLINE MED/94057163
Ku L; Sonenstein FL; Pleck JH; Urban Institute, Washington, DC 20037.
OBJECTIVES. This paper analyzes age- and period-related changes in risk behaviors for human immunodeficiency virus (HIV) infection and sexually transmitted diseases among young men in the United States between 1988 and 1991. METHODS. Data were from the 1988 and 1991 waves of the Nation
Anal Biochem. 1993 Aug 15;213(1):40-8. Unique Identifier : AIDSLINE MED/94057379
Lepage P; Heckel C; Humbert S; Stahl S; Rautmann G; Marion Merrell Dow Research Institute, Strasbourg, France.
Recombinant DNA technology has been widely used for the production of proteins in recent years. In this paper, we describe the expression and the purification of two specific peptides corresponding to parts of the human immunodeficiency virus Rev protein. The strategy of this method relies on the chemical synthesis of
Heymann SJ; Brewer TF; Harvard School of Public Health, Boston, MA.
INTRODUCTION: The development of AIDS as a result of HIV transmission and of cirrhosis as a result of chronic non-A, non-B hepatitis are the greatest infectious risks associated with transfusion in the United States . The goal of this study is to provide explicit quantitative guidelines
Am J Vet Res. 1993 Sep;54(9):1400-3. Unique Identifier : AIDSLINE MED/94057660
Pollari FL; DiGiacomo RF; Evermann JF; Department of Epidemiology, School of Public Health and Community; Medicine, University of Washington, Seattle 98195.
Bovine leukemia virus (BLV) infection and culling of cows in a commercial dairy herd were evaluated to determine whether a relation existed between the 2 factors. Cattle from the study population, a Holstein dairy herd consisting of approximately 400 milking cows, were tested for antibodies to BLV, using the agar gel
Israel-Biet D; Cadranel J; Even P; Laboratoire Universitaire d'Immunologie Pulmonaire, Hopital; Laennec, Paris, France.
Several factors are known to upregulate in vitro HIV expression by infected T cells, such as certain cytokines and cell-cell interactions. The effect of such factors, involved in immune responses, has never been evaluated in relation to HIV production by infected cells in vivo. To do so, we assessed HIV production by
Connolly MG Jr; Baughman RP; Dohn MN; Department of Internal Medicine, University of Cincinnati Medical; Center, Ohio.
Four patients underwent bronchoscopy to evaluate a cavitary lesion (one patient), pulmonic infiltrate (two patients), and a lingular mass (one patient). In all cases, an endobronchial obstruction was found. In three cases, forceps biopsy specimens revealed acid-fast bacilli, and all four cultures subsequently yielded
Am Surg. 1993 Nov;59(11):754-7. Unique Identifier : AIDSLINE MED/94057740
Binderow SR; Cavallo RJ; Freed J; Department of Surgery, Mount Sinai Medical Center, New York, New; York.
Surgeons throughout the country are frequently asked to consult on acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV)-infected patients experiencing abdominal pain. Disease processes vary remarkably within this population and often occur with confusing presentations and unusual pathologie
An Esp Pediatr. 1993 Aug;39(2):125-31. Unique Identifier : AIDSLINE MED/94057749
Casado Flores J; Bano Rodrigo A; Lirio Casero J; Solera Oliva R; Departamento de Pediatria, Hospital del Nino Jesus Universidad; Autonoma, Madrid.
In order to know the medical and social problems of children of heroin addicted parents (one or both), one-hundred and nineteen patients were studied. All children had been hospitalized suffering from different diseases. The age of these children ranged from 1 day to 17.3 years (19.6 +/- 30.9 months). Seventy-four of
Ann Intern Med. 1993 Dec 1;119(11):1093-104. Unique Identifier : AIDSLINE MED/94057771
Fine HA; Mayer RJ; Division of Medical Oncology, Dana-Farber Cancer Institute,; Boston, MA 02115.
OBJECTIVE: To compare the pathogenesis, clinical presentation, therapy, and prognosis of primary central nervous system lymphoma in immunocompetent persons with these characteristics of the disease in patients with AIDS. DATA SOURCES AND EXTRACTION: All English-language papers published between 1980 and 1992 dealing w
Ann Intern Med. 1993 Dec 15;119(12):1181-6. Unique Identifier : AIDSLINE MED/94057792
Telzak EE; Chiasson MA; Bevier PJ; Stoneburner RL; Castro KG; Jaffe HW; New York City Department of Health, New York.
OBJECTIVE: To determine the relative risk for human immunodeficiency virus (HIV-1) seroconversion in patients with and without genital ulcers caused by chancroid, syphilis, and herpes. DESIGN: A prospective cohort study. SETTING: An inner-city, sexually transmitted disease clinic. PATIENTS: Patients seronegative for H
Ann Dermatol Venereol. 1993;120(4):281-6. Unique Identifier : AIDSLINE MED/94057926
Van Landuyt H; Mougin C; Drobacheff C; Bernard C; Merle C; Lab M; Laurent R
Anal and genital lesions caused by human papilloma virus (HPV) may be associated with severe dysplasia and cancer, chiefly in cases of high risk HPV types 16, 18, 31, 35, 51. The frequency of HPV infections and the severity of genital cancers seem to be increased in patients with human immunodeficiency virus (HIV) inf
Santarpia G; Venza M; Salmeri FM; Valenti A; Sottile A; Teti D; Institute of General Pathology, University of Messina, Italy.
Prostaglandin E2 (PGE2) appears to have an immunosuppressive role in human immunodeficiency virus (HIV) infection. Therefore, the effect was studied of PGE2 pretreatment of T lymphocytes from patients with lymphadenopathy associated syndrome (LAS) on the expression of CD25 and CD71 as well as plaque forming cell (PFC)
Ann Neurol. 1993 Nov;34(5):670-5. Unique Identifier : AIDSLINE MED/94058136
Achiron A; Pinhas-Hamiel O; Doll L; Djaldetti R; Chen A; Ziv I; Avni A; Frankel G; Melamed E; Shohat B; Department of Neurology, Beilinson Medical Center, Petah-Tiqva,; Israel.
The Mashhadi-Jewish community originating in Iran is a closed and ethnically segregated population with a unique history and a high rate of intrafamilial marriage among its members. A high risk of infection by human T-lymphotropic virus type I (HTLV-I) and of adult T-cell leukemia as
Zhang R; Lu Z; Diasio CR; Liu T; Soong SJ; Department of Pharmacology, University of Alabama at Birmingham; 35294.
