Pediatric HIV associated non-Hodgkin's lymphomas (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

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Pediatric HIV associated non-Hodgkin's lymphomas (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 35:A1140 1994. Unique Identifier : AIDSLINE ICDB/94602826
Shad A; Bhatia K; Hamdy N; Mueller B; Pizzo P; Whang Peng J; Jaffe E; Magrath I; Pediatric Branch, Pathology Dept., NCI, Bethesda, MD 20892

Abstract: HIV infected children, like HIV infected adults, are at increased risk for development of non-Hodgkin's lymphomas (NHL). However, there is very little information available on the histological, cytogenetic and molecular features of pediatric HIV associated NHLs. We present here the pathological and biological features of 5 such pediatric lymphomas. Histologically, unlike non-immunosuppressed children, where Burkitt's lymphoma is the most common form of NHL seen, pediatric HIV associated NHLs are more variable. 3 tumors analyzed were small non-cleaved cell lymphomas (SNCC), 1 large cell immunoblastic lymphoma, 1 anaplastic large cell lymphoma (Ki-1+), and 1 B cell lymphoma with plasmacytoid features. Cytogenetic studies demonstrated that 2 of 3 SNCC lymphomas had t(8;14) while 1 had t(9;19); the large cell immunoblastic lymphoma had an inv(12). By Southern blot analyses, both tumors with t(8;14) had a rearrangement of the c-myc gene. EBV was identified in 2 SNCC lymphomas, but not in the other histological subtypes. Only 2 SNCC lymphomas carried a mutated p53. These findings suggest that the spectrum of lymphoma subtypes is broader in a pediatric HIV population compared to that seen in non-immunosuppressed children.
Keywords: Blotting, Southern Child Chromosome Aberrations Gene Expression Regulation, Neoplastic/PHYSIOLOGY Human Lymphoma, AIDS-Related/CLASSIFICATION/GENETICS/*PATHOLOGY Neoplasm Staging Tumor Markers, Biological/GENETICS ABSTRACTKWDblotting,southernchildchromosomeaberrationsgeneexpressionregulation,neoplastic/physiologyhumanlymphoma,aids-related/classification/genetics/KWDpathologyneoplasmstagingtumormarkers,biological/geneticsabstract
941230
M94C4331

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