3 -Azido-3 -deoxythymidine ( AZT ) is the drug most widely used in the treatment of AIDS. Its major drug-related toxicity is bone marrow suppression, which limits the dose of AZT that can be used. It is essential that AZT be phosphorylated for antiviral
Raffi F; Taburet AM; Ghaleh B; Huart A; Singlas E; Hopital Universitaire, Hotel-Dieu, Nantes, France.
The diffusion of foscarnet into cerebrospinal fluid (CSF) was studied in 27 patients with AIDS. Foscarnet was administered intravenously at various dosages at 12-h intervals. Concentrations in plasma and CSF at the end of foscarnet infusion or 1, 3, 5, 6, and 12 h after infusion were determined by high-performance liq
Cretton EM; Zhou Z; Kidd LB; McClure HM; Kaul S; Hitchcock MJ; Sommadossi JP; Department of Pharmacology, University of Alabama at Birmingham; 35294.
The disposition and metabolic fate of 3 -deoxy-2 ,3 -didehydrothymidine (D4T) were evaluated both in isolated hepatocytes and in nonhuman primates. Rapid formation of thymine and beta-aminoisobutyric acid (BAIBA) occurred following incubation of hepatocytes with 10 microM [5(-3)H]D4T. Substantial levels of tritiated w
Nightingale SD; Saletan SL; Swenson CE; Lawrence AJ; Watson DA; Pilkiewicz FG; Silverman EG; Cal SX; Division of General Internal Medicine, University of Texas; Southwestern Medical School, Dallas 75235-9103.
TLC G-65, a liposome-encapsulated gentamicin, was given intravenously twice weekly for 4 weeks to AIDS patients with Mycobacterium avium-M. intracellulare complex (MAC) bacteremia at 1.7 mg of gentamicin per kg of body weight per infusion (4 patients), 3.4 mg/kg (10 patients), and 5.1 mg/kg (7 patients). MAC colony co
Hancock JS; Taylor RN; Johnson CA; Gerber AR; Schalla WO; Centers for Disease Control and Prevention, US Department of; Health and Human Services, Atlanta, Ga.
To identify factors that may affect the quality of laboratory performance of human immunodeficiency virus type 1 (HIV-1) antibody testing, the Centers for Disease Control and Prevention Model Performance Evaluation Program surveyed laboratories in 1989 that performed enzyme immunoassay (EIA) and Western blot tests for
Greene WK; Meers J; del Fierro G; Carnegie PR; Robinson WF; School of Veterinary Studies, Murdoch University, Perth,; Australia.
In an investigation of the evolution of feline immunodeficiency virus (FIV) in vivo, sequential isolates from a persistently infected cat were examined by direct sequencing following amplification of selected subgenomic regions by polymerase chain reaction (PCR). Three isolates, T90, T91, and T92, obtained over a thre
Biochem Biophys Res Commun. 1993 Oct 29;196(2):935-42. Unique Identifier : AIDSLINE MED/94059126
Kaczmarski W; Khan SA; Wistar Institute, Philadelphia, PA 19104.
The control of HIV-1 gene expression depends upon interaction of Tat with the trans-activation responsive (TAR) element present at the 5 end of all HIV-1 transcripts. The TAR sequence forms a stable hair-pin structure that binds Tat and several cellular factors in vitro. In the absence of Tat, TAR acts as a transcrip
Yamamoto H; Sekiguchi T; Itagaki K; Saijo S; Iwakura Y; Laboratory of Experimental Pathology, Kohno Clinical Medicine; Research Institute, Tokyo, Japan.
OBJECTIVE. We have recently reported that arthropathy develops in high incidence among transgenic mice carrying the pX region of human T cell leukemia virus type I (HTLV-I). In the present study, the histopathologic features of the joints in these mice were examined in order to compare the animal disease with rheumato
Leowski J; Miller M; Instytut Gruzlicy i Chorob Pluc w Warszawie.
The paper describes the current epidemiological situation of tuberculosis in Poland , its trends in the last 2-3 decades and its place on comparison to the global world-wide situation. The incidence of tuberculosis in Poland declined
Hanlon MA; Marr JM; Hayes KA; Mathes LE; Stromberg PC; Ringler S; Krakowka S; Lafrado LJ; Ohio State University College of Dentistry, Columbus.
Experimental infection with the Mt. Airy isolate of feline immunodeficiency virus (FIVMA), a lentivirus isolated from a domestic cat exhibiting signs of an immunodeficiency-like syndrome, results in transient lymphadenopathy, fever, stomatitis, enteritis, neurologic abnormalities, and immunosuppression. The effects of
Ruby J; Sedger L; Ramshaw I; Division of Cell Biology, John Curtin School of Medical Research,; Australian National University, Canberra.
Antiviral activity of IFN-gamma and TNF has been demonstrated in vitro and in vivo. Recombinant vaccinia viruses that encode either of these cytokines are highly attenuated in vivo and, indeed, are no longer lethal when they are used to infect athymic nude mice. Thus, these cytokines are able to replace the requiremen
Dalgleish AG; Department of Cellular and Molecular Sciences, St. George's; Hospital Medical School, London, UK.
Recent information on the efficacy of anti-retroviral therapy and vaccination strategies has been disappointing as well as confusing. The recently announced Concorde study suggested that there is no advantage to early treatment of asymptomatic HIV infection with azidothymidine alone, even though the levels of CD4+ cel
Sheppard HW; Lang W; Ascher MS; Vittinghoff E; Winkelstein W; Viral and Rickettsial Disease Laboratory, California Department; of Health Services, Berkeley 947904.
OBJECTIVE: To identify and characterize individuals with long-term HIV-1 infection who have experienced little or no progressive CD4+ T-cell loss during follow-up. PATIENTS AND METHODS: The rate of CD4+ T-cell loss (CD4 slope) was determined for each of the 290 participants in the San Francisco Men s Health Study who
AIDS Res Hum Retroviruses. 1993 Aug;9(8):733-40. Unique Identifier : AIDSLINE MED/94031265
Fecondo JV; Pavuk NC; Silburn KA; Read DM; Mansell AS; Boyd AW; McPhee DA; Cellular Immunology Unit, Walter and Eliza Hall Institute of; Medical Research, Royal Melbourne Hospital, Victoria, Australia.
On the basis of reports demonstrating possible roles for leukocyte function-associated antigen 1 (LFA-1) and intercellular adhesion molecule 1 (ICAM-1), the ligand for LFA-1, in human immunodeficiency virus type 1 (HIV-1) infection, we have explored the involvement of the ICAM-1 molecule by using selected synthetic pe
AIDS Res Hum Retroviruses. 1993 Aug;9(8):761-73. Unique Identifier : AIDSLINE MED/94031269
Laurent-Crawford AG; Krust B; Riviere Y; Desgranges C; Muller S; Kieny MP; Dauguet C; Hovanessian AG; Institut Pasteur, Department of AIDS and Retroviruses, UA CNRS; 1157, Paris, France.
The cytopathic effect of HIV-1 and HIV-2 in CD4+ lymphocytes has been shown to be associated with apoptosis or programmed cell death. Using different experimental conditions, we demonstrate here that apoptosis is triggered by cell membrane expression of the mature HIV envelope glycoproteins, gp120-gp41 complex, and th
AIDS Res Hum Retroviruses. 1993 Aug;9(8):775-80. Unique Identifier : AIDSLINE MED/94031270
Sasaki Y; Honda M; Makino M; Sasaki T; Department of Safety Research on Biologics, National Institute of; Health, Tokyo, Japan.
Because mycoplasma infection has often been observed in individuals infected with human immunodeficiency virus type 1 (HIV-1), we investigated the influence of mycoplasmas on HIV replication in vitro. Replication of HIV-1 assessed by reverse transcriptase activity and the p24 antigen level in peripheral blood mononucl
Lin RY; Schwartz RA; Department of Medicine, St Vincent's Hospital, New York Medical; College, New York.
Three patients, all seropositive for HIV antibody, complained of swelling and pruritus on the head and limbs when exposed to the cold. All three had received zidovudine for significant CD4 cell depletion, but had no AIDS-defining illnesses. An ice-cube test was positive on each individual. There was no evidence of col
Newman LN; Tessman M; Hanslik T; Schulak J; Mayes J; Friedlander M; Department of Medical-Surgical Nursing, University Hospitals of; Cleveland, Case-Western Reserve University, Ohio.
To determine factors that lead to successful healing, the results of catheter placement were collected by retrospective chart review in 103 peritoneal dialysis patients between January 1988 and March 1992. There were a total of 112 catheter insertions. A healing time of less than 2 weeks was defined as an optimal outc
Pivetti-Pezzi P; Tamburi S; Accorinti M; Mezzaroma I; Vullo V; Sorice F; Aiuti F; Institute of Ophthalmology, University of Roma La Sapienza,; Italy.
The relationship between retinal microangiopathy and some features of human immunodeficiency virus (HIV) infection such as HIV antigenemia, antibodies to the viral proteins, T lymphocyte subsets, were studied in 71 patients with acquired immunodeficiency syndrome (AIDS). The absence of antibodies to the HIV p24 protei
Sale M; Sheiner LB; Volberding P; Blaschke TF; Division of Clinical Pharmacology, Stanford University School of; Medicine, Calif.
OBJECTIVE: To examine predictors of magnitude of CD4+ response to treatment of human immunodeficiency virus (HIV) infection with zidovudine. METHODS: This was a post hoc analysis of randomized placebo-controlled clinical trial in a multicenter trial, 1423 asymptomatic HIV-positive subjects with CD4+ cell counts less t
Zufferey J; Sugar A; Rudaz P; Bille J; Glauser MP; Chave JP; Institute of Microbiology, Centre Hospitalier Universitaire; Vaudois, Lausanne, Switzerland.
The seroprevalence of latent Toxoplasma gondii infection was determined in a cohort of 715 HIV-positive patients followed up at an HIV outpatient clinic. Using indirect immunofluorescence and direct agglutination assays for detecting IgG, the prevalence of anti-Toxoplasma gondii antibodies was shown to be 50%. During
Telenti A; Uehlinger DE; Marchesi F; Germann D; Malinverni R; Matter L; Institute of Medical Microbiology, University of Berne,; Switzerland.
The relationship between Epstein-Barr virus (EBV) viral load in peripheral blood and HIV infection was determined in 103 HIV-infected patients. Epstein-Barr virus was detected by polymerase chain reaction in 75% of the patients, 21% of whom had the more uncommon EBV subtype 2. The highest levels of EBV were found in p
Stellbrink HJ; Albrecht H; Plettenberg A; Stoehr A; Laufs R; Fenske S; Greten H; Medizinische Kernklinik und Poliklinik, Universitatskrankenhaus; Eppendorf, Hamburg, Germany.
Twenty-eight patients with different stages of HIV infection who had not undergone antiretroviral pretreatment were treated with an escalating dose regimen of zidovudine (4 weeks 2 x 50 mg, 4 weeks 2 x 100 mg, 4 weeks 2 x 250 mg). CD4+ cell counts and p24 antigen levels were monitored every four weeks. Twenty-one pati
Sule-Odu AO; Department of Obstetrics and Gynaecology, Obafemi Awolowo College; of Health Sciences, Ogun State University, Sagamu, Nigeria.
Human immunodeficiency virus, which causes acquired immunodeficiency syndrome can be transmitted vertically from mother to child and is associated with high morbidity and mortality in infants and children. A case of a mother transmitting the virus in-utero to the fetus is presented. The woman had a preterm emergency l
Hernandez Quero J; Ortego Centeno N; Munoz-Torres M; Martinez Perez MA; Higuera Torres-Puchol JM; Infectious Disease Unit, University of Granada Hospital, School; of Medicine, University of Granada, Spain.
Changes in mineral metabolism have recently been described in AIDS patients. To determine whether such changes affect bone turnover and bone mass, we studied 16 HIV-seropositive patients, classified according to Centers for Disease Control criteria, and 27 healthy controls. Biochemical markers of bone turnover and bon
Bansal AS; Moran A; Potter M; Taylor R; Haeney MR; Mandal BK; Department of Immunology, Hope Hospital, Salford.
AIMS--To determine whether the routine measurement of lymphocyte transformation responses to mitogenic stimuli provide any information additional to that available from routine T cell CD4 and CD8 analysis in patients with HIV infection. METHODS--The case records of 197 immunologically investigated HIV seropositive pat
Lu W; Grassi F; Tourani JM; Eme D; Israel-Biet D; Andrieu JM; Laboratory of Tumor Immunology, Hopital Laennec, Universite de; Paris V, France.
In a cohort of 103 asymptomatic seropositive subjects (Centers for Disease Control and Prevention [CDC] stage II/III) followed for 2 years, the concentration of peripheral blood mononuclear cells harboring infectious human immunodeficiency virus (HIV) type 1 (viral burden) was correlated with the rate of decrease of C
Jereb JA; Burwen DR; Dooley SW; Haas WH; Crawford JT; Geiter LJ; Edmond MB; Dowling JN; Shapiro R; Pasculle AW; et al; Division of Tuberculosis Elimination, Centers for Disease Control; and Prevention, Atlanta, GA 30333.
From January 1990 through February 1991, tuberculosis (TB) developed in 10 renal transplant (RT) patients at one hospital; 5 patients died. Possible nosocomial transmission was investigated. Mycobacterium tuberculosis isolates were compared by restriction fragment length polymorphism (RFLP) by a polymerase chain react
Vernazza PL; Eron JJ; Fiscus SA; Dept. of Medicine, University of North Carolina at Chapel Hill; 27599-7030.
Quantitation of human immunodeficiency virus type 1 (HIV-1) in plasma is frequently used to monitor virus load and assess the effect of antiviral agents, but information regarding the stability of the virus is limited. Plasma from patients with CD4 cell counts of
De Rossi A; Giaquinto C; Ometto L; Mammano F; Zanotto C; Dunn D; Chieco-Bianchi L; Institute of Oncology, InterUniversity Center for Cancer; Research, Padua, Italy.
In a series of 97 infants born to mothers who were seropositive for human immunodeficiency virus type 1 (HIV-1), 18 were identified as infected within the first 60 days of life on the basis of viral culture and polymerase chain reaction findings. We studied viral burden in vivo by quantitative polymerase chain reactio
Ammann AJ; Ariel Project for the Prevention of HIV Transmission from Mother; to Infant, Novato, CA 94949.
We hypothesize that graft-versus-host disease (GVHD) does not occur in HIV-1-infected subjects because graft cells (or host cells recognizing antigenic differences in other host cells) mediating the graft-versus-host reaction are CD4+ T cells that become infected with HIV-1 and are rendered immunologically incompetent
Visconti A; Visconti L; Bellocco R; Binkin N; Colucci G; Vernocchi L; Amendola M; Ciaci D; Institute of Medical Microbiology, University of Milan, Italy.
To determine whether coinfection with HTLV-II influences the course of HIV-1 infection, we evaluated the progression from asymptomatic HIV infection (CDC group II) to persistent generalized lymphadenopathy (CDC group III) to AIDS-related complex (CDC group IVA) to full-blown AIDS (CDC group IVC) to death from AIDS in
Birx DL; Brundage J; Larson K; Engler R; Smith L; Squire E; Carpenter G; Sullivan M; Rhoads J; Oster C; et al; Department of Retroviral Research, WRAIR, Washington, D.C.
Many reagents and techniques have been used for delayed-type hypersensitivity (DTH) skin testing in the evaluation of HIV-infected patients, resulting in varied interpretation of the utility of DTH skin testing in this population. We report the development of a simple algorithm for selection of DTH antigens and the cl
Graham NM; Piantadosi S; Park LP; Phair JP; Rinaldo CR; Fahey JL; Department of Epidemiology, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, Maryland 21205.
It is unknown whether the early rise in CD4+ lymphocyte count seen in zidovudine-treated patients is associated with increased AIDS-free time and survival time. To determine the association of this and other changes in immunologic and hematologic markers with prognosis for time to AIDS and survival, we followed 747 AI
JAMA. 1993 Dec 1;270(21):2563-7. Unique Identifier : AIDSLINE MED/94047568
Lyketsos CG; Hoover DR; Guccione M; Senterfitt W; Dew MA; Wesch J; VanRaden MJ; Treisman GJ; Morgenstern H; Department of Psychiatry, School of Medicine, Johns Hopkins; University, Baltimore, Md.
OBJECTIVE--To ascertain whether depressive symptoms as determined by the Center for Epidemiologic Studies-Depression scale (CES-D) predict accelerated mortality and worse medical outcomes in patients infected with human immunodeficiency virus (HIV). DESIGN--Eight-year cohort study with semiannual follow-up. SETTING--C
JAMA. 1993 Dec 1;270(21):2568-73. Unique Identifier : AIDSLINE MED/94047569
Burack JH; Barrett DC; Stall RD; Chesney MA; Ekstrand ML; Coates TJ; AIDS Program, San Francisco General Hospital, CA.
OBJECTIVE--To investigate whether high levels of depressive symptomatology at baseline predict more rapid decline of CD4 lymphocyte counts and progression of clinical disease in persons infected with the human immunodeficiency virus (HIV). DESIGN--Prospective cohort study with semiannual data collection waves and up t
JAMA. 1993 Dec 1;270(21):2583-9. Unique Identifier : AIDSLINE MED/94047572
Sande MA; Carpenter CC; Cobbs CG; Holmes KK; Sanford JP; Department of Medicine, University of California, San Francisco.
This document summarizes recommendations from a state-of-the-art conference convened to evaluate the role of nucleoside analogue reverse transcriptase inhibitors in the treatment of human immunodeficiency virus (HIV) infection. Data from controlled clinical trials of zidovudine, didanosine, and zalcitabine were review
Hubbard GB; Mone JP; Allan JS; Davis KJ 3d; Leland MM; Banks PM; Smir B; Southwest Foundation for Biomedical Research, San Antonio, TX; 78228.
Simian T-cell leukemia virus type 1 (STLV-1), a type C retrovirus associated with leukemia/lymphoma in Old World monkeys, is closely related to human T-cell leukemia virus type 1, the etiologic agent of adult T-cell leukemia/lymphoma in humans. In a colony of 3200 baboons, the prevalence of antibodies to STLV-1 is mor
Med Clin North Am. 1993 Nov;77(6):1219-34. Unique Identifier : AIDSLINE MED/94048411
Marks GL; Department of Medicine, University of South Alabama College of; Medicine, Mobile.
Molecular methods for identifying organisms, strain typing, and determining drug susceptibilities are extremely valuable for pathogens that are impossible to grow on artificial media, slow growing on artificial media, or exceptionally hazardous to grow in a clinical microbiology laboratory. DNA hybridization probes an
Lancet. 1993 Nov 27;342(8883):1348-51. Unique Identifier : AIDSLINE MED/94048766
Ziegler JL; Department of Clinical Sciences, London School of Hygiene and; Tropical Medicine, UK.
Endemic Kaposi s sarcoma (KS) in Africa has been attributed to a geographically-determined environmental factor. Endemic KS, a chronic nodular condition predominantly affecting the feet and legs, is believed to arise in the lymphatic endothelium and is associated with chronic lymphoedema. As such, KS bears a resemblan
Leibovitz E; Cooper D; Giurgiutiu D; Coman G; Straus I; Orlow SJ; Lawrence R; Department of Pediatrics, New York University School of Medicine,; NY.
OBJECTIVE. Varicella-zoster virus (VZV) infections can cause severe disease in immunocompromised individuals. To evaluate the spectrum of VZV infections in human immunodeficiency virus (HIV)-infected children, we retrospectively analyzed all the cases of VZV infection in a cohort of children cared for at a hospital fo
Reyes-Teran G; Ponce de Leon S; Departamento de Infectologia, Instituto Nacional de la; Nutricion Salvador Zubiran.
The hallmark of the HIV-1 infection is the progressive depletion of the circulating CD4+ T cells. The prophylactic, therapeutic and prognosis criteria of the HIV-1 infected patients are based on the measurement of these cells. However, there are serious analytical and biological variations in the count of CD4+T cells.
Zachariae CO; Department of Dermatology, Marselisborg Hospital, University of; Aarhus, Denmark.
This thesis discusses the phenotypic characteristics of different inflammatory dermatological diseases and sets this into context with the specific chemotactic ability of different cytokines. It further discusses the biological properties of different chemotactic cytokines and their relevance in certain inflammatory d
Adv Exp Med Biol. 1993;335:235-40. Unique Identifier : AIDSLINE MED/94055950
Yangco BG; Kenyon VS; St. Joseph's Hospital Infectious Disease Research Institute; Tampa, FL 33677-4227.
From July 1, 1991 to March 31, 1992, 156 patients (pts) with positive antibody titers to the human immunodeficiency virus (HIV) were seen in our clinic. A retrospective review of the epidemiology and infectious complications of these patients is presented. There were 129 males and 27 females (4.8:1, ratio). Only 10/15
Am J Epidemiol. 1993 Nov 15;138(10):870-8. Unique Identifier : AIDSLINE MED/94056357
Phillips AN; Sabin CA; Elford J; Bofill M; Janossy G; Lee CA; Academic Department of Genito-Urinary Medicine, University; College and Middlesex School of Medicine, London, England.
The loss of CD4 lymphocytes is known to be an important component of human immunodeficiency virus type 1 (HIV-1) pathogenesis. It remains unclear, however, whether the importance of the CD4 lymphocyte count is such that individuals who have been infected for widely different lengths of time, but for whom the CD4 lymph
Jones BE; Young SM; Antoniskis D; Davidson PT; Kramer F; Barnes PF; Department of Medicine, University of Southern California School; of Medicine, Los Angeles.
To evaluate the relationship between the clinical presentation of tuberculosis and the CD4 cell count in patients with human immunodeficiency virus (HIV) infection, we evaluated clinical and laboratory features of 97 HIV-infected patients with tuberculosis in whom CD4 cell counts were available. Extrapulmonary tubercu
Szkaradkiewicz A; Clinic of Infectious Diseases, Institute of Microbiology and; Infectious Diseases, Medical Academy, Poznan, Poland.
Interleukin 1 (IL-1) secretion was studied in cultures of peripheral blood monocytes originating from asymptomatic HIV carriers and patients with clinically apparent HIV infection, diagnosed as persistent, generalised lymphadenopathy (PGL) or AIDS-related complex (ARC). The spontaneous and LPS-stimulated release of th
Rabkin CS; Hatzakis A; Griffiths PD; Pillay D; Ragni MV; Hilgartner MW; Goedert JJ; Viral Epidemiology Branch, National Cancer Institute, Rockville,; MD 20852.
The effects of prevalent and incident cytomegalovirus ( CMV ) infection on human immunodeficiency virus (HIV) disease progression were examined in 393 hemophilia patients with known dates of HIV seroconversion. Of the cases, 19
Lima GC; Zyad A; Decreusefond C; Mevel JC; Stiffel C; Mouton D; Couderc J; Departamento de Imunologia, Universidade de Sao Paulo, Brazil.
The T-cell compartment was investigated in two high antibody responder lines of mice respectively susceptible (HI) and resistant (HII) to chicken collagen (CII)-induced arthritis (CIA). Previous data had shown that both lines were high anti-CII Ab producers, without any TCR V-beta gene defect or membrane expression im
Koup RA; Brewster F; Grob P; Sullivan JL; University of Massachusetts Medical School, Department of; Pediatrics, Worcester.
OBJECTIVE: To determine whether synergistic inhibition of HIV-1 replication would result from the in vitro use of nevirapine in combination with zidovudine, interferon (IFN)-alpha 2C, and CD4 immunoadhesin. DESIGN AND METHODS: The non-nucleoside rever
AIDS Res Hum Retroviruses. 1993 Aug;9(8):747-54. Unique Identifier : AIDSLINE MED/94031267
Yang JY; Schwartz A; Henderson EE; Department of Microbiology and Immunology, Temple University; School of Medicine, Philadelphia, Pennsylvania 19140.
The initial infection with human immunodeficiency virus type 1 (HIV-1) in most individuals usually results in the establishment of a latent or chronic infection before eventual progression toward acquired immunodeficiency syndrome. HIV-1 can also establish a latent or persistent infection in some T cell lines that sho
Biochemistry. 1993 Nov 16;32(45):12112-8. Unique Identifier : AIDSLINE MED/94032346
Sobol RW; Fisher WL; Reichenbach NL; Kumar A; Beard WA; Wilson SH; Charubala R; Pfleiderer W; Suhadolnik RJ; Department of Biochemistry, Temple University School of Medicine,; Philadelphia, Pennsylvania 19140.
2 ,5 -Oligoadenylates (2-5A) and derivatives are noncompetitive inhibitors of primer/HIV-1 reverse transcriptase complex formation. The mechanism and specificity of this inhibitory action of 2-5A and 2-5A derivatives have been evaluated with 2-5A molecules modified in ribosyl moiety, chain length, extent of 5 -phospho
Maury G; Divita G; Morvan F; Imbach JL; Goody RS; Universite de Montpellier II, URA 488 du C.N.R.S., Montpellier,; France.
Intrinsic fluorescence of human immunodeficiency virus type 1 reverse transcriptase (E.C. 2.7.7.49) and displacement experiments of a fluorescent template.primer probe were used to study the interaction of the enzyme with several types of 28- and 14-mer normal or phosphorothioate oligodeoxycytidinylates and their dupl
Buiser RG; Bambara RA; Fay PJ; Department of Biochemistry, University of Rochester, NY 14642.
We have examined the ability of reverse transcriptases (RT) to catalyze strand transfer from internal regions of RNA templates, resulting in switching of a primer from one template to another. To study this phenomenon, we employed a system of donor and acceptor templates in which homologous strand transfer can occur f
Blood. 1993 Nov 1;82(9):2774-80. Unique Identifier : AIDSLINE MED/94033562
Hofman FM; Wright AD; Dohadwala MM; Wong-Staal F; Walker SM; Department of Pathology, University of Southern California School; of Medicine, Los Angeles 90033.
tat protein, a human immunodeficiency virus (HIV) gene product that functions as a transactivator for HIV replication, is known to be secreted extracellularly by infected cells. To determine the potential role of tat in the dissemination of HIV into extravascular tissue, this protein was examined for its ability to ac
Blood. 1993 Nov 1;82(9):2823-8. Unique Identifier : AIDSLINE MED/94033568
Nagafuji K; Harada M; Teshima T; Eto T; Takamatsu Y; Okamura T; Murakawa M; Akashi K; Niho Y; First Department of Internal Medicine, Faculty of Medicine,; Kyushu University, Fukuoka, Japan.
The in vivo host range of human T-cell leukemia virus type 1 (HTLV-1) has not been definitively established. To determine if hematopoietic stem cells from patients with adult T-cell leukemia-lymphoma (ATL) are infected with HTLV-1, we used a clonogenic progenitor assay followed by the polymerase chain reaction for the
Imamura N; Abe K; Kuramoto A; Department of Internal Medicine, Hiroshima University, Japan.
We describe here a case of T-cell lymphocytic leukemia (T-CLL) which coexpressed CD4 and CD45RA cell-surface antigens and functioned as suppressor inducer cells. The patient, an 81 year-old man, had massive generalized lymphadenopathy. His hemoglobin was 9.4g/dl, the platelet count 94,000, and the WBC was 895,000/micr
Imboden P; Burkart T; Schopfer K; Institute of Medical Microbiology, University of Berne,; Switzerland.
A new technique, the differential polymerase chain reaction (DIFF-PCR), allows the simultaneous amplification of DNA and homologous RNA in a single assay by the combination of DNA-PCR and RNA-PCR on the same target. DNA-PCR amplifies a selected segment of dsDNA, whereas RNA-PCR amplifies a complementary DNA (cDNA), pr
Li BQ; Fu T; Yan YD; Baylor NW; Ruscetti FW; Kung HF; Biological Carcinogenesis and Development Program, Program; Resources Inc./DynCorp, National Cancer Institute-Frederick; Cancer Research and Development Center, MD 21202-1201.
Baicalin (BA), (formulated as 7-D-glucuronic acid-5,6-dihydroxy-flavone), was purified from the plant Scutellaria Baicalensis Georgi. It has been used as a traditional Chinese herbal medicine. The inhibitory effect of BA against human immunodeficiency virus (HIV-1) infection and replication has been studied in vitro.
The recent characterisation of a new species of the genus Rochalimaea is the culmination of a ten year search for the identity of the agent of bacillary angiomatosis , a condition that is increasingly recognised in association with AIDS. This work has also implicated Rochalima
Blair I; Gleave S; West Midlands Regional Health Authority.
We describe a new active surveillance system for human immunodeficiency virus (HIV) infection in the West Midlands region, a National Health Service administrative area in central England serving a population of five million. A detailed, confidential dataset is collected on each case of HIV infection identified throug
In a multicenter study on HIV prevalence the German Red Cross Blood Banks provide information on the safety of blood products and the epidemiology of HIV infections in blood donors in the FRG. Although statistically not yet significant, there are trends to an increasing number of HIV infections especially in young mal
In addition to several conventional methods for the detection of red cell antigens, the use of microplates has various advantages either as a solid-phase assay (enzyme immunoassay) or as native microplate. Microplates may also be used for the detection of red cell antibodies in pooled-cell solid-phase assays of the
The overall risk of autologous hemotherapy, consisting of the risks due to donation and transfusion, has to be lower than that of homologous hemotherapy. To maintain the advantage of autologous blood, for example preoperative blood deposit, it has to be collected and prepared according to the guidelines on the product
Weisshaar D; Blutspendedienst Hessen des DRK, Institut Kassel, BRD.
We report on the adaptation of a Walkaway instrument (ES 600, Boehringer Mannheim) to be used in a blood transfusion service for donor screening of HBsAG and anti-HIV 1 + 2. Anti- CMV is obtainable, and anti-HCV will be available in the near future. Sample proc
The evaluation of a new Walkaway instrument (Behring Elisa Processor III) for testing HBsAG, anti-HCV and anti-HIV 1/2 in three blood transfusion services with different sample volumes (from 60,000 to 450,000/year) gave the following results: the instrument fulfills the promises of being a real Walkaway system under r
The enormous progress made in biotechnology and purification of plasma proteins (pp) and the demands to avoid risks of transmitting HIV, hepatitis and other virus infections by these have resulted in the development of numerous recombinant human (rh) pp, which are now about to be used as replacement therapy in transfu
Since several years the frequency of HIV infections among screened blood donors in Baden-Wurttemberg (a state in southwest Germany ) shows no remarkable differences between the German Red Cross donors and the donors of other blood banks. The authors advocate the hypothesis that dif
Wilde MI; Langtry HD; Adis International Limited, Auckland, New Zealand.
Zidovudine remains the mainstay in the treatment of patients infected with human immunodeficiency virus (HIV). The drug delays disease progression to acquired immunodeficiency syndrome (AIDS) and to AIDS-related complex (ARC), reduces opportunistic infections, and increases survival in patients with advanced HIV infec
Salvetti A; Lilienbaum A; Portier MM; Gounon P; Paulin D; Gazzolo L; UMR 30 Centre National de la Recherche Scientifique, Universite; Claude Bernard Lyon I, Faculte de Medecine A. Carrel, France.
Intermediate filaments (IF) represent major components of the cytoskeletal network. These proteins which are differentially expressed according to the cell type, constitute a dynamic structure which not only contributes to the cell architecture but also defines its state of differentiation. Furthermore, numerous obser
Bergmann C; Stohlmann SA; McMillan M; Department of Neurology, University of Southern California School; of Medicine, Los Angeles 90033.
The immunodominant H-2Dd-restricted cytotoxic T lymphocyte (CTL) response to the HIV-1 gp160 envelope glycoprotein maps to a single determinant in the V3 loop, designated p18. Using a series of peptides synthesized on pins we have determined that the minimal core sequence of this determinant required for CTL recogniti
Jennings R; Clegg A; Department of Experimental and Clinical Microbiology, University; of Sheffield Medical School, UK.
Five spermicides including nonoxynol-9 were assessed under in-vitro conditions, for their inhibitory activity against two viruses capable of spread by sexual intercourse, herpes simplex virus type-2 (HSV-2) and the human immunodeficiency virus type-1. A further eight commercially-available spermicidal preparations con
Skalski V; Chang CN; Dutschman G; Cheng YC; Department of Pharmacology, Yale University School of Medicine,; New Haven, Connecticut 06510.
Two cis stereoisomers of 2 ,3 -dideoxy-3 -thiacytidine (SddC) were investigated for their activity against human immunodeficiency virus type 1 (HIV-1) in human acute lymphoblastic leukemia H-9 cells. (-)-SddC is six times more potent against HIV-1 and at least 1.7-fold less cytotoxic than (+)-SddC. Metabolism studies
Cai H; Bloom LB; Eritja R; Goodman MF; Department of Biological Sciences, University of Southern; California, Los Angeles 90089-1340.
Deoxyribonucleotide insertion efficiencies were measured opposite site-directed abasic template lesions using human immunodeficiency virus 1 reverse transcriptase (HIV-1RT), and the efficiencies to continue primer synthesis beyond the lesion, by addition of the next correct deoxynucleotide, were measured as a function
Hsieh JC; Zinnen S; Modrich P; Department of Biochemistry, Duke University Medical Center,; Durham, North Carolina 27710.
The kinetic pathway of DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase (HIV RT) as determined by pre-steady-state methods using a defined primer/template is as follows, [formula: see text] where E is RT, Dn,n+1 is primer/template, dNTP is deoxyribonucleoside triphosphate, an
Wannemuehler Y; Isaacson J; Wannemuehler M; Wood C; Roth JA; Carpenter S; Department of Microbiology, Immunology, and Preventive Medicine,; College of Veterinary Medicine, Iowa State University, Ames; 50011.
An Escherichia coli recombinant fusion protein containing the major core protein of bovine immunodeficiency-like virus (BIV) was used to immunize mice for generation of monoclonal antibodies to BIV p26. Eight hybridomas specific for BIV p26 were identified and two antibodies, designated 104 and 142, were further chara
J Immunol. 1993 Nov 15;151(10):5172-85. Unique Identifier : AIDSLINE MED/94044742
Hauser IA; Johnson DR; Madri JA; Department of Pathology, Yale University School of Medicine, New; Haven, CT 06510.
Venous and arterial large vessel endothelial cells (EC) were compared for their constitutive and TNF-alpha-induced expression of the cell-surface adhesion molecules ICAM-1 and -2, VCAM-1 and ELAM-1 by FACS analysis. Human iliac venous and arterial EC (HIVEC and HIAEC) constitutively express ICAM-1 and ICAM-2. TNF-alph
J Immunol. 1993 Nov 15;151(10):5408-15. Unique Identifier : AIDSLINE MED/94044765
Battegay M; Moskophidis D; Waldner H; Brundler MA; Fung-Leung WP; Mak TW; Hengartner H; Zinkernagel RM; Department of Pathology, University of Zurich, Switzerland.
After infection with some viruses that tend to persist, neutralizing antibodies are generated rather late, i.e., after 1 to 3 mo. This has been observed for HIV, Hepatitis B infection in man, or after infection with lymphocytic choriomeningitis virus (LCMV) in mice. In contrast, nonneutralizing antibodies to LCMV are
J Med Virol. 1993 Sep;41(1):71-8. Unique Identifier : AIDSLINE MED/94045591
St Luce S; Arts E; Geleziunas R; Bour S; Wainberg MA; Lady Davis Institute, Jewish General Hospital, Montreal, Quebec,; Canada.
We have infected ten-day-old primary cultures of human monocyte-derived macrophages (MDM) with HIV-1 by cocultivation with chronically infected monocytic cell lines. This work has involved the U-937 monocytoid cell line, chronically infected with the HIV-IIIB strain of HIV-1 (U-937HIV IIIB) as well as a number of cell
Snowden W; Coughlan N; Tisdale M; Stammers DK; Wellcome Research Laboratories, Beckenham, Kent, England.
Monoclonal antibodies to human immunodeficiency virus (HIV)-2 reverse transcriptase have been raised with the ultimate goal of generating Fab fragments for future co-crystallization studies. A number of mouse monoclonal antibodies to recombinant HIV-2 reverse transcriptase have been obtained and characterized in terms
Carr DJ; France CP; Department of Microbiology, Immunology and Parasitology,; Louisiana State University Medical Center, New Orleans.
The effect of morphine treatment on immunocompetence was investigated in rhesus monkeys (Mucaca mulatta). Monkeys that received morphine daily (3.2 mg/kg) had suppressed peripheral blood mononuclear cell (PBMC) natural killer (NK) activity as well as a decrease in the percentage of CD8+CD16+ cells compared with saline
J Med Primatol. 1993 Jun;22(4):263-8. Unique Identifier : AIDSLINE MED/94047039
Otteken A; Nick S; Bergter W; Luke W; Stahl-Hennig C; Peters JH; Voss G; Hunsmann G; Abteilung Virologie und Immunologie, Deutsches Primatenzentrum,; Gottingen, Germany.
Five monoclonal antibodies (mabs) specific for the envelope proteins of a simian immunodeficiency virus of African green monkeys (SIVagm) have been raised. Two mabs were directed against distinct epitopes on the transmembrane protein gp41. A conformational epitope on the gp130 was recognized by three mabs. This is the
Wang CT; Zhang Y; McDermott J; Barklis E; Vollum Institute for Advanced Biomedical Research, Oregon Health; Sciences University, Portland 97201-3098.
We constructed a human immunodeficiency virus (HIV) matrix (MA) deletion mutant by deletion of about 80% of the HIV type 1 Gag MA domain but retaining myristylation and proteolytic processing signals. The effects of this deletion matrix (dl.MA) mutant on HIV particle assembly, processing, and infectivity were analyzed
Sattentau QJ; Moore JP; Vignaux F; Traincard F; Poignard P; Centre d'Immunologie de Marseille-Luminy, Marseille, France.
We have investigated the molecular basis of biological differences observed among cell line-adapted isolates of the human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) and the simian immunodeficiency virus (SIV) in response to receptor binding by using a soluble form of CD4 (sCD4) as a receptor mimic. We find
Watkins BA; Reitz MS Jr; Wilson CA; Aldrich K; Davis AE; Robert-Guroff M; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892.
Sera from many HIV-1-infected individuals contain broadly reactive, specific neutralizing antibodies. Despite their broad reactivity, variant viruses, resistant to neutralization, can be selected in vitro in the presence of such antisera. We have previously shown that neutralization resistance of an escape mutant with
Lancet. 1993 Nov 20;342(8882):1274-5. Unique Identifier : AIDSLINE MED/94048707
Hohmann AW; Booth K; Peters V; Gordon DL; Comacchio RM; Department of Clinical Immunology, Flinders Medical Centre,; Bedford Park, Australia.
Mimicry of human antigen by HIV may underlie the autoreactivity seen in AIDS. A mouse monoclonal antibody (VIC8) raised against HIV p24 cross-reacted with human platelets; binding could be abolished by recombinant p24 antigen. VIC8 bound less well to platelets from patients with HIV than to those from healthy individu
Med Hypotheses. 1993 Jul;41(1):61-2. Unique Identifier : AIDSLINE MED/94049322
Harris PJ; AIDS Clinical Research Center of Washington, Washington, DC; 20009.
The development and maturation of blood cells in known to be regulated by soluble factors. We propose that immunologic alterations, specifically autoantibodies, to these soluble factors may affect hematopoiesis.
Disturbances of interferon synthesis with the hyperproduction of unusual kinds of interferons may be the initial step which triggers autoimmune disease through a concatenation of pathological reactions including the disturbance of several immunological and interferon cascades. This fundamental disturbance can result e
Faisst AC; Otteken A; Nick S; Hunsmann G; Deutsches Primatenzentrum, Abteilung Virologie und Immunologie,; Gottingen, Germany.
The purpose of this study was to characterize antigenic determinants on structural polypeptides of human immunodeficiency virus type 2 (HIV-2ben). Therefore, three HIV-2-specific monoclonal antibodies (mAbs) against the p24 core protein (gag) and one mAb against the gp130 envelope glycoprotein (env) were produced. In
Balzarini J; Karlsson A; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit,; Leuven, Belgium.
Of the class of the 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-thymine (HEPT) derivatives, several congeners were found to inhibit (at 50% effective concentrations ranging from 0.02 to 0.6 microgram/ml) the replication of mutant human immunodeficiency virus type 1 (HIV-1) strains that had been selected for resistance
Yuasa S; Sadakata Y; Takashima H; Sekiya K; Inouye N; Ubasawa M; Baba M; Laboratory of Pharmaceuticals, Mitsubishi Kasei Corp., Yokohama,; Japan.
In the search for 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives, we have found 6-benzyl-1-(ethoxymethyl)-5-isopropyl-uracil (MKC-442) to be a highly potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). The IC50 value of MKC-442 for HIV-1 RT was 8 nM.
Khodyreva SN; Podust VN; Sergeev DS; Ivanova EM; Frolova EI; Koshkin AA; Godovikova TS; Zarytova VF; Ricchetti M; Lavrik OI; Novosibirsk Institute of Bioorganic Chemistry, Siberian Division; of the Russian Academy of Sciences, Novosibirsk.
Km and Vmax values for d(pT8) and its derivatives containing various 5 -end groups were estimated in the reaction of DNA polymerization alpha catalyzed by DNA polymerase alpha and HIV-RT. The effect of 5 -end modification of primer is more pronounced in the case of HIV-RT. Strong influence is observed for an intercala
Mutat Res. 1993 Dec;303(4):143-50. Unique Identifier : AIDSLINE MED/94049934
Fix D; Department of Microbiology, Southern Illinois University,; Carbondale 62901.
Inactivation and mutagenesis of Escherichia coli by ultraviolet light and N-methyl-N-nitrosourea (MNU) were examined in isogenic strains that were (i) free of lambda phage, (ii) lysogenic for lambda or (iii) contained the lambda rexAB operon on a plasmid (prex20). Inactivation was enhanced when rex genes were present
Pol Tyg Lek. 1993 Mar 1-8;48(9-10):213-4. Unique Identifier : AIDSLINE MED/94051865
Caban J; Garlicki A; Dolezal M; Katedry i Kliniki Chorob Zakaznych AM, Krakowie.
Blood and blood products transfusions increase the risk of infection transfer from the donor to recipient. Recently, researchers focus on the post-transfusion hepatitis. Therefore, we surveyed 142 documentations of drug addicts treated at the AIDS out-patient clinic in Krakow. Anti-HCV antibodies have been found in 82
South Med J. 1993 Nov;86(11):1219-24. Unique Identifier : AIDSLINE MED/94053915
Sloand E; Kumar PN; Pierce PF; National Heart, Lung, and Blood Institute, National Institutes of; Health, Bethesda, Md. 20892.
Kaposi s sarcoma (KS) is common in individuals infected with the human immunodeficiency virus (HIV-1). Although KS is frequently indolent, it can also be aggressive and life-threatening, especially in patients with pulmonary involvement (PKS), who have poor survival rates when untreated. In an effort to develop treatm
Biochem Biophys Res Commun. 1993 Oct 29;196(2):914-20. Unique Identifier : AIDSLINE MED/94059123
Shaharabany M; Rice NR; Hizi A; Department of Cell Biology and Histology, Sackler School of; Medicine, Tel Aviv University, Israel.
The reverse transcriptase of equine infectious anemia virus (EIAV) shows sequence similarity with the reverse transcriptases of other lentiviruses, particularly with those of human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). We have constructed a plasmid that when introduced into E. coli induces the synt
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